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The map label for this gene is adhA

Identifier: 53722965

GI number: 53722965

Start: 2631078

End: 2632103

Strand: Reverse

Name: adhA

Synonym: BPSS1944

Alternate gene names: 53722965

Gene position: 2632103-2631078 (Counterclockwise)

Preceding gene: 53722966

Following gene: 53722964

Centisome position: 82.95

GC content: 67.93

Gene sequence:

>1026_bases
ATGGCGCAATACATGAAGGCCGCGGTGGTGCATGCATTCGGCGAACCGCTTCGGATCGAGGAGGTGCCCGTGCCGACGCC
CGGCGCGGGGCAGATTCTCGTGAACGTCAAGGCATCGGGCGTGTGCCATACCGATCTGCACGCGGCCGACGGCGACTGGC
CCGTCAAGCCGACGCTGCCGTTCATTCCGGGGCACGAGGGCGTCGGCTTCGTCGCGGCGGTGGGCGAAGGCGTGAGGCAC
GTGAAGGAGGGCGATCGCGTCGGCGTGCCTTGGCTCTATACCGCGTGCGGCCATTGCGAGTATTGCCAGACCGGCTGGGA
GACGCTGTGCCACGAGCAGCAGAACACCGGCTATTCGGTGTACGGCAGCTACGCGGAATACGTGCTCGCCGATCCGAACT
ACGTCGGCCATCTGCCGAGCAACGTCGCGTTCGACGAGATCGCGCCGATCCTGTGCGCGGGCGTGACCGTCTACAAGGGC
ATTCGGGTGACCGACACGCGCCCGGGGCAATGGATCGCGATCTCGGGGATCGGCGGGCTCGGGCACGTCGCGGTGCAGTA
CGCGAAGGCGATGGGGCTGCACGTGGTCGCGGTGGACGTCGCGCCGCAGAAGCTCGAGCTTGCGCGCAAGCTGGGCGCGG
CGTTCGTCGTCGATGCGTCGAAGGACGATCCGGCGGCGGTGATCCAGAAGGAGATCGGCGGCGTGCACGGCGTGCTCGTG
ACGGCCGTGTCGCGCGGCGCGTTCGCGCAGGCGCTCGGCATGGTGAGGCGCGGCGGGACGGTCTCGCTGAACGGGCTGCC
GCCGGGCGATTTTCCGCTGCCGATCTTCTCGACGGTGCTCAACGGGATCACGGTGCGAGGCTCGATCGTCGGCACGCGGC
GCGATCTCCAGGAATCGCTCGATTTCGCGGCCGAAGGGCTCGTGCGCGCGCATATCCATCGCGACAAGCTCGAGCACATC
AACGGCGTGTTCTCGGCGCTGCGTGAAGGGAAGGTCGACGGGCGGATCGTGTTGACCGGGCAATGA

Upstream 100 bases:

>100_bases
CGCAATCGCGCCTCGCGCCGGGCGCGGTTGACGCACGTCAACGCCGGGCGCCGTGCGTGACCGATACTCGATCGGACATC
GAACCAACCAGGAGCGATTG

Downstream 100 bases:

>100_bases
CGTCAGGACGCGCGCCCGCGCGGCACGCGCGCCGCCCGAGGTTCGAAAAGATGAAGCTGCCGCTTTGCGGCGGGCGATGC
GCGGCGCGGGCCGCGCATCG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MAQYMKAAVVHAFGEPLRIEEVPVPTPGAGQILVNVKASGVCHTDLHAADGDWPVKPTLPFIPGHEGVGFVAAVGEGVRH
VKEGDRVGVPWLYTACGHCEYCQTGWETLCHEQQNTGYSVYGSYAEYVLADPNYVGHLPSNVAFDEIAPILCAGVTVYKG
IRVTDTRPGQWIAISGIGGLGHVAVQYAKAMGLHVVAVDVAPQKLELARKLGAAFVVDASKDDPAAVIQKEIGGVHGVLV
TAVSRGAFAQALGMVRRGGTVSLNGLPPGDFPLPIFSTVLNGITVRGSIVGTRRDLQESLDFAAEGLVRAHIHRDKLEHI
NGVFSALREGKVDGRIVLTGQ

Sequences:

>Translated_341_residues
MAQYMKAAVVHAFGEPLRIEEVPVPTPGAGQILVNVKASGVCHTDLHAADGDWPVKPTLPFIPGHEGVGFVAAVGEGVRH
VKEGDRVGVPWLYTACGHCEYCQTGWETLCHEQQNTGYSVYGSYAEYVLADPNYVGHLPSNVAFDEIAPILCAGVTVYKG
IRVTDTRPGQWIAISGIGGLGHVAVQYAKAMGLHVVAVDVAPQKLELARKLGAAFVVDASKDDPAAVIQKEIGGVHGVLV
TAVSRGAFAQALGMVRRGGTVSLNGLPPGDFPLPIFSTVLNGITVRGSIVGTRRDLQESLDFAAEGLVRAHIHRDKLEHI
NGVFSALREGKVDGRIVLTGQ
>Mature_340_residues
AQYMKAAVVHAFGEPLRIEEVPVPTPGAGQILVNVKASGVCHTDLHAADGDWPVKPTLPFIPGHEGVGFVAAVGEGVRHV
KEGDRVGVPWLYTACGHCEYCQTGWETLCHEQQNTGYSVYGSYAEYVLADPNYVGHLPSNVAFDEIAPILCAGVTVYKGI
RVTDTRPGQWIAISGIGGLGHVAVQYAKAMGLHVVAVDVAPQKLELARKLGAAFVVDASKDDPAAVIQKEIGGVHGVLVT
AVSRGAFAQALGMVRRGGTVSLNGLPPGDFPLPIFSTVLNGITVRGSIVGTRRDLQESLDFAAEGLVRAHIHRDKLEHIN
GVFSALREGKVDGRIVLTGQ

