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The map label for this gene is pyrH

Identifier: 54020578

GI number: 54020578

Start: 699193

End: 699903

Strand: Reverse

Name: pyrH

Synonym: mhp552

Alternate gene names: 54020578

Gene position: 699903-699193 (Counterclockwise)

Preceding gene: 54020579

Following gene: 54020577

Centisome position: 78.4

GC content: 33.61

Gene sequence:

>711_bases
ATGGACTCAACTATTCTTATTAAACTTTCAGGCGAAAGTCTTGCAAATAAACAAAAATCTCTGGCAATCGATTATGAACT
TGTAAGACAAATCGGTTCTCAACTCAAAGAAATACAGAATTTAGGGCATAAAATTTTAATTGTTATCGGCGGCGGAAATT
TTTGGCGCGGTACTTCCGCGGCAAAAAATGGTATAAACAGGAACACCGCTGATTATATCGGGATGCTTGGAACTGTTATG
AACGGGCTTGCCCTTGATTCAGTTTTCCGCGATTTGGGAATTAAAACTCGAGTTTTATCCTCGATGAGTTTAGACCCGCG
AATTTGTGAGTATTTTGTCAGGGAAAAAGCGATGAAATATTTAGAAGATAACAATGTTTTAATTTTTGTTGGCGGGACCG
GCCGTCCATTTTTTACAACTGATAGTGCTGCAACACTTTTTGCATCCGAAATGGGTGCAAATATTATTTTAGTGGGCAAA
AATAATGTCAATGGCATTTTTGACTCTGATCCAAAAATTAATCCAAATGCGCTAAGATATGATAAAATTACTTATAATCA
AGTTATTGAAAAAAATTTAAAGGTAATGGACTCAACAGCTTTTTCAATGGCTCGTGATAATAAAATTAAATTACTAATTT
TTGATATTAAAGAAAAAAATAGCATTTCTAAATTAATCAAAAGACAAATTAAACACACGGAGGTTTATTAA

Upstream 100 bases:

>100_bases
CAAAAAAAATAAAATCTGCAACTTTTTCCTAAAATTTTCCTTTTTTTAATACATTTTTTTTCAAAAATAAAGTATAATAA
AAGAAACTTTTAAGGCTAAT

Downstream 100 bases:

>100_bases
ATAATGAAGAACGAAATTGAATTTAGTTTTTATAAAAACATCTTGATTGAAAAAGCTCAAGATGTTTTTTCCTATCTTGA
AAAAAGTTTTCAGAAAGTAA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MDSTILIKLSGESLANKQKSLAIDYELVRQIGSQLKEIQNLGHKILIVIGGGNFWRGTSAAKNGINRNTADYIGMLGTVM
NGLALDSVFRDLGIKTRVLSSMSLDPRICEYFVREKAMKYLEDNNVLIFVGGTGRPFFTTDSAATLFASEMGANIILVGK
NNVNGIFDSDPKINPNALRYDKITYNQVIEKNLKVMDSTAFSMARDNKIKLLIFDIKEKNSISKLIKRQIKHTEVY

Sequences:

>Translated_236_residues
MDSTILIKLSGESLANKQKSLAIDYELVRQIGSQLKEIQNLGHKILIVIGGGNFWRGTSAAKNGINRNTADYIGMLGTVM
NGLALDSVFRDLGIKTRVLSSMSLDPRICEYFVREKAMKYLEDNNVLIFVGGTGRPFFTTDSAATLFASEMGANIILVGK
NNVNGIFDSDPKINPNALRYDKITYNQVIEKNLKVMDSTAFSMARDNKIKLLIFDIKEKNSISKLIKRQIKHTEVY
>Mature_236_residues
MDSTILIKLSGESLANKQKSLAIDYELVRQIGSQLKEIQNLGHKILIVIGGGNFWRGTSAAKNGINRNTADYIGMLGTVM
NGLALDSVFRDLGIKTRVLSSMSLDPRICEYFVREKAMKYLEDNNVLIFVGGTGRPFFTTDSAATLFASEMGANIILVGK
NNVNGIFDSDPKINPNALRYDKITYNQVIEKNLKVMDSTAFSMARDNKIKLLIFDIKEKNSISKLIKRQIKHTEVY

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=222, Percent_Identity=39.6396396396396, Blast_Score=182, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_MYCH2 (Q600A4)

Other databases:

- EMBL:   AE017332
- RefSeq:   YP_116061.1
- HSSP:   P65932
- ProteinModelPortal:   Q600A4
- SMR:   Q600A4
- STRING:   Q600A4
- GeneID:   3105555
- GenomeReviews:   AE017332_GR
- KEGG:   mhy:mhp552
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   MHYO295358:MHP552-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26319; Mature: 26319

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: NA

Important sites: BINDING 51-51 BINDING 52-52 BINDING 56-56 BINDING 71-71 BINDING 161-161 BINDING 167-167 BINDING 170-170

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSTILIKLSGESLANKQKSLAIDYELVRQIGSQLKEIQNLGHKILIVIGGGNFWRGTSA
CCCEEEEEECCCHHHCHHHHEEHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHH
AKNGINRNTADYIGMLGTVMNGLALDSVFRDLGIKTRVLSSMSLDPRICEYFVREKAMKY
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHH
LEDNNVLIFVGGTGRPFFTTDSAATLFASEMGANIILVGKNNVNGIFDSDPKINPNALRY
HCCCCEEEEECCCCCCEEECCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCEEE
DKITYNQVIEKNLKVMDSTAFSMARDNKIKLLIFDIKEKNSISKLIKRQIKHTEVY
CCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDSTILIKLSGESLANKQKSLAIDYELVRQIGSQLKEIQNLGHKILIVIGGGNFWRGTSA
CCCEEEEEECCCHHHCHHHHEEHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHH
AKNGINRNTADYIGMLGTVMNGLALDSVFRDLGIKTRVLSSMSLDPRICEYFVREKAMKY
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHH
LEDNNVLIFVGGTGRPFFTTDSAATLFASEMGANIILVGKNNVNGIFDSDPKINPNALRY
HCCCCEEEEECCCCCCEEECCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCEEE
DKITYNQVIEKNLKVMDSTAFSMARDNKIKLLIFDIKEKNSISKLIKRQIKHTEVY
CCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA