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The map label for this gene is csd [H]

Identifier: 54025527

GI number: 54025527

Start: 3764796

End: 3766058

Strand: Reverse

Name: csd [H]

Synonym: nfa35570

Alternate gene names: 54025527

Gene position: 3766058-3764796 (Counterclockwise)

Preceding gene: 54025528

Following gene: 54025526

Centisome position: 62.55

GC content: 71.34

Gene sequence:

>1263_bases
ATGACCGCTGCGCCTGTCACGGGCCGGACACTCGACGTCGCCCGGATCCGGGCCGACTTCCCGATCCTGAGCCGCACGGT
CCGGGACGGTAAGCCGTTGGTGTACCTGGACTCCGGCGCCACCTCGCAGCGACCGCTGGCCGTGCTCGACGCCGAACGCG
AATTCCTCACCGAGCGCAACTCCGCGGTGCATCGCGGGGCGCATCAGCTGGCCGAGGAGGCGACCGACGCCTACGAGGGC
GCCCGCGCCGACATCGCCCGCTTCGTCGGGGTCGATGCCGGGGAGATCGTGTTCACCAAGAACGCGACCGAGTCGCTGAA
CCTGGTGACCTACTCCTTCGCCGACAACCGGTTCCCCTACCACGTGGGACCGGGCGACGAGATCGTGGTCACCGAACTCG
AGCACCACGCGAACCTGGTGCCGTGGCAGGAGCTCGCGCGGCGTACCGGCGCCACCCTGAAGTGGTACGGCATCACCGAC
GACGGCCGCATCGACCTGGACTCGCTGGAGCTCTCGCCCGCCACCAAGGTCGTCGCGTTCACCCACCAGTCCAACGTGAC
CGGCGCGGTGTCGCCGGTCGAGGAACTGGTGCGGCGCGCGACGGCGGTGGGCGCGCTCACCGTGCTCGACGCCTGCCAGT
CGGTGCCGCACATGCCGGTGGACTTCCGGGCGCTCGGCGTGGACTTCGCCGCCTTCTCCGGACACAAGATGCTCGGCCCC
TCCGGTGTCGGCGTGCTCTACGGCCGCCGCGCGCTGCTCGAGGAGACCCCGCCGTTCATCACCGGCGGCTCGATGATCGA
GACCGTGACGATGGAGGGCAGCACCTTCGCCCCGCCGCCGCAGCGGTTCGAGGCCGGCGTGCCGATGACCTCGCAGGTCG
TCGGCCTCGGCGCGGCCGTGCGGTATCTCGAGGGCATCGGCATGGCCGCGGTCGCCGAGCACGAGCACGCGCTCACCGGT
GCCGCGCTCGCGGGTCTGGGCGCCATCGACGGCGTGCGGATCGTCGGCCCCACCGAGAACGTGGACCGTGGCGGCGCGGT
GTCGTTCGTGGTGGACGGCATCCACGCCCACGACGTCGGCCAGATCCTCGACGACGAGGGCGTGGCCATCCGGGTCGGGC
ACCACTGCGCCTGGCCGCTGATGCGCCGCCTCGGCGTGCCCGCCACCGCCCGTGCCTCCTTCGCGGTCTACAACACCCTC
GACGAGGTCGAGCAGTTGGTGGCCGCGGTGCGGAAGGCTCAGCGCTTCTTCGGGGTTGCATAG

Upstream 100 bases:

>100_bases
GGCGGCCGCATCGTCGCCGAGGGCGGCCCCGAGCTCGCCGAGGAACTCGACGCCAACGGCTACGTCCGCTTCACCCAGAC
CGCGACCGCGGGAGCCTGAC

Downstream 100 bases:

>100_bases
ACCATGCGCATGGAGCAGATGTACCAGGAAGTGATCCTGGACCACTACAAGCACCCGCATCACCGCGGTCTGCGTGAGCC
CTTCGGCGCCGAGGTGCATC

Product: putative aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTAAPVTGRTLDVARIRADFPILSRTVRDGKPLVYLDSGATSQRPLAVLDAEREFLTERNSAVHRGAHQLAEEATDAYEG
ARADIARFVGVDAGEIVFTKNATESLNLVTYSFADNRFPYHVGPGDEIVVTELEHHANLVPWQELARRTGATLKWYGITD
DGRIDLDSLELSPATKVVAFTHQSNVTGAVSPVEELVRRATAVGALTVLDACQSVPHMPVDFRALGVDFAAFSGHKMLGP
SGVGVLYGRRALLEETPPFITGGSMIETVTMEGSTFAPPPQRFEAGVPMTSQVVGLGAAVRYLEGIGMAAVAEHEHALTG
AALAGLGAIDGVRIVGPTENVDRGGAVSFVVDGIHAHDVGQILDDEGVAIRVGHHCAWPLMRRLGVPATARASFAVYNTL
DEVEQLVAAVRKAQRFFGVA

Sequences:

>Translated_420_residues
MTAAPVTGRTLDVARIRADFPILSRTVRDGKPLVYLDSGATSQRPLAVLDAEREFLTERNSAVHRGAHQLAEEATDAYEG
ARADIARFVGVDAGEIVFTKNATESLNLVTYSFADNRFPYHVGPGDEIVVTELEHHANLVPWQELARRTGATLKWYGITD
DGRIDLDSLELSPATKVVAFTHQSNVTGAVSPVEELVRRATAVGALTVLDACQSVPHMPVDFRALGVDFAAFSGHKMLGP
SGVGVLYGRRALLEETPPFITGGSMIETVTMEGSTFAPPPQRFEAGVPMTSQVVGLGAAVRYLEGIGMAAVAEHEHALTG
AALAGLGAIDGVRIVGPTENVDRGGAVSFVVDGIHAHDVGQILDDEGVAIRVGHHCAWPLMRRLGVPATARASFAVYNTL
DEVEQLVAAVRKAQRFFGVA
>Mature_419_residues
TAAPVTGRTLDVARIRADFPILSRTVRDGKPLVYLDSGATSQRPLAVLDAEREFLTERNSAVHRGAHQLAEEATDAYEGA
RADIARFVGVDAGEIVFTKNATESLNLVTYSFADNRFPYHVGPGDEIVVTELEHHANLVPWQELARRTGATLKWYGITDD
GRIDLDSLELSPATKVVAFTHQSNVTGAVSPVEELVRRATAVGALTVLDACQSVPHMPVDFRALGVDFAAFSGHKMLGPS
GVGVLYGRRALLEETPPFITGGSMIETVTMEGSTFAPPPQRFEAGVPMTSQVVGLGAAVRYLEGIGMAAVAEHEHALTGA
ALAGLGAIDGVRIVGPTENVDRGGAVSFVVDGIHAHDVGQILDDEGVAIRVGHHCAWPLMRRLGVPATARASFAVYNTLD
EVEQLVAAVRKAQRFFGVA

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=272, Percent_Identity=30.5147058823529, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI156713448, Length=296, Percent_Identity=26.6891891891892, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1787970, Length=412, Percent_Identity=44.1747572815534, Blast_Score=355, Evalue=4e-99,
Organism=Escherichia coli, GI1789175, Length=403, Percent_Identity=37.468982630273, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI48994898, Length=400, Percent_Identity=29, Blast_Score=115, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI25143064, Length=231, Percent_Identity=26.8398268398268, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193211090, Length=340, Percent_Identity=25.2941176470588, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319831, Length=278, Percent_Identity=30.2158273381295, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI20129463, Length=237, Percent_Identity=32.4894514767932, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44732; Mature: 44601

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAPVTGRTLDVARIRADFPILSRTVRDGKPLVYLDSGATSQRPLAVLDAEREFLTERN
CCCCCCCCCEEEHHHHHCCCHHHHHHHCCCCCEEEECCCCCCCCCEEEECCHHHHHHHHH
SAVHRGAHQLAEEATDAYEGARADIARFVGVDAGEIVFTKNATESLNLVTYSFADNRFPY
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEECCCCCCEEEEEEEECCCCCCE
HVGPGDEIVVTELEHHANLVPWQELARRTGATLKWYGITDDGRIDLDSLELSPATKVVAF
EECCCCCEEEEEEHHCCCCCCHHHHHHHCCCEEEEEECCCCCCEECCCCCCCCCCEEEEE
THQSNVTGAVSPVEELVRRATAVGALTVLDACQSVPHMPVDFRALGVDFAAFSGHKMLGP
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECEEEEECCCCCEECC
SGVGVLYGRRALLEETPPFITGGSMIETVTMEGSTFAPPPQRFEAGVPMTSQVVGLGAAV
CCCCHHHCCHHHHHCCCCCEECCCEEEEEEECCCCCCCCHHHHCCCCCHHHHHHHHHHHH
RYLEGIGMAAVAEHEHALTGAALAGLGAIDGVRIVGPTENVDRGGAVSFVVDGIHAHDVG
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEEEEECCCHHHHH
QILDDEGVAIRVGHHCAWPLMRRLGVPATARASFAVYNTLDEVEQLVAAVRKAQRFFGVA
HHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TAAPVTGRTLDVARIRADFPILSRTVRDGKPLVYLDSGATSQRPLAVLDAEREFLTERN
CCCCCCCCEEEHHHHHCCCHHHHHHHCCCCCEEEECCCCCCCCCEEEECCHHHHHHHHH
SAVHRGAHQLAEEATDAYEGARADIARFVGVDAGEIVFTKNATESLNLVTYSFADNRFPY
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEECCCCCCEEEEEEEECCCCCCE
HVGPGDEIVVTELEHHANLVPWQELARRTGATLKWYGITDDGRIDLDSLELSPATKVVAF
EECCCCCEEEEEEHHCCCCCCHHHHHHHCCCEEEEEECCCCCCEECCCCCCCCCCEEEEE
THQSNVTGAVSPVEELVRRATAVGALTVLDACQSVPHMPVDFRALGVDFAAFSGHKMLGP
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECEEEEECCCCCEECC
SGVGVLYGRRALLEETPPFITGGSMIETVTMEGSTFAPPPQRFEAGVPMTSQVVGLGAAV
CCCCHHHCCHHHHHCCCCCEECCCEEEEEEECCCCCCCCHHHHCCCCCHHHHHHHHHHHH
RYLEGIGMAAVAEHEHALTGAALAGLGAIDGVRIVGPTENVDRGGAVSFVVDGIHAHDVG
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEEEEECCCHHHHH
QILDDEGVAIRVGHHCAWPLMRRLGVPATARASFAVYNTLDEVEQLVAAVRKAQRFFGVA
HHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]