BacMap

Definition	Nocardia farcinica IFM 10152 chromosome, complete genome.
Accession	NC_006361
Length	6,021,225

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The map label for this gene is fabG [C]

Identifier: 54025381

GI number: 54025381

Start: 3614570

End: 3615325

Strand: Reverse

Name: fabG [C]

Synonym: nfa34120

Alternate gene names: 54025381

Gene position: 3615325-3614570 (Counterclockwise)

Preceding gene: 54025382

Following gene: 54025380

Centisome position: 60.04

GC content: 71.3

Gene sequence:

>756_bases
GTGACCGGCCGTTTCGCCGGCAGGACCGCGATCGTCACCGGCGCCAGCCGCGGCATCGGCCTGGCCATCGCGCAGCGCCT
GGTGGACGACGGCGCGAAGGTGGTGATCACCGCGCGCAAGCAGGACGCCCTCGACGAGGCGGTCCGGCAGCTGGGCGGGG
CCGAGCACGCGCTCGGCGTCGCCGGACGTGCCGACGACCTCGAGCACCAGGAGGAGACCGTCGCGCGGGCGATCGAGACC
TTCGGCGGCGCCGACCTGCTGGTCAACAACACCGGGATCAACCCGGTCTACGGTGCGCTGATCGACATGGACCTGGCCGC
GGCGCGCAAGATCATCGAGGTCAACTGCCTGGCCGCGCTGTCGTGGACCCAGCGCGCGCACAAGGCGTGGATGGCCGAAC
ACGGCGGCGCGGTGGTCAACGTGTCCTCGGTGGCCGGGATCAAACCGGCGCCCGGGATCGGCTTCTACGGCGCCAGCAAG
GCCATGCTGACCTACCTCACCCAGGAACTGGCCGTGGAACTCGGGCCGGACCTGCGCGTCAACGCGGTCGCCCCGGCCGT
GGTGAAGACGAAGTTCGCCACCGCGCTCTACGAGGGCCGCGAACAGGAACTCGCCGGAACCTATCCGCTGAAGCGGCTCG
GCGTGCCCGAGGACATCGCGGGTGCGGTGGCGTTCCTGCTCTCCGACGACGCCGCCTGGATCACCGGCCAGCTCCTCGTC
CTCGACGGCGGCATCACCCTGACCGGCGGCGTCTGA

Upstream 100 bases:

>100_bases
CCCTGATCAACTCGCTGCGCTTCCACGACAAGCAGTTCGGGTTGGAGACCATGTGTGTCGGCGGCGGCCAGGGCATGGCC
ATGGTGCTGGAGCGGCTGTC

Downstream 100 bases:

>100_bases
CAACCACATCGACTCCAGGAGATATTCATGAGCACCCCGACCACGACCGCTGTCGTCACCGGCGCCGCCCGCGGCATCGG
CGCGGGCATCGCCCGGCGCC

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: ORFC [H]

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MTGRFAGRTAIVTGASRGIGLAIAQRLVDDGAKVVITARKQDALDEAVRQLGGAEHALGVAGRADDLEHQEETVARAIET
FGGADLLVNNTGINPVYGALIDMDLAAARKIIEVNCLAALSWTQRAHKAWMAEHGGAVVNVSSVAGIKPAPGIGFYGASK
AMLTYLTQELAVELGPDLRVNAVAPAVVKTKFATALYEGREQELAGTYPLKRLGVPEDIAGAVAFLLSDDAAWITGQLLV
LDGGITLTGGV

Sequences:

>Translated_251_residues
MTGRFAGRTAIVTGASRGIGLAIAQRLVDDGAKVVITARKQDALDEAVRQLGGAEHALGVAGRADDLEHQEETVARAIET
FGGADLLVNNTGINPVYGALIDMDLAAARKIIEVNCLAALSWTQRAHKAWMAEHGGAVVNVSSVAGIKPAPGIGFYGASK
AMLTYLTQELAVELGPDLRVNAVAPAVVKTKFATALYEGREQELAGTYPLKRLGVPEDIAGAVAFLLSDDAAWITGQLLV
LDGGITLTGGV
>Mature_250_residues
TGRFAGRTAIVTGASRGIGLAIAQRLVDDGAKVVITARKQDALDEAVRQLGGAEHALGVAGRADDLEHQEETVARAIETF
GGADLLVNNTGINPVYGALIDMDLAAARKIIEVNCLAALSWTQRAHKAWMAEHGGAVVNVSSVAGIKPAPGIGFYGASKA
MLTYLTQELAVELGPDLRVNAVAPAVVKTKFATALYEGREQELAGTYPLKRLGVPEDIAGAVAFLLSDDAAWITGQLLVL
DGGITLTGGV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=41.2698412698413, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=39.6761133603239, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI126723750, Length=254, Percent_Identity=35.4330708661417, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI33667109, Length=200, Percent_Identity=41, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI19923817, Length=267, Percent_Identity=33.7078651685393, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI126723191, Length=189, Percent_Identity=38.6243386243386, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=34.6938775510204, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI40254992, Length=242, Percent_Identity=32.6446280991736, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI109715829, Length=240, Percent_Identity=32.5, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI10190704, Length=249, Percent_Identity=29.3172690763052, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI15277342, Length=259, Percent_Identity=32.046332046332, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI32455239, Length=156, Percent_Identity=37.8205128205128, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI5031765, Length=156, Percent_Identity=37.8205128205128, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI7705855, Length=195, Percent_Identity=30.2564102564103, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI31542939, Length=250, Percent_Identity=27.6, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4503301, Length=252, Percent_Identity=28.968253968254, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI59889578, Length=233, Percent_Identity=29.6137339055794, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI302344755, Length=108, Percent_Identity=37.037037037037, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI20149619, Length=192, Percent_Identity=28.125, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4758504, Length=257, Percent_Identity=26.8482490272374, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI7706318, Length=204, Percent_Identity=31.8627450980392, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=244, Percent_Identity=35.2459016393443, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787905, Length=251, Percent_Identity=33.4661354581673, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=31.7647058823529, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87082160, Length=243, Percent_Identity=30.8641975308642, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI2367365, Length=244, Percent_Identity=31.5573770491803, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1786812, Length=256, Percent_Identity=32.8125, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790717, Length=249, Percent_Identity=29.3172690763052, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788459, Length=244, Percent_Identity=30.7377049180328, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI2367175, Length=255, Percent_Identity=31.7647058823529, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1789208, Length=243, Percent_Identity=27.9835390946502, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1787820, Length=224, Percent_Identity=29.0178571428571, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789378, Length=253, Percent_Identity=26.8774703557312, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786701, Length=197, Percent_Identity=28.9340101522843, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=42.1259842519685, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=35.0806451612903, Blast_Score=143, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17562906, Length=269, Percent_Identity=36.0594795539033, Blast_Score=134, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17562910, Length=268, Percent_Identity=33.955223880597, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17562908, Length=270, Percent_Identity=35.5555555555556, Blast_Score=130, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=34.5864661654135, Blast_Score=121, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI72000259, Length=269, Percent_Identity=33.8289962825279, Blast_Score=121, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17560150, Length=268, Percent_Identity=33.2089552238806, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17538480, Length=280, Percent_Identity=33.5714285714286, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17563726, Length=262, Percent_Identity=32.4427480916031, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17562990, Length=268, Percent_Identity=32.8358208955224, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI193204405, Length=271, Percent_Identity=32.4723247232472, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17565030, Length=271, Percent_Identity=32.8413284132841, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17560220, Length=276, Percent_Identity=31.1594202898551, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=30.7984790874525, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17562904, Length=269, Percent_Identity=31.5985130111524, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17559104, Length=275, Percent_Identity=30.9090909090909, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71994604, Length=246, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71994600, Length=252, Percent_Identity=32.9365079365079, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17551412, Length=272, Percent_Identity=30.5147058823529, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI115534694, Length=253, Percent_Identity=33.596837944664, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17538486, Length=268, Percent_Identity=29.8507462686567, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=30.7086614173228, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17555706, Length=247, Percent_Identity=30.7692307692308, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17536025, Length=261, Percent_Identity=28.735632183908, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17508651, Length=252, Percent_Identity=27.3809523809524, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17544670, Length=270, Percent_Identity=27.4074074074074, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17536651, Length=263, Percent_Identity=27.7566539923954, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=255, Percent_Identity=27.4509803921569, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17561272, Length=266, Percent_Identity=26.6917293233083, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6324126, Length=252, Percent_Identity=29.7619047619048, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323882, Length=249, Percent_Identity=26.9076305220884, Blast_Score=75, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6322861, Length=237, Percent_Identity=25.3164556962025, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=200, Percent_Identity=27.5, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=38.1526104417671, Blast_Score=161, Evalue=3e-40,
Organism=Drosophila melanogaster, GI23397609, Length=247, Percent_Identity=36.8421052631579, Blast_Score=127, Evalue=6e-30,
Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=33.6, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=31.9838056680162, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24644337, Length=251, Percent_Identity=33.8645418326693, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24644339, Length=251, Percent_Identity=31.4741035856574, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24643142, Length=254, Percent_Identity=31.8897637795276, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24641388, Length=239, Percent_Identity=33.0543933054393, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641232, Length=203, Percent_Identity=33.4975369458128, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24648693, Length=242, Percent_Identity=33.0578512396694, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355889, Length=242, Percent_Identity=33.0578512396694, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI116007236, Length=238, Percent_Identity=27.3109243697479, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI116007234, Length=246, Percent_Identity=31.3008130081301, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28571387, Length=202, Percent_Identity=33.6633663366337, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24649181, Length=194, Percent_Identity=28.3505154639175, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24580925, Length=204, Percent_Identity=26.9607843137255, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24640442, Length=198, Percent_Identity=28.2828282828283, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24584744, Length=191, Percent_Identity=27.7486910994764, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574402, Length=191, Percent_Identity=27.7486910994764, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357673, Length=269, Percent_Identity=27.1375464684015, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI161076933, Length=187, Percent_Identity=26.7379679144385, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24584748, Length=187, Percent_Identity=26.7379679144385, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281364494, Length=237, Percent_Identity=28.6919831223629, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI116007238, Length=208, Percent_Identity=27.8846153846154, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI116007232, Length=185, Percent_Identity=35.1351351351351, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24665247, Length=176, Percent_Identity=34.0909090909091, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26054; Mature: 25923

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRFAGRTAIVTGASRGIGLAIAQRLVDDGAKVVITARKQDALDEAVRQLGGAEHALGV
CCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCHHHCC
AGRADDLEHQEETVARAIETFGGADLLVNNTGINPVYGALIDMDLAAARKIIEVNCLAAL
CCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SWTQRAHKAWMAEHGGAVVNVSSVAGIKPAPGIGFYGASKAMLTYLTQELAVELGPDLRV
HHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEE
NAVAPAVVKTKFATALYEGREQELAGTYPLKRLGVPEDIAGAVAFLLSDDAAWITGQLLV
ECCCHHHHHHHHHHHHHCCCHHHHCCCCCHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEE
LDGGITLTGGV
EECCEEEECCC
>Mature Secondary Structure 
TGRFAGRTAIVTGASRGIGLAIAQRLVDDGAKVVITARKQDALDEAVRQLGGAEHALGV
CCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCHHHCC
AGRADDLEHQEETVARAIETFGGADLLVNNTGINPVYGALIDMDLAAARKIIEVNCLAAL
CCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SWTQRAHKAWMAEHGGAVVNVSSVAGIKPAPGIGFYGASKAMLTYLTQELAVELGPDLRV
HHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEE
NAVAPAVVKTKFATALYEGREQELAGTYPLKRLGVPEDIAGAVAFLLSDDAAWITGQLLV
ECCCHHHHHHHHHHHHHCCCHHHHCCCCCHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEE
LDGGITLTGGV
EECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]