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The map label for this gene is obgE

Identifier: 54019994

GI number: 54019994

Start: 55489

End: 56748

Strand: Direct

Name: obgE

Synonym: mhp043

Alternate gene names: 54019994

Gene position: 55489-56748 (Clockwise)

Preceding gene: 54019993

Following gene: 54019995

Centisome position: 6.22

GC content: 30.79

Gene sequence:

>1260_bases
ATGCGATTTGTCGACTATGTTTCAATCGAAGTCGTGGCCGGAAAAGGTGGCGATGGGATAATATCGTTTCGCCGGGAAGC
TCATGTCGACAAAGGTGGGCCGGACGGTGGCGATGGTGGATGAGGTGGTTCAATTTATTTTGTTGGTGATTCAGGTATGA
ATACTTTATTACCTTTTTATCAAACCAAGAAGATTTTCGGTTATAATGGCGAAAATGGTAGGCCAAAAAGACAGACTGGT
GCTAATGGGAAAGATATTTTTATAAAAGTTCCTTTAGGTACACAAGTTTTTCTAAAAAAGTCTTTAATTTGTGATATAAT
TTTAGAAAAAAAATACTTAATAGCCAAAGGAGGTCGAGGAGGTCTTGGAAATTTTCATTTCAGAAATTCAAAAAATAAGG
CACCTCGAATTTCTGAAAATGGGGAATTAGGTCAAAATTTTTATCTTGATTTACAACTAAAAGTTATGGCTGATATCGGT
TTGGTAGGTAAGCCTAATGCCGGTAAATCGACACTTTTATCACTAATTTCTAACTCAAAACCAAAAATTGCAAATTATGA
ATTTACAACTTTAGTCCCACAATTAGGTGTTGTGAAAATTTATGAAAATTCATTTGTAACAGCTGATCTTCCCGGATTAA
TCCAGGGCGCTAGTTCGGGGAAGGGAATGGGAATTATTTTTTTAAAGCACATTGAAAGGTGTCGAGCAATTGTTCATGTA
ATTGATTTTGGTTCAGATAACAAAAATCCAATTAAGGATTTTATCGAGATAAAATCAGAATTAGAAAAATTCAATAAAAA
GTTATTGGATTTAAACCAAATAGTTATTGCAAATAAGTGTGATCTACCTAATTTTCAGTTTAATTTAGCAAATTTTAAAA
GAAAATTTCCAAAAATCAAAATAATTAAAAGTAGTTTAATTTCTGCAAAACAAAACGAAATTAATATAATCAAAGAGAAA
ATGTTTGGTTTGTTGGAAGAAAAACAAAAAAAATTAGAAATTCAAGAGATAAATACCTCAAAAATTGAATTTAACTTAAA
AGCTCCCTTTTTAATTAAGAGCAGAAATAACGGGTTTTTTGAAATTACAGGAGAACTTATTCAAAAAATTATTCAAAAAA
TTCCGCTAAATTCTCAAGAGAACATTTTACGTTTTAATGCAAAAGTTAAAAAAATTGGACTTTGGGATGAATTGATCAAA
AAAGGAATTAAACCAGGGGATTTAGTTAGAATCTATGAATTTGAATTTCACTGGAATTAA

Upstream 100 bases:

>100_bases
TTGTGAGTAAATGCGCAAGAAACAAAACATTTTGATGATACACCTTATGCGAAAAAACTAGAAGATTTATATTTGGTTTT
TGCATCTCGAAAGGAATAAA

Downstream 100 bases:

>100_bases
AATTATTTTATCAGAGCGAAAATCGCTCCAAATCACCAATATTATTCAAAAAAAATACAAAACATATGAAAGTGAGGAAA
CGCAATGAGCGTAGTTGCCA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MRFVDYVSIEVVAGKGGDGIISFRREAHVDKGGPDGGDGGWGGSIYFVGDSGMNTLLPFYQTKKIFGYNGENGRPKRQTG
ANGKDIFIKVPLGTQVFLKKSLICDIILEKKYLIAKGGRGGLGNFHFRNSKNKAPRISENGELGQNFYLDLQLKVMADIG
LVGKPNAGKSTLLSLISNSKPKIANYEFTTLVPQLGVVKIYENSFVTADLPGLIQGASSGKGMGIIFLKHIERCRAIVHV
IDFGSDNKNPIKDFIEIKSELEKFNKKLLDLNQIVIANKCDLPNFQFNLANFKRKFPKIKIIKSSLISAKQNEINIIKEK
MFGLLEEKQKKLEIQEINTSKIEFNLKAPFLIKSRNNGFFEITGELIQKIIQKIPLNSQENILRFNAKVKKIGLWDELIK
KGIKPGDLVRIYEFEFHWN

Sequences:

>Translated_419_residues
MRFVDYVSIEVVAGKGGDGIISFRREAHVDKGGPDGGDGG*GGSIYFVGDSGMNTLLPFYQTKKIFGYNGENGRPKRQTG
ANGKDIFIKVPLGTQVFLKKSLICDIILEKKYLIAKGGRGGLGNFHFRNSKNKAPRISENGELGQNFYLDLQLKVMADIG
LVGKPNAGKSTLLSLISNSKPKIANYEFTTLVPQLGVVKIYENSFVTADLPGLIQGASSGKGMGIIFLKHIERCRAIVHV
IDFGSDNKNPIKDFIEIKSELEKFNKKLLDLNQIVIANKCDLPNFQFNLANFKRKFPKIKIIKSSLISAKQNEINIIKEK
MFGLLEEKQKKLEIQEINTSKIEFNLKAPFLIKSRNNGFFEITGELIQKIIQKIPLNSQENILRFNAKVKKIGLWDELIK
KGIKPGDLVRIYEFEFHWN
>Mature_419_residues
MRFVDYVSIEVVAGKGGDGIISFRREAHVDKGGPDGGDGG*GGSIYFVGDSGMNTLLPFYQTKKIFGYNGENGRPKRQTG
ANGKDIFIKVPLGTQVFLKKSLICDIILEKKYLIAKGGRGGLGNFHFRNSKNKAPRISENGELGQNFYLDLQLKVMADIG
LVGKPNAGKSTLLSLISNSKPKIANYEFTTLVPQLGVVKIYENSFVTADLPGLIQGASSGKGMGIIFLKHIERCRAIVHV
IDFGSDNKNPIKDFIEIKSELEKFNKKLLDLNQIVIANKCDLPNFQFNLANFKRKFPKIKIIKSSLISAKQNEINIIKEK
MFGLLEEKQKKLEIQEINTSKIEFNLKAPFLIKSRNNGFFEITGELIQKIIQKIPLNSQENILRFNAKVKKIGLWDELIK
KGIKPGDLVRIYEFEFHWN

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=310, Percent_Identity=38.0645161290323, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI111955139, Length=276, Percent_Identity=36.231884057971, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI111955063, Length=209, Percent_Identity=36.8421052631579, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI58761500, Length=136, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4758796, Length=112, Percent_Identity=39.2857142857143, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1789574, Length=287, Percent_Identity=47.7351916376307, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1787454, Length=128, Percent_Identity=33.59375, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=283, Percent_Identity=37.1024734982332, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17552324, Length=306, Percent_Identity=34.3137254901961, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17509631, Length=128, Percent_Identity=28.125, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71981008, Length=111, Percent_Identity=35.1351351351351, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17555344, Length=112, Percent_Identity=37.5, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=165, Percent_Identity=46.0606060606061, Blast_Score=131, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6319281, Length=87, Percent_Identity=39.0804597701149, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321612, Length=86, Percent_Identity=40.6976744186046, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI20129375, Length=297, Percent_Identity=39.0572390572391, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24585318, Length=291, Percent_Identity=36.0824742268041, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI21356473, Length=87, Percent_Identity=42.5287356321839, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917 [H]

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 46798; Mature: 46798

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFVDYVSIEVVAGKGGDGIISFRREAHVDKGGPDGGDGGGGSIYFVGDSGMNTLLPFYQ
CCCEEEEEEEEEECCCCCCEEEEHHHHCCCCCCCCCCCCCCEEEEEEECCCCCHHCCHHH
TKKIFGYNGENGRPKRQTGANGKDIFIKVPLGTQVFLKKSLICDIILEKKYLIAKGGRGG
CCEEEECCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCC
LGNFHFRNSKNKAPRISENGELGQNFYLDLQLKVMADIGLVGKPNAGKSTLLSLISNSKP
CCCEEEECCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCC
KIANYEFTTLVPQLGVVKIYENSFVTADLPGLIQGASSGKGMGIIFLKHIERCRAIVHVI
CCCCEEHHHHCCCCCEEEEECCCEEEECCCHHHCCCCCCCCEEEHHHHHHHHHHHHHHEE
DFGSDNKNPIKDFIEIKSELEKFNKKLLDLNQIVIANKCDLPNFQFNLANFKRKFPKIKI
ECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEHHHHHHHCCEEEE
IKSSLISAKQNEINIIKEKMFGLLEEKQKKLEIQEINTSKIEFNLKAPFLIKSRNNGFFE
EHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEEEECCCEEEEECCCCEEE
ITGELIQKIIQKIPLNSQENILRFNAKVKKIGLWDELIKKGIKPGDLVRIYEFEFHWN
EHHHHHHHHHHHCCCCCCCCEEEECCEEEEECCHHHHHHCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure
MRFVDYVSIEVVAGKGGDGIISFRREAHVDKGGPDGGDGGGGSIYFVGDSGMNTLLPFYQ
CCCEEEEEEEEEECCCCCCEEEEHHHHCCCCCCCCCCCCCCEEEEEEECCCCCHHCCHHH
TKKIFGYNGENGRPKRQTGANGKDIFIKVPLGTQVFLKKSLICDIILEKKYLIAKGGRGG
CCEEEECCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCC
LGNFHFRNSKNKAPRISENGELGQNFYLDLQLKVMADIGLVGKPNAGKSTLLSLISNSKP
CCCEEEECCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCC
KIANYEFTTLVPQLGVVKIYENSFVTADLPGLIQGASSGKGMGIIFLKHIERCRAIVHVI
CCCCEEHHHHCCCCCEEEEECCCEEEECCCHHHCCCCCCCCEEEHHHHHHHHHHHHHHEE
DFGSDNKNPIKDFIEIKSELEKFNKKLLDLNQIVIANKCDLPNFQFNLANFKRKFPKIKI
ECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEHHHHHHHCCEEEE
IKSSLISAKQNEINIIKEKMFGLLEEKQKKLEIQEINTSKIEFNLKAPFLIKSRNNGFFE
EHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEEEECCCEEEEECCCCEEE
ITGELIQKIIQKIPLNSQENILRFNAKVKKIGLWDELIKKGIKPGDLVRIYEFEFHWN
EHHHHHHHHHHHCCCCCCCCEEEECCEEEEECCHHHHHHCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA