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The map label for this gene is hsrA [H]

Identifier: 53721699

GI number: 53721699

Start: 907100

End: 908497

Strand: Reverse

Name: hsrA [H]

Synonym: BPSS0670

Alternate gene names: 53721699

Gene position: 908497-907100 (Counterclockwise)

Preceding gene: 53721704

Following gene: 53721698

Centisome position: 28.63

GC content: 69.03

Gene sequence:

>1398_bases
ATGCCGTCCGCCCTCTACGCTTTCATCGCACCGCTGATCGTCGCTTGCGCGTTGTTCATGGAGAGCGTGGATGCCAACAT
CATCGTCACGGCATTGCCCGCGATGGCGCGCGACTTCGGGCAGAACCCCGTCACGCTGAACATCGCGATCACGAGCTACG
TCGTCGGCCTCGGCGTGTTCATCCCGATCTGCGGGTGGCTCGCGGACCGCTTCGGCGCACGCACCGTGTTCCGCACCGCG
ATCGGCATCTTCGTCGCGGGCTCGCTGCTGTGCGCGGCATCGAACAATCTCGAGCTCTTCACGTTCGCGCGCTTCGTACA
AGGCGTCGGCGGCGCGATGATGGTGCCCGTCGGGCGCATCATCATCTTCCGCGCGGTGCCGCGCACGGAGCTCGTGCGCG
CGATGAACTACCTGAGCGTGCCCGCGCTCTTCGGGCCGGCGGCCGGGCCGCTCCTCGGCGGCTTCATCACGACGTACCTG
CACTGGCGGCTGATCTTCTTCATCAACGTGCCGATCGGCATCCTCGGCATCTATCTCGCGAACAGGCACATCGCGAACAC
GCACGAGCTCGATCCCGGCCCGCTCGACGGGTTCGGCTTCGTGCTGTCCGCCGCCGGCGCGGCGCTCCTGCTGATGGGGC
TCACGCTGCTCGACGGCGCGCTCGTCACGCGCGGCGCGGCGCTCGCGATGGGCGCGACGGGCGCGGCGCTCCTCGGCGGC
TACGTGCTGTATGCGCGGCGCGTCGAGCGGCCGGTGCTCGATCTGCGCTTTCTGCGCATTCCGACCTATCACGCAAGCGT
CGTCGGCGGCTCGCTGTTCCGGATCGGCCTCGGCGCAGTGCCGTTTCTGCTGCCGCTCGCGCTGCAGGAAGGGCTCGGCA
TGAGCGCGTTCCATTCCGGCGCGATCACGTGCGCGTCGGCCGTCGGCGGCGCGCTCACGCGGATGCTCGCGCCGCGCACG
CTCAAGCGCTTCGGCTTTCGCACGGTGCTGATGTACAACGCGGCGTTCTCCGGGCTCGCGATCGCCGCGTACGGCGTGTT
CCATCCCGGCATGTCGACGCTCGCGATCTGGCTCATCGTGCTCGTCGGCGGCATCTTTCCGGCGCTGCAGTTCACGAGCC
TCAATTCGATGATCTACGCGGAAATCGCGGCGCGCGACGCGGGCCGCGCGACGAGCCTCGGCAGCGTCGTCCAGCAGATG
TCGCTCGGCCTCGGCGTGACGGTCGCGGCGCTCGTGCTGCACGTGTCGCATTGGGCGCAGGGGCATCCGGCGATGGTCTG
GTCGGACTTCTGGCCGGCGTTCGTCGTGGTCGGCCTATGCTCGTTCGCATCGATTCCGATCACGCGCCGGCTGTCGCCGA
ACGCGGGCGACGAGGTGGCGCGCGGCAAGCGCGGCTGA

Upstream 100 bases:

>100_bases
CGGCGCGCGAACGGCAACGCGTGACGGCAACACGTCGTTGCGCGCGCAAGCATGCCGCAACAATCGATGCAATAATGGCG
TCTTTACGCGCGTCGTTGCC

Downstream 100 bases:

>100_bases
AGCAGGCCGCACGGCCGAAGCGATCAGGAAAACGAAGCAAGCGAAGCCGCGTGCGGGGCGCGCTGCGCGCCGCCGCCGGG
CATGGTCAGCCGGAATTGAG

Product: transporter protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MPSALYAFIAPLIVACALFMESVDANIIVTALPAMARDFGQNPVTLNIAITSYVVGLGVFIPICGWLADRFGARTVFRTA
IGIFVAGSLLCAASNNLELFTFARFVQGVGGAMMVPVGRIIIFRAVPRTELVRAMNYLSVPALFGPAAGPLLGGFITTYL
HWRLIFFINVPIGILGIYLANRHIANTHELDPGPLDGFGFVLSAAGAALLLMGLTLLDGALVTRGAALAMGATGAALLGG
YVLYARRVERPVLDLRFLRIPTYHASVVGGSLFRIGLGAVPFLLPLALQEGLGMSAFHSGAITCASAVGGALTRMLAPRT
LKRFGFRTVLMYNAAFSGLAIAAYGVFHPGMSTLAIWLIVLVGGIFPALQFTSLNSMIYAEIAARDAGRATSLGSVVQQM
SLGLGVTVAALVLHVSHWAQGHPAMVWSDFWPAFVVVGLCSFASIPITRRLSPNAGDEVARGKRG

Sequences:

>Translated_465_residues
MPSALYAFIAPLIVACALFMESVDANIIVTALPAMARDFGQNPVTLNIAITSYVVGLGVFIPICGWLADRFGARTVFRTA
IGIFVAGSLLCAASNNLELFTFARFVQGVGGAMMVPVGRIIIFRAVPRTELVRAMNYLSVPALFGPAAGPLLGGFITTYL
HWRLIFFINVPIGILGIYLANRHIANTHELDPGPLDGFGFVLSAAGAALLLMGLTLLDGALVTRGAALAMGATGAALLGG
YVLYARRVERPVLDLRFLRIPTYHASVVGGSLFRIGLGAVPFLLPLALQEGLGMSAFHSGAITCASAVGGALTRMLAPRT
LKRFGFRTVLMYNAAFSGLAIAAYGVFHPGMSTLAIWLIVLVGGIFPALQFTSLNSMIYAEIAARDAGRATSLGSVVQQM
SLGLGVTVAALVLHVSHWAQGHPAMVWSDFWPAFVVVGLCSFASIPITRRLSPNAGDEVARGKRG
>Mature_464_residues
PSALYAFIAPLIVACALFMESVDANIIVTALPAMARDFGQNPVTLNIAITSYVVGLGVFIPICGWLADRFGARTVFRTAI
GIFVAGSLLCAASNNLELFTFARFVQGVGGAMMVPVGRIIIFRAVPRTELVRAMNYLSVPALFGPAAGPLLGGFITTYLH
WRLIFFINVPIGILGIYLANRHIANTHELDPGPLDGFGFVLSAAGAALLLMGLTLLDGALVTRGAALAMGATGAALLGGY
VLYARRVERPVLDLRFLRIPTYHASVVGGSLFRIGLGAVPFLLPLALQEGLGMSAFHSGAITCASAVGGALTRMLAPRTL
KRFGFRTVLMYNAAFSGLAIAAYGVFHPGMSTLAIWLIVLVGGIFPALQFTSLNSMIYAEIAARDAGRATSLGSVVQQMS
LGLGVTVAALVLHVSHWAQGHPAMVWSDFWPAFVVVGLCSFASIPITRRLSPNAGDEVARGKRG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=457, Percent_Identity=36.7614879649891, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1788392, Length=406, Percent_Identity=36.6995073891626, Blast_Score=221, Evalue=8e-59,
Organism=Escherichia coli, GI1789042, Length=416, Percent_Identity=25.9615384615385, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1788710, Length=409, Percent_Identity=24.6943765281174, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI87081983, Length=295, Percent_Identity=28.135593220339, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322958, Length=247, Percent_Identity=30.3643724696356, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325455, Length=231, Percent_Identity=26.4069264069264, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49023; Mature: 48892

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSALYAFIAPLIVACALFMESVDANIIVTALPAMARDFGQNPVTLNIAITSYVVGLGVF
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHH
IPICGWLADRFGARTVFRTAIGIFVAGSLLCAASNNLELFTFARFVQGVGGAMMVPVGRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCEEHHHHHHE
IIFRAVPRTELVRAMNYLSVPALFGPAAGPLLGGFITTYLHWRLIFFINVPIGILGIYLA
EEEECCCHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
NRHIANTHELDPGPLDGFGFVLSAAGAALLLMGLTLLDGALVTRGAALAMGATGAALLGG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHH
YVLYARRVERPVLDLRFLRIPTYHASVVGGSLFRIGLGAVPFLLPLALQEGLGMSAFHSG
HHHHHHHHCCCHHHEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
AITCASAVGGALTRMLAPRTLKRFGFRTVLMYNAAFSGLAIAAYGVFHPGMSTLAIWLIV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LVGGIFPALQFTSLNSMIYAEIAARDAGRATSLGSVVQQMSLGLGVTVAALVLHVSHWAQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
GHPAMVWSDFWPAFVVVGLCSFASIPITRRLSPNAGDEVARGKRG
CCCCEEEHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHCCCCC
>Mature Secondary Structure 
PSALYAFIAPLIVACALFMESVDANIIVTALPAMARDFGQNPVTLNIAITSYVVGLGVF
CHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHH
IPICGWLADRFGARTVFRTAIGIFVAGSLLCAASNNLELFTFARFVQGVGGAMMVPVGRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCEEHHHHHHE
IIFRAVPRTELVRAMNYLSVPALFGPAAGPLLGGFITTYLHWRLIFFINVPIGILGIYLA
EEEECCCHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
NRHIANTHELDPGPLDGFGFVLSAAGAALLLMGLTLLDGALVTRGAALAMGATGAALLGG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHH
YVLYARRVERPVLDLRFLRIPTYHASVVGGSLFRIGLGAVPFLLPLALQEGLGMSAFHSG
HHHHHHHHCCCHHHEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
AITCASAVGGALTRMLAPRTLKRFGFRTVLMYNAAFSGLAIAAYGVFHPGMSTLAIWLIV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LVGGIFPALQFTSLNSMIYAEIAARDAGRATSLGSVVQQMSLGLGVTVAALVLHVSHWAQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
GHPAMVWSDFWPAFVVVGLCSFASIPITRRLSPNAGDEVARGKRG
CCCCEEEHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]