BacMap

Definition	Burkholderia pseudomallei K96243 chromosome 2, complete sequence.
Accession	NC_006351
Length	3,173,005

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The map label for this gene is pldh-t [H]

Identifier: 53723086

GI number: 53723086

Start: 2803594

End: 2804364

Strand: Reverse

Name: pldh-t [H]

Synonym: BPSS2068

Alternate gene names: 53723086

Gene position: 2804364-2803594 (Counterclockwise)

Preceding gene: 53723087

Following gene: 53723085

Centisome position: 88.38

GC content: 57.07

Gene sequence:

>771_bases
ATGAATGCTTCTGCTCAGCTTGCATCTCGTCGCGTGCTGCTTACCGGCGGACTGGGTAGCCTGGGCCAGGCCCAGGTGCG
CAAGCTTCGCGCCGCAGGCGCGGACGTCTATATTCTAGATCTCCCTTCTCCTCGTGGCGACGAGCTCGCCGAGGCACTGA
ACAGTGAGACCGGTGCGGGCATGGGACATGTGACCTTTGTGCCTGCAGACCTGAGAGAGCTAGCCTCTGCGCAAGCTCTC
GTTTCGGACCTTGGCCATGAGATTGGTGGCTTCGATATCCTGATCAACAACGCGGCGCTGATCACCCACAAGCCCTACGA
CGAGTTCACACTTTCGGAATATGAAGATGTAATGCGAGTCAATAGCACGGCGGGGTTCGCCTTGACACAGGCAGTGACTC
CCATGATGAAGGCCAATGGTTGGGGCCGAATTATCAATTTTTGCAGCATCACGCTTAACGGCCGTTGGGAAAAGTATGTC
CCTTACGTATCGTCAAAAGGTGCAATGCTGGGGCAGACCAAGACGTTTGCGAGAGCGCTTGGACCCTTCGGCATTACCGT
CAACGCCGTCAGTCCTGGTGCCATCGTATCCGACGCCGAGGAACGGGTTTTCGGCGACAAATTGAAAGAGTACAACGACT
GGGTGCTGGAGAACCAGTCGCTCAAGCGCCGAGGCGAACCGGAAGACGTCGCTAACCTTGTCGCGTTCCTGGCCAGCGAT
CAGGCCAGCTTTCTGACAGGCCAGATTATCTCGCTGGACGGGGGTTGGTAA

Upstream 100 bases:

>100_bases
GCATCGTGGTTATGTCGCGCGGTCAGATTGTCGCGGACCGCCTGGTAGACGACATCACCATGGACGAAGTTCAGGAAATC
TTGTGATATCGAGACCGATC

Downstream 100 bases:

>100_bases
GCATGACGAAGCTTGTCGAGCTCAAAAACAGCGAGGCCAGTGCGGTTGTACTTCCGCGGCATGGCGCCGGCCTGGCGAGC
TTCGATTTTCTGTGGCGCGG

Product: short chain dehydrogenase

Products: NA

Alternate protein names: tPLDH [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MNASAQLASRRVLLTGGLGSLGQAQVRKLRAAGADVYILDLPSPRGDELAEALNSETGAGMGHVTFVPADLRELASAQAL
VSDLGHEIGGFDILINNAALITHKPYDEFTLSEYEDVMRVNSTAGFALTQAVTPMMKANGWGRIINFCSITLNGRWEKYV
PYVSSKGAMLGQTKTFARALGPFGITVNAVSPGAIVSDAEERVFGDKLKEYNDWVLENQSLKRRGEPEDVANLVAFLASD
QASFLTGQIISLDGGW

Sequences:

>Translated_256_residues
MNASAQLASRRVLLTGGLGSLGQAQVRKLRAAGADVYILDLPSPRGDELAEALNSETGAGMGHVTFVPADLRELASAQAL
VSDLGHEIGGFDILINNAALITHKPYDEFTLSEYEDVMRVNSTAGFALTQAVTPMMKANGWGRIINFCSITLNGRWEKYV
PYVSSKGAMLGQTKTFARALGPFGITVNAVSPGAIVSDAEERVFGDKLKEYNDWVLENQSLKRRGEPEDVANLVAFLASD
QASFLTGQIISLDGGW
>Mature_256_residues
MNASAQLASRRVLLTGGLGSLGQAQVRKLRAAGADVYILDLPSPRGDELAEALNSETGAGMGHVTFVPADLRELASAQAL
VSDLGHEIGGFDILINNAALITHKPYDEFTLSEYEDVMRVNSTAGFALTQAVTPMMKANGWGRIINFCSITLNGRWEKYV
PYVSSKGAMLGQTKTFARALGPFGITVNAVSPGAIVSDAEERVFGDKLKEYNDWVLENQSLKRRGEPEDVANLVAFLASD
QASFLTGQIISLDGGW

Specific function: Involved in the degradation of pyridoxine or pyridoxamine (free, phosphate-unbound, forms of vitamin B6). Oxidizes pyridoxal to 4-pyridoxolactone, but does not have activity toward pyridoxal 5'-phosphate, pyridoxine, pyridoxamine, pyridoxamine 5'-phosphat

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=254, Percent_Identity=33.0708661417323, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI15277342, Length=258, Percent_Identity=32.1705426356589, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI7705925, Length=260, Percent_Identity=29.2307692307692, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI19923817, Length=258, Percent_Identity=28.2945736434109, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI5031737, Length=253, Percent_Identity=32.4110671936759, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI66933014, Length=181, Percent_Identity=29.2817679558011, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI126723750, Length=263, Percent_Identity=28.8973384030418, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI4758504, Length=260, Percent_Identity=28.4615384615385, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI59889578, Length=236, Percent_Identity=28.8135593220339, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4503301, Length=209, Percent_Identity=28.7081339712919, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI83715985, Length=260, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI10190704, Length=250, Percent_Identity=26.8, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1790717, Length=255, Percent_Identity=29.8039215686275, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI87082160, Length=254, Percent_Identity=28.740157480315, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=31.640625, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1789208, Length=252, Percent_Identity=30.5555555555556, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=29.9610894941634, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787905, Length=250, Percent_Identity=28.4, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI2367365, Length=251, Percent_Identity=31.4741035856574, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789378, Length=259, Percent_Identity=27.4131274131274, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788459, Length=192, Percent_Identity=30.7291666666667, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1789057, Length=252, Percent_Identity=26.1904761904762, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI2367175, Length=251, Percent_Identity=31.0756972111554, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=254, Percent_Identity=28.740157480315, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=30.3501945525292, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=265, Percent_Identity=31.3207547169811, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=29.1187739463602, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71994604, Length=189, Percent_Identity=31.7460317460317, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=211, Percent_Identity=29.3838862559242, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=28.6259541984733, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17561402, Length=247, Percent_Identity=27.9352226720648, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17565030, Length=255, Percent_Identity=31.3725490196078, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=257, Percent_Identity=29.9610894941634, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17551412, Length=262, Percent_Identity=27.4809160305344, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=27.6515151515151, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=265, Percent_Identity=25.2830188679245, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=260, Percent_Identity=26.5384615384615, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=256, Percent_Identity=27.34375, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=259, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=260, Percent_Identity=26.9230769230769, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=268, Percent_Identity=27.6119402985075, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=259, Percent_Identity=26.6409266409266, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=29.277566539924, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71982365, Length=218, Percent_Identity=27.5229357798165, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17561272, Length=212, Percent_Identity=27.3584905660377, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=25.9398496240602, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=26.615969581749, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17536651, Length=249, Percent_Identity=27.3092369477912, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=266, Percent_Identity=28.1954887218045, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=266, Percent_Identity=25.187969924812, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324126, Length=245, Percent_Identity=24.0816326530612, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323882, Length=202, Percent_Identity=27.7227722772277, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21357041, Length=213, Percent_Identity=32.8638497652582, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=30.6772908366534, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24644339, Length=252, Percent_Identity=28.968253968254, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24643142, Length=254, Percent_Identity=29.5275590551181, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=29.6442687747036, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI23397609, Length=253, Percent_Identity=28.8537549407115, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24644337, Length=169, Percent_Identity=31.9526627218935, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17737361, Length=256, Percent_Identity=26.5625, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355319, Length=257, Percent_Identity=27.2373540856031, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.107 [H]

Molecular weight: Translated: 27452; Mature: 27452

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNASAQLASRRVLLTGGLGSLGQAQVRKLRAAGADVYILDLPSPRGDELAEALNSETGAG
CCCCHHHHHCEEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCCC
MGHVTFVPADLRELASAQALVSDLGHEIGGFDILINNAALITHKPYDEFTLSEYEDVMRV
CCEEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEEECEEEEEECCCCCCCHHHHHHHHHH
NSTAGFALTQAVTPMMKANGWGRIINFCSITLNGRWEKYVPYVSSKGAMLGQTKTFARAL
CCCCCHHHHHHHHHHHHCCCHHHEEEEEEEEECCCCHHHCCEECCCCCCCCCHHHHHHHH
GPFGITVNAVSPGAIVSDAEERVFGDKLKEYNDWVLENQSLKRRGEPEDVANLVAFLASD
CCCCEEEECCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHCC
QASFLTGQIISLDGGW
CCHHHEEEEEEECCCC
>Mature Secondary Structure
MNASAQLASRRVLLTGGLGSLGQAQVRKLRAAGADVYILDLPSPRGDELAEALNSETGAG
CCCCHHHHHCEEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCCC
MGHVTFVPADLRELASAQALVSDLGHEIGGFDILINNAALITHKPYDEFTLSEYEDVMRV
CCEEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEEECEEEEEECCCCCCCHHHHHHHHHH
NSTAGFALTQAVTPMMKANGWGRIINFCSITLNGRWEKYVPYVSSKGAMLGQTKTFARAL
CCCCCHHHHHHHHHHHHCCCHHHEEEEEEEEECCCCHHHCCEECCCCCCCCCHHHHHHHH
GPFGITVNAVSPGAIVSDAEERVFGDKLKEYNDWVLENQSLKRRGEPEDVANLVAFLASD
CCCCEEEECCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHCC
QASFLTGQIISLDGGW
CCHHHEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]