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The map label for this gene is fadA6 [H]

Identifier: 54025382

GI number: 54025382

Start: 3615322

End: 3616542

Strand: Reverse

Name: fadA6 [H]

Synonym: nfa34130

Alternate gene names: 54025382

Gene position: 3616542-3615322 (Counterclockwise)

Preceding gene: 54025392

Following gene: 54025381

Centisome position: 60.06

GC content: 70.84

Gene sequence:

>1221_bases
ATGCCGGAAGCTGTGATCGTCGCCGCTGCCCGTTCCCCGATCGGGCGGGCGGGCAAGGGCTCGCTGAAGGAGATGCGTCC
CGACGACCTGACCGTGCAGATGGTGCGGGCCGCGCTGGCCCAGGTGCCCGCCCTGGACCCGGCCCAGGTCGAGGACCTTC
TGCTCGGCTGCGGGCAGCCCGCGGGCGAATCGGGCTTCAACATGGCCCGCACGGTCGCGGTGCTGGCCGGGCTGGACACG
GTTCCCGGGACCACCGTGAACCGCTACTGTTCCTCCAGCTTGCAGACCACCCGGATGGCGCTGCACGCCATCAAGGCGGG
CGAGGGTGAGGTGTTCATCTCCGCGGGCGTGGAGACGGTGAGCCGGCTCGGCAAGGGCAGCGCCGACGGGTGGCCCGACA
CCCAGAATCCGGTCTTCGCCGACGCCGTCGCCCGCACGGCCGAACGAGCGAGCGGGGGCGCCGCCGACTGGGCCGACCCG
CGCGCGCAGGGTCTCCTGCCCGACGTCTACATCGCGATGGGCCAGACCGCGGAGAACGTCGCGCAGTTCACCGGCATCAC
TCGCGCCGAACAGGACGCGTTCGGTGTCCGTTCGCAGAACCTCGCCGAGAAGGCCATCGCCGACGGCTTCTGGGCCACCG
ACATCACCCCGGTCACGCTGCCGGACGGCACCGTGGTCAGTGCCGACGACGGCCCGCGCGCGGGCGTCACCCTCGAGGCG
GTGAGCCAGTTGAAGCCGGTGTTCCGGCCCGACGGCACCGTCACCGCGGGCAACTGCTGCGCGCTCAACGACGGCGCGGC
GGCGCTGGTCATCATGTCCGACACCAAGGCCAGGGATCTGGGCATCACCCCGCTCGCGCGCATCGTCAGCACCGGCGTCT
CCGCGCTGTCCCCGGAGATCATGGGCCTGGGCCCGATCGAGGCGTCCAAGCAGGCGCTGGGCCGGGCCGGTCTCACCATC
GACGACATCGACCTGGTCGAGATCAACGAGGCGTTCGCCGTGCAGGTGCTCGGCTCGGCCCGCGAACTCGGTATCCCGGA
AGACAAGCTGAACGTCAACGGCGGCGCGATCGCGGTGGGCCACCCGTTCGGCATGACCGGCGCCCGCATCACCAGCACCC
TGATCAACTCGCTGCGCTTCCACGACAAGCAGTTCGGGTTGGAGACCATGTGTGTCGGCGGCGGCCAGGGCATGGCCATG
GTGCTGGAGCGGCTGTCGTGA

Upstream 100 bases:

>100_bases
ATGTGGTCAACAGGGGACGAGTCCTGATCACTGTTGACGGTGACCCGGACCACCCTGCACTATGCTACTAAGCAAGCGCT
TAGTCATCAAAGGAGATTCG

Downstream 100 bases:

>100_bases
CCGGCCGTTTCGCCGGCAGGACCGCGATCGTCACCGGCGCCAGCCGCGGCATCGGCCTGGCCATCGCGCAGCGCCTGGTG
GACGACGGCGCGAAGGTGGT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MPEAVIVAAARSPIGRAGKGSLKEMRPDDLTVQMVRAALAQVPALDPAQVEDLLLGCGQPAGESGFNMARTVAVLAGLDT
VPGTTVNRYCSSSLQTTRMALHAIKAGEGEVFISAGVETVSRLGKGSADGWPDTQNPVFADAVARTAERASGGAADWADP
RAQGLLPDVYIAMGQTAENVAQFTGITRAEQDAFGVRSQNLAEKAIADGFWATDITPVTLPDGTVVSADDGPRAGVTLEA
VSQLKPVFRPDGTVTAGNCCALNDGAAALVIMSDTKARDLGITPLARIVSTGVSALSPEIMGLGPIEASKQALGRAGLTI
DDIDLVEINEAFAVQVLGSARELGIPEDKLNVNGGAIAVGHPFGMTGARITSTLINSLRFHDKQFGLETMCVGGGQGMAM
VLERLS

Sequences:

>Translated_406_residues
MPEAVIVAAARSPIGRAGKGSLKEMRPDDLTVQMVRAALAQVPALDPAQVEDLLLGCGQPAGESGFNMARTVAVLAGLDT
VPGTTVNRYCSSSLQTTRMALHAIKAGEGEVFISAGVETVSRLGKGSADGWPDTQNPVFADAVARTAERASGGAADWADP
RAQGLLPDVYIAMGQTAENVAQFTGITRAEQDAFGVRSQNLAEKAIADGFWATDITPVTLPDGTVVSADDGPRAGVTLEA
VSQLKPVFRPDGTVTAGNCCALNDGAAALVIMSDTKARDLGITPLARIVSTGVSALSPEIMGLGPIEASKQALGRAGLTI
DDIDLVEINEAFAVQVLGSARELGIPEDKLNVNGGAIAVGHPFGMTGARITSTLINSLRFHDKQFGLETMCVGGGQGMAM
VLERLS
>Mature_405_residues
PEAVIVAAARSPIGRAGKGSLKEMRPDDLTVQMVRAALAQVPALDPAQVEDLLLGCGQPAGESGFNMARTVAVLAGLDTV
PGTTVNRYCSSSLQTTRMALHAIKAGEGEVFISAGVETVSRLGKGSADGWPDTQNPVFADAVARTAERASGGAADWADPR
AQGLLPDVYIAMGQTAENVAQFTGITRAEQDAFGVRSQNLAEKAIADGFWATDITPVTLPDGTVVSADDGPRAGVTLEAV
SQLKPVFRPDGTVTAGNCCALNDGAAALVIMSDTKARDLGITPLARIVSTGVSALSPEIMGLGPIEASKQALGRAGLTID
DIDLVEINEAFAVQVLGSARELGIPEDKLNVNGGAIAVGHPFGMTGARITSTLINSLRFHDKQFGLETMCVGGGQGMAMV
LERLS

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=412, Percent_Identity=38.1067961165049, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=35.5721393034826, Blast_Score=225, Evalue=7e-59,
Organism=Homo sapiens, GI148539872, Length=408, Percent_Identity=37.2549019607843, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI4557237, Length=416, Percent_Identity=34.8557692307692, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI4504327, Length=428, Percent_Identity=32.0093457943925, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI194353979, Length=404, Percent_Identity=29.7029702970297, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1787663, Length=418, Percent_Identity=43.5406698564593, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI48994986, Length=414, Percent_Identity=40.5797101449275, Blast_Score=287, Evalue=7e-79,
Organism=Escherichia coli, GI1788554, Length=411, Percent_Identity=42.5790754257908, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI87082165, Length=412, Percent_Identity=37.8640776699029, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1788683, Length=387, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI133906874, Length=405, Percent_Identity=37.037037037037, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI25147385, Length=410, Percent_Identity=32.4390243902439, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=33.5802469135802, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=442, Percent_Identity=31.6742081447964, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17535917, Length=415, Percent_Identity=28.433734939759, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322031, Length=405, Percent_Identity=34.0740740740741, Blast_Score=210, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6325229, Length=411, Percent_Identity=33.5766423357664, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24655093, Length=412, Percent_Identity=35.9223300970874, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI17648125, Length=408, Percent_Identity=35.5392156862745, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24640423, Length=412, Percent_Identity=33.495145631068, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17137578, Length=431, Percent_Identity=30.1624129930394, Blast_Score=154, Evalue=9e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41848; Mature: 41717

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEAVIVAAARSPIGRAGKGSLKEMRPDDLTVQMVRAALAQVPALDPAQVEDLLLGCGQP
CCCCEEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
AGESGFNMARTVAVLAGLDTVPGTTVNRYCSSSLQTTRMALHAIKAGEGEVFISAGVETV
CCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHH
SRLGKGSADGWPDTQNPVFADAVARTAERASGGAADWADPRAQGLLPDVYIAMGQTAENV
HHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHCCCCCHHHHCCCCCHHHH
AQFTGITRAEQDAFGVRSQNLAEKAIADGFWATDITPVTLPDGTVVSADDGPRAGVTLEA
HHHHCCCCCHHHHHCCCHHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCCCCCCCHHHH
VSQLKPVFRPDGTVTAGNCCALNDGAAALVIMSDTKARDLGITPLARIVSTGVSALSPEI
HHHCCCCCCCCCCEECCCEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHCHHHHCCCC
MGLGPIEASKQALGRAGLTIDDIDLVEINEAFAVQVLGSARELGIPEDKLNVNGGAIAVG
EECCCCHHHHHHHHHCCCEECCCEEEEECCHHEEEECCCHHHCCCCHHHEECCCCEEEEC
HPFGMTGARITSTLINSLRFHDKQFGLETMCVGGGQGMAMVLERLS
CCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCC
>Mature Secondary Structure 
PEAVIVAAARSPIGRAGKGSLKEMRPDDLTVQMVRAALAQVPALDPAQVEDLLLGCGQP
CCCEEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
AGESGFNMARTVAVLAGLDTVPGTTVNRYCSSSLQTTRMALHAIKAGEGEVFISAGVETV
CCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHH
SRLGKGSADGWPDTQNPVFADAVARTAERASGGAADWADPRAQGLLPDVYIAMGQTAENV
HHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHCCCCCHHHHCCCCCHHHH
AQFTGITRAEQDAFGVRSQNLAEKAIADGFWATDITPVTLPDGTVVSADDGPRAGVTLEA
HHHHCCCCCHHHHHCCCHHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCCCCCCCHHHH
VSQLKPVFRPDGTVTAGNCCALNDGAAALVIMSDTKARDLGITPLARIVSTGVSALSPEI
HHHCCCCCCCCCCEECCCEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHCHHHHCCCC
MGLGPIEASKQALGRAGLTIDDIDLVEINEAFAVQVLGSARELGIPEDKLNVNGGAIAVG
EECCCCHHHHHHHHHCCCEECCCEEEEECCHHEEEECCCHHHCCCCHHHEECCCCEEEEC
HPFGMTGARITSTLINSLRFHDKQFGLETMCVGGGQGMAMVLERLS
CCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]