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The map label for this gene is gmk

Identifier: 54025586

GI number: 54025586

Start: 3827778

End: 3828359

Strand: Reverse

Name: gmk

Synonym: nfa36160

Alternate gene names: 54025586

Gene position: 3828359-3827778 (Counterclockwise)

Preceding gene: 54025587

Following gene: 54025585

Centisome position: 63.58

GC content: 68.56

Gene sequence:

>582_bases
GTGGTCGAACACACGCGGAAGGGTCGGCTGGTCGTGCTGGTCGGCCCCTCGGCCGTGGGGAAATCGACGGTCGTGCGGTG
CGTGCGGGAACGCCTGCCCGAACTGGTCTTCAGTGTGTCGGCGACAACCCGGGCCCCCCGGCCCGGGGAGGTCGACGGCC
GGGACTACCGGTTCGTCACCCGGGCCGAGTTCGACGCCATGATCGAGGCCGGTGAACTGCTCGAATGGGCGGAGATCCAC
GGCGGGTTGCAGCGCTCGGGTACCCCCGCCGCCCCGGTGCGCGAGGCACTGGCGGCGGGCAAGAACGTGCTGCTCGAGGT
GGATCTCGAAGGGGCGCGCTCGGTGCGCAAGGTCATGCCGGAGGCGCGGCTGGTCTTTCTGGCCCCGCCGAGCTGGGACG
AACTCGTCGCCCGGCTCACCGCGCGCGGCACCGAAACACCCGAGGTGATCGCGCGCAGGCTGGAGACCGCCAGGATCGAA
CTCGCCGCCTGTGACGAGTTCGACAACGTCATCGTGAACGACGAGGTGACCAGCGCCTGCGAGCAGTTGGTATCGTTGTT
CGTTAGCACAAATTCGAGATAG

Upstream 100 bases:

>100_bases
GCGAGCTGGAGATCGCCCCCACCCGCCGGCTGCGCGGACTCGGTGATCGGCAGCGCAAGGCGCTGCTGGCCCGGTTCGAC
TTCGACGCCTGATTCCGAGG

Downstream 100 bases:

>100_bases
TGCCCGGTCCGGCGGCCGCCGCGTGCCGGCCGCCGACTCGGATCGCGATACCCATCCGCGATACCGACCGAGACACCCAC
CGAAACAAGCACCCACCGAC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MVEHTRKGRLVVLVGPSAVGKSTVVRCVRERLPELVFSVSATTRAPRPGEVDGRDYRFVTRAEFDAMIEAGELLEWAEIH
GGLQRSGTPAAPVREALAAGKNVLLEVDLEGARSVRKVMPEARLVFLAPPSWDELVARLTARGTETPEVIARRLETARIE
LAACDEFDNVIVNDEVTSACEQLVSLFVSTNSR

Sequences:

>Translated_193_residues
MVEHTRKGRLVVLVGPSAVGKSTVVRCVRERLPELVFSVSATTRAPRPGEVDGRDYRFVTRAEFDAMIEAGELLEWAEIH
GGLQRSGTPAAPVREALAAGKNVLLEVDLEGARSVRKVMPEARLVFLAPPSWDELVARLTARGTETPEVIARRLETARIE
LAACDEFDNVIVNDEVTSACEQLVSLFVSTNSR
>Mature_193_residues
MVEHTRKGRLVVLVGPSAVGKSTVVRCVRERLPELVFSVSATTRAPRPGEVDGRDYRFVTRAEFDAMIEAGELLEWAEIH
GGLQRSGTPAAPVREALAAGKNVLLEVDLEGARSVRKVMPEARLVFLAPPSWDELVARLTARGTETPEVIARRLETARIE
LAACDEFDNVIVNDEVTSACEQLVSLFVSTNSR

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=179, Percent_Identity=40.7821229050279, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI4504221, Length=179, Percent_Identity=40.7821229050279, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI226874831, Length=179, Percent_Identity=40.7821229050279, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI38570142, Length=183, Percent_Identity=32.2404371584699, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI21361598, Length=190, Percent_Identity=32.6315789473684, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI4505237, Length=182, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI262118259, Length=182, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI262118263, Length=182, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI262118255, Length=182, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI14780902, Length=195, Percent_Identity=30.2564102564103, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI111154074, Length=163, Percent_Identity=27.6073619631902, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1790080, Length=182, Percent_Identity=40.1098901098901, Blast_Score=139, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI193203132, Length=184, Percent_Identity=38.5869565217391, Blast_Score=122, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17508835, Length=184, Percent_Identity=38.5869565217391, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320662, Length=180, Percent_Identity=44.4444444444444, Blast_Score=152, Evalue=4e-38,
Organism=Drosophila melanogaster, GI21356141, Length=185, Percent_Identity=37.8378378378378, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI221330164, Length=190, Percent_Identity=35.7894736842105, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI221330162, Length=190, Percent_Identity=35.7894736842105, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI221330166, Length=190, Percent_Identity=35.7894736842105, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI161077626, Length=181, Percent_Identity=30.3867403314917, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI116007136, Length=185, Percent_Identity=30.8108108108108, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45554489, Length=185, Percent_Identity=30.8108108108108, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45554481, Length=185, Percent_Identity=30.8108108108108, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24640542, Length=185, Percent_Identity=30.8108108108108, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI85724806, Length=185, Percent_Identity=30.8108108108108, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_NOCFA (Q5YTM7)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_119828.1
- ProteinModelPortal:   Q5YTM7
- SMR:   Q5YTM7
- GeneID:   3109612
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa36160
- NMPDR:   fig|247156.1.peg.3529
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- BioCyc:   NFAR247156:NFA36160-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 21136; Mature: 21136

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEHTRKGRLVVLVGPSAVGKSTVVRCVRERLPELVFSVSATTRAPRPGEVDGRDYRFVT
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
RAEFDAMIEAGELLEWAEIHGGLQRSGTPAAPVREALAAGKNVLLEVDLEGARSVRKVMP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEECHHHHHHHHHCC
EARLVFLAPPSWDELVARLTARGTETPEVIARRLETARIELAACDEFDNVIVNDEVTSAC
CCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEECCCCCCEEECHHHHHHH
EQLVSLFVSTNSR
HHHHHHHHHCCCC
>Mature Secondary Structure
MVEHTRKGRLVVLVGPSAVGKSTVVRCVRERLPELVFSVSATTRAPRPGEVDGRDYRFVT
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
RAEFDAMIEAGELLEWAEIHGGLQRSGTPAAPVREALAAGKNVLLEVDLEGARSVRKVMP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEECHHHHHHHHHCC
EARLVFLAPPSWDELVARLTARGTETPEVIARRLETARIELAACDEFDNVIVNDEVTSAC
CCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEECCCCCCEEECHHHHHHH
EQLVSLFVSTNSR
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA