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The map label for this gene is cirA [C]

Identifier: 53721278

GI number: 53721278

Start: 330905

End: 333184

Strand: Reverse

Name: cirA [C]

Synonym: BPSS0244

Alternate gene names: 53721278

Gene position: 333184-330905 (Counterclockwise)

Preceding gene: 53721279

Following gene: 53721277

Centisome position: 10.5

GC content: 68.38

Gene sequence:

>2280_bases
TTGGCGCGGCGGCCGCTTCGCGCCGCGCTGTTCGGGGCCTTCGGCCTCTATGCGGCGGCCGCGCGCGCCGCCGGCCCCGC
TTCCGAACCCGCGGCCGCCGCATCCGCCGCATCCACGTCGCAGGTGCGGCACGCGGCGATCGCCGCCGCACGCAAGGACG
CGCCGGCACTCGATCCGATCACCGTCACCGCGACGCGCACCGCGTCGGCCGCGAGCCGCACCGCGGCGAGCGTATCGGTG
ATCACCGATTCAGACCTCGAGGAGCAGCAGGCCGACAACATCAAGGACGCGCTGCGCTACGAGCCGGGCGTCACCGTGCG
ACGCACCGCGTACCGCCCGGCGAACGCCGCGCTCGGCGGCGGCCGCGACGGCGATTCGAGCATCAACATCCGCGGCCTCG
AAGGCAACCGCGTGCTGCTGATGGAAGACGGCATCCGGCTGCCGAGCGCGTTCTCGTTCGGCCCGCTCGAAGCCGGCCGC
GGCGATTACGCCGATCTCGACACGCTCGCGCGCATCGAGATCCTGCGCGGTCCGGCGTCCGCGCTGTATGGCAGCGACGG
CCTGACGGGCGCCGTCAACTTCATCACGAAAGATCCGTCCGATCTGCTGTCGATCCATCGAAAAAAGACCTATTTCTCGT
TCCGGCCGAGCTACGACTCGGTCGACCGCAGCATCGGCGCGACCGTGACGGCGGCGGGCGGCAACGATCGCGTGCAGGCG
ATGCTGATCGCGTCCGGCCGCCGCGGCCACGAACTCGACACGCACGGCGACGACAATTCCGCGAGCACGCGGCGCACGCG
CGCGAATCCTCAGGATGTCTACACGGAATCGCTGCTCGGCAAGCTGACGATCACGCCGACCGCGCGCGACACGATCAAGC
TCGCCGCCGAAACGGTGCGGCGGCGGATCGACACGAACGTGCTGTCGGCGATCAATCCGCCGACAACGCTCGGCCTCACC
GCGAACGACAGGCTCGAGCGCAACCGCTTCAGTATCGACTACGATTTGCGCGACGCCGCCGCGCGCGGGTTCCAGACCGC
GCACGTGCAGTTCTACTATCAGGAGTCGACGCAGGATCAGGACGCGTTCGAGACGCGCGGCGGGCGGCTCCAATCGCGTT
CGCGCTCGAACCACTACAGCGAGCGCGCGCTCGGCGGCTCCGCGTTCGCCGAGAGCGGCTTCGCGACCGGGCCGCTCGCG
CACAAGCTGCTGTACGGCGTCGACGGCAGCATCGACCGCATCAAGAGCCTGCGCGAGGGCACCGTCGCGAGCCCCGGCGA
ATCGTTCCCGAACAAGGCGTTTCCGGACACCGACTACTCGCTGTTCGGCGCGTTCGTGCAGGATCAGATCGGCTTCGGCA
AGCTGCTCGTCACGCCGGGCCTGCGCTTCGACGCGTATCGGCTCAGCCCGAGCTCGGGCGATCCGCTGTTCACCGGCAAG
ACGGTCAGCTCGAGCGATCACGAGCTGTCGCCGCGCGTCGCGATGCTCTATGAAGTGTCGCCCGCGCTGATTCCCTACGC
GCAGTATGCGCACGGCTTTCGCACGCCGACGCCCGATCAGATCAACAACAGCTTCTCGAATCCGATCTATGGCTATACGT
CGATCGGCAATCCGAACCTGAAGCCCGAGACGAGCGACACGCTCGAAGCGGGCCTGCGCGGCACGCTCGGCACCGGCTAC
GGGCCGCTGCGCTACAGCGTCGCCGCGTTCGCCGGCCGCTATCGCAACTTCATCTCGCAGCGCACGGTGGGCGGCAGTGG
CCGGCCGAACGATCCGCTCGTGTTCCAGTACGTGAACTTCGCGAACGCGCGCATTCACGGCTTCGAGGGACGCGCCGAAT
GGGTGATGCCGAATGGCTTCACGCTGAAGACGGCGATGGCGTTCACGAAGGGCACGACGCAGGACAACGGCGCGGCGAGC
GAGCCGCTCGATACGGTCAACCCGTTCTCCGCCGTGTTCGGCGTGCGCTACGAGCCGAGCGAGCGCTGGTTCGCGCAGGC
GGACCTGCTGTGGCAGGCGGGCAAGCGCGGCCGCGACGTGTCGTCGGCCGCGTGCCAGAAAAAGACCTGCTTCACGCCGC
CGTCGTCGTTCGTCGTCGATCTGCGCGGCGGCTACCGCTTCAACAAGCACGTGAGCGCCTACCTCGGCATTCACAACCTG
TTCGACCGCAAGTACTGGAACTGGTCGGACGTGCGCGGCATCGCCGCCGATTCGAACGTGCTCGACGCATACACCGCCCC
GGGCCGCAGCGTCGCGGTCAGCATGAAGGTGGATTTCTGA

Upstream 100 bases:

>100_bases
CGCCGTCCAGACGCGCGGGCGCCAGCCAGGTGCACGCGTCACCCAGCCAGCCTCCGGGCTCAAACGTCACTGGGAGACCA
ACACCGTGCATCAACCTCTG

Downstream 100 bases:

>100_bases
TGCGGCCCGCACGCTTTTTTCCCAACCCGACCGCCCGGCAATCGAGGATCTCCGACATGATGAACACCGCCGCCCCCGCC
GCTTCGCCCGCCCGCGCGCT

Product: exported heme receptor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 759; Mature: 758

Protein sequence:

>759_residues
MARRPLRAALFGAFGLYAAAARAAGPASEPAAAASAASTSQVRHAAIAAARKDAPALDPITVTATRTASAASRTAASVSV
ITDSDLEEQQADNIKDALRYEPGVTVRRTAYRPANAALGGGRDGDSSINIRGLEGNRVLLMEDGIRLPSAFSFGPLEAGR
GDYADLDTLARIEILRGPASALYGSDGLTGAVNFITKDPSDLLSIHRKKTYFSFRPSYDSVDRSIGATVTAAGGNDRVQA
MLIASGRRGHELDTHGDDNSASTRRTRANPQDVYTESLLGKLTITPTARDTIKLAAETVRRRIDTNVLSAINPPTTLGLT
ANDRLERNRFSIDYDLRDAAARGFQTAHVQFYYQESTQDQDAFETRGGRLQSRSRSNHYSERALGGSAFAESGFATGPLA
HKLLYGVDGSIDRIKSLREGTVASPGESFPNKAFPDTDYSLFGAFVQDQIGFGKLLVTPGLRFDAYRLSPSSGDPLFTGK
TVSSSDHELSPRVAMLYEVSPALIPYAQYAHGFRTPTPDQINNSFSNPIYGYTSIGNPNLKPETSDTLEAGLRGTLGTGY
GPLRYSVAAFAGRYRNFISQRTVGGSGRPNDPLVFQYVNFANARIHGFEGRAEWVMPNGFTLKTAMAFTKGTTQDNGAAS
EPLDTVNPFSAVFGVRYEPSERWFAQADLLWQAGKRGRDVSSAACQKKTCFTPPSSFVVDLRGGYRFNKHVSAYLGIHNL
FDRKYWNWSDVRGIAADSNVLDAYTAPGRSVAVSMKVDF

Sequences:

>Translated_759_residues
MARRPLRAALFGAFGLYAAAARAAGPASEPAAAASAASTSQVRHAAIAAARKDAPALDPITVTATRTASAASRTAASVSV
ITDSDLEEQQADNIKDALRYEPGVTVRRTAYRPANAALGGGRDGDSSINIRGLEGNRVLLMEDGIRLPSAFSFGPLEAGR
GDYADLDTLARIEILRGPASALYGSDGLTGAVNFITKDPSDLLSIHRKKTYFSFRPSYDSVDRSIGATVTAAGGNDRVQA
MLIASGRRGHELDTHGDDNSASTRRTRANPQDVYTESLLGKLTITPTARDTIKLAAETVRRRIDTNVLSAINPPTTLGLT
ANDRLERNRFSIDYDLRDAAARGFQTAHVQFYYQESTQDQDAFETRGGRLQSRSRSNHYSERALGGSAFAESGFATGPLA
HKLLYGVDGSIDRIKSLREGTVASPGESFPNKAFPDTDYSLFGAFVQDQIGFGKLLVTPGLRFDAYRLSPSSGDPLFTGK
TVSSSDHELSPRVAMLYEVSPALIPYAQYAHGFRTPTPDQINNSFSNPIYGYTSIGNPNLKPETSDTLEAGLRGTLGTGY
GPLRYSVAAFAGRYRNFISQRTVGGSGRPNDPLVFQYVNFANARIHGFEGRAEWVMPNGFTLKTAMAFTKGTTQDNGAAS
EPLDTVNPFSAVFGVRYEPSERWFAQADLLWQAGKRGRDVSSAACQKKTCFTPPSSFVVDLRGGYRFNKHVSAYLGIHNL
FDRKYWNWSDVRGIAADSNVLDAYTAPGRSVAVSMKVDF
>Mature_758_residues
ARRPLRAALFGAFGLYAAAARAAGPASEPAAAASAASTSQVRHAAIAAARKDAPALDPITVTATRTASAASRTAASVSVI
TDSDLEEQQADNIKDALRYEPGVTVRRTAYRPANAALGGGRDGDSSINIRGLEGNRVLLMEDGIRLPSAFSFGPLEAGRG
DYADLDTLARIEILRGPASALYGSDGLTGAVNFITKDPSDLLSIHRKKTYFSFRPSYDSVDRSIGATVTAAGGNDRVQAM
LIASGRRGHELDTHGDDNSASTRRTRANPQDVYTESLLGKLTITPTARDTIKLAAETVRRRIDTNVLSAINPPTTLGLTA
NDRLERNRFSIDYDLRDAAARGFQTAHVQFYYQESTQDQDAFETRGGRLQSRSRSNHYSERALGGSAFAESGFATGPLAH
KLLYGVDGSIDRIKSLREGTVASPGESFPNKAFPDTDYSLFGAFVQDQIGFGKLLVTPGLRFDAYRLSPSSGDPLFTGKT
VSSSDHELSPRVAMLYEVSPALIPYAQYAHGFRTPTPDQINNSFSNPIYGYTSIGNPNLKPETSDTLEAGLRGTLGTGYG
PLRYSVAAFAGRYRNFISQRTVGGSGRPNDPLVFQYVNFANARIHGFEGRAEWVMPNGFTLKTAMAFTKGTTQDNGAASE
PLDTVNPFSAVFGVRYEPSERWFAQADLLWQAGKRGRDVSSAACQKKTCFTPPSSFVVDLRGGYRFNKHVSAYLGIHNLF
DRKYWNWSDVRGIAADSNVLDAYTAPGRSVAVSMKVDF

Specific function: Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family. Hemoglobin/haptoglobin binding protein subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=701, Percent_Identity=25.2496433666191, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1790405, Length=149, Percent_Identity=35.5704697986577, Blast_Score=76, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR006970
- InterPro:   IPR000531
- InterPro:   IPR010949
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF04886 PT; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 81927; Mature: 81796

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRPLRAALFGAFGLYAAAARAAGPASEPAAAASAASTSQVRHAAIAAARKDAPALDPI
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
TVTATRTASAASRTAASVSVITDSDLEEQQADNIKDALRYEPGVTVRRTAYRPANAALGG
EEEEECCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
GRDGDSSINIRGLEGNRVLLMEDGIRLPSAFSFGPLEAGRGDYADLDTLARIEILRGPAS
CCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHH
ALYGSDGLTGAVNFITKDPSDLLSIHRKKTYFSFRPSYDSVDRSIGATVTAAGGNDRVQA
HHCCCCCCCEEEEEEECCHHHHHHHHHHHEEEEECCCHHHHHHHCCCEEEECCCCCCEEE
MLIASGRRGHELDTHGDDNSASTRRTRANPQDVYTESLLGKLTITPTARDTIKLAAETVR
EEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCEEEECCCCHHHHHHHHHHHH
RRIDTNVLSAINPPTTLGLTANDRLERNRFSIDYDLRDAAARGFQTAHVQFYYQESTQDQ
HHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEECHHHHHHCCCEEEEEEEEECCCCCCH
DAFETRGGRLQSRSRSNHYSERALGGSAFAESGFATGPLAHKLLYGVDGSIDRIKSLREG
HHHHHCCCCCCCCCCCCCHHHHHCCCHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHCC
TVASPGESFPNKAFPDTDYSLFGAFVQDQIGFGKLLVTPGLRFDAYRLSPSSGDPLFTGK
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCCCCEEECC
TVSSSDHELSPRVAMLYEVSPALIPYAQYAHGFRTPTPDQINNSFSNPIYGYTSIGNPNL
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCEEEECCCCCCC
KPETSDTLEAGLRGTLGTGYGPLRYSVAAFAGRYRNFISQRTVGGSGRPNDPLVFQYVNF
CCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECC
ANARIHGFEGRAEWVMPNGFTLKTAMAFTKGTTQDNGAASEPLDTVNPFSAVFGVRYEPS
CCCEEECCCCCEEEECCCCEEEEEEHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCEECCC
ERWFAQADLLWQAGKRGRDVSSAACQKKTCFTPPSSFVVDLRGGYRFNKHVSAYLGIHNL
HHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCEEEECCCCEEECCHHHHHHHHHHH
FDRKYWNWSDVRGIAADSNVLDAYTAPGRSVAVSMKVDF
HHCCCCCHHHCCCEECCCCEEECCCCCCCEEEEEEEECC
>Mature Secondary Structure 
ARRPLRAALFGAFGLYAAAARAAGPASEPAAAASAASTSQVRHAAIAAARKDAPALDPI
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
TVTATRTASAASRTAASVSVITDSDLEEQQADNIKDALRYEPGVTVRRTAYRPANAALGG
EEEEECCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
GRDGDSSINIRGLEGNRVLLMEDGIRLPSAFSFGPLEAGRGDYADLDTLARIEILRGPAS
CCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHH
ALYGSDGLTGAVNFITKDPSDLLSIHRKKTYFSFRPSYDSVDRSIGATVTAAGGNDRVQA
HHCCCCCCCEEEEEEECCHHHHHHHHHHHEEEEECCCHHHHHHHCCCEEEECCCCCCEEE
MLIASGRRGHELDTHGDDNSASTRRTRANPQDVYTESLLGKLTITPTARDTIKLAAETVR
EEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCEEEECCCCHHHHHHHHHHHH
RRIDTNVLSAINPPTTLGLTANDRLERNRFSIDYDLRDAAARGFQTAHVQFYYQESTQDQ
HHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEECHHHHHHCCCEEEEEEEEECCCCCCH
DAFETRGGRLQSRSRSNHYSERALGGSAFAESGFATGPLAHKLLYGVDGSIDRIKSLREG
HHHHHCCCCCCCCCCCCCHHHHHCCCHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHCC
TVASPGESFPNKAFPDTDYSLFGAFVQDQIGFGKLLVTPGLRFDAYRLSPSSGDPLFTGK
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCCCCEEECC
TVSSSDHELSPRVAMLYEVSPALIPYAQYAHGFRTPTPDQINNSFSNPIYGYTSIGNPNL
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCEEEECCCCCCC
KPETSDTLEAGLRGTLGTGYGPLRYSVAAFAGRYRNFISQRTVGGSGRPNDPLVFQYVNF
CCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECC
ANARIHGFEGRAEWVMPNGFTLKTAMAFTKGTTQDNGAASEPLDTVNPFSAVFGVRYEPS
CCCEEECCCCCEEEECCCCEEEEEEHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCEECCC
ERWFAQADLLWQAGKRGRDVSSAACQKKTCFTPPSSFVVDLRGGYRFNKHVSAYLGIHNL
HHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCEEEECCCCEEECCHHHHHHHHHHH
FDRKYWNWSDVRGIAADSNVLDAYTAPGRSVAVSMKVDF
HHCCCCCHHHCCCEECCCCEEECCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]