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The map label for this gene is fdh [H]

Identifier: 54026079

GI number: 54026079

Start: 4258059

End: 4259228

Strand: Reverse

Name: fdh [H]

Synonym: nfa41080

Alternate gene names: 54026079

Gene position: 4259228-4258059 (Counterclockwise)

Preceding gene: 54026080

Following gene: 54026078

Centisome position: 70.74

GC content: 69.15

Gene sequence:

>1170_bases
ATGCGCGCACTGTGCTGGAACGGCGTCAACGACCTCGCCGTCGAAACCGTGGAGGACCCCAGGCTGGTCAACCCGCACGA
CGTGATCGTGCGCGTGCGGCTGACCACCACCTGCGGCTCCGACCTGCACTTCATCGACGGCTACCTGCCGGGGATGCGGG
CGGGCGACGTGTTCGGCCACGAGTTCATGGGCGAGATCGTCGAGGTCGGCCGGGAGGTCCGCGACCGCAAGGTCGGCGAC
CGGGTGGTGGTGCCCTCCTTCATCGGCTGCGGCACCTGCTTCTACTGCACCCGCGACATGTACTCGCTGTGCGACACCAC
CAACCCCAACGCCGAACTGCAACAACCGGTGTTCGGTTATCCGACCGGCGGCATCTACGGCTACACCCACCCGTTCGGCG
GCTATCAGGGCTCGCACGCGGAGTACGTCCGGGTGCCGTTCGGCGATGTGAACAGCTTCGTCGTGCCCGAGGGCATCACC
GACGAGCAGGCGCTGTTCGTCTCCGACGCGGTGCCGACCGGGCTGATGGGTGCCGACTTCTGCGACATCGCCCCCGGCGA
CACCGTCGCGGTGTGGGGCAGCGGCGGCGTCGGCCTGATGGCCGGGCACACCGCGCGCCTGCTCGGTGCGGGCCGGGTCG
TCGTGATCGATCGCATCCCGGAGCGACTCGCCTTGGCGCGCAAGCACTTCGACGCCGAGACCATCGACTACACCGCGGTG
GACAGCGTCCAGGAGGCGCTGCGGGAGATGACCGGCGGCCGCGGGCCCGACGCCTGCATCGACGCGGTCGGCATGGAGGG
CCACGGCACCGGATTGCAGCAGATCTACGACCGCGCCAAGCAGTTGCTGCGGCTCGAGACCGACCGGGCCACTCCGCTGC
GCGAGGCGATCCTGGCCTGCCGCAAGGGCGGTGTGGTCGCGGTGCTCGGCATCTACGGGCTCACCGACAAGTTCCCGATG
GGCGTGGTCACCAACAAGGGCCTGACCATCCGCACCGCCCAGCAGCACGGGCAGCGGTACGTGCCGCGCATGTTCGACCA
CATCCTGCAGGGCGACCTCGATCCCTCCTACCTCGTCACGCACGACCTGTCGCTCGAGGACGGGCCGCGCGGCTACGAGG
TGTTCAAGAACAAGGACGAGGGGTGTGTCCGCGCGGTGTTCCGGCCGTGA

Upstream 100 bases:

>100_bases
GGTGCTCTACCGGGCGCGTGCCCTGCTGCAGACCGGTGAACTGCCCACCCTCGCCCACAACCCGAGCGCGCGTGCGGGCG
CGCGCTGAACAGGAGACGAG

Downstream 100 bases:

>100_bases
GGCGCGTGAGCGCGGCCGGCCCGGGTAACCGTCCGGTATGACCGAACCCGAACACACCGAGCCCGAACGTCCCGGTTCCG
CGGAACGACCCGCCGACCGC

Product: putative dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MRALCWNGVNDLAVETVEDPRLVNPHDVIVRVRLTTTCGSDLHFIDGYLPGMRAGDVFGHEFMGEIVEVGREVRDRKVGD
RVVVPSFIGCGTCFYCTRDMYSLCDTTNPNAELQQPVFGYPTGGIYGYTHPFGGYQGSHAEYVRVPFGDVNSFVVPEGIT
DEQALFVSDAVPTGLMGADFCDIAPGDTVAVWGSGGVGLMAGHTARLLGAGRVVVIDRIPERLALARKHFDAETIDYTAV
DSVQEALREMTGGRGPDACIDAVGMEGHGTGLQQIYDRAKQLLRLETDRATPLREAILACRKGGVVAVLGIYGLTDKFPM
GVVTNKGLTIRTAQQHGQRYVPRMFDHILQGDLDPSYLVTHDLSLEDGPRGYEVFKNKDEGCVRAVFRP

Sequences:

>Translated_389_residues
MRALCWNGVNDLAVETVEDPRLVNPHDVIVRVRLTTTCGSDLHFIDGYLPGMRAGDVFGHEFMGEIVEVGREVRDRKVGD
RVVVPSFIGCGTCFYCTRDMYSLCDTTNPNAELQQPVFGYPTGGIYGYTHPFGGYQGSHAEYVRVPFGDVNSFVVPEGIT
DEQALFVSDAVPTGLMGADFCDIAPGDTVAVWGSGGVGLMAGHTARLLGAGRVVVIDRIPERLALARKHFDAETIDYTAV
DSVQEALREMTGGRGPDACIDAVGMEGHGTGLQQIYDRAKQLLRLETDRATPLREAILACRKGGVVAVLGIYGLTDKFPM
GVVTNKGLTIRTAQQHGQRYVPRMFDHILQGDLDPSYLVTHDLSLEDGPRGYEVFKNKDEGCVRAVFRP
>Mature_389_residues
MRALCWNGVNDLAVETVEDPRLVNPHDVIVRVRLTTTCGSDLHFIDGYLPGMRAGDVFGHEFMGEIVEVGREVRDRKVGD
RVVVPSFIGCGTCFYCTRDMYSLCDTTNPNAELQQPVFGYPTGGIYGYTHPFGGYQGSHAEYVRVPFGDVNSFVVPEGIT
DEQALFVSDAVPTGLMGADFCDIAPGDTVAVWGSGGVGLMAGHTARLLGAGRVVVIDRIPERLALARKHFDAETIDYTAV
DSVQEALREMTGGRGPDACIDAVGMEGHGTGLQQIYDRAKQLLRLETDRATPLREAILACRKGGVVAVLGIYGLTDKFPM
GVVTNKGLTIRTAQQHGQRYVPRMFDHILQGDLDPSYLVTHDLSLEDGPRGYEVFKNKDEGCVRAVFRP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501929, Length=394, Percent_Identity=25.3807106598985, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI71565152, Length=273, Percent_Identity=26.3736263736264, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI71565154, Length=388, Percent_Identity=23.7113402061856, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1786825, Length=393, Percent_Identity=39.9491094147583, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI1787863, Length=391, Percent_Identity=24.8081841432225, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788073, Length=368, Percent_Identity=24.4565217391304, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790045, Length=362, Percent_Identity=26.7955801104972, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87082125, Length=292, Percent_Identity=28.7671232876712, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI226510992, Length=241, Percent_Identity=26.5560165975104, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788075, Length=362, Percent_Identity=22.9281767955801, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786552, Length=375, Percent_Identity=25.0666666666667, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081918, Length=239, Percent_Identity=28.4518828451883, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=386, Percent_Identity=25.3886010362694, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=266, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=391, Percent_Identity=25.5754475703325, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=393, Percent_Identity=25.4452926208651, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323099, Length=385, Percent_Identity=22.0779220779221, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=406, Percent_Identity=24.8768472906404, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=291, Percent_Identity=27.1477663230241, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137530, Length=397, Percent_Identity=23.1738035264484, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17737895, Length=403, Percent_Identity=24.317617866005, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17737897, Length=395, Percent_Identity=22.5316455696203, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42405; Mature: 42405

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALCWNGVNDLAVETVEDPRLVNPHDVIVRVRLTTTCGSDLHFIDGYLPGMRAGDVFGH
CCCCCCCCCCHHEEEECCCCCCCCCCCEEEEEEEEECCCCCCHHHHCCCCCCCCCCHHHH
EFMGEIVEVGREVRDRKVGDRVVVPSFIGCGTCFYCTRDMYSLCDTTNPNAELQQPVFGY
HHHHHHHHHHHHHHHHHCCCEEECCCHHCCCHHHHHHHHHHHHHCCCCCCCHHCCCCCCC
PTGGIYGYTHPFGGYQGSHAEYVRVPFGDVNSFVVPEGITDEQALFVSDAVPTGLMGADF
CCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEECCCCCCCCCEEEEECCCCCCCCCCCC
CDIAPGDTVAVWGSGGVGLMAGHTARLLGAGRVVVIDRIPERLALARKHFDAETIDYTAV
CCCCCCCEEEEECCCCEEEECCCHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCCCHHHH
DSVQEALREMTGGRGPDACIDAVGMEGHGTGLQQIYDRAKQLLRLETDRATPLREAILAC
HHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
RKGGVVAVLGIYGLTDKFPMGVVTNKGLTIRTAQQHGQRYVPRMFDHILQGDLDPSYLVT
CCCCEEEEEEECCCCCCCCCCEEECCCEEEEEHHHCCCHHHHHHHHHHHHCCCCCCEEEE
HDLSLEDGPRGYEVFKNKDEGCVRAVFRP
EECCCCCCCCCHHHHCCCCCCHHHEECCC
>Mature Secondary Structure
MRALCWNGVNDLAVETVEDPRLVNPHDVIVRVRLTTTCGSDLHFIDGYLPGMRAGDVFGH
CCCCCCCCCCHHEEEECCCCCCCCCCCEEEEEEEEECCCCCCHHHHCCCCCCCCCCHHHH
EFMGEIVEVGREVRDRKVGDRVVVPSFIGCGTCFYCTRDMYSLCDTTNPNAELQQPVFGY
HHHHHHHHHHHHHHHHHCCCEEECCCHHCCCHHHHHHHHHHHHHCCCCCCCHHCCCCCCC
PTGGIYGYTHPFGGYQGSHAEYVRVPFGDVNSFVVPEGITDEQALFVSDAVPTGLMGADF
CCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEECCCCCCCCCEEEEECCCCCCCCCCCC
CDIAPGDTVAVWGSGGVGLMAGHTARLLGAGRVVVIDRIPERLALARKHFDAETIDYTAV
CCCCCCCEEEEECCCCEEEECCCHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCCCHHHH
DSVQEALREMTGGRGPDACIDAVGMEGHGTGLQQIYDRAKQLLRLETDRATPLREAILAC
HHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
RKGGVVAVLGIYGLTDKFPMGVVTNKGLTIRTAQQHGQRYVPRMFDHILQGDLDPSYLVT
CCCCEEEEEEECCCCCCCCCCEEECCCEEEEEHHHCCCHHHHHHHHHHHHCCCCCCEEEE
HDLSLEDGPRGYEVFKNKDEGCVRAVFRP
EECCCCCCCCCHHHHCCCCCCHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]