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The map label for this gene is dfp [H]

Identifier: 54025584

GI number: 54025584

Start: 3826109

End: 3827335

Strand: Reverse

Name: dfp [H]

Synonym: nfa36140

Alternate gene names: 54025584

Gene position: 3827335-3826109 (Counterclockwise)

Preceding gene: 54025585

Following gene: 54025583

Centisome position: 63.56

GC content: 72.05

Gene sequence:

>1227_bases
GTGAGCACACGCATCGTCGTCGGCGTCGGCGGCGGGATCGCCGCCTACAAGGCCTGCGCGTTGATCCGGCGGTTCACCGA
GACCGGTCATCAGGTCCGGGTGATCCCCACCGAGTCGGCGCTGCAGTTCGTCGGCAAGGCCACCTTCGAGGCGCTGTCCG
GGAATCCGGTGCACACCGACGTGTTCACCGATGTACCCGAAGTGCCGCACGTCCGGCTCGGGCAGGAGGCCGACCTCGTC
GTCATCGCCCCCGCCACGGCGGACCTGATGGCCCGCGCGGCACACGGCCGCGCCGACGACCTGCTCACCGCCACCCTGCT
CACCGCCCGATGTCCGGTGCTGTTCGCGCCCGCGATGCACACCGAGATGTGGGAGCACCCCGCCACCCAGGCCAACGTCG
AGACCCTGCGCAGGCACGGCGCCGTCGTGATGGAGCCCGCCTCCGGCAGGCTCACCGGCACCGACACCGGCCCGGGCAGG
CTGCCGGAGCCGGAGGAGATCTTCGGCCTCGCCTCGCTGCTGCAGGAACGGCAGGACGCCGTGCCGCGCGACCTGGTCGG
CCGCCGTCTGGTGATCACAGCGGGCGGCACCCGCGAACCGCTGGACCCGGTCCGGTTCCTGGGCAACCGCAGCTCCGGCA
AACAGGGCTATGCCCTGGCCAGGGTGGCGGCCCAGCGCGGTGCGCAGGTGACCCTCATCGCGGGCAACACCATCGAGATG
GCGGCGCCCGCCGCGGTCGAGCTGGTGCACATCACCACCGCCGAACAGCTCAAGACCGCGGTCGACAAGCACGCCGTCGG
CGCCGACGCGGTGATCATGGCCGCGGCGGTGGCCGATTTCCGGCCGACCAACGTCGCGGCCGCCAAGATCAAGAAGGGTG
CCGGCGAGCCGGACGTCATCCCGCTGACCAAGACCGACGACATTCTCGCCGGGCTGGTCCAGTCCCGCCGGGACGGCCAG
CTGCCCGGCACCGCGATCGTCGGGTTCGCCGCCGAGACCGGCGACGAACACGGCGATGTGCTCACCCACGCGCGGGCCAA
GCTGGCCCGCAAGGGGTGCGATCTGCTGGTGGTCAACGCCGTGGGCGAGGGCAAGGCCTTCGAGGTGGACACCAACGACG
GCTGGCTGCTCGGCGCCGACGGCACCGAACAGGCGCTCGACCACGGTTCCAAGGCGCTGCTGGCCAGCCGGGTACTCGAC
GCGCTGGCGCCCCTGCTGCGCTCCTGA

Upstream 100 bases:

>100_bases
GTCGCGCTGCGCGAGATCCACGCCGACCTGCTCGAGCACTCCGAAGGCGAGTGACTCCTCCTCGGCGCCCCGCCGAGGAC
CGCATGAACACGGAGGCGTA

Downstream 100 bases:

>100_bases
GCGGTGAAAGACGGCGGCCCCGTGGCTGTTTCGGTGAACAGCGGGTCCGCCCGGAGGTAGTGGACGCGAACGTGCGGTGA
ATGCCGACACCGACGGCCGC

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MSTRIVVGVGGGIAAYKACALIRRFTETGHQVRVIPTESALQFVGKATFEALSGNPVHTDVFTDVPEVPHVRLGQEADLV
VIAPATADLMARAAHGRADDLLTATLLTARCPVLFAPAMHTEMWEHPATQANVETLRRHGAVVMEPASGRLTGTDTGPGR
LPEPEEIFGLASLLQERQDAVPRDLVGRRLVITAGGTREPLDPVRFLGNRSSGKQGYALARVAAQRGAQVTLIAGNTIEM
AAPAAVELVHITTAEQLKTAVDKHAVGADAVIMAAAVADFRPTNVAAAKIKKGAGEPDVIPLTKTDDILAGLVQSRRDGQ
LPGTAIVGFAAETGDEHGDVLTHARAKLARKGCDLLVVNAVGEGKAFEVDTNDGWLLGADGTEQALDHGSKALLASRVLD
ALAPLLRS

Sequences:

>Translated_408_residues
MSTRIVVGVGGGIAAYKACALIRRFTETGHQVRVIPTESALQFVGKATFEALSGNPVHTDVFTDVPEVPHVRLGQEADLV
VIAPATADLMARAAHGRADDLLTATLLTARCPVLFAPAMHTEMWEHPATQANVETLRRHGAVVMEPASGRLTGTDTGPGR
LPEPEEIFGLASLLQERQDAVPRDLVGRRLVITAGGTREPLDPVRFLGNRSSGKQGYALARVAAQRGAQVTLIAGNTIEM
AAPAAVELVHITTAEQLKTAVDKHAVGADAVIMAAAVADFRPTNVAAAKIKKGAGEPDVIPLTKTDDILAGLVQSRRDGQ
LPGTAIVGFAAETGDEHGDVLTHARAKLARKGCDLLVVNAVGEGKAFEVDTNDGWLLGADGTEQALDHGSKALLASRVLD
ALAPLLRS
>Mature_407_residues
STRIVVGVGGGIAAYKACALIRRFTETGHQVRVIPTESALQFVGKATFEALSGNPVHTDVFTDVPEVPHVRLGQEADLVV
IAPATADLMARAAHGRADDLLTATLLTARCPVLFAPAMHTEMWEHPATQANVETLRRHGAVVMEPASGRLTGTDTGPGRL
PEPEEIFGLASLLQERQDAVPRDLVGRRLVITAGGTREPLDPVRFLGNRSSGKQGYALARVAAQRGAQVTLIAGNTIEMA
APAAVELVHITTAEQLKTAVDKHAVGADAVIMAAAVADFRPTNVAAAKIKKGAGEPDVIPLTKTDDILAGLVQSRRDGQL
PGTAIVGFAAETGDEHGDVLTHARAKLARKGCDLLVVNAVGEGKAFEVDTNDGWLLGADGTEQALDHGSKALLASRVLDA
LAPLLRS

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=172, Percent_Identity=31.9767441860465, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI87082301, Length=404, Percent_Identity=40.8415841584158, Blast_Score=233, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24657262, Length=176, Percent_Identity=29.5454545454545, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42736; Mature: 42605

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRIVVGVGGGIAAYKACALIRRFTETGHQVRVIPTESALQFVGKATFEALSGNPVHTD
CCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHCCCCCCEEH
VFTDVPEVPHVRLGQEADLVVIAPATADLMARAAHGRADDLLTATLLTARCPVLFAPAMH
HHCCCCCCCCEECCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCHHH
TEMWEHPATQANVETLRRHGAVVMEPASGRLTGTDTGPGRLPEPEEIFGLASLLQERQDA
HHHHHCCCCHHHHHHHHHCCCEEEECCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
VPRDLVGRRLVITAGGTREPLDPVRFLGNRSSGKQGYALARVAAQRGAQVTLIAGNTIEM
CCHHHHCCEEEEEECCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECCEEEE
AAPAAVELVHITTAEQLKTAVDKHAVGADAVIMAAAVADFRPTNVAAAKIKKGAGEPDVI
CCCCEEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEE
PLTKTDDILAGLVQSRRDGQLPGTAIVGFAAETGDEHGDVLTHARAKLARKGCDLLVVNA
ECCCCHHHHHHHHHCCCCCCCCCCEEEEEEHHCCCCCCHHHHHHHHHHHHCCCCEEEEEE
VGEGKAFEVDTNDGWLLGADGTEQALDHGSKALLASRVLDALAPLLRS
CCCCCEEEEECCCCEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STRIVVGVGGGIAAYKACALIRRFTETGHQVRVIPTESALQFVGKATFEALSGNPVHTD
CCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHCCCCCCEEH
VFTDVPEVPHVRLGQEADLVVIAPATADLMARAAHGRADDLLTATLLTARCPVLFAPAMH
HHCCCCCCCCEECCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCHHH
TEMWEHPATQANVETLRRHGAVVMEPASGRLTGTDTGPGRLPEPEEIFGLASLLQERQDA
HHHHHCCCCHHHHHHHHHCCCEEEECCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
VPRDLVGRRLVITAGGTREPLDPVRFLGNRSSGKQGYALARVAAQRGAQVTLIAGNTIEM
CCHHHHCCEEEEEECCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECCEEEE
AAPAAVELVHITTAEQLKTAVDKHAVGADAVIMAAAVADFRPTNVAAAKIKKGAGEPDVI
CCCCEEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEE
PLTKTDDILAGLVQSRRDGQLPGTAIVGFAAETGDEHGDVLTHARAKLARKGCDLLVVNA
ECCCCHHHHHHHHHCCCCCCCCCCEEEEEEHHCCCCCCHHHHHHHHHHHHCCCCEEEEEE
VGEGKAFEVDTNDGWLLGADGTEQALDHGSKALLASRVLDALAPLLRS
CCCCCEEEEECCCCEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]