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The map label for this gene is moaA [H]

Identifier: 53719818

GI number: 53719818

Start: 2652831

End: 2653820

Strand: Reverse

Name: moaA [H]

Synonym: BPSL2209

Alternate gene names: 53719818

Gene position: 2653820-2652831 (Counterclockwise)

Preceding gene: 53719819

Following gene: 53719817

Centisome position: 65.13

GC content: 71.21

Gene sequence:

>990_bases
ATGGCGCGCGCGCTCGTCGATCGCTTCGGCCGCGCTGTCACGTATGTGCGTCTGTCGGTGACGGACCGGTGCGACTTCCG
TTGCGTGTACCGCATGACGCAGGACATGCGATTCCTGCCGCGCTCGGACGTGCTGACGCTCGACGCGCTCGCCGCTCTCG
CGCGGGCGTGCGTCGCGCTCGGCGTGCGCCGGATCCGGCTCACGGGCGGCGAGCCGCTCGTGCGCCCCGGCTTGACGACG
CTCGTCGAGCGCATCGCGCGCCTGCCCGGGCTCGACGAACTCGCCCTGACGACCAACGGGGCGCGCCTCGCGCAGTTCGC
CGCGCCGTTGAAGGCGGCGGGCCTCGCTCGCGTCAACGTCAGCCTGGACAGCCTGCGCGAGGACCGTTTCGGCGCGTTGA
CGCGCACGGGCCGCCTGCGCGACGTGCCGGCCGGCATCGCCGCGGCGAAGCGCGCCGGGTTTCGGCGCATCAGGCTGAAC
TGCGTGATCCTGCGCGGCCGCAACGACGACGAAGTGCTGGATCTCGTGCGTTTCGCGCGCGCGCAGCGGCTCGATCTGGC
GTTCATCGAGGAAATGCCGCTTGGCGCGATCGACGAGCACGACCGCGCTTCGTGCTTCGTGTCGAGCGACGAGGTACTCG
CGCGGATTCGCGGCCGTTACGCGCTTTTCCCGAGCGACGTTTCGACGGGCGGCCCCGCGCGTTATTTCCGCATGGCGGAC
AGCGAGATTCGCGTCGGCGTGATCGCGCCGCACAGCCACAACTTCTGCGGCGACTGCAACCGGGTGCGCGTCACGGCGAG
CGGCCGCCTGCTGCTGTGTCTCGGCAACGAGCACGGCGCCGAGCTGCGCGACGTGCTGCGCACGAGCCCCGGCGACGATG
CGCGGCTGCGCGGCGCGATCGCCGCCGCGATGCCGCTCAAGCCCGAGCGGCATCGGTTCGATCTGGACGCGCCGCACATC
GTGCGCTTCATGAACATGACGGGAGGATGA

Upstream 100 bases:

>100_bases
ACCGCAACGGCGCGTGAGGCGCGTGATGCCGCCTCGTTCGGAGCCGGGCGCGCGCCGCGGCGAACCGCGCGCCGGCGGCG
AGCCGGCGCCGCGCGCGTCG

Downstream 100 bases:

>100_bases
AGAGAAGATGTCCGCGAATGCCCACGAAACCGTGCTGTCCGTTCATCACTGGAACGACACGCTGTTCAGCTTCAAGACGA
CGCGCGCGCCGGGCCTGCGT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MARALVDRFGRAVTYVRLSVTDRCDFRCVYRMTQDMRFLPRSDVLTLDALAALARACVALGVRRIRLTGGEPLVRPGLTT
LVERIARLPGLDELALTTNGARLAQFAAPLKAAGLARVNVSLDSLREDRFGALTRTGRLRDVPAGIAAAKRAGFRRIRLN
CVILRGRNDDEVLDLVRFARAQRLDLAFIEEMPLGAIDEHDRASCFVSSDEVLARIRGRYALFPSDVSTGGPARYFRMAD
SEIRVGVIAPHSHNFCGDCNRVRVTASGRLLLCLGNEHGAELRDVLRTSPGDDARLRGAIAAAMPLKPERHRFDLDAPHI
VRFMNMTGG

Sequences:

>Translated_329_residues
MARALVDRFGRAVTYVRLSVTDRCDFRCVYRMTQDMRFLPRSDVLTLDALAALARACVALGVRRIRLTGGEPLVRPGLTT
LVERIARLPGLDELALTTNGARLAQFAAPLKAAGLARVNVSLDSLREDRFGALTRTGRLRDVPAGIAAAKRAGFRRIRLN
CVILRGRNDDEVLDLVRFARAQRLDLAFIEEMPLGAIDEHDRASCFVSSDEVLARIRGRYALFPSDVSTGGPARYFRMAD
SEIRVGVIAPHSHNFCGDCNRVRVTASGRLLLCLGNEHGAELRDVLRTSPGDDARLRGAIAAAMPLKPERHRFDLDAPHI
VRFMNMTGG
>Mature_328_residues
ARALVDRFGRAVTYVRLSVTDRCDFRCVYRMTQDMRFLPRSDVLTLDALAALARACVALGVRRIRLTGGEPLVRPGLTTL
VERIARLPGLDELALTTNGARLAQFAAPLKAAGLARVNVSLDSLREDRFGALTRTGRLRDVPAGIAAAKRAGFRRIRLNC
VILRGRNDDEVLDLVRFARAQRLDLAFIEEMPLGAIDEHDRASCFVSSDEVLARIRGRYALFPSDVSTGGPARYFRMADS
EIRVGVIAPHSHNFCGDCNRVRVTASGRLLLCLGNEHGAELRDVLRTSPGDDARLRGAIAAAMPLKPERHRFDLDAPHIV
RFMNMTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=311, Percent_Identity=36.3344051446945, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI116734668, Length=311, Percent_Identity=36.3344051446945, Blast_Score=201, Evalue=5e-52,
Organism=Escherichia coli, GI1786999, Length=334, Percent_Identity=35.0299401197605, Blast_Score=184, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17561210, Length=316, Percent_Identity=35.4430379746835, Blast_Score=193, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI32566331, Length=311, Percent_Identity=34.4051446945338, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI32566329, Length=311, Percent_Identity=34.4051446945338, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28574490, Length=314, Percent_Identity=38.2165605095541, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI28574488, Length=314, Percent_Identity=38.2165605095541, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36273; Mature: 36141

Theoretical pI: Translated: 10.65; Mature: 10.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARALVDRFGRAVTYVRLSVTDRCDFRCVYRMTQDMRFLPRSDVLTLDALAALARACVAL
CCHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
GVRRIRLTGGEPLVRPGLTTLVERIARLPGLDELALTTNGARLAQFAAPLKAAGLARVNV
CCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCHHHCCEEEEEC
SLDSLREDRFGALTRTGRLRDVPAGIAAAKRAGFRRIRLNCVILRGRNDDEVLDLVRFAR
CHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEEEEEEEECCCCHHHHHHHHHHH
AQRLDLAFIEEMPLGAIDEHDRASCFVSSDEVLARIRGRYALFPSDVSTGGPARYFRMAD
HHHCCHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHCCCEEECCCCCCCCCCEEEEEECC
SEIRVGVIAPHSHNFCGDCNRVRVTASGRLLLCLGNEHGAELRDVLRTSPGDDARLRGAI
CCEEEEEECCCCCCCCCCCCEEEEEECCEEEEEECCCCCHHHHHHHHCCCCCCHHHHHHH
AAAMPLKPERHRFDLDAPHIVRFMNMTGG
HHHCCCCCCCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
ARALVDRFGRAVTYVRLSVTDRCDFRCVYRMTQDMRFLPRSDVLTLDALAALARACVAL
CHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
GVRRIRLTGGEPLVRPGLTTLVERIARLPGLDELALTTNGARLAQFAAPLKAAGLARVNV
CCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCHHHCCEEEEEC
SLDSLREDRFGALTRTGRLRDVPAGIAAAKRAGFRRIRLNCVILRGRNDDEVLDLVRFAR
CHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEEEEEEEECCCCHHHHHHHHHHH
AQRLDLAFIEEMPLGAIDEHDRASCFVSSDEVLARIRGRYALFPSDVSTGGPARYFRMAD
HHHCCHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHCCCEEECCCCCCCCCCEEEEEECC
SEIRVGVIAPHSHNFCGDCNRVRVTASGRLLLCLGNEHGAELRDVLRTSPGDDARLRGAI
CCEEEEEECCCCCCCCCCCCEEEEEECCEEEEEECCCCCHHHHHHHHCCCCCCHHHHHHH
AAAMPLKPERHRFDLDAPHIVRFMNMTGG
HHHCCCCCCCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA