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The map label for this gene is pyrC [H]

Identifier: 54025592

GI number: 54025592

Start: 3835067

End: 3836380

Strand: Reverse

Name: pyrC [H]

Synonym: nfa36220

Alternate gene names: 54025592

Gene position: 3836380-3835067 (Counterclockwise)

Preceding gene: 54025593

Following gene: 54025591

Centisome position: 63.71

GC content: 72.22

Gene sequence:

>1314_bases
ATGAGTGGACTGTTGATCAAGGGCGCCGTCCTCTACGGCGAGGGTGAGCCGGTCGACGTCTTCGTCGACGAGGGCGAGAT
CCGCCAGATCGGCACGGACCTGGGCGTGGTGGACGCCGAGATCGTCGAGGCGCGCGGCCAGGTGCTGCTGCCCGGCTTCG
TCGATCTGCACACCCACCTGCGCGAGCCCGGCCGCGAGGACACCGAGACCATCGAGACGGGCTCGGCCGCGGCCGCACTG
GGCGGCTACACCGCGGTGTTCGCGATGGCGAACACCAACCCGGTGGCCGACTCGGTGGTCGTCACCGACCATGTGTGGCG
GCGCGGTCAGGAGGTCGGGCTGGTCGACGTGCACCCGGTGGGCGCGGTGACGGTCGGACTGGCGGGCAAGCAACTGGCCG
AGATGGGCACGATGGCCGCCGGGGTCGGCGGGGTGCGGATGTTCTCCGACGACGGGCACTGCGTCTACGACCCGCTGATC
ATGCGCCGCGCGCTGGAGTACTCGAACTCCCTCGGCGTGCTGATCGCCCAGCACGCCGAGGAGCCGCGACTGACCAAGGG
CGCGGTCGCCCACGAGGGCCCGACGGCGGCGCGCCTGGGGCTCGCGGGCTGGCCGCGCGCGGCCGAGGAGTCCATCGTGG
CCCGCGACGCGCTGCTGGCCCGGGACGCGGGCGCGCGCGTGCACATCTGCCACGCCTCCACCGCGGGCACCGTCGAGCTG
GTGAAATGGGCCAAGGCGCAAGGTATTTCGATCACCGCCGAGGTCACCCCGCACCACCTGCTGCTGGACGACTCGCGACT
GGAGACCTACGACGCGGTCAACAAGGTGAACCCGCCGCTGCGGGAGGCCTCCGACACGGCGGCTCTGCGCGCGGCGCTGG
CCGAGGGCATCATCGATTGCGTCGCCACCGACCACGCCCCGCATGCCGAGCAGGACAAGTGCTGCGAGTTCGCCGCCGCC
CGCCCCGGCATGCTCGGTCTGGAGACCGCCCTGTCGATCGTCGTCGAGACGATGGTGCGGCCCGGGCTGCTGGACTGGCG
GGGAGTGGCGCGGGTGATGAGCGAGCGGCCCGCCGAGATCGTCGGCCTCGACGACCAGGGCCGTCCGATCGCGGTCGGCG
AGCCCGCCAACCTGGTGCTGGTGGATCCGGACGCGACCTGGACGGTGCGCGCGAGCGAGCTGGCCAGCATCTCGAACAAC
ACCCCGTTCGAGGAGATGACCTTCCCGGCCAGGGTGACCATGACACTGCTGCGCGGACGGATCACCGCCCGTGCCGGTCG
CGCGGCGCAGCCGCAGGGCGCGGGAGGTGCGTGA

Upstream 100 bases:

>100_bases
AACGGTGTGCACCTGCGGATGGCGGTGCTGTTCCGGCTGCTGGTCGGGGCGCAGGAGGCGATCGCGTGAACGGCGGGGCA
CACGACCGGGAGGAGCGGGC

Downstream 100 bases:

>100_bases
TGGAACGAACACTGTGGGTGCTGGGTTGCCTGGTGCTGTTCCTGCTCGGCCTGTGGCTGATGTACCGGGGGTGGCAGAAC
CGGGCCGCGCGCCAGGCCGA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MSGLLIKGAVLYGEGEPVDVFVDEGEIRQIGTDLGVVDAEIVEARGQVLLPGFVDLHTHLREPGREDTETIETGSAAAAL
GGYTAVFAMANTNPVADSVVVTDHVWRRGQEVGLVDVHPVGAVTVGLAGKQLAEMGTMAAGVGGVRMFSDDGHCVYDPLI
MRRALEYSNSLGVLIAQHAEEPRLTKGAVAHEGPTAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASTAGTVEL
VKWAKAQGISITAEVTPHHLLLDDSRLETYDAVNKVNPPLREASDTAALRAALAEGIIDCVATDHAPHAEQDKCCEFAAA
RPGMLGLETALSIVVETMVRPGLLDWRGVARVMSERPAEIVGLDDQGRPIAVGEPANLVLVDPDATWTVRASELASISNN
TPFEEMTFPARVTMTLLRGRITARAGRAAQPQGAGGA

Sequences:

