Click here to switch to the map view.

The map label for this gene is guaA

Identifier: 53719738

GI number: 53719738

Start: 2555410

End: 2557053

Strand: Reverse

Name: guaA

Synonym: BPSL2127

Alternate gene names: 53719738

Gene position: 2557053-2555410 (Counterclockwise)

Preceding gene: 53719739

Following gene: 53719736

Centisome position: 62.76

GC content: 66.24

Gene sequence:

>1644_bases
TTGTTCCTTTCCCCGTCCGCTGCCATGCACGACAAAATCCTGATTCTCGACTTCGGTTCGCAAGTCACTCAACTGATCGC
GCGGCGCGTCCGCGAAGCGCACGTCTACTGCGAGATCCATCCGAACGACGTTTCCGACGACTTCGTTCGCGAGTTCGCCC
CGAAGGGCGTGATTCTGTCCGGCAGCCACGCGAGCACCTACGAGGACCACCAGTTGCGCGCGCCGCAGGCGGTATGGGAT
CTCGGCGTGCCCGTGCTCGGCATTTGCTACGGGATGCAGACGATGGCCGTACAACTGGGCGGCAAGGTCGAGTGGAGCGA
CCACCGCGAGTTCGGCTATGCGGAAGTGCGCGCGCATGGCCGCACGCGCCTGCTCGACGGCATCCAGGATTTCGCGACGC
CCGAAGGCCACGGGATGCTGAAGGTCTGGATGAGCCACGGCGACAAGGTCGGCGAGATGCCGCCGGGCTTCGCGCTGATG
GCGTCGACGCCGAGCTGCCCGATCGCCGGCATGGCCGACGAGGCGCGCGGCTACTACGCGGTGCAGTTCCACCCGGAAGT
CACGCACACGGTGCAGGGCCGCAAGCTGCTCGAGCGCTTCGTGCTCGACATCGCCGGCGCGAAACCCGACTGGATCATGC
GCGACCACATCGAGGAGGCGGTCGCGCGGATTCGCGAGCAGGTCGGCGACGAGGAAGTGATCCTCGGCCTGTCGGGCGGC
GTGGATTCGAGCGTCGCGGCGGCGCTCATCCACCGTGCGATCGGCGATCAATTGACTTGCGTGTTCGTCGACCACGGCCT
GCTGCGCCTGAACGAAGGCAAGATGGTGCTCGACATGTTCGAAGGCCGGCTGCATGCGAAGGTCGTCCACGTCGACGCGT
CCGAGCAGTTCCTCGGCCATCTCGCGGGCGTCGCCGATCCGGAGCACAAACGCAAGATCATCGGCCGCGAGTTCGTCGAA
GTGTTCCAGGCGGAAGCGAAGAAGCTGACGAACGCGAAGTGGCTCGCGCAGGGGACGATCTACCCGGACGTGATCGAATC
GGGCGGCGCGAAGACGAAGAAGGCGACGACGATCAAGAGCCATCACAACGTGGGCGGCTTGCCGGAGACGCTCGGCCTGA
AGCTGCTCGAGCCGCTGCGCGATCTGTTCAAGGACGAAGTGCGCGAGCTTGGCGTCGCGCTCGGCTTGCCGGCGGAGATG
GTGTATCGCCATCCGTTCCCGGGCCCGGGCCTCGGCGTGCGGATTCTGGGCGAAGTGAAGCGCGACTACGCGGAGCTGCT
GCGCCGCGCGGATGCGATCTTCATCGAAGAGCTCTGCGGGACGCTCGCGACCGAGCAGGATGCGGCGGCGGGCCTGTGCG
AGCCGTCGCAGGTCGGCAAGAGCTGGTACGACCTGACGAGCCAGGCGTTCGCGGTGTTCCTGCCGGTGAAGTCGGTCGGC
GTGATGGGCGACGGCCGCACGTACGACTACGTGGCCGCGTTGCGCGCGGTGCAGACGACCGATTTCATGACGGCGCACTG
GGCGCATCTGCCGTATGCGCTGCTCGGCCGCGCGTCGAACCGGATCATCAACGAAGTGCGCGGGATCAATCGGGTGGTGT
ACGACGTGTCGGGTAAGCCGCCGGCGACAATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
GCGCGGTTTTCCGGCCCGTCAGGCCGCCGCGCTTCGCGGCGGCGCGATCGCCCCGATACATATTCGATGCAGCGCCGCGT
GCGCTGCTTTTGTTATTCCC

Downstream 100 bases:

>100_bases
TCCGGCGTCCTTCGACGACTATCGCCTGATCGTCGAGCGCTGCCGTGATGTATCGATTGATTGCGAAATGCATCGCGGCG
GCTATTGGGGGTTACCGTCG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MFLSPSAAMHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKGVILSGSHASTYEDHQLRAPQAVWD
LGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGRTRLLDGIQDFATPEGHGMLKVWMSHGDKVGEMPPGFALM
ASTPSCPIAGMADEARGYYAVQFHPEVTHTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGG
VDSSVAAALIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVADPEHKRKIIGREFVE
VFQAEAKKLTNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPAEM
VYRHPFPGPGLGVRILGEVKRDYAELLRRADAIFIEELCGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVG
VMGDGRTYDYVAALRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDVSGKPPATIEWE

Sequences:

>Translated_547_residues
MFLSPSAAMHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKGVILSGSHASTYEDHQLRAPQAVWD
LGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGRTRLLDGIQDFATPEGHGMLKVWMSHGDKVGEMPPGFALM
ASTPSCPIAGMADEARGYYAVQFHPEVTHTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGG
VDSSVAAALIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVADPEHKRKIIGREFVE
VFQAEAKKLTNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPAEM
VYRHPFPGPGLGVRILGEVKRDYAELLRRADAIFIEELCGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVG
VMGDGRTYDYVAALRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDVSGKPPATIEWE
>Mature_547_residues
MFLSPSAAMHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKGVILSGSHASTYEDHQLRAPQAVWD
LGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGRTRLLDGIQDFATPEGHGMLKVWMSHGDKVGEMPPGFALM
ASTPSCPIAGMADEARGYYAVQFHPEVTHTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGG
VDSSVAAALIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVADPEHKRKIIGREFVE
VFQAEAKKLTNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPAEM
VYRHPFPGPGLGVRILGEVKRDYAELLRRADAIFIEELCGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVG
VMGDGRTYDYVAALRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDVSGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=563, Percent_Identity=34.6358792184725, Blast_Score=274, Evalue=2e-73,
Organism=Escherichia coli, GI1788854, Length=536, Percent_Identity=64.1791044776119, Blast_Score=685, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=580, Percent_Identity=35.3448275862069, Blast_Score=287, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI71992717, Length=580, Percent_Identity=35.3448275862069, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI133901714, Length=580, Percent_Identity=35.3448275862069, Blast_Score=286, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6323873, Length=550, Percent_Identity=48, Blast_Score=496, Evalue=1e-141,
Organism=Drosophila melanogaster, GI281365319, Length=560, Percent_Identity=35.5357142857143, Blast_Score=282, Evalue=3e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_BURP1 (Q3JR65)

Other databases:

- EMBL:   CP000124
- RefSeq:   YP_333938.1
- ProteinModelPortal:   Q3JR65
- SMR:   Q3JR65
- STRING:   Q3JR65
- GeneID:   3691279
- GenomeReviews:   CP000124_GR
- KEGG:   bpm:BURPS1710b_2546
- TIGR:   BURPS1710b_2546
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- ProtClustDB:   PRK00074
- HAMAP:   MF_00344
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 60175; Mature: 60175

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 89-89 ACT_SITE 184-184 ACT_SITE 186-186

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLSPSAAMHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKGVILS
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCCCCEEEE
GSHASTYEDHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHG
CCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHCC
RTRLLDGIQDFATPEGHGMLKVWMSHGDKVGEMPPGFALMASTPSCPIAGMADEARGYYA
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEE
VQFHPEVTHTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGG
EEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
VDSSVAAALIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGH
CCHHHHHHHHHHHHCCCEEEEEEECCEEEECCCCEEEEHHCCCEEEEEEEECCHHHHHHH
LAGVADPEHKRKIIGREFVEVFQAEAKKLTNAKWLAQGTIYPDVIESGGAKTKKATTIKS
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHCCCCCCCHHHEECC
HHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPAEMVYRHPFPGPGLGVRILGEVK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHH
RDYAELLRRADAIFIEELCGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVG
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHCHHHHHHHHHHEEEEEEHHHHC
VMGDGRTYDYVAALRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDVSGKP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEECCCCC
PATIEWE
CCEEECC
>Mature Secondary Structure
MFLSPSAAMHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKGVILS
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCCCCEEEE
GSHASTYEDHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHG
CCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHCC
RTRLLDGIQDFATPEGHGMLKVWMSHGDKVGEMPPGFALMASTPSCPIAGMADEARGYYA
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEE
VQFHPEVTHTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGG
EEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
VDSSVAAALIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGH
CCHHHHHHHHHHHHCCCEEEEEEECCEEEECCCCEEEEHHCCCEEEEEEEECCHHHHHHH
LAGVADPEHKRKIIGREFVEVFQAEAKKLTNAKWLAQGTIYPDVIESGGAKTKKATTIKS
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHCCCCCCCHHHEECC
HHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPAEMVYRHPFPGPGLGVRILGEVK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHH
RDYAELLRRADAIFIEELCGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVG
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHCHHHHHHHHHHEEEEEEHHHHC
VMGDGRTYDYVAALRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDVSGKP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEECCCCC
PATIEWE
CCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA