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The map label for this gene is tycA [H]

Identifier: 53719841

GI number: 53719841

Start: 2685503

End: 2687395

Strand: Reverse

Name: tycA [H]

Synonym: BPSL2232

Alternate gene names: 53719841

Gene position: 2687395-2685503 (Counterclockwise)

Preceding gene: 53719842

Following gene: 53719840

Centisome position: 65.96

GC content: 72.79

Gene sequence:

>1893_bases
GTGACGCCGCCGCTCCGTTCCTTCCTTCGCCGACGGCCAATAGCGAGACAAACGATGAGCGTTCACGACATGACTCACCC
GGGCGAGCTCGCACCGGTGCGAGCGGACCGATTCGGCCGGCGGTTCGCGACGGCGGCCGCGGCCGAGATCGCCGCCGCCG
ATTCGCTGACGGCGCGATTCGCCGACGTGGCCGCGCGCCGGGGCGATGCGCTCGCGGTGACGTGCGGCGACGAACGCTGG
ACGTACGGCGCGCTTGCGGCACGCGCGCGCCGCATCGCCGAAGCGGTTCGCGCGGCGGGCGAGGCGGGCGGCGAACCGGT
CGCGCTCCTCTATCCGCACGGCGCGCCGATGATCGCCGCGATGTTCGGCGTGCTCGGCGCCGGCAAGTTCTACGTCCCGC
TGATCGCCGACCATCCGCTGCCGCACCTGCAATCGATCGTGCGCGAGTGCGGCTGCCGGCTCGTGCTCGCCGCGCCCGAG
CTCGCCGAGACGGCCGCGCGCCTCGGCGTCTCGGCGCGCGTCATCGACGACGCGCGCCTGCCGCCGGCGCACGGCCCGTT
CGACGCGCGCGGCGGCGACGCGGTTTCGTATCTGCTGTTCACGTCGGGCACGACCGGCGTGCCGAAGGGCGTGATGCAGT
GCGACCGCAATGTGCTGCACCACGCCGCGTGCTACGCGGCGTCGATCGGCCTTGACGACGACGACCGGATGACGCTGCTG
CCGTACTACGGCTTCGACGCGTCGGTGATGGACATCTTCGCCACGCTGCTGACGGGCGCGAGCCTGCATCTGTGGGACGT
GCGCGAGCGCGGCGTCGACGGCATCGGTGAATGGCTCGCGCGCGAGCGCATGACGATCTGGCATTCGACGCCGAGCGTGC
TGCGCGCCACGTTTGCCGCCTTCGCGCGGCCGGCCGCGCTGCGCTGGGTCGTGCTGGGCGGCGAGGCCGCGACGGGCGGC
GACGTCGCGCTCGTCGCGCGGCACGGCGGCCCGCGATGCCGGCTGCTCAACGGCCTGGGGCCGACCGAATGCACGACGGC
GCTGCAATACGTCGCCGATCCCGCGGCCGATGCGAGTATCGCGCGTCTGCCCGTCGGCCGGCCGGTGCCGGGCGTCGAGG
TCGAGCTCGCCGATGCGCGGGGCGAAGCCTGCGCGACCGAGGGCGAACTCGTGATCGTCAGCCCCTTCGTCGCGCTCGGG
TACTGGGGGCGCGCGGAGCTGAGCGCCGAGCGCTTTCGCCAGACGGCGCGCCCGGACGGCGCGCGGCGGTATCGCACGGG
CGATCTGCTGCGGATCGACGCGCGCGGCTGCTACGAACATCTGACGCGGGTCGACGATCAGATCAAGATTCGCGGCCTGC
GCGTCGAACTCGGCGAAATCCAGGCGACGCTCGCCGCGCATGACGACGTGCTTCAGGCGGTCGTGCTGCCGCGCCTTGAC
GAAGCCACGCAGCAGCAGACGATCGTCGCGTACGTCGTGCCGCGCGCGGCGTCGGCCGACGTCGCGGCGCTGCGCGAATA
CGTCGCGAGCCGTTTGCCCGCGCACATGGTGCCGCGCGCGATCGTTCGCGTCGATGCGATGCCGTTGCTGCCGAACGGCA
AGCTGAATCGCCGCGCGCTGCCGGCGCCGCCGCGCGCGGAAGTGGCGGCGGGCGAGCGCAAGGCGCCGCGCACGCCGTTG
CACCGGCTGCTCGCCGCATGCTGGGCCGACGTGCTGCGGCGCGACACGGTGGGCATCGACGAGAACTTCTTCGAACTCGG
CGGCGATTCGCTGCTCGGCGCGCAACTGCTGTCGCGCGTGAAGCGCGACCTCGAGCTCGACGCGCGGCTCGGCGACCTGT
TTCGCCATCCGACAGTCGAGTCGCTGGCCGAGCATCTGCTGGCTTGCCGATGA

Upstream 100 bases:

>100_bases
CGACGACGCACGACGTCGAGGACGCGACGCAGATGCTGCGCCGCTACTACGTCGACGCGCGCCTGTCCGGCGCGCGTGCG
GGCACCGCCGAGTGCGCGGC

Downstream 100 bases:

>100_bases
TCGGCCTCGCGGCCGCGGACATGGCGATGCGAATTCCGATGCGATCAACCGATTCGGCGAGACGGACATGACCGACAGCA
TGCAGGACAGCCTCGACGAA

Product: putative non-ribosomal peptide synthase

Products: NA

Alternate protein names: Tyrocidine synthase I; ATP-dependent D-phenylalanine adenylase; D-PheA; D-phenylalanine activase; Phenylalanine racemase [ATP-hydrolyzing] [H]

Number of amino acids: Translated: 630; Mature: 629

Protein sequence:

>630_residues
MTPPLRSFLRRRPIARQTMSVHDMTHPGELAPVRADRFGRRFATAAAAEIAAADSLTARFADVAARRGDALAVTCGDERW
TYGALAARARRIAEAVRAAGEAGGEPVALLYPHGAPMIAAMFGVLGAGKFYVPLIADHPLPHLQSIVRECGCRLVLAAPE
LAETAARLGVSARVIDDARLPPAHGPFDARGGDAVSYLLFTSGTTGVPKGVMQCDRNVLHHAACYAASIGLDDDDRMTLL
PYYGFDASVMDIFATLLTGASLHLWDVRERGVDGIGEWLARERMTIWHSTPSVLRATFAAFARPAALRWVVLGGEAATGG
DVALVARHGGPRCRLLNGLGPTECTTALQYVADPAADASIARLPVGRPVPGVEVELADARGEACATEGELVIVSPFVALG
YWGRAELSAERFRQTARPDGARRYRTGDLLRIDARGCYEHLTRVDDQIKIRGLRVELGEIQATLAAHDDVLQAVVLPRLD
EATQQQTIVAYVVPRAASADVAALREYVASRLPAHMVPRAIVRVDAMPLLPNGKLNRRALPAPPRAEVAAGERKAPRTPL
HRLLAACWADVLRRDTVGIDENFFELGGDSLLGAQLLSRVKRDLELDARLGDLFRHPTVESLAEHLLACR

Sequences:

>Translated_630_residues
MTPPLRSFLRRRPIARQTMSVHDMTHPGELAPVRADRFGRRFATAAAAEIAAADSLTARFADVAARRGDALAVTCGDERW
TYGALAARARRIAEAVRAAGEAGGEPVALLYPHGAPMIAAMFGVLGAGKFYVPLIADHPLPHLQSIVRECGCRLVLAAPE
LAETAARLGVSARVIDDARLPPAHGPFDARGGDAVSYLLFTSGTTGVPKGVMQCDRNVLHHAACYAASIGLDDDDRMTLL
PYYGFDASVMDIFATLLTGASLHLWDVRERGVDGIGEWLARERMTIWHSTPSVLRATFAAFARPAALRWVVLGGEAATGG
DVALVARHGGPRCRLLNGLGPTECTTALQYVADPAADASIARLPVGRPVPGVEVELADARGEACATEGELVIVSPFVALG
YWGRAELSAERFRQTARPDGARRYRTGDLLRIDARGCYEHLTRVDDQIKIRGLRVELGEIQATLAAHDDVLQAVVLPRLD
EATQQQTIVAYVVPRAASADVAALREYVASRLPAHMVPRAIVRVDAMPLLPNGKLNRRALPAPPRAEVAAGERKAPRTPL
HRLLAACWADVLRRDTVGIDENFFELGGDSLLGAQLLSRVKRDLELDARLGDLFRHPTVESLAEHLLACR
>Mature_629_residues
TPPLRSFLRRRPIARQTMSVHDMTHPGELAPVRADRFGRRFATAAAAEIAAADSLTARFADVAARRGDALAVTCGDERWT
YGALAARARRIAEAVRAAGEAGGEPVALLYPHGAPMIAAMFGVLGAGKFYVPLIADHPLPHLQSIVRECGCRLVLAAPEL
AETAARLGVSARVIDDARLPPAHGPFDARGGDAVSYLLFTSGTTGVPKGVMQCDRNVLHHAACYAASIGLDDDDRMTLLP
YYGFDASVMDIFATLLTGASLHLWDVRERGVDGIGEWLARERMTIWHSTPSVLRATFAAFARPAALRWVVLGGEAATGGD
VALVARHGGPRCRLLNGLGPTECTTALQYVADPAADASIARLPVGRPVPGVEVELADARGEACATEGELVIVSPFVALGY
WGRAELSAERFRQTARPDGARRYRTGDLLRIDARGCYEHLTRVDDQIKIRGLRVELGEIQATLAAHDDVLQAVVLPRLDE
ATQQQTIVAYVVPRAASADVAALREYVASRLPAHMVPRAIVRVDAMPLLPNGKLNRRALPAPPRAEVAAGERKAPRTPLH
RLLAACWADVLRRDTVGIDENFFELGGDSLLGAQLLSRVKRDLELDARLGDLFRHPTVESLAEHLLACR

Specific function: In the first step of peptide synthesis this enzyme activates phenylalanine and racemizes it to the D-isomer [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 acyl carrier domain [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=453, Percent_Identity=25.60706401766, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI13325057, Length=523, Percent_Identity=26.5774378585086, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI156151445, Length=528, Percent_Identity=21.780303030303, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1786801, Length=626, Percent_Identity=28.9137380191693, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI145693145, Length=504, Percent_Identity=25.9920634920635, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788107, Length=564, Percent_Identity=24.468085106383, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789201, Length=351, Percent_Identity=28.4900284900285, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790505, Length=379, Percent_Identity=26.1213720316623, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531443, Length=442, Percent_Identity=23.5294117647059, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17556356, Length=304, Percent_Identity=25.6578947368421, Blast_Score=77, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319591, Length=650, Percent_Identity=25.6923076923077, Blast_Score=173, Evalue=9e-44,
Organism=Drosophila melanogaster, GI18859661, Length=375, Percent_Identity=25.3333333333333, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24581924, Length=358, Percent_Identity=25.9776536312849, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020459
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR006162 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding [H]

EC number: =5.1.1.11 [H]

Molecular weight: Translated: 67878; Mature: 67746

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPPLRSFLRRRPIARQTMSVHDMTHPGELAPVRADRFGRRFATAAAAEIAAADSLTARF
CCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ADVAARRGDALAVTCGDERWTYGALAARARRIAEAVRAAGEAGGEPVALLYPHGAPMIAA
HHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHH
MFGVLGAGKFYVPLIADHPLPHLQSIVRECGCRLVLAAPELAETAARLGVSARVIDDARL
HHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCEEEECCCCC
PPAHGPFDARGGDAVSYLLFTSGTTGVPKGVMQCDRNVLHHAACYAASIGLDDDDRMTLL
CCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
PYYGFDASVMDIFATLLTGASLHLWDVRERGVDGIGEWLARERMTIWHSTPSVLRATFAA
EECCCCHHHHHHHHHHHCCCCEEEEECHHHCCCHHHHHHHHCCCEEECCCHHHHHHHHHH
FARPAALRWVVLGGEAATGGDVALVARHGGPRCRLLNGLGPTECTTALQYVADPAADASI
HHCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCE
ARLPVGRPVPGVEVELADARGEACATEGELVIVSPFVALGYWGRAELSAERFRQTARPDG
EECCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHCCCCCCHHHHHHHHHHCCCCC
ARRYRTGDLLRIDARGCYEHLTRVDDQIKIRGLRVELGEIQATLAAHDDVLQAVVLPRLD
CCCCCCCCEEEECCHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCC
EATQQQTIVAYVVPRAASADVAALREYVASRLPAHMVPRAIVRVDAMPLLPNGKLNRRAL
HHHHHCEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
PAPPRAEVAAGERKAPRTPLHRLLAACWADVLRRDTVGIDENFFELGGDSLLGAQLLSRV
CCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHH
KRDLELDARLGDLFRHPTVESLAEHLLACR
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
TPPLRSFLRRRPIARQTMSVHDMTHPGELAPVRADRFGRRFATAAAAEIAAADSLTARF
CCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ADVAARRGDALAVTCGDERWTYGALAARARRIAEAVRAAGEAGGEPVALLYPHGAPMIAA
HHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHH
MFGVLGAGKFYVPLIADHPLPHLQSIVRECGCRLVLAAPELAETAARLGVSARVIDDARL
HHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCEEEECCCCC
PPAHGPFDARGGDAVSYLLFTSGTTGVPKGVMQCDRNVLHHAACYAASIGLDDDDRMTLL
CCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
PYYGFDASVMDIFATLLTGASLHLWDVRERGVDGIGEWLARERMTIWHSTPSVLRATFAA
EECCCCHHHHHHHHHHHCCCCEEEEECHHHCCCHHHHHHHHCCCEEECCCHHHHHHHHHH
FARPAALRWVVLGGEAATGGDVALVARHGGPRCRLLNGLGPTECTTALQYVADPAADASI
HHCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCE
ARLPVGRPVPGVEVELADARGEACATEGELVIVSPFVALGYWGRAELSAERFRQTARPDG
EECCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHCCCCCCHHHHHHHHHHCCCCC
ARRYRTGDLLRIDARGCYEHLTRVDDQIKIRGLRVELGEIQATLAAHDDVLQAVVLPRLD
CCCCCCCCEEEECCHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCC
EATQQQTIVAYVVPRAASADVAALREYVASRLPAHMVPRAIVRVDAMPLLPNGKLNRRAL
HHHHHCEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
PAPPRAEVAAGERKAPRTPLHRLLAACWADVLRRDTVGIDENFFELGGDSLLGAQLLSRV
CCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHH
KRDLELDARLGDLFRHPTVESLAEHLLACR
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3267240; 9352938; 3032912; 8193142 [H]