>Translated_437_residues
MSGLLIKGAVLYGEGEPVDVFVDEGEIRQIGTDLGVVDAEIVEARGQVLLPGFVDLHTHLREPGREDTETIETGSAAAAL
GGYTAVFAMANTNPVADSVVVTDHVWRRGQEVGLVDVHPVGAVTVGLAGKQLAEMGTMAAGVGGVRMFSDDGHCVYDPLI
MRRALEYSNSLGVLIAQHAEEPRLTKGAVAHEGPTAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASTAGTVEL
VKWAKAQGISITAEVTPHHLLLDDSRLETYDAVNKVNPPLREASDTAALRAALAEGIIDCVATDHAPHAEQDKCCEFAAA
RPGMLGLETALSIVVETMVRPGLLDWRGVARVMSERPAEIVGLDDQGRPIAVGEPANLVLVDPDATWTVRASELASISNN
TPFEEMTFPARVTMTLLRGRITARAGRAAQPQGAGGA
>Mature_436_residues
SGLLIKGAVLYGEGEPVDVFVDEGEIRQIGTDLGVVDAEIVEARGQVLLPGFVDLHTHLREPGREDTETIETGSAAAALG
GYTAVFAMANTNPVADSVVVTDHVWRRGQEVGLVDVHPVGAVTVGLAGKQLAEMGTMAAGVGGVRMFSDDGHCVYDPLIM
RRALEYSNSLGVLIAQHAEEPRLTKGAVAHEGPTAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASTAGTVELV
KWAKAQGISITAEVTPHHLLLDDSRLETYDAVNKVNPPLREASDTAALRAALAEGIIDCVATDHAPHAEQDKCCEFAAAR
PGMLGLETALSIVVETMVRPGLLDWRGVARVMSERPAEIVGLDDQGRPIAVGEPANLVLVDPDATWTVRASELASISNNT
PFEEMTFPARVTMTLLRGRITARAGRAAQPQGAGGA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=403, Percent_Identity=29.2803970223325, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI19923821, Length=465, Percent_Identity=26.6666666666667, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4503375, Length=462, Percent_Identity=25.3246753246753, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI4503051, Length=456, Percent_Identity=24.1228070175439, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI62422571, Length=456, Percent_Identity=24.1228070175439, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4503379, Length=460, Percent_Identity=25.2173913043478, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI4503377, Length=475, Percent_Identity=23.5789473684211, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786722, Length=434, Percent_Identity=30.184331797235, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI87082175, Length=452, Percent_Identity=25.2212389380531, Blast_Score=115, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI193204318, Length=399, Percent_Identity=29.3233082706767, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71989490, Length=459, Percent_Identity=24.8366013071895, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17539558, Length=461, Percent_Identity=24.295010845987, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI86575075, Length=452, Percent_Identity=25, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322218, Length=406, Percent_Identity=27.3399014778325, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24642586, Length=403, Percent_Identity=30.272952853598, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI17137462, Length=442, Percent_Identity=24.8868778280543, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI221377917, Length=447, Percent_Identity=25.0559284116331, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI18859883, Length=417, Percent_Identity=28.0575539568345, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 46012; Mature: 45881

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLLIKGAVLYGEGEPVDVFVDEGEIRQIGTDLGVVDAEIVEARGQVLLPGFVDLHTHL
CCCEEEEEEEEECCCCCEEEEECCCCHHHHCCCCCCHHHHHHHCCCCEEECHHHHHHHHH
REPGREDTETIETGSAAAALGGYTAVFAMANTNPVADSVVVTDHVWRRGQEVGLVDVHPV
CCCCCCCHHHHHCCCHHHHHCCEEEEEEECCCCCCCCEEEEEHHHHHCCCCCCEEEECCC
GAVTVGLAGKQLAEMGTMAAGVGGVRMFSDDGHCVYDPLIMRRALEYSNSLGVLIAQHAE
CEEEECCCHHHHHHHHHHHCCCCCEEEECCCCCEEECHHHHHHHHHHCCCCCEEEEECCC
EPRLTKGAVAHEGPTAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASTAGTVEL
CCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHH
VKWAKAQGISITAEVTPHHLLLDDSRLETYDAVNKVNPPLREASDTAALRAALAEGIIDC
HHHHCCCCCEEEEECCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VATDHAPHAEQDKCCEFAAARPGMLGLETALSIVVETMVRPGLLDWRGVARVMSERPAEI
HHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEE
VGLDDQGRPIAVGEPANLVLVDPDATWTVRASELASISNNTPFEEMTFPARVTMTLLRGR
EECCCCCCEEEECCCCCEEEECCCCCEEEEHHHHHHCCCCCCHHHHCCCHHHHHHHHHHH
ITARAGRAAQPQGAGGA
HHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SGLLIKGAVLYGEGEPVDVFVDEGEIRQIGTDLGVVDAEIVEARGQVLLPGFVDLHTHL
CCEEEEEEEEECCCCCEEEEECCCCHHHHCCCCCCHHHHHHHCCCCEEECHHHHHHHHH
REPGREDTETIETGSAAAALGGYTAVFAMANTNPVADSVVVTDHVWRRGQEVGLVDVHPV
CCCCCCCHHHHHCCCHHHHHCCEEEEEEECCCCCCCCEEEEEHHHHHCCCCCCEEEECCC
GAVTVGLAGKQLAEMGTMAAGVGGVRMFSDDGHCVYDPLIMRRALEYSNSLGVLIAQHAE
CEEEECCCHHHHHHHHHHHCCCCCEEEECCCCCEEECHHHHHHHHHHCCCCCEEEEECCC
EPRLTKGAVAHEGPTAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASTAGTVEL
CCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHH
VKWAKAQGISITAEVTPHHLLLDDSRLETYDAVNKVNPPLREASDTAALRAALAEGIIDC
HHHHCCCCCEEEEECCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VATDHAPHAEQDKCCEFAAARPGMLGLETALSIVVETMVRPGLLDWRGVARVMSERPAEI
HHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEE
VGLDDQGRPIAVGEPANLVLVDPDATWTVRASELASISNNTPFEEMTFPARVTMTLLRGR
EECCCCCCEEEECCCCCEEEECCCCCEEEEHHHHHHCCCCCCHHHHCCCHHHHHHHHHHH
ITARAGRAAQPQGAGGA
HHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]