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The map label for this gene is ilvC [H]

Identifier: 53721340

GI number: 53721340

Start: 409804

End: 410859

Strand: Reverse

Name: ilvC [H]

Synonym: BPSS0305

Alternate gene names: 53721340

Gene position: 410859-409804 (Counterclockwise)

Preceding gene: 53721341

Following gene: 53721339

Centisome position: 12.95

GC content: 70.93

Gene sequence:

>1056_bases
ATGAACGATCTCATCTATCAAGACGAACATGCGTCGCTTCAACCGCTGGAAGGGCTCACCGTCACCGTGATCGGCTACGG
CATCCAGGGGCGCGCGTTCGCCGCGAATCTGCGCGACAGCGGCGTTGCGGTGCGCGTCGGCAACATCGACGACCGCTACT
TCGAGCTCGCGCGCGCGGAAGGCCACCGCGTGACGGACATCGCCGAGGCCGTCGCGCACGCGGACATCGTGCTGCTGCTG
ATTCCGGACGAGGCGCACGGCGCGGTGTTCGACGTCGACATCGCGCCGAACCTGCGCGAGGGCGCGCTGCTATGCGTCGC
GCACGGGCACTCGCTCGTGCAGGGCGACGTGCGCCCGCTCGCGGGGCGCGACCTCGCGATGCTCGCGCCGCGCATGTACG
GCGATCCGATCCGCCGCTACTACCTCGCCGGCCAGGGCGCGCCCGCGTACTTCGATATCGTCGCGGACCACACCGGCCGC
GCGCGCGACAGGGTGCTCGCGATCGCGCGCGCGGTCGGCTTCACGCGCGCGGGCGTGATGGCGCTCGGCTACCGGCAGGA
GACATTCCTCGATCTGTTCCAGGAGCAGTTCCTCGCGCCCGCGCTCGTCGATCTCGTCGAAACGGGCTTTCAGGTGCTCG
TCGAGCGCGGCTTCAACCCGAAGGCCGCGCTGCTCGAAGTCTACGGCTCGGGCGAGATGGGCAAGATGATGCTCGACGGC
GCGGACATCGGGCTCGACGAAGTCGTCGCGCTGCAAGGCTCGCCGACTTGCCAGGTCGGCTATCACCGCTGGCGCGGCCG
CACGCTGCCCGCCGCCGTGCGCGAGCTGGCCGCGCGCGTGCTCGATCAGATCGACAGCGGCGACTTCGCCGCGTATCTGA
AGGAACACGCGGCGAACGACTACGCAGCGCTCGATGAAGCGCGCCGCGCGGCGCTGAAGCGGCCGCTCAACGTCGCGCAC
GCGCAAGTGCGCGCGGCGTTCCGGTTCCCGACCGAGGCCGCGGGCGGGCTCTACCAGGCGGCGCCGGCCGGCGCCGAGCC
GGAGCTCGCGCGATGA

Upstream 100 bases:

>100_bases
TGCGCGGCATGTTCAACGACGACGCGGACCTGCGCGCGCTCGCCGCCCAGCTCGACGGCGGCGAGTGCGCTTCTCCCCTT
CACTCCCACACGTGATACTC

Downstream 100 bases:

>100_bases
GCGCCCGTCGCCTCTACGTCGGCGCGACGTTCACCGCTTCGCCGCTCGATCCGCTGCTGCGCGCGCGAGGCTTCGGCGAC
GTCGCGTTCGCGCGCTACAA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MNDLIYQDEHASLQPLEGLTVTVIGYGIQGRAFAANLRDSGVAVRVGNIDDRYFELARAEGHRVTDIAEAVAHADIVLLL
IPDEAHGAVFDVDIAPNLREGALLCVAHGHSLVQGDVRPLAGRDLAMLAPRMYGDPIRRYYLAGQGAPAYFDIVADHTGR
ARDRVLAIARAVGFTRAGVMALGYRQETFLDLFQEQFLAPALVDLVETGFQVLVERGFNPKAALLEVYGSGEMGKMMLDG
ADIGLDEVVALQGSPTCQVGYHRWRGRTLPAAVRELAARVLDQIDSGDFAAYLKEHAANDYAALDEARRAALKRPLNVAH
AQVRAAFRFPTEAAGGLYQAAPAGAEPELAR

