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The map label for this gene is recU

Identifier: 54020007

GI number: 54020007

Start: 66905

End: 67399

Strand: Direct

Name: recU

Synonym: mhp057

Alternate gene names: 54020007

Gene position: 66905-67399 (Clockwise)

Preceding gene: 54020006

Following gene: 54020008

Centisome position: 7.49

GC content: 25.86

Gene sequence:

>495_bases
ATGTTATATATGAACCACAAAAACCGCGGAATGTTTCTCGAAAAAATTATTAACAACACAATTGAATTTTACTGTGAAAA
CGGTATTGGTATTTTCCATAAAAAAAATTTAGATATTAGTTTTAAGGCGGTTAGTAAAGATTTAGCAGTCAATGATGCTT
TTATTTTTAAGAAATCAACAGTTGATTATTATGGAATTTATAAAGGAATTTTTGTTGCTTTTGAGGCAAAAAGTACAAAC
GAAAATGTTCTAAATTTAAAGCAAATACCTGAACATCAACTAAGTTATCTTCAAAAAATTCGAGAACATTTTGGTTGTGC
TTTTTTTATAATTTTTTTCAAACAACTAGAAAAATTTTATATTGTAAGTATTGACAAAATTAATTTATCCTGAAAATCTA
TTCCTGTTGCATTTTTACAAAAAGAAGGTTTTGAAATCCCGCTAACATATCCAGGGATAATCGATTTTATAGGTTATATT
GATCAGATGATTTAA

Upstream 100 bases:

>100_bases
ATATTAATTTTTTTATGGAAAATTTCATAAAAAAAGGAAAAACAGCTTGTTTTTCCCAATTTTTTCCTTTTTTCTGCCAA
AAAGTGAAAAAAAACTTAAT

Downstream 100 bases:

>100_bases
TTTTTTAGTTTAATTTGTAAATTTAAAGCAGAATTACAGGTAGTAATTGTATCAGAAAAAGATTAAATTGTTTTTAATTT
TTAATTTTATGATATAATTT

Product: Holliday junction-specific endonuclease

Products: NA

Alternate protein names: Recombination protein U homolog [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MLYMNHKNRGMFLEKIINNTIEFYCENGIGIFHKKNLDISFKAVSKDLAVNDAFIFKKSTVDYYGIYKGIFVAFEAKSTN
ENVLNLKQIPEHQLSYLQKIREHFGCAFFIIFFKQLEKFYIVSIDKINLSWKSIPVAFLQKEGFEIPLTYPGIIDFIGYI
DQMI

Sequences:

>Translated_164_residues
MLYMNHKNRGMFLEKIINNTIEFYCENGIGIFHKKNLDISFKAVSKDLAVNDAFIFKKSTVDYYGIYKGIFVAFEAKSTN
ENVLNLKQIPEHQLSYLQKIREHFGCAFFIIFFKQLEKFYIVSIDKINLS*KSIPVAFLQKEGFEIPLTYPGIIDFIGYI
DQMI
>Mature_164_residues
MLYMNHKNRGMFLEKIINNTIEFYCENGIGIFHKKNLDISFKAVSKDLAVNDAFIFKKSTVDYYGIYKGIFVAFEAKSTN
ENVLNLKQIPEHQLSYLQKIREHFGCAFFIIFFKQLEKFYIVSIDKINLS*KSIPVAFLQKEGFEIPLTYPGIIDFIGYI
DQMI

Specific function: Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair

COG id: COG3331

COG function: function code R; Penicillin-binding protein-related factor A, putative recombinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the recU family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004612
- InterPro:   IPR011335 [H]

Pfam domain/function: PF03838 RecU [H]

EC number: NA

Molecular weight: Translated: 19018; Mature: 19018

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYMNHKNRGMFLEKIINNTIEFYCENGIGIFHKKNLDISFKAVSKDLAVNDAFIFKKST
CEEECCCCCCHHHHHHHHHHHEEEECCCEEEEEECCCCEEEEECCCCCCCCCEEEEEECC
VDYYGIYKGIFVAFEAKSTNENVLNLKQIPEHQLSYLQKIREHFGCAFFIIFFKQLEKFY
CCHHHHHEEEEEEEECCCCCCCEEEHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHEE
IVSIDKINLSKSIPVAFLQKEGFEIPLTYPGIIDFIGYIDQMI
EEEEEEECCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHCC
>Mature Secondary Structure
MLYMNHKNRGMFLEKIINNTIEFYCENGIGIFHKKNLDISFKAVSKDLAVNDAFIFKKST
CEEECCCCCCHHHHHHHHHHHEEEECCCEEEEEECCCCEEEEECCCCCCCCCEEEEEECC
VDYYGIYKGIFVAFEAKSTNENVLNLKQIPEHQLSYLQKIREHFGCAFFIIFFKQLEKFY
CCHHHHHEEEEEEEECCCCCCCEEEHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHEE
IVSIDKINLSKSIPVAFLQKEGFEIPLTYPGIIDFIGYIDQMI
EEEEEEECCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11353084 [H]