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The map label for this gene is irlS

Identifier: 53722060

GI number: 53722060

Start: 1415018

End: 1416412

Strand: Reverse

Name: irlS

Synonym: BPSS1039

Alternate gene names: 53722060

Gene position: 1416412-1415018 (Counterclockwise)

Preceding gene: 53722061

Following gene: 53722058

Centisome position: 44.64

GC content: 69.25

Gene sequence:

>1395_bases
ATGATCAGACGCCTGCTGCCCCGCACGCTGCGCGCGCGCCTGACGGCGCTCATCATCCTGTCGACCGCGGCGACGCTCGC
GCTGAGCGGCGTCGCGCTCTACAGCGCGCTGCACAACCGGCTCGTCGGCATGTCGTCGTACGAGATGTCGGCGACGCTCG
CGGCGATGCGCACGCATCTCGCGAACGTCGCGAACGTCGACGATATCCCGCGCAAATCGGATCTGTGGATCGATCAACTG
CACGGCCATCAGAATCTGGATCTCGCGATCTACGACACCGACGGCCGCCTGCGCTTCGCCACGCGCGGCTTCGTCGCGCC
GCGGCCCGCGCTCGGCGCGCCGCAAACGCGCGTGCCGGCGAGCGCCGCGCCCGCCGGCGCGACGTTCAGCTATCTCGCGG
ACGACGCGCCGCTGCGCGGCGGGAACCCGCGCACCGCGCGCATCGTCGTGCAGTACGACGGCAAGAACGATCATGCGCTG
CTGCGCGCATACGCGTACACGGTCGTCGTGATCGAGGTGCTCGCGGTCGTGCTGACGGCGGCGCTCGCCTACGGCATCGC
GATGCTCGGCCTGAGCCCGCTGCGGCGGCTCGTCGCGCGCGCCGAGCAGATGTCGTCGAGCCGGCTCGCGCAGCCGCTGC
CGGAGCTCGACACGTCGGGCGAGCTCAAGGAAATGGAGCACGCGTTCAACGCCATGCTCAAGCGCCTCGACGAATCGTTC
GTCCGGCTGAGCCAGTTCTCGTCGAATCTCGCGCACGACATGCGCACGCCGCTCACGAACCTGCTCGCCGAGGCGCAGGT
CGCGCTATCGAAGCCGCGCACGGCCGACGAATATCGCGACGTGATCGAATCGAGCATCGACGAGTATCAGCGTCTGTCGC
GCATGATCGAGGACATGCTGTTCCTCGCGCGCTCCGACAACGCGCAGAGCCACCTGGCGATCCGCACGCTCGACGCGGCG
GCGCAAGCCGAGCGCGTCGCCGGCTATTACGAGCCGATGGCCGAGGATGCCGACGTGCGCATCGTCGTGCGCGGCAAGGC
CGAGGTTCGGGCGGACGCGCTGCTCTATCACCGCGCGCTCAGCAACCTGATCAGCAATGCGCTCAATCACGCGCCGCGCG
GCTCGACGATCACGATCGAATGCGCGCAAGCCGCCGACGCGGCGACGATCAGCGTATCGGACACGGGCCGCGGCATCGAG
GCGCCGCACCGCGAACGGATCTTCGAGCGGTTCTACCGCGTCGATCCGGCGCGGCACAATTCGGCGTCCGGCACGGGGCT
CGGCCTGGCGATCGTGCGCTCGATCATGGAAAACCACGGCGGCACGTGCGGCGTCGACAGCGAGCCGCACGTGCGCACGA
CGTTCTGGCTGAAGTTTCCCGCGCACGCGGCCTGA

Upstream 100 bases:

>100_bases
TGCGCTCGAAGATCGACGACGCGTACGAGCCGAAGCTGATCCACACGGTGCGCGGGATGGGCTACGTGCTCGAAGTCAGA
AGCGCGAGCGCGCCGAGCCG

Downstream 100 bases:

>100_bases
TCCGCCGCGTCAGCGGAGTCAGCGGCGCTAGCGGCGGCCCGCGGGCGCGGACGCGCCCGGGCGCGCGGGCCGCCCGGCTT
CGGTCGCCCGCGCATCAGCG

Product: transmembrane invasion-related two-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MIRRLLPRTLRARLTALIILSTAATLALSGVALYSALHNRLVGMSSYEMSATLAAMRTHLANVANVDDIPRKSDLWIDQL
HGHQNLDLAIYDTDGRLRFATRGFVAPRPALGAPQTRVPASAAPAGATFSYLADDAPLRGGNPRTARIVVQYDGKNDHAL
LRAYAYTVVVIEVLAVVLTAALAYGIAMLGLSPLRRLVARAEQMSSSRLAQPLPELDTSGELKEMEHAFNAMLKRLDESF
VRLSQFSSNLAHDMRTPLTNLLAEAQVALSKPRTADEYRDVIESSIDEYQRLSRMIEDMLFLARSDNAQSHLAIRTLDAA
AQAERVAGYYEPMAEDADVRIVVRGKAEVRADALLYHRALSNLISNALNHAPRGSTITIECAQAADAATISVSDTGRGIE
APHRERIFERFYRVDPARHNSASGTGLGLAIVRSIMENHGGTCGVDSEPHVRTTFWLKFPAHAA

Sequences:

>Translated_464_residues
MIRRLLPRTLRARLTALIILSTAATLALSGVALYSALHNRLVGMSSYEMSATLAAMRTHLANVANVDDIPRKSDLWIDQL
HGHQNLDLAIYDTDGRLRFATRGFVAPRPALGAPQTRVPASAAPAGATFSYLADDAPLRGGNPRTARIVVQYDGKNDHAL
LRAYAYTVVVIEVLAVVLTAALAYGIAMLGLSPLRRLVARAEQMSSSRLAQPLPELDTSGELKEMEHAFNAMLKRLDESF
VRLSQFSSNLAHDMRTPLTNLLAEAQVALSKPRTADEYRDVIESSIDEYQRLSRMIEDMLFLARSDNAQSHLAIRTLDAA
AQAERVAGYYEPMAEDADVRIVVRGKAEVRADALLYHRALSNLISNALNHAPRGSTITIECAQAADAATISVSDTGRGIE
APHRERIFERFYRVDPARHNSASGTGLGLAIVRSIMENHGGTCGVDSEPHVRTTFWLKFPAHAA
>Mature_464_residues
MIRRLLPRTLRARLTALIILSTAATLALSGVALYSALHNRLVGMSSYEMSATLAAMRTHLANVANVDDIPRKSDLWIDQL
HGHQNLDLAIYDTDGRLRFATRGFVAPRPALGAPQTRVPASAAPAGATFSYLADDAPLRGGNPRTARIVVQYDGKNDHAL
LRAYAYTVVVIEVLAVVLTAALAYGIAMLGLSPLRRLVARAEQMSSSRLAQPLPELDTSGELKEMEHAFNAMLKRLDESF
VRLSQFSSNLAHDMRTPLTNLLAEAQVALSKPRTADEYRDVIESSIDEYQRLSRMIEDMLFLARSDNAQSHLAIRTLDAA
AQAERVAGYYEPMAEDADVRIVVRGKAEVRADALLYHRALSNLISNALNHAPRGSTITIECAQAADAATISVSDTGRGIE
APHRERIFERFYRVDPARHNSASGTGLGLAIVRSIMENHGGTCGVDSEPHVRTTFWLKFPAHAA

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance. Probably activates irlR by phosphorylation

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1786783, Length=332, Percent_Identity=36.144578313253, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1788279, Length=286, Percent_Identity=33.5664335664336, Blast_Score=172, Evalue=6e-44,
Organism=Escherichia coli, GI1786600, Length=205, Percent_Identity=31.7073170731707, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787894, Length=307, Percent_Identity=28.9902280130293, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=30.5147058823529, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=28.8135593220339, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI145693157, Length=255, Percent_Identity=25.4901960784314, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790861, Length=266, Percent_Identity=29.3233082706767, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1789403, Length=450, Percent_Identity=25.7777777777778, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788393, Length=253, Percent_Identity=23.7154150197628, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=27.7533039647577, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1789808, Length=295, Percent_Identity=28.4745762711864, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789149, Length=233, Percent_Identity=24.8927038626609, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788713, Length=226, Percent_Identity=21.6814159292035, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=237, Percent_Identity=27.8481012658228, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI48994928, Length=223, Percent_Identity=26.0089686098655, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=26.9565217391304, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790551, Length=290, Percent_Identity=25.5172413793103, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IRLS_BURPS (O31396)

Other databases:

- EMBL:   AF005358
- EMBL:   BX571966
- RefSeq:   YP_111045.1
- ProteinModelPortal:   O31396
- SMR:   O31396
- GeneID:   3096238
- GenomeReviews:   BX571966_GR
- KEGG:   bps:BPSS1039
- NMPDR:   fig|272560.3.peg.1020
- HOGENOM:   HBG643531
- OMA:   AGHTEVR
- ProtClustDB:   CLSK929982
- BioCyc:   BPSE272560:BPSS1039-MONOMER
- BRENDA:   2.7.13.3
- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00304
- SMART:   SM00387
- SMART:   SM00388
- TIGRFAMs:   TIGR01386

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 50708; Mature: 50708

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: PS50885 HAMP; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf63e890)-; HASH(0x45e36c3c)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRRLLPRTLRARLTALIILSTAATLALSGVALYSALHNRLVGMSSYEMSATLAAMRTHL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ANVANVDDIPRKSDLWIDQLHGHQNLDLAIYDTDGRLRFATRGFVAPRPALGAPQTRVPA
HHHCCCCCCCCCCCCHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCC
SAAPAGATFSYLADDAPLRGGNPRTARIVVQYDGKNDHALLRAYAYTVVVIEVLAVVLTA
CCCCCCCCHHHHCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
ALAYGIAMLGLSPLRRLVARAEQMSSSRLAQPLPELDTSGELKEMEHAFNAMLKRLDESF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VRLSQFSSNLAHDMRTPLTNLLAEAQVALSKPRTADEYRDVIESSIDEYQRLSRMIEDML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FLARSDNAQSHLAIRTLDAAAQAERVAGYYEPMAEDADVRIVVRGKAEVRADALLYHRAL
HHHCCCCCCHHEEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHH
SNLISNALNHAPRGSTITIECAQAADAATISVSDTGRGIEAPHRERIFERFYRVDPARHN
HHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCC
SASGTGLGLAIVRSIMENHGGTCGVDSEPHVRTTFWLKFPAHAA
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCH
>Mature Secondary Structure
MIRRLLPRTLRARLTALIILSTAATLALSGVALYSALHNRLVGMSSYEMSATLAAMRTHL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ANVANVDDIPRKSDLWIDQLHGHQNLDLAIYDTDGRLRFATRGFVAPRPALGAPQTRVPA
HHHCCCCCCCCCCCCHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCC
SAAPAGATFSYLADDAPLRGGNPRTARIVVQYDGKNDHALLRAYAYTVVVIEVLAVVLTA
CCCCCCCCHHHHCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
ALAYGIAMLGLSPLRRLVARAEQMSSSRLAQPLPELDTSGELKEMEHAFNAMLKRLDESF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VRLSQFSSNLAHDMRTPLTNLLAEAQVALSKPRTADEYRDVIESSIDEYQRLSRMIEDML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FLARSDNAQSHLAIRTLDAAAQAERVAGYYEPMAEDADVRIVVRGKAEVRADALLYHRAL
HHHCCCCCCHHEEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHH
SNLISNALNHAPRGSTITIECAQAADAATISVSDTGRGIEAPHRERIFERFYRVDPARHN
HHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCC
SASGTGLGLAIVRSIMENHGGTCGVDSEPHVRTTFWLKFPAHAA
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9393784