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The map label for this gene is acsA [H]

Identifier: 54026122

GI number: 54026122

Start: 4298761

End: 4300410

Strand: Reverse

Name: acsA [H]

Synonym: nfa41510

Alternate gene names: 54026122

Gene position: 4300410-4298761 (Counterclockwise)

Preceding gene: 54026125

Following gene: 54026121

Centisome position: 71.42

GC content: 72.67

Gene sequence:

>1650_bases
ATGACGATCGACGTGGACGCACGGGTGCGTGAGTTCCTGGACACCTACGACGGACCCGACGCCTGCGCCGCGGAACTGCT
GTGCGACCGGCACCCCGCGGACGCGGTCGCCTTCACGGTGATCGAGTCGGATCTGTCCTCGACCGACCTCACCTACGGTG
AGCTGCGCGAGCGATCCGCACGGTTCGCCGCGGCGCTCGCCGGTCTCGGCGTCGGCCCGGGTGATCGGGTCGCCACGCTG
ATGGCCAAGTCCGCGGACCTGGTGGTCGCGCTGCTGGGCATCTGGCGGCGCGGCGCGGTGCACGTGCCGCTGTTCACCGC
CTTCGCCCCGCCCGCGATCGCGCTGCGGCTGGACGCGAGCCGCACGGTGGCGGTGATCGCCGACGCCGATCAGGCCGCCA
AGCTGCTGCCGGGTGAGGACATCCCGACCGAGGTCCCGTGGCGGCTGATCGTCGCCGGTCAGGTCCCCGAGTCGCTGGCC
GTGCGCGAGCCGCTGCGCTTCGCCGAGCTGCTGGAGTCCTACGACGCCGACGACCCGCGGGGCGCGGCCGTCGCGGTCGG
CGGTGACGGGCTGCTGGTGCAGCTGTTCACCAGTGGTACCACCGGCACGCCGAAGGGCGTCCCGATTCCGGTGCGCGCGC
TGGCCTCGTTCCACGCCTACCAGGAGTTCGCCCTCGACGTGCGCCCGGACGACGTGTTCTGGAACGCCGCCGACCCGGGC
TGGGCCTACGGCCTCTACTACGCGATCCTGGCGCCGCTGGCCGCCGGCACCCGCAGCCTGCTGCTGCACGCCGGGTTCTC
GCCCGCGCTGACCTGGCAGGTGCTGGAGAAGTTCGGCGTCACCAACTTCGCCGCCGCCCCCACCGTGTACCGGGCGCTGC
GCTCCGACGACGGGCCCGCGCCCGCCGGTATCTCGCTGCGCCGGGCGTCCTCGGCGGGCGAACCGCTCACCCCGGAGGTG
GTGGCCTGGTCCGCGCGCACCCTCGGTGTGCCGGTGCGCGACCACTACGGGCAGACCGAGCACGGCATGGTCATCTGCAA
CGCCTGGCACGACCAGCTGAACGCGGCCGCGCCGCTGGGCTCGATGGGCCGCCAGCTGCCGGGCTGGACCTGCGCGGTGC
TCTCCGACACCGCCGACGTCGAGGCCGCCCCCGGCGAGCTTGGCAGGCTGGCCATCGACACCACCCGCAGCCCGCTGATG
TGGTTCCTCGGCTACCTCGACGCCCCCGAGCGCACCGCGCAACGCTTCACCGCCGACGGCCGCTGGTACCTGACCGGTGA
CGCCGGCTCCCGCGACGCCGACGGCTTCTTCACCTTCTCGGCCCGCGACGACGACGTCATCATCATGGCCGGGTACCGCA
TCGGCCCGTTCGAGGTCGAGAGCGTGCTGGTGATGCACGACGACGTCGCCGAGGCCGCCGTGGTCGGCCTGCCCGACGAA
CTGCGCGGCGAGGTGCTCGAGGCGTTCGTGGTGCTGCGCTCCGGCGTCGACGGCAGCGCGGAGCTCGCCGCGGAGCTGCA
GCAGTTGGTGAAGCAGAAGTTCGCGGCGCACGCCTACCCGCGCCGCGTGCATTTCGTGGACAGTCTGCCCAAGACGCCCA
GTGGCAAGGTGCAGCGTTTCGTGCTGCGCGAACAGGAGGCCAAGCGATGA