Sequences:

>Translated_351_residues
MNDLIYQDEHASLQPLEGLTVTVIGYGIQGRAFAANLRDSGVAVRVGNIDDRYFELARAEGHRVTDIAEAVAHADIVLLL
IPDEAHGAVFDVDIAPNLREGALLCVAHGHSLVQGDVRPLAGRDLAMLAPRMYGDPIRRYYLAGQGAPAYFDIVADHTGR
ARDRVLAIARAVGFTRAGVMALGYRQETFLDLFQEQFLAPALVDLVETGFQVLVERGFNPKAALLEVYGSGEMGKMMLDG
ADIGLDEVVALQGSPTCQVGYHRWRGRTLPAAVRELAARVLDQIDSGDFAAYLKEHAANDYAALDEARRAALKRPLNVAH
AQVRAAFRFPTEAAGGLYQAAPAGAEPELAR
>Mature_351_residues
MNDLIYQDEHASLQPLEGLTVTVIGYGIQGRAFAANLRDSGVAVRVGNIDDRYFELARAEGHRVTDIAEAVAHADIVLLL
IPDEAHGAVFDVDIAPNLREGALLCVAHGHSLVQGDVRPLAGRDLAMLAPRMYGDPIRRYYLAGQGAPAYFDIVADHTGR
ARDRVLAIARAVGFTRAGVMALGYRQETFLDLFQEQFLAPALVDLVETGFQVLVERGFNPKAALLEVYGSGEMGKMMLDG
ADIGLDEVVALQGSPTCQVGYHRWRGRTLPAAVRELAARVLDQIDSGDFAAYLKEHAANDYAALDEARRAALKRPLNVAH
AQVRAAFRFPTEAAGGLYQAAPAGAEPELAR

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=321, Percent_Identity=27.4143302180685, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323387, Length=201, Percent_Identity=27.8606965174129, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 37927; Mature: 37927

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLIYQDEHASLQPLEGLTVTVIGYGIQGRAFAANLRDSGVAVRVGNIDDRYFELARAE
CCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCEEEEECCCCHHHHHHHHCC
GHRVTDIAEAVAHADIVLLLIPDEAHGAVFDVDIAPNLREGALLCVAHGHSLVQGDVRPL
CCCHHHHHHHHHHCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEECCCCCHHCCCCCC
AGRDLAMLAPRMYGDPIRRYYLAGQGAPAYFDIVADHTGRARDRVLAIARAVGFTRAGVM
CCCCHHHHCCHHCCCHHHHEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
ALGYRQETFLDLFQEQFLAPALVDLVETGFQVLVERGFNPKAALLEVYGSGEMGKMMLDG
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEECC
ADIGLDEVVALQGSPTCQVGYHRWRGRTLPAAVRELAARVLDQIDSGDFAAYLKEHAAND
CCCCHHHEEEECCCCCEEECHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
YAALDEARRAALKRPLNVAHAQVRAAFRFPTEAAGGLYQAAPAGAEPELAR
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHCCCCEECCCCCCCCCCCC
>Mature Secondary Structure
MNDLIYQDEHASLQPLEGLTVTVIGYGIQGRAFAANLRDSGVAVRVGNIDDRYFELARAE
CCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCEEEEECCCCHHHHHHHHCC
GHRVTDIAEAVAHADIVLLLIPDEAHGAVFDVDIAPNLREGALLCVAHGHSLVQGDVRPL
CCCHHHHHHHHHHCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEECCCCCHHCCCCCC
AGRDLAMLAPRMYGDPIRRYYLAGQGAPAYFDIVADHTGRARDRVLAIARAVGFTRAGVM
CCCCHHHHCCHHCCCHHHHEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
ALGYRQETFLDLFQEQFLAPALVDLVETGFQVLVERGFNPKAALLEVYGSGEMGKMMLDG
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEECC
ADIGLDEVVALQGSPTCQVGYHRWRGRTLPAAVRELAARVLDQIDSGDFAAYLKEHAAND
CCCCHHHEEEECCCCCEEECHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
YAALDEARRAALKRPLNVAHAQVRAAFRFPTEAAGGLYQAAPAGAEPELAR
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHCCCCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA