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The map label for this gene is glcD [H]

Identifier: 53722343

GI number: 53722343

Start: 1805789

End: 1807282

Strand: Reverse

Name: glcD [H]

Synonym: BPSS1318

Alternate gene names: 53722343

Gene position: 1807282-1805789 (Counterclockwise)

Preceding gene: 53722344

Following gene: 53722342

Centisome position: 56.96

GC content: 72.02

Gene sequence:

>1494_bases
ATGCGCGAAGTGACCGACGACGGGCAGCAGTGGGACGGGCGGGCGGCGGCTTTCGCGGGCGTGCCGTCCGGCGGCGGCGC
GCCTGCCGCGTTCGCCACGCCGCAGACGATCGGGCGCTGTGTCGAGGCGTTGCGCGCGATCGTCGGCGAGCGCCTCGCAG
TCGGGCGCGCGGTGCGCGAGCAGCACGGCAAGGACATCTCGTTCCATCCGGGCGCGCCGCCCGACGCCGTCGCGTTCGTG
CGGACGACGGCCGAGGTCGCCGAGATCACACGCGCGTGCCATCGGCTGCGCGTGCCGCTGATTCCGTTCGGCACCGGCAC
GTCGTGCGAGGGGCACATCGCCGCGCTGCGCGGCGGCGTATGCATCGATCTGTCCGGCATGAACCGGATTCTGCGCGTGA
GCGCCGAGGATCTCGACTGCACGGTCGAGGCGGGGGTGACGCGCAAGCAGCTCAATGCGCACCTGCGCGACACGGGGCTC
TTCTTTCCGATCGACCCGGGCGCGGACGCGTCGATCGGCGGCATGTGCTCGACGCGCGCTTCCGGCACGAACGCGGTGCG
CTACGGGACGATGCGCGAGAGCGTGCTCGCGCTCGAAGTCGTGCTGCCGAACGGCGACGTCGTCTCGGTCGGCTCGCGTG
CGCGCAAGTCGGCGGCGGGCTACGATCTCGCGCGCCTGTTCGTCGGCGCGGAAGGCACGCTCGGCACGATCACGGGCGTC
ACGCTGCGGCTGCATCCGCGCCCGGACCGGTTATCCGCCGCGGTGTGCAGTTTCCCGGACCTGAAGGCCGCGGTCGACTC
GGTGATCGGCGTCATCCGCAGCGGCGTGCCGATCGCGCGCGTCGAGTTGCTCGACGCACTGCAGATCGTCGCGTGCAACC
GCTATGCGAAGCTGAGCCTCGACGAGCGGCCGACGCTCTTTTTCGAGTTCGCGGGGTTCGGCGCGGCCGTCGACGAGCAG
ATCGACTGGGTCGGGGAGATTTGCGCGGGCTACGGCGGCGGTGAATTCCGCTGGGCGTCGCGCCCGGAGGAGCGCAGCGC
GCTGTGGGCGGCGCGGCACGACGCGTGGTGGGCGGCGCTCGCGCTGCGGCCCGGCTGCGAGGGGATGCCGACCGATTCGT
GCGTGCCCGTGTCGCGGCTCGCGGAGGCGGTGCTCGCCGCGCGCGCGGACGTGGACGCGCTCGGCCTCGTCGCGACGATC
TGCGGGCACGTCGGCGACGGCAACTTTCACGTATGCATCGCGATCGATCCGGCCGACGCGGACGAACTCGCGCGCGCAAC
CGAGCTGAACCGGCGGCTCGCGCTGCGCGCGATCGCGTTGGGCGGCACCTGCACGGGCGAGCACGGCGTCGGTTACGGGA
AGATCGGCTACCTGGAGCGTGAGCATCCGACGGCGCTGCAACTGATGGCGGCCGTCAAGCGCGCGCTCGATCCGCGCGGC
ATCATGAATCCGGGCAAGGTGCTGCATCACGACCGGTATCCGCCGTTCGACTGA

Upstream 100 bases:

>100_bases
GCGCGGGGCGCGCACGGCGGCGCGGGGATGGGGGCGGCCCCGCGTGTGCGCGGGCTGCGCGCCGCGGCGAGCGGGCGCGA
TCGACGAACGGAGGCGACGC

Downstream 100 bases:

>100_bases
GTTCTGGACGGCGCGCGGGCGGGGCGAGCGGCCGATCCGGCCGTGCGCGGCCCGACCCGGCGGGCCGGCCGACGAACGGA
CGCGGCGCGGCGTGCGTCGC

Product: D-lactate dehydrogenase

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MREVTDDGQQWDGRAAAFAGVPSGGGAPAAFATPQTIGRCVEALRAIVGERLAVGRAVREQHGKDISFHPGAPPDAVAFV
RTTAEVAEITRACHRLRVPLIPFGTGTSCEGHIAALRGGVCIDLSGMNRILRVSAEDLDCTVEAGVTRKQLNAHLRDTGL
FFPIDPGADASIGGMCSTRASGTNAVRYGTMRESVLALEVVLPNGDVVSVGSRARKSAAGYDLARLFVGAEGTLGTITGV
TLRLHPRPDRLSAAVCSFPDLKAAVDSVIGVIRSGVPIARVELLDALQIVACNRYAKLSLDERPTLFFEFAGFGAAVDEQ
IDWVGEICAGYGGGEFRWASRPEERSALWAARHDAWWAALALRPGCEGMPTDSCVPVSRLAEAVLAARADVDALGLVATI
CGHVGDGNFHVCIAIDPADADELARATELNRRLALRAIALGGTCTGEHGVGYGKIGYLEREHPTALQLMAAVKRALDPRG
IMNPGKVLHHDRYPPFD

Sequences:

>Translated_497_residues
MREVTDDGQQWDGRAAAFAGVPSGGGAPAAFATPQTIGRCVEALRAIVGERLAVGRAVREQHGKDISFHPGAPPDAVAFV
RTTAEVAEITRACHRLRVPLIPFGTGTSCEGHIAALRGGVCIDLSGMNRILRVSAEDLDCTVEAGVTRKQLNAHLRDTGL
FFPIDPGADASIGGMCSTRASGTNAVRYGTMRESVLALEVVLPNGDVVSVGSRARKSAAGYDLARLFVGAEGTLGTITGV
TLRLHPRPDRLSAAVCSFPDLKAAVDSVIGVIRSGVPIARVELLDALQIVACNRYAKLSLDERPTLFFEFAGFGAAVDEQ
IDWVGEICAGYGGGEFRWASRPEERSALWAARHDAWWAALALRPGCEGMPTDSCVPVSRLAEAVLAARADVDALGLVATI
CGHVGDGNFHVCIAIDPADADELARATELNRRLALRAIALGGTCTGEHGVGYGKIGYLEREHPTALQLMAAVKRALDPRG
IMNPGKVLHHDRYPPFD
>Mature_497_residues
MREVTDDGQQWDGRAAAFAGVPSGGGAPAAFATPQTIGRCVEALRAIVGERLAVGRAVREQHGKDISFHPGAPPDAVAFV
RTTAEVAEITRACHRLRVPLIPFGTGTSCEGHIAALRGGVCIDLSGMNRILRVSAEDLDCTVEAGVTRKQLNAHLRDTGL
FFPIDPGADASIGGMCSTRASGTNAVRYGTMRESVLALEVVLPNGDVVSVGSRARKSAAGYDLARLFVGAEGTLGTITGV
TLRLHPRPDRLSAAVCSFPDLKAAVDSVIGVIRSGVPIARVELLDALQIVACNRYAKLSLDERPTLFFEFAGFGAAVDEQ
IDWVGEICAGYGGGEFRWASRPEERSALWAARHDAWWAALALRPGCEGMPTDSCVPVSRLAEAVLAARADVDALGLVATI
CGHVGDGNFHVCIAIDPADADELARATELNRRLALRAIALGGTCTGEHGVGYGKIGYLEREHPTALQLMAAVKRALDPRG
IMNPGKVLHHDRYPPFD

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=453, Percent_Identity=54.083885209713, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI37595754, Length=476, Percent_Identity=51.4705882352941, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI119964728, Length=421, Percent_Identity=30.8788598574822, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI4501993, Length=222, Percent_Identity=28.8288288288288, Blast_Score=102, Evalue=9e-22,
Organism=Escherichia coli, GI1789351, Length=419, Percent_Identity=31.2649164677804, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1787977, Length=498, Percent_Identity=27.3092369477912, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI48994907, Length=438, Percent_Identity=24.4292237442922, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI48994914, Length=192, Percent_Identity=26.0416666666667, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71992373, Length=461, Percent_Identity=46.2039045553145, Blast_Score=408, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71992381, Length=461, Percent_Identity=44.9023861171367, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71992392, Length=378, Percent_Identity=48.1481481481481, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17534361, Length=453, Percent_Identity=26.2693156732892, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17556096, Length=457, Percent_Identity=22.9759299781182, Blast_Score=102, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6320027, Length=495, Percent_Identity=37.1717171717172, Blast_Score=301, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6320023, Length=489, Percent_Identity=25.7668711656442, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320764, Length=433, Percent_Identity=27.0207852193995, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI18921117, Length=429, Percent_Identity=28.4382284382284, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24639277, Length=429, Percent_Identity=28.4382284382284, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24639275, Length=429, Percent_Identity=28.4382284382284, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24653753, Length=459, Percent_Identity=27.2331154684096, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 52549; Mature: 52549

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREVTDDGQQWDGRAAAFAGVPSGGGAPAAFATPQTIGRCVEALRAIVGERLAVGRAVRE
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QHGKDISFHPGAPPDAVAFVRTTAEVAEITRACHRLRVPLIPFGTGTSCEGHIAALRGGV
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHEECCCE
CIDLSGMNRILRVSAEDLDCTVEAGVTRKQLNAHLRDTGLFFPIDPGADASIGGMCSTRA
EEEECCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCC
SGTNAVRYGTMRESVLALEVVLPNGDVVSVGSRARKSAAGYDLARLFVGAEGTLGTITGV
CCCCEEEECCHHHCEEEEEEEECCCCEEECCHHHHHHHCCCCEEHHEECCCCCCEEEEEE
TLRLHPRPDRLSAAVCSFPDLKAAVDSVIGVIRSGVPIARVELLDALQIVACNRYAKLSL
EEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECC
DERPTLFFEFAGFGAAVDEQIDWVGEICAGYGGGEFRWASRPEERSALWAARHDAWWAAL
CCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHCCCEEEEE
ALRPGCEGMPTDSCVPVSRLAEAVLAARADVDALGLVATICGHVGDGNFHVCIAIDPADA
EECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCH
DELARATELNRRLALRAIALGGTCTGEHGVGYGKIGYLEREHPTALQLMAAVKRALDPRG
HHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCC
IMNPGKVLHHDRYPPFD
CCCCCHHHCCCCCCCCC
>Mature Secondary Structure
MREVTDDGQQWDGRAAAFAGVPSGGGAPAAFATPQTIGRCVEALRAIVGERLAVGRAVRE
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QHGKDISFHPGAPPDAVAFVRTTAEVAEITRACHRLRVPLIPFGTGTSCEGHIAALRGGV
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHEECCCE
CIDLSGMNRILRVSAEDLDCTVEAGVTRKQLNAHLRDTGLFFPIDPGADASIGGMCSTRA
EEEECCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCC
SGTNAVRYGTMRESVLALEVVLPNGDVVSVGSRARKSAAGYDLARLFVGAEGTLGTITGV
CCCCEEEECCHHHCEEEEEEEECCCCEEECCHHHHHHHCCCCEEHHEECCCCCCEEEEEE
TLRLHPRPDRLSAAVCSFPDLKAAVDSVIGVIRSGVPIARVELLDALQIVACNRYAKLSL
EEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECC
DERPTLFFEFAGFGAAVDEQIDWVGEICAGYGGGEFRWASRPEERSALWAARHDAWWAAL
CCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHCCCEEEEE
ALRPGCEGMPTDSCVPVSRLAEAVLAARADVDALGLVATICGHVGDGNFHVCIAIDPADA
EECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCH
DELARATELNRRLALRAIALGGTCTGEHGVGYGKIGYLEREHPTALQLMAAVKRALDPRG
HHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCC
IMNPGKVLHHDRYPPFD
CCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]