Upstream 100 bases:

>100_bases
GTCAAGGGTTTCACCCCTTTTCGGGGGTAGTCGTCAACGTGATCCGACCCACATTCTATTCGACACCGGGGAGCTGGATC
ACCGAGGAGGAGAGAGCACG

Downstream 100 bases:

>100_bases
CGACGGCGACAACGACGACGGCGACGAGAGCACTGCCGAGTTATGACTCCGGCCCGTCTCCCACCCCGCTGCTCGGCGAC
ACGATCGGCGCGAACCTCGA

Product: putative acyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acetyl-CoA synthase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MTIDVDARVREFLDTYDGPDACAAELLCDRHPADAVAFTVIESDLSSTDLTYGELRERSARFAAALAGLGVGPGDRVATL
MAKSADLVVALLGIWRRGAVHVPLFTAFAPPAIALRLDASRTVAVIADADQAAKLLPGEDIPTEVPWRLIVAGQVPESLA
VREPLRFAELLESYDADDPRGAAVAVGGDGLLVQLFTSGTTGTPKGVPIPVRALASFHAYQEFALDVRPDDVFWNAADPG
WAYGLYYAILAPLAAGTRSLLLHAGFSPALTWQVLEKFGVTNFAAAPTVYRALRSDDGPAPAGISLRRASSAGEPLTPEV
VAWSARTLGVPVRDHYGQTEHGMVICNAWHDQLNAAAPLGSMGRQLPGWTCAVLSDTADVEAAPGELGRLAIDTTRSPLM
WFLGYLDAPERTAQRFTADGRWYLTGDAGSRDADGFFTFSARDDDVIIMAGYRIGPFEVESVLVMHDDVAEAAVVGLPDE
LRGEVLEAFVVLRSGVDGSAELAAELQQLVKQKFAAHAYPRRVHFVDSLPKTPSGKVQRFVLREQEAKR

Sequences:

>Translated_549_residues
MTIDVDARVREFLDTYDGPDACAAELLCDRHPADAVAFTVIESDLSSTDLTYGELRERSARFAAALAGLGVGPGDRVATL
MAKSADLVVALLGIWRRGAVHVPLFTAFAPPAIALRLDASRTVAVIADADQAAKLLPGEDIPTEVPWRLIVAGQVPESLA
VREPLRFAELLESYDADDPRGAAVAVGGDGLLVQLFTSGTTGTPKGVPIPVRALASFHAYQEFALDVRPDDVFWNAADPG
WAYGLYYAILAPLAAGTRSLLLHAGFSPALTWQVLEKFGVTNFAAAPTVYRALRSDDGPAPAGISLRRASSAGEPLTPEV
VAWSARTLGVPVRDHYGQTEHGMVICNAWHDQLNAAAPLGSMGRQLPGWTCAVLSDTADVEAAPGELGRLAIDTTRSPLM
WFLGYLDAPERTAQRFTADGRWYLTGDAGSRDADGFFTFSARDDDVIIMAGYRIGPFEVESVLVMHDDVAEAAVVGLPDE
LRGEVLEAFVVLRSGVDGSAELAAELQQLVKQKFAAHAYPRRVHFVDSLPKTPSGKVQRFVLREQEAKR
>Mature_548_residues
TIDVDARVREFLDTYDGPDACAAELLCDRHPADAVAFTVIESDLSSTDLTYGELRERSARFAAALAGLGVGPGDRVATLM
AKSADLVVALLGIWRRGAVHVPLFTAFAPPAIALRLDASRTVAVIADADQAAKLLPGEDIPTEVPWRLIVAGQVPESLAV
REPLRFAELLESYDADDPRGAAVAVGGDGLLVQLFTSGTTGTPKGVPIPVRALASFHAYQEFALDVRPDDVFWNAADPGW
AYGLYYAILAPLAAGTRSLLLHAGFSPALTWQVLEKFGVTNFAAAPTVYRALRSDDGPAPAGISLRRASSAGEPLTPEVV
AWSARTLGVPVRDHYGQTEHGMVICNAWHDQLNAAAPLGSMGRQLPGWTCAVLSDTADVEAAPGELGRLAIDTTRSPLMW
FLGYLDAPERTAQRFTADGRWYLTGDAGSRDADGFFTFSARDDDVIIMAGYRIGPFEVESVLVMHDDVAEAAVVGLPDEL
RGEVLEAFVVLRSGVDGSAELAAELQQLVKQKFAAHAYPRRVHFVDSLPKTPSGKVQRFVLREQEAKR

Specific function: Has a role in growth and sporulation on acetate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=522, Percent_Identity=34.6743295019157, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI122937307, Length=508, Percent_Identity=34.8425196850394, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI58082049, Length=521, Percent_Identity=32.6295585412668, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38505220, Length=523, Percent_Identity=34.0344168260038, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI157311624, Length=521, Percent_Identity=32.2456813819578, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI157311622, Length=521, Percent_Identity=32.2456813819578, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI115511026, Length=506, Percent_Identity=31.2252964426877, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI28416953, Length=539, Percent_Identity=31.1688311688312, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI8923896, Length=556, Percent_Identity=30.0359712230216, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI253970489, Length=560, Percent_Identity=30, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI13375727, Length=546, Percent_Identity=30.5860805860806, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI187761345, Length=531, Percent_Identity=27.683615819209, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI187761343, Length=531, Percent_Identity=27.683615819209, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI42544134, Length=347, Percent_Identity=29.1066282420749, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI156151445, Length=536, Percent_Identity=24.4402985074627, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI195947378, Length=411, Percent_Identity=25.3041362530414, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1790505, Length=560, Percent_Identity=33.2142857142857, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI1786529, Length=546, Percent_Identity=30.7692307692308, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI145693145, Length=510, Percent_Identity=28.8235294117647, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1788107, Length=529, Percent_Identity=27.0321361058601, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI221142682, Length=498, Percent_Identity=26.1044176706827, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786810, Length=551, Percent_Identity=26.6787658802178, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786801, Length=440, Percent_Identity=25, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71983001, Length=535, Percent_Identity=31.7757009345794, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI71982997, Length=535, Percent_Identity=31.7757009345794, Blast_Score=201, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI17558820, Length=521, Percent_Identity=26.4875239923225, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32563687, Length=503, Percent_Identity=26.2425447316103, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17557194, Length=554, Percent_Identity=24.7292418772563, Blast_Score=128, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17538037, Length=537, Percent_Identity=25.512104283054, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17531443, Length=562, Percent_Identity=23.6654804270463, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71996755, Length=508, Percent_Identity=24.6062992125984, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17559526, Length=383, Percent_Identity=26.6318537859008, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71985884, Length=385, Percent_Identity=28.3116883116883, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71994690, Length=363, Percent_Identity=24.7933884297521, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994694, Length=363, Percent_Identity=24.7933884297521, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994703, Length=363, Percent_Identity=24.7933884297521, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560140, Length=215, Percent_Identity=31.1627906976744, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560308, Length=360, Percent_Identity=25.5555555555556, Blast_Score=82, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6323182, Length=559, Percent_Identity=28.8014311270125, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6319264, Length=532, Percent_Identity=29.6992481203008, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6319699, Length=538, Percent_Identity=26.2081784386617, Blast_Score=150, Evalue=5e-37,
Organism=Drosophila melanogaster, GI62472339, Length=552, Percent_Identity=29.5289855072464, Blast_Score=201, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24667955, Length=552, Percent_Identity=29.5289855072464, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI21355225, Length=520, Percent_Identity=29.8076923076923, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24667959, Length=515, Percent_Identity=28.5436893203883, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI24581924, Length=534, Percent_Identity=27.9026217228464, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI19922652, Length=536, Percent_Identity=25.5597014925373, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24656500, Length=535, Percent_Identity=26.9158878504673, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI18859661, Length=523, Percent_Identity=27.151051625239, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24648257, Length=519, Percent_Identity=26.5895953757225, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24648260, Length=515, Percent_Identity=26.0194174757282, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21356441, Length=540, Percent_Identity=22.962962962963, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21355181, Length=521, Percent_Identity=25.7197696737044, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI20130357, Length=375, Percent_Identity=28, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356947, Length=358, Percent_Identity=27.3743016759777, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24653035, Length=363, Percent_Identity=23.9669421487603, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI161076582, Length=373, Percent_Identity=23.5924932975871, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 58885; Mature: 58754

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDVDARVREFLDTYDGPDACAAELLCDRHPADAVAFTVIESDLSSTDLTYGELRERSA
CEECCHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHEEEEEECCCCCCCCCCHHHHHHHHH
RFAAALAGLGVGPGDRVATLMAKSADLVVALLGIWRRGAVHVPLFTAFAPPAIALRLDAS
HHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCEECEEHHCCCCCEEEEEECCC
RTVAVIADADQAAKLLPGEDIPTEVPWRLIVAGQVPESLAVREPLRFAELLESYDADDPR
CEEEEEECCCHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHCHHHHHHHHHHCCCCCCC
GAAVAVGGDGLLVQLFTSGTTGTPKGVPIPVRALASFHAYQEFALDVRPDDVFWNAADPG
CCEEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCEEEECCCCC
WAYGLYYAILAPLAAGTRSLLLHAGFSPALTWQVLEKFGVTNFAAAPTVYRALRSDDGPA
HHHHHHHHHHHHHHCCCHHEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
PAGISLRRASSAGEPLTPEVVAWSARTLGVPVRDHYGQTEHGMVICNAWHDQLNAAAPLG
CCCCEEEECCCCCCCCCCHHEEECCHHCCCCHHHHCCCCCCCEEEEECCHHHHHHCCCHH
SMGRQLPGWTCAVLSDTADVEAAPGELGRLAIDTTRSPLMWFLGYLDAPERTAQRFTADG
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHCCCC
RWYLTGDAGSRDADGFFTFSARDDDVIIMAGYRIGPFEVESVLVMHDDVAEAAVVGLPDE
CEEEECCCCCCCCCCEEEEECCCCCEEEEECCEECCEEEEEEEEEECCHHHHHEECCCHH
LRGEVLEAFVVLRSGVDGSAELAAELQQLVKQKFAAHAYPRRVHFVDSLPKTPSGKVQRF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCCCCCCHHHHHH
VLREQEAKR
HHHHHHHCC
>Mature Secondary Structure 
TIDVDARVREFLDTYDGPDACAAELLCDRHPADAVAFTVIESDLSSTDLTYGELRERSA
EECCHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHEEEEEECCCCCCCCCCHHHHHHHHH
RFAAALAGLGVGPGDRVATLMAKSADLVVALLGIWRRGAVHVPLFTAFAPPAIALRLDAS
HHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCEECEEHHCCCCCEEEEEECCC
RTVAVIADADQAAKLLPGEDIPTEVPWRLIVAGQVPESLAVREPLRFAELLESYDADDPR
CEEEEEECCCHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHCHHHHHHHHHHCCCCCCC
GAAVAVGGDGLLVQLFTSGTTGTPKGVPIPVRALASFHAYQEFALDVRPDDVFWNAADPG
CCEEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCEEEECCCCC
WAYGLYYAILAPLAAGTRSLLLHAGFSPALTWQVLEKFGVTNFAAAPTVYRALRSDDGPA
HHHHHHHHHHHHHHCCCHHEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
PAGISLRRASSAGEPLTPEVVAWSARTLGVPVRDHYGQTEHGMVICNAWHDQLNAAAPLG
CCCCEEEECCCCCCCCCCHHEEECCHHCCCCHHHHCCCCCCCEEEEECCHHHHHHCCCHH
SMGRQLPGWTCAVLSDTADVEAAPGELGRLAIDTTRSPLMWFLGYLDAPERTAQRFTADG
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHCCCC
RWYLTGDAGSRDADGFFTFSARDDDVIIMAGYRIGPFEVESVLVMHDDVAEAAVVGLPDE
CEEEECCCCCCCCCCEEEEECCCCCEEEEECCEECCEEEEEEEEEECCHHHHHEECCCHH
LRGEVLEAFVVLRSGVDGSAELAAELQQLVKQKFAAHAYPRRVHFVDSLPKTPSGKVQRF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCCCCCCHHHHHH
VLREQEAKR
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]