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=30.6233062330623, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI34577061, Length=368, Percent_Identity=29.6195652173913, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI4501929, Length=360, Percent_Identity=29.1666666666667, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI71565152, Length=367, Percent_Identity=26.4305177111717, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI71565154, Length=256, Percent_Identity=29.6875, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI156523966, Length=366, Percent_Identity=27.0491803278689, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI4501939, Length=359, Percent_Identity=27.0194986072423, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI156627571, Length=300, Percent_Identity=29, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI71743840, Length=254, Percent_Identity=27.5590551181102, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI262073058, Length=254, Percent_Identity=27.5590551181102, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI194239674, Length=270, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI13236495, Length=270, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI194239676, Length=199, Percent_Identity=30.1507537688442, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI87081918, Length=310, Percent_Identity=46.1290322580645, Blast_Score=246, Evalue=1e-66,
Organism=Escherichia coli, GI1786518, Length=349, Percent_Identity=32.0916905444126, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1790045, Length=348, Percent_Identity=29.3103448275862, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI87082401, Length=308, Percent_Identity=30.5194805194805, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI87082125, Length=204, Percent_Identity=35.7843137254902, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788073, Length=273, Percent_Identity=32.6007326007326, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1786552, Length=365, Percent_Identity=28.7671232876712, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI226510992, Length=293, Percent_Identity=28.3276450511945, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787863, Length=342, Percent_Identity=26.3157894736842, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788075, Length=283, Percent_Identity=30.7420494699647, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786825, Length=360, Percent_Identity=26.9444444444444, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788407, Length=208, Percent_Identity=28.8461538461538, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790718, Length=317, Percent_Identity=24.6056782334385, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=336, Percent_Identity=39.8809523809524, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI71988145, Length=335, Percent_Identity=35.2238805970149, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17562582, Length=338, Percent_Identity=38.1656804733728, Blast_Score=217, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI17562876, Length=357, Percent_Identity=30.5322128851541, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17562878, Length=225, Percent_Identity=32.4444444444444, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25146526, Length=369, Percent_Identity=26.2872628726287, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71997431, Length=371, Percent_Identity=26.1455525606469, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17507255, Length=265, Percent_Identity=27.5471698113208, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=377, Percent_Identity=24.1379310344828, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=340, Percent_Identity=42.3529411764706, Blast_Score=268, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6319621, Length=342, Percent_Identity=41.2280701754386, Blast_Score=262, Evalue=5e-71,
Organism=Saccharomyces cerevisiae, GI6324486, Length=326, Percent_Identity=42.638036809816, Blast_Score=261, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6323729, Length=340, Percent_Identity=40, Blast_Score=256, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6319949, Length=326, Percent_Identity=28.5276073619632, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6320033, Length=369, Percent_Identity=27.10027100271, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323980, Length=320, Percent_Identity=25.9375, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=340, Percent_Identity=27.3529411764706, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6319955, Length=340, Percent_Identity=27.3529411764706, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=235, Percent_Identity=26.3829787234043, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137530, Length=350, Percent_Identity=28.5714285714286, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI17737895, Length=230, Percent_Identity=28.695652173913, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17737897, Length=348, Percent_Identity=27.8735632183908, Blast_Score=95, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36088; Mature: 35957

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQYMKAAVVHAFGEPLRIEEVPVPTPGAGQILVNVKASGVCHTDLHAADGDWPVKPTLP
CCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCEEECCCCCCCCCCCCCCCCC
FIPGHEGVGFVAAVGEGVRHVKEGDRVGVPWLYTACGHCEYCQTGWETLCHEQQNTGYSV
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCEEE
YGSYAEYVLADPNYVGHLPSNVAFDEIAPILCAGVTVYKGIRVTDTRPGQWIAISGIGGL
EECCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCH
GHVAVQYAKAMGLHVVAVDVAPQKLELARKLGAAFVVDASKDDPAAVIQKEIGGVHGVLV
HHHHHHHHHHCCEEEEEEECCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCHHHHHH
TAVSRGAFAQALGMVRRGGTVSLNGLPPGDFPLPIFSTVLNGITVRGSIVGTRRDLQESL
HHHHCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHCCEEEEEEEECCHHHHHHHH
DFAAEGLVRAHIHRDKLEHINGVFSALREGKVDGRIVLTGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure 
AQYMKAAVVHAFGEPLRIEEVPVPTPGAGQILVNVKASGVCHTDLHAADGDWPVKPTLP
CHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCEEECCCCCCCCCCCCCCCCC
FIPGHEGVGFVAAVGEGVRHVKEGDRVGVPWLYTACGHCEYCQTGWETLCHEQQNTGYSV
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCEEE
YGSYAEYVLADPNYVGHLPSNVAFDEIAPILCAGVTVYKGIRVTDTRPGQWIAISGIGGL
EECCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCH
GHVAVQYAKAMGLHVVAVDVAPQKLELARKLGAAFVVDASKDDPAAVIQKEIGGVHGVLV
HHHHHHHHHHCCEEEEEEECCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCHHHHHH
TAVSRGAFAQALGMVRRGGTVSLNGLPPGDFPLPIFSTVLNGITVRGSIVGTRRDLQESL
HHHHCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHCCEEEEEEEECCHHHHHHHH
DFAAEGLVRAHIHRDKLEHINGVFSALREGKVDGRIVLTGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9659380; 11481432 [H]