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The map label for this gene is thiD [H]

Identifier: 53722132

GI number: 53722132

Start: 1483079

End: 1483879

Strand: Reverse

Name: thiD [H]

Synonym: BPSS1104

Alternate gene names: 53722132

Gene position: 1483879-1483079 (Counterclockwise)

Preceding gene: 53722133

Following gene: 53722131

Centisome position: 46.77

GC content: 71.29

Gene sequence:

>801_bases
ATGATCGCGAACGTACTGACGATCGCCGGCACCGACCCGACGGGCGGAGCGGGCATTCAGGCCGATCTCAAGGCATTTTC
GGCAATGCGCGCATACGGGATGGCGGCGATCACCGCGGTCGTCGCGCAGAACACCACCGGCGTGCGCAGCTTCCGCGCGC
TCGATCCGGCGTTCGTCGCCGATCAGATCGACGCGGTGTTCGACGACGTCGCCGTGCACGCGGTGAAGATCGGCATGATC
GCGACGGCCGCGATCGCCGAGGCGGTCGCCGCGGCGCTCGCCAGGCATCGCGCGGCGCCCGTCGTGCTCGATCCGGTGAT
GGTCGCGAAAAGCGGCGACCGGCTGCTCGATCCGGACGCCGTCGACGCGATCCGCGACAAGCTCGTGCCGATCTCCACGC
TGATCACGCCGAACCTGCCGGAAGCGGGCGTGCTGCTCGGCCGAAGCGAGCCGCGCACGCTCGCCGAGATGCACGCGGCG
GCCGCCGAGCTGCACGCGCTCGGTTCGCGCTGGGTGCTGCTCAAGGGCGGGCATCTGGCGGGCGAGCGCAGCGTCGACGT
GCTGCGCGGCCCGGCCGCCGCGACGGTCGAGCTCTCCGCGCCGCGCGTCGCGACGAACAACGATCACGGCACCGGCTGCA
CGCTGTCGGCCGCGATCGCGGCGCTGCTGCCGAGCCATTCGGTCGAGGACAGCGTCTGCCAAGCCAAGGCTTACCTGAGC
GACGCGCTCGCCGCGTCGGGCGAGCTCGAGGTCGGTCGCGGGCACGGCCCGGTCCATCATTTCCACGCGCTATGGAACTG
A

Upstream 100 bases:

>100_bases
CCGGCCCGACCGACGGCCCACCGACGACGTGACGCGCGGCTCGCCGACGGCGCAGCGGCACAATCACAACACGACGCAAC
ATAACGAAACACGAGGGAAC

Downstream 100 bases:

>100_bases
CGCCCGCGCCGCGCGCCGGCATGCGCGCGCATCGACAAACACCAAGACAAGCGCATCGTTTCGCACGCGTCATTCGACAA
GGAACCATCATGCGTCGCCT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MIANVLTIAGTDPTGGAGIQADLKAFSAMRAYGMAAITAVVAQNTTGVRSFRALDPAFVADQIDAVFDDVAVHAVKIGMI
ATAAIAEAVAAALARHRAAPVVLDPVMVAKSGDRLLDPDAVDAIRDKLVPISTLITPNLPEAGVLLGRSEPRTLAEMHAA
AAELHALGSRWVLLKGGHLAGERSVDVLRGPAAATVELSAPRVATNNDHGTGCTLSAAIAALLPSHSVEDSVCQAKAYLS
DALAASGELEVGRGHGPVHHFHALWN

Sequences:

>Translated_266_residues
MIANVLTIAGTDPTGGAGIQADLKAFSAMRAYGMAAITAVVAQNTTGVRSFRALDPAFVADQIDAVFDDVAVHAVKIGMI
ATAAIAEAVAAALARHRAAPVVLDPVMVAKSGDRLLDPDAVDAIRDKLVPISTLITPNLPEAGVLLGRSEPRTLAEMHAA
AAELHALGSRWVLLKGGHLAGERSVDVLRGPAAATVELSAPRVATNNDHGTGCTLSAAIAALLPSHSVEDSVCQAKAYLS
DALAASGELEVGRGHGPVHHFHALWN
>Mature_266_residues
MIANVLTIAGTDPTGGAGIQADLKAFSAMRAYGMAAITAVVAQNTTGVRSFRALDPAFVADQIDAVFDDVAVHAVKIGMI
ATAAIAEAVAAALARHRAAPVVLDPVMVAKSGDRLLDPDAVDAIRDKLVPISTLITPNLPEAGVLLGRSEPRTLAEMHAA
AAELHALGSRWVLLKGGHLAGERSVDVLRGPAAATVELSAPRVATNNDHGTGCTLSAAIAALLPSHSVEDSVCQAKAYLS
DALAASGELEVGRGHGPVHHFHALWN

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=263, Percent_Identity=56.6539923954373, Blast_Score=272, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6324997, Length=277, Percent_Identity=35.3790613718412, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324517, Length=275, Percent_Identity=34.9090909090909, Blast_Score=117, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6325378, Length=274, Percent_Identity=30.6569343065693, Blast_Score=117, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 27279; Mature: 27279

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIANVLTIAGTDPTGGAGIQADLKAFSAMRAYGMAAITAVVAQNTTGVRSFRALDPAFVA
CCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHH
DQIDAVFDDVAVHAVKIGMIATAAIAEAVAAALARHRAAPVVLDPVMVAKSGDRLLDPDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEECCCCCCCCCHH
VDAIRDKLVPISTLITPNLPEAGVLLGRSEPRTLAEMHAAAAELHALGSRWVLLKGGHLA
HHHHHHCCCCHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GERSVDVLRGPAAATVELSAPRVATNNDHGTGCTLSAAIAALLPSHSVEDSVCQAKAYLS
CCCCHHHHCCCCCEEEEECCCEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
DALAASGELEVGRGHGPVHHFHALWN
HHHHCCCCEEECCCCCCHHHHHHHCC
>Mature Secondary Structure
MIANVLTIAGTDPTGGAGIQADLKAFSAMRAYGMAAITAVVAQNTTGVRSFRALDPAFVA
CCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHH
DQIDAVFDDVAVHAVKIGMIATAAIAEAVAAALARHRAAPVVLDPVMVAKSGDRLLDPDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEECCCCCCCCCHH
VDAIRDKLVPISTLITPNLPEAGVLLGRSEPRTLAEMHAAAAELHALGSRWVLLKGGHLA
HHHHHHCCCCHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GERSVDVLRGPAAATVELSAPRVATNNDHGTGCTLSAAIAALLPSHSVEDSVCQAKAYLS
CCCCHHHHCCCCCEEEEECCCEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
DALAASGELEVGRGHGPVHHFHALWN
HHHHCCCCEEECCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075431; 9097040; 9278503 [H]