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The map label for this gene is mcl1 [H]

Identifier: 53722662

GI number: 53722662

Start: 2257163

End: 2258044

Strand: Reverse

Name: mcl1 [H]

Synonym: BPSS1639

Alternate gene names: 53722662

Gene position: 2258044-2257163 (Counterclockwise)

Preceding gene: 53722663

Following gene: 53722661

Centisome position: 71.16

GC content: 72.0

Gene sequence:

>882_bases
ATGTCGATATCGATTCCGCACGACGCAGCCGCTCCGGCGGCGTGCGATCGGCTCCACAGTGCGTTGCGCAGCTGGCTCTT
CACGCCGGCCACGCGCGCCGATCGCTTTTCAAACGCCTCCGAGTGCGGCGCTGACGTGCTCATCGTCGATCTGGAGGATT
CGGTCGCCCCGGCCGACAAGGCGTACGCCCGAGACCACGCGCGCGCGTGGCTCTCGAGCGGGCAGGCGCACGCGCGGCCG
GCTTCGGCCGTCCGCATCAACGCGCCCGATACGGTGGCGGGCCACGCGGACCTCGGGATGCTGATCGACGCGCCGCGCGC
GCCCGATTTCATCGTGGTGCCGAAAGTCGAAACGCAGCAGCGCATCGCGCATCTCGATGCGCTGTTGCGCGACGCGGGCC
GCCTGCCCCGATACGGCTTCGTCGCGATGATCGAATCCGCGGCGGGCGCCGATGCGGCCGACGCGATCGTGCGCGCGTGC
GGCTCGATCGGGGCGCTGATGTTCGGCGCGGCCGACTACGCGTCCGATGTCGCCGCACAACCCGATGCGCTCGCGCTGCA
GATCGCGCGCGTGCGGCTCGCCGCGGCCTGCGCGCGTGGCCGCATCGCCGCGATCGATGCGCCCTGCTTTGCATTGCGCG
ACGCGGCGGCCCTCGATACCGAGCTTGCGTTTGCCGTGCGCAACGGCCTTCGCGGCAAGGCGGCGATTCACCCGGCGCAC
GTCGCACCGATCAATGCGGCATTCGCGCCTTCGCCGCAGCGGATCGCATGGGCGCGCCGCGTGATCGGCGCGGCGTCGCA
AGGCGCGGCCGTCGTCGACGGCCGCATGGTCGACGAAGCCGTCGCGCGCGAGGCGAGGGACGTTCTCGCCGCGGCGCGAT
GA

Upstream 100 bases:

>100_bases
CCGATTCGCCGAAGGCTGCCCCCGAAAATGCCGCATTGTCCGGCGCGCGACGGGTGGCGACAATGCACTCGTCGTTTCGC
TCAACGAGGAGTGCCGGTTC

Downstream 100 bases:

>100_bases
CGGATACCCCGTTCTTTCTTCAACCAGGAGGCGAGCATGAGCACGACGATTTCCGCGTACCGACAGATCGGCGACAAGCG
GTTTCGCGAGATATCCGGCC

Product: citrate lyase beta chain

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MSISIPHDAAAPAACDRLHSALRSWLFTPATRADRFSNASECGADVLIVDLEDSVAPADKAYARDHARAWLSSGQAHARP
ASAVRINAPDTVAGHADLGMLIDAPRAPDFIVVPKVETQQRIAHLDALLRDAGRLPRYGFVAMIESAAGADAADAIVRAC
GSIGALMFGAADYASDVAAQPDALALQIARVRLAAACARGRIAAIDAPCFALRDAAALDTELAFAVRNGLRGKAAIHPAH
VAPINAAFAPSPQRIAWARRVIGAASQGAAVVDGRMVDEAVAREARDVLAAAR

Sequences:

>Translated_293_residues
MSISIPHDAAAPAACDRLHSALRSWLFTPATRADRFSNASECGADVLIVDLEDSVAPADKAYARDHARAWLSSGQAHARP
ASAVRINAPDTVAGHADLGMLIDAPRAPDFIVVPKVETQQRIAHLDALLRDAGRLPRYGFVAMIESAAGADAADAIVRAC
GSIGALMFGAADYASDVAAQPDALALQIARVRLAAACARGRIAAIDAPCFALRDAAALDTELAFAVRNGLRGKAAIHPAH
VAPINAAFAPSPQRIAWARRVIGAASQGAAVVDGRMVDEAVAREARDVLAAAR
>Mature_292_residues
SISIPHDAAAPAACDRLHSALRSWLFTPATRADRFSNASECGADVLIVDLEDSVAPADKAYARDHARAWLSSGQAHARPA
SAVRINAPDTVAGHADLGMLIDAPRAPDFIVVPKVETQQRIAHLDALLRDAGRLPRYGFVAMIESAAGADAADAIVRACG
SIGALMFGAADYASDVAAQPDALALQIARVRLAAACARGRIAAIDAPCFALRDAAALDTELAFAVRNGLRGKAAIHPAHV
APINAAFAPSPQRIAWARRVIGAASQGAAVVDGRMVDEAVAREARDVLAAAR

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=291, Percent_Identity=24.3986254295533, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI87081764, Length=286, Percent_Identity=28.6713286713287, Blast_Score=78, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17557458, Length=296, Percent_Identity=24.6621621621622, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 30439; Mature: 30308

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISIPHDAAAPAACDRLHSALRSWLFTPATRADRFSNASECGADVLIVDLEDSVAPADK
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHCCCCEEEEECCCCCCCCHH
AYARDHARAWLSSGQAHARPASAVRINAPDTVAGHADLGMLIDAPRAPDFIVVPKVETQQ
HHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCEEEECCCCCCEEEECCCHHHH
RIAHLDALLRDAGRLPRYGFVAMIESAAGADAADAIVRACGSIGALMFGAADYASDVAAQ
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCC
PDALALQIARVRLAAACARGRIAAIDAPCFALRDAAALDTELAFAVRNGLRGKAAIHPAH
CHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCC
VAPINAAFAPSPQRIAWARRVIGAASQGAAVVDGRMVDEAVAREARDVLAAAR
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SISIPHDAAAPAACDRLHSALRSWLFTPATRADRFSNASECGADVLIVDLEDSVAPADK
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHCCCCEEEEECCCCCCCCHH
AYARDHARAWLSSGQAHARPASAVRINAPDTVAGHADLGMLIDAPRAPDFIVVPKVETQQ
HHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCEEEECCCCCCEEEECCCHHHH
RIAHLDALLRDAGRLPRYGFVAMIESAAGADAADAIVRACGSIGALMFGAADYASDVAAQ
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCC
PDALALQIARVRLAAACARGRIAAIDAPCFALRDAAALDTELAFAVRNGLRGKAAIHPAH
CHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCC
VAPINAAFAPSPQRIAWARRVIGAASQGAAVVDGRMVDEAVAREARDVLAAAR
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA