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The map label for this gene is dapA [H]

Identifier: 54025839

GI number: 54025839

Start: 4084572

End: 4085480

Strand: Reverse

Name: dapA [H]

Synonym: nfa38690

Alternate gene names: 54025839

Gene position: 4085480-4084572 (Counterclockwise)

Preceding gene: 54025841

Following gene: 54025838

Centisome position: 67.85

GC content: 68.87

Gene sequence:

>909_bases
ATGACGAACGGTGAATCGACGCCAACGGAGCTGCGTGCGTCCGGCACGGTAGGTGTCGCGATGGTGACCCCCTTCAGTGC
CGACGGCAAGCTGGATGTCGACGCCGGGGTATCGCTGGCCGCCCATCTCGTCGACCGCGGCGTCGACCTGCTCGCCATCT
CCGGCACCACCGGCGAGTCGCCGACCACCACCGAGTCGGAGAAGTTCGATCTGCTGCACGCCGTCGTCGACGCCGTCGGC
GATCGCGCCACCGTCATCGCGGGCGCGGGCACCTATGACACCGCCCACTCCATCGAGCTGGCCCGCAACGCCGAGCGCGC
GGGCGCGCACGGCCTGCTCGTCGTCACCCCGTACTACTCCCGGCCGAGCCAGGACGGCCTCTACGCGCACTTCACCGCCG
TCGCCGATGCGACCGATCTGCCGGTGACGCTCTACGACATTCCACCCAGATCGATCATTCCGATCGGCCCCGAAACCCTG
CGCAGGCTCGCCGACCACCCGCGCATCGTCGCGGTGAAGGACGCCAAGGGCGACCTCAACTCCGGCGCGGACATCATCGC
GCACACCAGCCTGGACTACTACTCCGGCGACGACTGCCTCAACCTGCCTTGGCTGTCCATCGGCGCGGTGGGCTTCATCA
GCGTGATCGGTCACCTGGTCCCCGAGCGGCTCCGGGAGATGTACGACGCCTTCGTCGCCGGTGACGTGGTGCGCGCCCGC
GAGATCAACGCGAGCCTGGTGCCGTTGAACGCCGCGATGGCCCGCCTCGGCGGCGTGTCCATGACCAAGGCCGGTTTGCG
CCTGCTCGGCATCGACGTGGGCGAGCCCCGGCTGCCGCAGCTCATGCCCAACACCGCCCAACTCGATCAGCTGTCCGCGG
ATCTGCGGACAGCGGGGGTTCTCGTATGA

Upstream 100 bases:

>100_bases
GTCATTTCGATGTCGGTCCGTCGCCGGGCGGCTCGGCGTCCGGCGTGTAGGGCGGTCACGGTGTCGAGGGCGCGCAGGGG
ACCGGGTAGCCTTTCTGACC

Downstream 100 bases:

>100_bases
CCACACCGCGCCGTCCCCGCCGCACGGCGAGCCGCCCCGCGGGCGCGCCCGACCCGGCCGAACAACGCCGCGCCGCCGAA
GCCGCCGCCGAGCGTGCGGA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTNGESTPTELRASGTVGVAMVTPFSADGKLDVDAGVSLAAHLVDRGVDLLAISGTTGESPTTTESEKFDLLHAVVDAVG
DRATVIAGAGTYDTAHSIELARNAERAGAHGLLVVTPYYSRPSQDGLYAHFTAVADATDLPVTLYDIPPRSIIPIGPETL
RRLADHPRIVAVKDAKGDLNSGADIIAHTSLDYYSGDDCLNLPWLSIGAVGFISVIGHLVPERLREMYDAFVAGDVVRAR
EINASLVPLNAAMARLGGVSMTKAGLRLLGIDVGEPRLPQLMPNTAQLDQLSADLRTAGVLV

Sequences:

>Translated_302_residues
MTNGESTPTELRASGTVGVAMVTPFSADGKLDVDAGVSLAAHLVDRGVDLLAISGTTGESPTTTESEKFDLLHAVVDAVG
DRATVIAGAGTYDTAHSIELARNAERAGAHGLLVVTPYYSRPSQDGLYAHFTAVADATDLPVTLYDIPPRSIIPIGPETL
RRLADHPRIVAVKDAKGDLNSGADIIAHTSLDYYSGDDCLNLPWLSIGAVGFISVIGHLVPERLREMYDAFVAGDVVRAR
EINASLVPLNAAMARLGGVSMTKAGLRLLGIDVGEPRLPQLMPNTAQLDQLSADLRTAGVLV
>Mature_301_residues
TNGESTPTELRASGTVGVAMVTPFSADGKLDVDAGVSLAAHLVDRGVDLLAISGTTGESPTTTESEKFDLLHAVVDAVGD
RATVIAGAGTYDTAHSIELARNAERAGAHGLLVVTPYYSRPSQDGLYAHFTAVADATDLPVTLYDIPPRSIIPIGPETLR
RLADHPRIVAVKDAKGDLNSGADIIAHTSLDYYSGDDCLNLPWLSIGAVGFISVIGHLVPERLREMYDAFVAGDVVRARE
INASLVPLNAAMARLGGVSMTKAGLRLLGIDVGEPRLPQLMPNTAQLDQLSADLRTAGVLV

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=289, Percent_Identity=25.9515570934256, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI13540533, Length=293, Percent_Identity=27.3037542662116, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1788823, Length=286, Percent_Identity=34.965034965035, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI87082415, Length=285, Percent_Identity=29.1228070175439, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1786463, Length=269, Percent_Identity=30.4832713754647, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789620, Length=237, Percent_Identity=29.957805907173, Blast_Score=92, Evalue=5e-20,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31685; Mature: 31554

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNGESTPTELRASGTVGVAMVTPFSADGKLDVDAGVSLAAHLVDRGVDLLAISGTTGES
CCCCCCCCCCEECCCCEEEEEEECCCCCCCEECCCCHHHHHHHHHCCCEEEEEECCCCCC
PTTTESEKFDLLHAVVDAVGDRATVIAGAGTYDTAHSIELARNAERAGAHGLLVVTPYYS
CCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCHHHCCCCEEEEEECCCC
RPSQDGLYAHFTAVADATDLPVTLYDIPPRSIIPIGPETLRRLADHPRIVAVKDAKGDLN
CCCCCCCEEEEEEECCCCCCCEEEEECCCCCEEECCHHHHHHHHCCCCEEEEECCCCCCC
SGADIIAHTSLDYYSGDDCLNLPWLSIGAVGFISVIGHLVPERLREMYDAFVAGDVVRAR
CCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHE
EINASLVPLNAAMARLGGVSMTKAGLRLLGIDVGEPRLPQLMPNTAQLDQLSADLRTAGV
ECCCEEEEHHHHHHHHCCCHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCC
LV
CC
>Mature Secondary Structure 
TNGESTPTELRASGTVGVAMVTPFSADGKLDVDAGVSLAAHLVDRGVDLLAISGTTGES
CCCCCCCCCEECCCCEEEEEEECCCCCCCEECCCCHHHHHHHHHCCCEEEEEECCCCCC
PTTTESEKFDLLHAVVDAVGDRATVIAGAGTYDTAHSIELARNAERAGAHGLLVVTPYYS
CCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCHHHCCCCEEEEEECCCC
RPSQDGLYAHFTAVADATDLPVTLYDIPPRSIIPIGPETLRRLADHPRIVAVKDAKGDLN
CCCCCCCEEEEEEECCCCCCCEEEEECCCCCEEECCHHHHHHHHCCCCEEEEECCCCCCC
SGADIIAHTSLDYYSGDDCLNLPWLSIGAVGFISVIGHLVPERLREMYDAFVAGDVVRAR
CCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHE
EINASLVPLNAAMARLGGVSMTKAGLRLLGIDVGEPRLPQLMPNTAQLDQLSADLRTAGV
ECCCEEEEHHHHHHHHCCCHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCC
LV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA