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The map label for this gene is cusC [C]

Identifier: 53721659

GI number: 53721659

Start: 849810

End: 851192

Strand: Reverse

Name: cusC [C]

Synonym: BPSS0623

Alternate gene names: 53721659

Gene position: 851192-849810 (Counterclockwise)

Preceding gene: 53721660

Following gene: 53721652

Centisome position: 26.83

GC content: 72.45

Gene sequence:

>1383_bases
ATGACGACACGCCCGATTCATCGTCTCGCGCGGCGCGCCGCCGCGCTCGCCGGCACGCTCGCGCTGCTGTCCGGCTGCAC
GAGCGCCTCGCGCAACGCGCCGCCGCCCGCGCCCGAGCTGCCCGCGCAATGGGCCGGCCCCGTCGCGCGACAGGCGAGCG
CCACGCCCGACGGCTGGTGGCGCCGTTTCGGCGATCCGATGCTCGATCGCCTGATCGACGACGCGCTGCGCACGAACAAC
GATCTCGCGGCCGCGGCGATCCGCGTCTATCGCGCGCAATTGCAGGCGGGGCTCGCGGATACGAACCTGACGCCGAACGT
GACGCTCGGCGCGACGGGCAACGCCTCGCGCACGCTCGACACGCACCAGACGCGCCGCACGAGCGGCGTGACGGCGACGC
TCGGCTACGAGCTCGACCTGTGGGGCAAGCTCGCCGCGCAGCGCGACGCCGCGCGCTGGGAGCTCGAAGCGACGCAAGCC
GACCGCGATGCGGCGAGGCTCGCGCTGATCGGCACGACGGCCGCGCTGTACTGGCAACTCGCCTATCTGAACCAGCAGAT
CGCGTTCGGCGACGCGAACATCGCGTATGCCGAACGCACGCTGAAGCTCGTGCAGTCGCGCCACGCGGCGGGGGCGACGT
CCGGGCTCGACCTCGCGCAGGCCGAGCGCAACCTGGCCGCGCTGCGCGCCGACCAGACGCAGTTGATCCAGCAGCGCACC
GAGAATCGCAACGCGCTCGCGATCCTGTTCGGCCGCCCGCCGCAGCGGCAGGCGGCCGAGCGCGACGCGCTGCCCGATAC
GCCGCTGCCGGAGGTCGCCGCGGGCGTGCCGGCCGAGCTGCTCGGCCGCCGGCCCGATCTGCGCGCGGCCGAGTTCCGGC
TGCGCGAATCGCTCGCGAATGTCGACGTGACGCGCACGAGCTTCTATCCGACCTTCACGCTCACCGGCAGCGTCGGCACC
GCGAGCACGAGCCTCGAGCGCGTGCTGCAGAATCCCGTCGCGACGCTCGGCCTCGGGCTCGCGCTGCCGTTCATCCAGTG
GAACACGATGCAGTTGCAGATCAAGGTGTCGCAATCGCAGTACGAGGAGGCCGTCGTCAATTTCCGGCAAAGCCTGTACC
GCGCGCTCGGCGAGGTCGAGAACGCGCTGGCCGCGCGCGTGCAGCTCGACGCCGAGGCCGACGAACGCGGCCGCGCGCTC
GCGCTGGCGCGGCGCGCCGAAACGCTCGCGAAGGCACGCTTCGCGGCCGGCGCGACGGGCGTGCAGCCGTGGCTGGACGA
GCAGCAGCGGCTGCGCGATGCCCAAAGCGCGCTCGCGCGCAATCAATTGGGACGACTCAACAACCGGATGAACCTGTACC
AGGTGCTGGGCGGCGCGGGATAG

Upstream 100 bases:

>100_bases
GTGCTCGACGCTGATCGGCGTCGTGTTCGGCTTCATGCCCGCGCGCAACGCGTCGCGGCTCGATCCGATCGATGCGCTCG
CGCGCGATTGAGGTGACGCG

Downstream 100 bases:

>100_bases
CGGCACGCCGGCGCACGGCGCTCGGGCCGCGGGCGTCGTTCGGCGGGCGCGCGGCGCGATCGGCGATCACCGTATTCGTG
GAAATAGCGGGTTGCGTGCG

Product: outer membrane efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTTRPIHRLARRAAALAGTLALLSGCTSASRNAPPPAPELPAQWAGPVARQASATPDGWWRRFGDPMLDRLIDDALRTNN
DLAAAAIRVYRAQLQAGLADTNLTPNVTLGATGNASRTLDTHQTRRTSGVTATLGYELDLWGKLAAQRDAARWELEATQA
DRDAARLALIGTTAALYWQLAYLNQQIAFGDANIAYAERTLKLVQSRHAAGATSGLDLAQAERNLAALRADQTQLIQQRT
ENRNALAILFGRPPQRQAAERDALPDTPLPEVAAGVPAELLGRRPDLRAAEFRLRESLANVDVTRTSFYPTFTLTGSVGT
ASTSLERVLQNPVATLGLGLALPFIQWNTMQLQIKVSQSQYEEAVVNFRQSLYRALGEVENALAARVQLDAEADERGRAL
ALARRAETLAKARFAAGATGVQPWLDEQQRLRDAQSALARNQLGRLNNRMNLYQVLGGAG

Sequences:

>Translated_460_residues
MTTRPIHRLARRAAALAGTLALLSGCTSASRNAPPPAPELPAQWAGPVARQASATPDGWWRRFGDPMLDRLIDDALRTNN
DLAAAAIRVYRAQLQAGLADTNLTPNVTLGATGNASRTLDTHQTRRTSGVTATLGYELDLWGKLAAQRDAARWELEATQA
DRDAARLALIGTTAALYWQLAYLNQQIAFGDANIAYAERTLKLVQSRHAAGATSGLDLAQAERNLAALRADQTQLIQQRT
ENRNALAILFGRPPQRQAAERDALPDTPLPEVAAGVPAELLGRRPDLRAAEFRLRESLANVDVTRTSFYPTFTLTGSVGT
ASTSLERVLQNPVATLGLGLALPFIQWNTMQLQIKVSQSQYEEAVVNFRQSLYRALGEVENALAARVQLDAEADERGRAL
ALARRAETLAKARFAAGATGVQPWLDEQQRLRDAQSALARNQLGRLNNRMNLYQVLGGAG
>Mature_459_residues
TTRPIHRLARRAAALAGTLALLSGCTSASRNAPPPAPELPAQWAGPVARQASATPDGWWRRFGDPMLDRLIDDALRTNND
LAAAAIRVYRAQLQAGLADTNLTPNVTLGATGNASRTLDTHQTRRTSGVTATLGYELDLWGKLAAQRDAARWELEATQAD
RDAARLALIGTTAALYWQLAYLNQQIAFGDANIAYAERTLKLVQSRHAAGATSGLDLAQAERNLAALRADQTQLIQQRTE
NRNALAILFGRPPQRQAAERDALPDTPLPEVAAGVPAELLGRRPDLRAAEFRLRESLANVDVTRTSFYPTFTLTGSVGTA
STSLERVLQNPVATLGLGLALPFIQWNTMQLQIKVSQSQYEEAVVNFRQSLYRALGEVENALAARVQLDAEADERGRALA
LARRAETLAKARFAAGATGVQPWLDEQQRLRDAQSALARNQLGRLNNRMNLYQVLGGAG

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Attached To The Outer Membrane By A Lipid Anchor [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=458, Percent_Identity=29.0393013100437, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI2367348, Length=408, Percent_Identity=26.7156862745098, Blast_Score=105, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 49905; Mature: 49774

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRPIHRLARRAAALAGTLALLSGCTSASRNAPPPAPELPAQWAGPVARQASATPDGWW
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCHHHHCCCCCCHHH
RRFGDPMLDRLIDDALRTNNDLAAAAIRVYRAQLQAGLADTNLTPNVTLGATGNASRTLD
HHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCH
THQTRRTSGVTATLGYELDLWGKLAAQRDAARWELEATQADRDAARLALIGTTAALYWQL
HHHHHHCCCCEEEECCCHHHHHHHHHHHCHHHEEEEHHHCCCCHHHEEEHHHHHHHHHHH
AYLNQQIAFGDANIAYAERTLKLVQSRHAAGATSGLDLAQAERNLAALRADQTQLIQQRT
HHHCCHHEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ENRNALAILFGRPPQRQAAERDALPDTPLPEVAAGVPAELLGRRPDLRAAEFRLRESLAN
CCCCEEEEEECCCCCHHHHHHCCCCCCCCCHHHCCCCHHHHCCCCCCHHHHHHHHHHHHC
VDVTRTSFYPTFTLTGSVGTASTSLERVLQNPVATLGLGLALPFIQWNTMQLQIKVSQSQ
CCEEECCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHEEECEEEEEEEECHHH
YEEAVVNFRQSLYRALGEVENALAARVQLDAEADERGRALALARRAETLAKARFAAGATG
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
VQPWLDEQQRLRDAQSALARNQLGRLNNRMNLYQVLGGAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCC
>Mature Secondary Structure 
TTRPIHRLARRAAALAGTLALLSGCTSASRNAPPPAPELPAQWAGPVARQASATPDGWW
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCHHHHCCCCCCHHH
RRFGDPMLDRLIDDALRTNNDLAAAAIRVYRAQLQAGLADTNLTPNVTLGATGNASRTLD
HHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCH
THQTRRTSGVTATLGYELDLWGKLAAQRDAARWELEATQADRDAARLALIGTTAALYWQL
HHHHHHCCCCEEEECCCHHHHHHHHHHHCHHHEEEEHHHCCCCHHHEEEHHHHHHHHHHH
AYLNQQIAFGDANIAYAERTLKLVQSRHAAGATSGLDLAQAERNLAALRADQTQLIQQRT
HHHCCHHEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ENRNALAILFGRPPQRQAAERDALPDTPLPEVAAGVPAELLGRRPDLRAAEFRLRESLAN
CCCCEEEEEECCCCCHHHHHHCCCCCCCCCHHHCCCCHHHHCCCCCCHHHHHHHHHHHHC
VDVTRTSFYPTFTLTGSVGTASTSLERVLQNPVATLGLGLALPFIQWNTMQLQIKVSQSQ
CCEEECCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHEEECEEEEEEEECHHH
YEEAVVNFRQSLYRALGEVENALAARVQLDAEADERGRALALARRAETLAKARFAAGATG
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
VQPWLDEQQRLRDAQSALARNQLGRLNNRMNLYQVLGGAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]