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The map label for this gene is selB

Identifier: 53722683

GI number: 53722683

Start: 2282552

End: 2284477

Strand: Reverse

Name: selB

Synonym: BPSS1662

Alternate gene names: 53722683

Gene position: 2284477-2282552 (Counterclockwise)

Preceding gene: 53722684

Following gene: 53722675

Centisome position: 72.0

GC content: 72.79

Gene sequence:

>1926_bases
ATGATCGTCGGGACCGCAGGCCACATCGATCACGGCAAGACGACGCTCGTGCGCGCGCTGACGGGCGTCGACACCGATCG
GCTGAAGGAAGAGAAGGCGCGCGGAATCTCGATCGAGCTCGGCTACGCGTACACGCCGCTGCCGAACGGCGACGTGCTCG
GCTTCATCGACGTGCCCGGCCATGAAAAGCTCGTCCACACGATGGCCGCGGGCGCGTGCGGGATCGACTTCGCGCTCGTC
GTGATCGCGGCCGACGACGGCGTGATGCCGCAGACCCGCGAACATCTGTCGATTCTGCAACTGCTGGGCGTCGCGCATGG
CGCGCTCGCGCTGACGAAATGCGATCGCGTCGACGCGGCGCGCGTCGCGCGGGTGCGCGACGAGATCCGCGCGTGGCTCG
CGGCCTCGCCGCTCGCCGATGCGCCGGTTTTCGAGACGCGCGCGAGCGAGCCGGACGACGCGGGCGTTGCCGCATTGAAC
GCGCACCTGCGCGACACGGCGCTCGCCTGGCGCGCGCGGCGCGACGACGGCCTGTTCCGGCTCGCGGTCGATCGCGTGTT
CACGCTCGCGGGGCAAGGCACCGTCGTGACGGGCACCGCGGTCGCGGGGCGCGTGCGCACGGGCGACTCGCTCGCCGTCG
CGCGCACGGGCGAAACGGTGCGCGTGCGCAGCATCCATGCGCAGAACCGCGCGACCGACGTCGGCCATGCGGGCGAGCGC
TGCGCGCTGAATCTCGCGGGCATCGACAAGGCGGCGCTCGCGCGCGGCGATGCGATCGTCGACGCGCGGCTCGCGACGCT
TTCGCCACGCATCGACGTCGAATTGACGTTGACGGCGGACGCCGACCTGACGATCACGCACTGGACGCCGCTGCACGTGC
ATCTCGGCACGCTGCACCGGGTCGCGCACGTTGCGCTGCTCGAAGGCGAGACGCTCGGGCCCGGCCGGCGCGCCCGCGCG
CAGTTGAATTTCACGGAGCCGGTGTTCGCCGCGCCGGGCGATCGCTTCATCGTGCGCGACGCGCAGGCGACGCGCACCGT
GGGCGGCGGGCGCGTGCTCGATCCGTTCGGCCCCGCGCGCAAGCGGCGCACGCGCGCGCGACGCGCGTGGCTCGACGCGC
TCGCGGCGTGGCTCGACGAAGGCCGTCTCGACGCGTTGCTCGACGAGGCGCCGCTCGGCATCGCGCGCGCGACGCTGATG
CATCTGACCGGCTTGCCGGCGCAGGCGTGGGCGTTGCCGGCCGATGCGGTGAGCGTCGCCGCGCCGGGCAAGCACGCGGA
CGAAGCGCGCGTGCTTGCGCGCGGGCATTGGGACGCGCTGCGCACGCGCGTGCTCGATGCGCTCGCGGCATTCCATCAGC
GCTCGCCGGACGAGCAGGGGCCGGATGTCGCGCGGCTGCGCCGGATCGCCGCGCCGCTCGCGGACGACGCGTTGTGGCGC
GCGCTGACCGATGCGCTGATCGCCGAGGGCGCGATCGTGCGCAGCGGCCCGTGGCTGCATTTGCCGTCGCATGCGGTGAG
CTTCGACGCGGCCGAAGAGGCGTTGGCCGGGCGCTTGCTGCCGCTCGTCGCGGCGGGCCGCTACGATCCGCCGTGGGTGC
GCGATCACGCGGCGGCGACGCTCATGGCGGAGGACGCGGTGCGCGCGCTGCTGCGCAAGCTCGCGCGGCGCGGCGACGTG
CATCAGGTCGTGCGGGATCTGTTCTATCACCGCGACGTGATCGCGGAGCTTGCGCGACTGATCGCGCGACTCGCGGGCGA
GCACGGCGGCGGGCTCGATGCGGCGACGTTTCGCGACGCGACCGGGCTCGGCCGCAAGCGGGCGATTCAAATTCTCGAGT
TCTTCGATCGCGTTGGGTATACTCGCTTCCACCGCGACCTGCACTGGTTGCGGGCTGATAGCCGGTTGCTGGCCGGCTCG
CGGTAG

Upstream 100 bases:

>100_bases
TCGCCGACGACGCGCTGCGGCTCGACCTGCGCTGCCTCGAAGCGGGCGACGAAGCCGCATTCATCGCGCAATGCGCGCAG
GCGCCGACGGGCCCGCGCGC

Downstream 100 bases:

>100_bases
TCCGGTTTTTCGGGCTCGTGGGGGTTGCCGCGGTATTCGACGGTTCTCGACGGTTTTTTGACGGGGCGGGGTGCGCTTGA
TGTCGGCTTCCGTTTCCCGT

Product: selenocysteine-specific elongation factor

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 641; Mature: 641

Protein sequence:

>641_residues
MIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLPNGDVLGFIDVPGHEKLVHTMAAGACGIDFALV
VIAADDGVMPQTREHLSILQLLGVAHGALALTKCDRVDAARVARVRDEIRAWLAASPLADAPVFETRASEPDDAGVAALN
AHLRDTALAWRARRDDGLFRLAVDRVFTLAGQGTVVTGTAVAGRVRTGDSLAVARTGETVRVRSIHAQNRATDVGHAGER
CALNLAGIDKAALARGDAIVDARLATLSPRIDVELTLTADADLTITHWTPLHVHLGTLHRVAHVALLEGETLGPGRRARA
QLNFTEPVFAAPGDRFIVRDAQATRTVGGGRVLDPFGPARKRRTRARRAWLDALAAWLDEGRLDALLDEAPLGIARATLM
HLTGLPAQAWALPADAVSVAAPGKHADEARVLARGHWDALRTRVLDALAAFHQRSPDEQGPDVARLRRIAAPLADDALWR
ALTDALIAEGAIVRSGPWLHLPSHAVSFDAAEEALAGRLLPLVAAGRYDPPWVRDHAAATLMAEDAVRALLRKLARRGDV
HQVVRDLFYHRDVIAELARLIARLAGEHGGGLDAATFRDATGLGRKRAIQILEFFDRVGYTRFHRDLHWLRADSRLLAGS
R

Sequences:

>Translated_641_residues
MIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLPNGDVLGFIDVPGHEKLVHTMAAGACGIDFALV
VIAADDGVMPQTREHLSILQLLGVAHGALALTKCDRVDAARVARVRDEIRAWLAASPLADAPVFETRASEPDDAGVAALN
AHLRDTALAWRARRDDGLFRLAVDRVFTLAGQGTVVTGTAVAGRVRTGDSLAVARTGETVRVRSIHAQNRATDVGHAGER
CALNLAGIDKAALARGDAIVDARLATLSPRIDVELTLTADADLTITHWTPLHVHLGTLHRVAHVALLEGETLGPGRRARA
QLNFTEPVFAAPGDRFIVRDAQATRTVGGGRVLDPFGPARKRRTRARRAWLDALAAWLDEGRLDALLDEAPLGIARATLM
HLTGLPAQAWALPADAVSVAAPGKHADEARVLARGHWDALRTRVLDALAAFHQRSPDEQGPDVARLRRIAAPLADDALWR
ALTDALIAEGAIVRSGPWLHLPSHAVSFDAAEEALAGRLLPLVAAGRYDPPWVRDHAAATLMAEDAVRALLRKLARRGDV
HQVVRDLFYHRDVIAELARLIARLAGEHGGGLDAATFRDATGLGRKRAIQILEFFDRVGYTRFHRDLHWLRADSRLLAGS
R
>Mature_641_residues
MIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLPNGDVLGFIDVPGHEKLVHTMAAGACGIDFALV
VIAADDGVMPQTREHLSILQLLGVAHGALALTKCDRVDAARVARVRDEIRAWLAASPLADAPVFETRASEPDDAGVAALN
AHLRDTALAWRARRDDGLFRLAVDRVFTLAGQGTVVTGTAVAGRVRTGDSLAVARTGETVRVRSIHAQNRATDVGHAGER
CALNLAGIDKAALARGDAIVDARLATLSPRIDVELTLTADADLTITHWTPLHVHLGTLHRVAHVALLEGETLGPGRRARA
QLNFTEPVFAAPGDRFIVRDAQATRTVGGGRVLDPFGPARKRRTRARRAWLDALAAWLDEGRLDALLDEAPLGIARATLM
HLTGLPAQAWALPADAVSVAAPGKHADEARVLARGHWDALRTRVLDALAAFHQRSPDEQGPDVARLRRIAAPLADDALWR
ALTDALIAEGAIVRSGPWLHLPSHAVSFDAAEEALAGRLLPLVAAGRYDPPWVRDHAAATLMAEDAVRALLRKLARRGDV
HQVVRDLFYHRDVIAELARLIARLAGEHGGGLDAATFRDATGLGRKRAIQILEFFDRVGYTRFHRDLHWLRADSRLLAGS
R

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=393, Percent_Identity=28.498727735369, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI54607086, Length=309, Percent_Identity=26.2135922330097, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI4503475, Length=324, Percent_Identity=24.3827160493827, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI53729339, Length=222, Percent_Identity=29.7297297297297, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI53729337, Length=222, Percent_Identity=29.7297297297297, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI2367247, Length=639, Percent_Identity=42.4100156494523, Blast_Score=418, Evalue=1e-118,
Organism=Escherichia coli, GI1789737, Length=386, Percent_Identity=30.5699481865285, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1790412, Length=381, Percent_Identity=30.7086614173228, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1789108, Length=265, Percent_Identity=28.3018867924528, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789559, Length=96, Percent_Identity=38.5416666666667, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556456, Length=395, Percent_Identity=27.5949367088608, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI25141371, Length=378, Percent_Identity=28.8359788359788, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17506081, Length=259, Percent_Identity=27.027027027027, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17565438, Length=322, Percent_Identity=23.9130434782609, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI115532065, Length=329, Percent_Identity=24.6200607902736, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115532067, Length=329, Percent_Identity=24.6200607902736, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324761, Length=398, Percent_Identity=26.6331658291457, Blast_Score=113, Evalue=9e-26,
Organism=Drosophila melanogaster, GI281363316, Length=406, Percent_Identity=26.3546798029557, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17864358, Length=406, Percent_Identity=26.3546798029557, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19921738, Length=380, Percent_Identity=28.4210526315789, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI19922690, Length=271, Percent_Identity=30.6273062730627, Blast_Score=109, Evalue=7e-24,
Organism=Drosophila melanogaster, GI28572034, Length=120, Percent_Identity=40, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17137380, Length=346, Percent_Identity=24.2774566473988, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550900, Length=363, Percent_Identity=23.9669421487603, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 69032; Mature: 69032

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLPNGDVLGFIDVPG
CEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEECEEECCCCCCCEEEEEECCC
HEKLVHTMAAGACGIDFALVVIAADDGVMPQTREHLSILQLLGVAHGALALTKCDRVDAA
HHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
RVARVRDEIRAWLAASPLADAPVFETRASEPDDAGVAALNAHLRDTALAWRARRDDGLFR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
LAVDRVFTLAGQGTVVTGTAVAGRVRTGDSLAVARTGETVRVRSIHAQNRATDVGHAGER
HHHHHHHHHCCCCEEEECCCEECEEECCCCEEEEECCCEEEEEEECCCCCCCCCCCCCCC
CALNLAGIDKAALARGDAIVDARLATLSPRIDVELTLTADADLTITHWTPLHVHLGTLHR
EEEEECCCCHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCEEEEEHHHHHH
VAHVALLEGETLGPGRRARAQLNFTEPVFAAPGDRFIVRDAQATRTVGGGRVLDPFGPAR
HHHHHEECCCCCCCCCHHEEEECCCCCEEECCCCEEEEECCHHHHCCCCCEEECCCCHHH
KRRTRARRAWLDALAAWLDEGRLDALLDEAPLGIARATLMHLTGLPAQAWALPADAVSVA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCHHHHCCCCCCEEEC
APGKHADEARVLARGHWDALRTRVLDALAAFHQRSPDEQGPDVARLRRIAAPLADDALWR
CCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHH
ALTDALIAEGAIVRSGPWLHLPSHAVSFDAAEEALAGRLLPLVAAGRYDPPWVRDHAAAT
HHHHHHHHCCCEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LMAEDAVRALLRKLARRGDVHQVVRDLFYHRDVIAELARLIARLAGEHGGGLDAATFRDA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCC
TGLGRKRAIQILEFFDRVGYTRFHRDLHWLRADSRLLAGSR
CCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure
MIVGTAGHIDHGKTTLVRALTGVDTDRLKEEKARGISIELGYAYTPLPNGDVLGFIDVPG
CEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEECEEECCCCCCCEEEEEECCC
HEKLVHTMAAGACGIDFALVVIAADDGVMPQTREHLSILQLLGVAHGALALTKCDRVDAA
HHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
RVARVRDEIRAWLAASPLADAPVFETRASEPDDAGVAALNAHLRDTALAWRARRDDGLFR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
LAVDRVFTLAGQGTVVTGTAVAGRVRTGDSLAVARTGETVRVRSIHAQNRATDVGHAGER
HHHHHHHHHCCCCEEEECCCEECEEECCCCEEEEECCCEEEEEEECCCCCCCCCCCCCCC
CALNLAGIDKAALARGDAIVDARLATLSPRIDVELTLTADADLTITHWTPLHVHLGTLHR
EEEEECCCCHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCEEEEEHHHHHH
VAHVALLEGETLGPGRRARAQLNFTEPVFAAPGDRFIVRDAQATRTVGGGRVLDPFGPAR
HHHHHEECCCCCCCCCHHEEEECCCCCEEECCCCEEEEECCHHHHCCCCCEEECCCCHHH
KRRTRARRAWLDALAAWLDEGRLDALLDEAPLGIARATLMHLTGLPAQAWALPADAVSVA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCHHHHCCCCCCEEEC
APGKHADEARVLARGHWDALRTRVLDALAAFHQRSPDEQGPDVARLRRIAAPLADDALWR
CCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHH
ALTDALIAEGAIVRSGPWLHLPSHAVSFDAAEEALAGRLLPLVAAGRYDPPWVRDHAAAT
HHHHHHHHCCCEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LMAEDAVRALLRKLARRGDVHQVVRDLFYHRDVIAELARLIARLAGEHGGGLDAATFRDA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCC
TGLGRKRAIQILEFFDRVGYTRFHRDLHWLRADSRLLAGSR
CCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2531290; 8041620; 9278503; 2140572 [H]