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The map label for this gene is livH [H]

Identifier: 53719612

GI number: 53719612

Start: 2385207

End: 2386142

Strand: Reverse

Name: livH [H]

Synonym: BPSL2000

Alternate gene names: 53719612

Gene position: 2386142-2385207 (Counterclockwise)

Preceding gene: 53719613

Following gene: 53719611

Centisome position: 58.56

GC content: 72.97

Gene sequence:

>936_bases
GTGCAGTCGGTCGTCCTCGATCTGCTCAACGGCCTGAGCTACGGCCTGTTGCTGTTCATGCTGTGCGCGGGGCTCACGCT
GATCTTCGGCATGCTCGGCGTGCTCAATTTCGCGCACGCGAGCTTCTACATGCTCGGCGCGTACGCGGGCTACGCGATCG
CCGCGCGCACGAGCTTCTGGGTCGCGCTCGTCGCCGCGCCGCTCGCCGTCGGCGCGCTCGGCGCGCTGTGCGAGCGCACG
CTGCTCAGGCGGGTGAGGGCGAGCGGCCATCTCGACGAATTGCTGCTCACGTTCGGGCTCGCGTATCTGATCGCCGAGGG
CGTGAAGCTCGTCTGGGGGCTCGCGCCGCTCGCCGCGCCGGTGCCCGCCGCGCTCGACGGCGCGGCGTTCACCGTCTACG
GCGCGGTGTTTTCGCGTTATCGCGCGTTCATGATGCTCGTGTCGATCGCGATGCTCGGCGCGCTGTGGGCGGTGCTGCGC
GCCTCGAGGACGGGGCTCGTCGTGCGCGCGGCGCTCACGCGGCGCGCGGCCGTCGAGGCGCTCGGCCACGACGTGCCGCG
CGTGATGACGCTCGTGTTCGCCGCGGGCACCGCGCTCGCCGCGCTCGCCGGCGTGATCGGCGCGCCGCTCGCGGTGATCG
AGCCCGCGATGGCGCAGACGCTCGGCTCGGTCGTGTTCGCGGTCATCGTGATCGGCGGGCTCGGCTCGCTCGCGGGCGCG
CTCGTCGCGTCGCTCGTGCTCGGCTGCGCGCAGACGTTCGCCGCGGCGAGCCGCGCGTCGCTGAGCGACGCGGCGCAGTG
GGCGGGCATCGCGCTGCCTGACGCGTGGCGCGCGTTGACGCTCGCGCAGTTCGCGCCGTTGATTCCGTATCTGCTGCTGA
TCGTGGTGCTCGCGTGCCGCGCGCGCGGCCTGTTCGGCGAGCGCGCCGATGTCTAG

Upstream 100 bases:

>100_bases
GTGCACGTGTACGTCGATCGCGCGACGCGCCGGCCGGTGCCGCTGCCCGAGCCGCTGCGCGCCGCGCTCGCGCCGCTCGT
CGCGCCGGCGGCCTGACGCG

Downstream 100 bases:

>100_bases
CGCGCGCGCCGTTGCCGTGCGAAGCCGCTTGCCGGAGGCGCTGGCGTGGCTCGCGTTCGTCGCGCTGCTCGTCGTGCCCG
CCCTTGCGTGGCCGCGCGGC

Product: putative branched amino acid transport system, membrane protein

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MQSVVLDLLNGLSYGLLLFMLCAGLTLIFGMLGVLNFAHASFYMLGAYAGYAIAARTSFWVALVAAPLAVGALGALCERT
LLRRVRASGHLDELLLTFGLAYLIAEGVKLVWGLAPLAAPVPAALDGAAFTVYGAVFSRYRAFMMLVSIAMLGALWAVLR
ASRTGLVVRAALTRRAAVEALGHDVPRVMTLVFAAGTALAALAGVIGAPLAVIEPAMAQTLGSVVFAVIVIGGLGSLAGA
LVASLVLGCAQTFAAASRASLSDAAQWAGIALPDAWRALTLAQFAPLIPYLLLIVVLACRARGLFGERADV

Sequences:

>Translated_311_residues
MQSVVLDLLNGLSYGLLLFMLCAGLTLIFGMLGVLNFAHASFYMLGAYAGYAIAARTSFWVALVAAPLAVGALGALCERT
LLRRVRASGHLDELLLTFGLAYLIAEGVKLVWGLAPLAAPVPAALDGAAFTVYGAVFSRYRAFMMLVSIAMLGALWAVLR
ASRTGLVVRAALTRRAAVEALGHDVPRVMTLVFAAGTALAALAGVIGAPLAVIEPAMAQTLGSVVFAVIVIGGLGSLAGA
LVASLVLGCAQTFAAASRASLSDAAQWAGIALPDAWRALTLAQFAPLIPYLLLIVVLACRARGLFGERADV
>Mature_311_residues
MQSVVLDLLNGLSYGLLLFMLCAGLTLIFGMLGVLNFAHASFYMLGAYAGYAIAARTSFWVALVAAPLAVGALGALCERT
LLRRVRASGHLDELLLTFGLAYLIAEGVKLVWGLAPLAAPVPAALDGAAFTVYGAVFSRYRAFMMLVSIAMLGALWAVLR
ASRTGLVVRAALTRRAAVEALGHDVPRVMTLVFAAGTALAALAGVIGAPLAVIEPAMAQTLGSVVFAVIVIGGLGSLAGA
LVASLVLGCAQTFAAASRASLSDAAQWAGIALPDAWRALTLAQFAPLIPYLLLIVVLACRARGLFGERADV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=320, Percent_Identity=27.1875, Blast_Score=85, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 32099; Mature: 32099

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCCCCCCCC
>Mature Secondary Structure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HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]