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The map label for this gene is lgrD [H]

Identifier: 53719391

GI number: 53719391

Start: 2099061

End: 2104307

Strand: Reverse

Name: lgrD [H]

Synonym: BPSL1777

Alternate gene names: 53719391

Gene position: 2104307-2099061 (Counterclockwise)

Preceding gene: 53719392

Following gene: 53719390

Centisome position: 51.65

GC content: 75.87

Gene sequence:

>5247_bases
ATGAGGAGCACGCATGAAGGAGCCCGCATGACCCCCCCCGATCTGCTGTCGCTCGCCGCGCGTTTCGCGCGGCTGCCCGA
CACGCAGCGCAAGCAGTTCCTCGCGAAGCTCGGCGACGCGGGAATCGATTTCCGGATGCTGCCGATTCCGCCGCGCGAGG
ACCGCGCGGCGAGCGTGCCGGCATCATTCGCGCAGACGCGCCTCTGGCTGCACGCGCGCCTGCTCGGCGAATCGGCCGCG
TACCACATCACCGAGCGGCTGCGCCTCGACGGCGGGCTCGACGCGAACGCGCTGCGGCTGTCGTGCGACGCGCTGATCGC
GCGCCACGAGGCGCTGCGCACGACGTTCGCCGAGGGCGCGGCCGGCGTGCTGCAGACGGTGCACGCGCCGATGCGCTGCC
CGTGGCGCTTCACCGATCTCGCGGACGCGAGCGCCGGGTCGCGCGAGCAGCGCGCGGCCGCCATCGCCGAGCGCGACGAG
GCCGAGCCGTTCGATCTCGCGCACGGCCCGCTCGTGCGCGCGCACCTGATCCGGCTCGATGCGGCCACGCACTGGTTCGT
GCTGACGACGCACCACATCGTGTCGGACGGTTGGTCGGCCGACGTGATGCTCGCGGAGCTGTCGTCGTTCTACCGGTCGT
ACGCGACGGGCGACGCGGTGTCGCTCGCGCCGCTGCCGGTGCAGTACGCGGACTACGCGCTCTGGCAGCGCCGCTGGCTC
GACGCGGGCGAGGGCGAGCGCCAGCTCGCGTACTGGCGCGCGACGCTCGACGCGAGCCGTGACGCGCTGCTGCTGCCGGG
CGCCGCGACGCGGCCCGCGCAGCGCGGCGCGAGCGGCGCGCGCCATGCGTTCGACATATCCGCCGAACTCGCGCGGCGCA
TGCGTGCGCTGGCGCAGGCGCGCCGGGCGACGCCGTTCGCCGTGCTGCTCGCCGCGCTCGCGACGCTGCTCGCGCGCGCG
AGCGGCGAGACCGGGATCCGGATCGGCGTGCCGTCGGCGAATCGCGAGCGCGGCGAGACCGTCGGGCTGATCGGCTTTTT
CGTCAATACGCTGACGCTCGCGGCGAGCACGCCCGCGACGCTCGCGTTCGACGCGCTCGTCGACGCGACGCAGCGCGGCC
TGATCGACGCGCAGTCGCACCAGGACGTGCCGTTCGATCAGGTGGTCGACGCGCTCGGCGTCGCGCGCAGCGCGAGCCAC
CATCCGCTTTTTCAGGTGATGGCCGCCTACGGCGCGCGGCGCGTGCTGCCGTCGTTCGCCGAGGTGCGCGCGACCGAGCT
GCCCTCGGGCATGCCGTATGCGAAATTCGATCTCGCGCTCAGCTTCGACGAGCGCGACGACGGCGGGCTCGACGCGCGCT
TCGTCTATGCGACCGATCTGTTCGACGCCGACGCGATCGAGCGCTTCGCCGCGCGCTACGTCGAGCTGCTCGCGCACGCG
CTCGACACGCCCGGCGCGGCGATCGGCGATCTGCAATGGCTGCCCGAAGCGGAGCGCCGCCAGCTCGCCGCGTGGAACGG
GCAGACGCACGACTTCACCGGGCGCGCGTCGCCGGCGCGCGCCGGCGCCGGCGTCTCCGGCGAGCCCGCCGGCGCGGCGG
TGCCCCGCGAACGCGCCGGCCAAGCCGGCGGCGAGCCGTTCGTCCCGGTCCATGACCGGATTGCGCAGCACGCGCGCCGC
CGCCCCGACGCGCGCGGCGTCGCCGACATCGGGCGCGCGCTCACGCGCGGCGAGGTCGACGCGCGCGCGACGCGGCTCGC
GAAGCGCCTCGTCGCGGCGGGCGTGGGCGCGGAGATGCGCGTGGGCGTCGCGCTGTCGCGCTCGGTCGATCTGCTCGTCG
GGCTGATCGCCGCGCTCAAGTCGGGCGGCGCGTTCGTGCCGCTCGATCCGAGCCACCCGCGCGAGCGCCTCGCGCAGATG
CTGGAGGACGCGCAGATCGCGCACGTGATCACCGAGCGCGGCAGCGTCGACGCGCTGCCGCTCGCGGGCGCGACGCGCGC
GTGGCTTGTCGACGACGCGATCGCCGACGCGGAGATCGACGGCGTCGCGCTGCCCGCCGTGTCGCCGCATCAGGCCGCGT
ACGTGATCTACACGTCGGGCTCGACCGGCAAGCCGAAGGGCGTCGTCGTCGATCACGGCGCGTTCGCGCGCCATTGCGAG
GCGATCGCCGCGCGCTACGGCGCGACCGAGCGCGACGTGTTCATGCTGTTCCAGTCGGTCAATTTCGACGGCGCGCACGA
AGGCTGGTTCTCGCAGTACATGTCGGGCGCGGCCGTCGCGGTGACGGCCGACACGCTGTGGCCGCCCGCGCGCACCTGCG
CGCTCGCCGCGCGCGAAGGCGTGACGATGACCTACGTGCCGCCCGGCTGCGCGACGCAGCTCGCCGAATGGGCGCTCGAG
CACGGCGCGCCGCCGTCGCTGCGCTCGATCACGGTGGGCGGCGAGGCGACGTCGCGCGAGGCGTTCGCGCTGATGCGCCG
CGCGTTTCCGAACGCGCGCGTCGTCAACGGCTATGGGCCGACCGAAACGGTGATCACGCCGATGCTGTGGATGTTCGCGC
CGGGCGACGATCCCGCCAAGCTCGCGGACGCCGCGTATCTGCCGATCGGCACGCTCGTCGGCGCGCGCACCGCGCACGTG
CTGGACGCGCGCCTGAATCCGCTGCCCGTCGGCGTGATCGGCGAGTTGTATCTGGGCGGCGAGGGCGTCGGGCTCGCACG
CGGCTACCTGGGCCGCGCGGCGCTCACCGCCGAGCGCTTCGTGCCCGATCCGTACGGCGCGCCGGGCGCGCGGCTGTACC
GCACGGGCGACCTCGTGCGCCGCCGCGCCGACGGCGTGTTCGACTTCATCGGCCGCATCGATCACCAGGTGAAGCTGCGC
GGCTTGCGCATCGAGCTCGGCGAGATCGAGGCGCAACTCGCCGCGCACGACGACGTGCGCGAGGCGGTGGCGGTCGTGTT
CGGCGAGGGCGCGCACGCGCGGCTCGCCGCGTTCGTCGAGCTCACGGGCGACGCGCGCGCGCGCGCGCGGCGCGCGGATG
CGGCCGAGCTCGACGCGCATTTGCGCCGCACGCTGCCCGATTACATGGTGCCCGCGCACATCGTCGTGCTCGACGCGCTG
CCGCGCAACGCGAACAGCAAGGTCGACCGCGCGGCGCTGCCCGAGCCCGCGCACGTCGCGCGCGCGTACGAGGCGCCCGA
CGGCGAGCTCGAGACGGCGCTCGCCGAGATCTGGCGCGAGGTGCTCGGCGTCGAGCGCGTCGGGCGCGCCGATCATTTCT
TCGAGCTGGGCGGCCATTCGCTCGCGGCGGTGCGGGTGGCCACGCGCGTCGCCGAGCGGCTTGCGCGCGACGTGCCGGTG
CGCGCGCTGTTCGAGGCGCCGATTCTCGCGCCGTACGCGCAGCGCGTCGCCGCCGCCGCGCCAGCGCACGCGCCGCAACG
CGCGGGCAGCGCATCGTACGCGCCCGATGCCGACGGCGTGCTGCCGCTGTCGGCCGCGCAGCGCGGCCTGTGGTTCCTGT
GGCGCGCGCAGCCGGACAGCGCCGCGTACAACATTCCCGTCGCGCTGCGGCTGCGCGGCGCGCTCGACGTCGATGCGCTC
GCCGATGCGCTCGCGCATGCGGCTGTCCGCCACCCGGCGCTGCGCACGCGGATCGTCGCGCGGGCGGACGGCGCGCCGGG
GCAGCGGATTGCGCCGGCGCGGCGCATCGAGCTGCCGGTCGTCGACCTGCGCGCCGACGCGCGCATCGCGGACGACGACG
CGCGGCTCGCCGCCGCGATCGCGCTGACCGACGCCGACGCGCTCGCGCCGTTCGATCTCGCCGCCGACGCGCCGCTCTGG
CGCGCGCGCGTGATCCGGCTCGGCGCGCACGACCACGTGCTGTCGCTCGTCGTCCATCACATCGTGTCGGACGGGCAATC
GATCGATCTGTGGCTCGACGCGGTGCGCGCGGCGTACGTCGCGCGGCGCGCGGACGAACCCGCGACGGCGGCGGCGCGCG
CAGCGGCGGACAGGCGAACCGACAGGCACGCGGGCTCGCGGGCGGCGTCGCTTGCGCCGGCACGCGCGAAGGAAGCGCCC
GCGCAATCGGCGACGATTGCGCCGATACAAGCGCCCGCCGACGCGCCTCAGCCCGCGCCGGACGCACCGGTGCTGCCGGC
CGCCGCGCCGCACGCGCGGCTCGCGTTCTGGCGCGAGGCGCTCGCCGGCGCGCCGTCGCACGCGCTGCCGCCGCCGCGCG
CGGGCCGCGCGTGCGCGCCGCGCTGGGACGCGGGCCGTCTCGCGTTCGAATTCGACGCCGCGCTCGTGCGCCGCGCGCGC
GCGATGGCGCTCGACGCGCACGCGACGCTGCCGATGCTGCTGCACGCGGCGCTGAACGCGGCGTTCTACCGCGCGACGGG
CGCGACCGATCAGCCGGTCGGCGTGCTCGCGTCGACCCGCGAACTGACGGGCGACGCGGCCGAGCGCGCGCTCGGGCTCT
TCATCAACGCGGTCGTCGTGCGCACGCGGCTGTCGGGCGCCGATACGCCGGCCACGCTCGTCGCCGCGGTGCGCGACGCG
GCGCTCGCCGCGTATGCGCACGCGGACGCGCCGTTCTGCGATGTCGTCGCCGCGCTGCGCGCGCCGCGCACGGTCAACGG
CAATCCGCTGTTCCAGGTGATGTTCAACTACCTGCGGCCGGCGGGCGCCGCCGCGCGCGACTGGGCGGGGCTCGCGGTCG
ACGCGTTCAACGATGTCCGGCACCGCGTCGTGTTCGAGCTCGAGCTCGACATCGTCGAGCATCCGGACGGCCGCGTGACG
GGCGCGTTCTCGTATGCGGCCGAGCGCGTCGACGGCGCGTTCGTCGCCGCGCTCGCCGCCGACTATCTCGACGTCGTGCG
CGGCTTCGTCGACGCGCCCGCGCGCGCGCTCGGCGCGTGCGCCGCGCGTTTCCCGCTCGCCTCGCACGAGGCGTACGCGC
CGCCGCCGCCCGCCGCGGCGGACGCGCGCGCCGCCGCGCGCGCGGCGCGCGCGCTCGCCGAGCTGTGGCGCGCGTCGCTC
GGCCATGCCGCGCCCGCGCCCGAGGCCAACCTGTTCGAAGCGGGCGCGACGTCGTTCGACGTCGTGCGCTTCGTCGACGC
GGCGCGCTCGGCCGGCTTCGCGCTCGCGATCGCCGACGTGTTCGCCGCGCCGAGCCTCGCGGCGCTCGGCGAGCGCGCCG
CGCACACCGCCGGCCAGCCCGCCACGCAGGCGCGCGATGCCGATTGA

Upstream 100 bases:

>100_bases
CCGCGCGCGCGACGCCGGCCGCGAGCGCGACGCCGCGGGCGCGATCGACGCGCTGCTCGGCGAGCTCGAAGCCCAGTAAG
GCACTCAATCAGGAACACGC

Downstream 100 bases:

>100_bases
GCGCCGCCCGCCGCGGCCGCGCCTGGCGCGGGCCGAGCACGATGGCCGCATCGGGCGCATCGATGAACGGCGCGGTCCGC
ATCACGTTTTCGTCCGGCCG

Product: putative siderophore-related non-ribosomal peptide synthase

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent D-leucine adenylase; D-LeuA; D-Leucine activase; Leucine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent glycine adenylase; GlyA; Glycine activase; Linear gramicidin--PCP reductase [H]

Number of amino acids: Translated: 1748; Mature: 1748

Protein sequence:

>1748_residues
MRSTHEGARMTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVPASFAQTRLWLHARLLGESAA
YHITERLRLDGGLDANALRLSCDALIARHEALRTTFAEGAAGVLQTVHAPMRCPWRFTDLADASAGSREQRAAAIAERDE
AEPFDLAHGPLVRAHLIRLDAATHWFVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWL
DAGEGERQLAYWRATLDASRDALLLPGAATRPAQRGASGARHAFDISAELARRMRALAQARRATPFAVLLAALATLLARA
SGETGIRIGVPSANRERGETVGLIGFFVNTLTLAASTPATLAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASH
HPLFQVMAAYGARRVLPSFAEVRATELPSGMPYAKFDLALSFDERDDGGLDARFVYATDLFDADAIERFAARYVELLAHA
LDTPGAAIGDLQWLPEAERRQLAAWNGQTHDFTGRASPARAGAGVSGEPAGAAVPRERAGQAGGEPFVPVHDRIAQHARR
RPDARGVADIGRALTRGEVDARATRLAKRLVAAGVGAEMRVGVALSRSVDLLVGLIAALKSGGAFVPLDPSHPRERLAQM
LEDAQIAHVITERGSVDALPLAGATRAWLVDDAIADAEIDGVALPAVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCE
AIAARYGATERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTADTLWPPARTCALAAREGVTMTYVPPGCATQLAEWALE
HGAPPSLRSITVGGEATSREAFALMRRAFPNARVVNGYGPTETVITPMLWMFAPGDDPAKLADAAYLPIGTLVGARTAHV
LDARLNPLPVGVIGELYLGGEGVGLARGYLGRAALTAERFVPDPYGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLR
GLRIELGEIEAQLAAHDDVREAVAVVFGEGAHARLAAFVELTGDARARARRADAAELDAHLRRTLPDYMVPAHIVVLDAL
PRNANSKVDRAALPEPAHVARAYEAPDGELETALAEIWREVLGVERVGRADHFFELGGHSLAAVRVATRVAERLARDVPV
RALFEAPILAPYAQRVAAAAPAHAPQRAGSASYAPDADGVLPLSAAQRGLWFLWRAQPDSAAYNIPVALRLRGALDVDAL
ADALAHAAVRHPALRTRIVARADGAPGQRIAPARRIELPVVDLRADARIADDDARLAAAIALTDADALAPFDLAADAPLW
RARVIRLGAHDHVLSLVVHHIVSDGQSIDLWLDAVRAAYVARRADEPATAAARAAADRRTDRHAGSRAASLAPARAKEAP
AQSATIAPIQAPADAPQPAPDAPVLPAAAPHARLAFWREALAGAPSHALPPPRAGRACAPRWDAGRLAFEFDAALVRRAR
AMALDAHATLPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAVVVRTRLSGADTPATLVAAVRDA
ALAAYAHADAPFCDVVAALRAPRTVNGNPLFQVMFNYLRPAGAAARDWAGLAVDAFNDVRHRVVFELELDIVEHPDGRVT
GAFSYAAERVDGAFVAALAADYLDVVRGFVDAPARALGACAARFPLASHEAYAPPPPAAADARAAARAARALAELWRASL
GHAAPAPEANLFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSLAALGERAAHTAGQPATQARDAD

Sequences:

>Translated_1748_residues
MRSTHEGARMTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVPASFAQTRLWLHARLLGESAA
YHITERLRLDGGLDANALRLSCDALIARHEALRTTFAEGAAGVLQTVHAPMRCPWRFTDLADASAGSREQRAAAIAERDE
AEPFDLAHGPLVRAHLIRLDAATHWFVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWL
DAGEGERQLAYWRATLDASRDALLLPGAATRPAQRGASGARHAFDISAELARRMRALAQARRATPFAVLLAALATLLARA
SGETGIRIGVPSANRERGETVGLIGFFVNTLTLAASTPATLAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASH
HPLFQVMAAYGARRVLPSFAEVRATELPSGMPYAKFDLALSFDERDDGGLDARFVYATDLFDADAIERFAARYVELLAHA
LDTPGAAIGDLQWLPEAERRQLAAWNGQTHDFTGRASPARAGAGVSGEPAGAAVPRERAGQAGGEPFVPVHDRIAQHARR
RPDARGVADIGRALTRGEVDARATRLAKRLVAAGVGAEMRVGVALSRSVDLLVGLIAALKSGGAFVPLDPSHPRERLAQM
LEDAQIAHVITERGSVDALPLAGATRAWLVDDAIADAEIDGVALPAVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCE
AIAARYGATERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTADTLWPPARTCALAAREGVTMTYVPPGCATQLAEWALE
HGAPPSLRSITVGGEATSREAFALMRRAFPNARVVNGYGPTETVITPMLWMFAPGDDPAKLADAAYLPIGTLVGARTAHV
LDARLNPLPVGVIGELYLGGEGVGLARGYLGRAALTAERFVPDPYGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLR
GLRIELGEIEAQLAAHDDVREAVAVVFGEGAHARLAAFVELTGDARARARRADAAELDAHLRRTLPDYMVPAHIVVLDAL
PRNANSKVDRAALPEPAHVARAYEAPDGELETALAEIWREVLGVERVGRADHFFELGGHSLAAVRVATRVAERLARDVPV
RALFEAPILAPYAQRVAAAAPAHAPQRAGSASYAPDADGVLPLSAAQRGLWFLWRAQPDSAAYNIPVALRLRGALDVDAL
ADALAHAAVRHPALRTRIVARADGAPGQRIAPARRIELPVVDLRADARIADDDARLAAAIALTDADALAPFDLAADAPLW
RARVIRLGAHDHVLSLVVHHIVSDGQSIDLWLDAVRAAYVARRADEPATAAARAAADRRTDRHAGSRAASLAPARAKEAP
AQSATIAPIQAPADAPQPAPDAPVLPAAAPHARLAFWREALAGAPSHALPPPRAGRACAPRWDAGRLAFEFDAALVRRAR
AMALDAHATLPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAVVVRTRLSGADTPATLVAAVRDA
ALAAYAHADAPFCDVVAALRAPRTVNGNPLFQVMFNYLRPAGAAARDWAGLAVDAFNDVRHRVVFELELDIVEHPDGRVT
GAFSYAAERVDGAFVAALAADYLDVVRGFVDAPARALGACAARFPLASHEAYAPPPPAAADARAAARAARALAELWRASL
GHAAPAPEANLFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSLAALGERAAHTAGQPATQARDAD
>Mature_1748_residues
MRSTHEGARMTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVPASFAQTRLWLHARLLGESAA
YHITERLRLDGGLDANALRLSCDALIARHEALRTTFAEGAAGVLQTVHAPMRCPWRFTDLADASAGSREQRAAAIAERDE
AEPFDLAHGPLVRAHLIRLDAATHWFVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWL
DAGEGERQLAYWRATLDASRDALLLPGAATRPAQRGASGARHAFDISAELARRMRALAQARRATPFAVLLAALATLLARA
SGETGIRIGVPSANRERGETVGLIGFFVNTLTLAASTPATLAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASH
HPLFQVMAAYGARRVLPSFAEVRATELPSGMPYAKFDLALSFDERDDGGLDARFVYATDLFDADAIERFAARYVELLAHA
LDTPGAAIGDLQWLPEAERRQLAAWNGQTHDFTGRASPARAGAGVSGEPAGAAVPRERAGQAGGEPFVPVHDRIAQHARR
RPDARGVADIGRALTRGEVDARATRLAKRLVAAGVGAEMRVGVALSRSVDLLVGLIAALKSGGAFVPLDPSHPRERLAQM
LEDAQIAHVITERGSVDALPLAGATRAWLVDDAIADAEIDGVALPAVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCE
AIAARYGATERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTADTLWPPARTCALAAREGVTMTYVPPGCATQLAEWALE
HGAPPSLRSITVGGEATSREAFALMRRAFPNARVVNGYGPTETVITPMLWMFAPGDDPAKLADAAYLPIGTLVGARTAHV
LDARLNPLPVGVIGELYLGGEGVGLARGYLGRAALTAERFVPDPYGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLR
GLRIELGEIEAQLAAHDDVREAVAVVFGEGAHARLAAFVELTGDARARARRADAAELDAHLRRTLPDYMVPAHIVVLDAL
PRNANSKVDRAALPEPAHVARAYEAPDGELETALAEIWREVLGVERVGRADHFFELGGHSLAAVRVATRVAERLARDVPV
RALFEAPILAPYAQRVAAAAPAHAPQRAGSASYAPDADGVLPLSAAQRGLWFLWRAQPDSAAYNIPVALRLRGALDVDAL
ADALAHAAVRHPALRTRIVARADGAPGQRIAPARRIELPVVDLRADARIADDDARLAAAIALTDADALAPFDLAADAPLW
RARVIRLGAHDHVLSLVVHHIVSDGQSIDLWLDAVRAAYVARRADEPATAAARAAADRRTDRHAGSRAASLAPARAKEAP
AQSATIAPIQAPADAPQPAPDAPVLPAAAPHARLAFWREALAGAPSHALPPPRAGRACAPRWDAGRLAFEFDAALVRRAR
AMALDAHATLPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAVVVRTRLSGADTPATLVAAVRDA
ALAAYAHADAPFCDVVAALRAPRTVNGNPLFQVMFNYLRPAGAAARDWAGLAVDAFNDVRHRVVFELELDIVEHPDGRVT
GAFSYAAERVDGAFVAALAADYLDVVRGFVDAPARALGACAARFPLASHEAYAPPPPAAADARAAARAARALAELWRASL
GHAAPAPEANLFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSLAALGERAAHTAGQPATQARDAD

Specific function: Activates the 13th to the 16th (Trp, D-Leu, Trp and Gly) amino acids in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 14th (D-Leu) amino acid. It also catalyzes

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=469, Percent_Identity=24.3070362473348, Blast_Score=100, Evalue=1e-20,
Organism=Homo sapiens, GI42544132, Length=476, Percent_Identity=21.0084033613445, Blast_Score=72, Evalue=4e-12,
Organism=Homo sapiens, GI28416953, Length=572, Percent_Identity=23.2517482517483, Blast_Score=69, Evalue=3e-11,
Organism=Escherichia coli, GI1786801, Length=1083, Percent_Identity=28.808864265928, Blast_Score=270, Evalue=4e-73,
Organism=Escherichia coli, GI1790505, Length=379, Percent_Identity=27.9683377308707, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI221142682, Length=512, Percent_Identity=22.265625, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17550940, Length=568, Percent_Identity=23.0633802816901, Blast_Score=114, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17556356, Length=521, Percent_Identity=24.9520153550864, Blast_Score=110, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71983001, Length=397, Percent_Identity=28.7153652392947, Blast_Score=83, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71982997, Length=397, Percent_Identity=28.7153652392947, Blast_Score=83, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319591, Length=1007, Percent_Identity=23.9324726911619, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24648676, Length=612, Percent_Identity=28.5947712418301, Blast_Score=168, Evalue=3e-41,
Organism=Drosophila melanogaster, GI18859661, Length=382, Percent_Identity=24.6073298429319, Blast_Score=78, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24581924, Length=417, Percent_Identity=25.1798561151079, Blast_Score=77, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR013120
- InterPro:   IPR016040
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR010080 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF07993 NAD_binding_4; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 185454; Mature: 185454

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSTHEGARMTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVP
CCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCC
ASFAQTRLWLHARLLGESAAYHITERLRLDGGLDANALRLSCDALIARHEALRTTFAEGA
HHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AGVLQTVHAPMRCPWRFTDLADASAGSREQRAAAIAERDEAEPFDLAHGPLVRAHLIRLD
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHEEC
AATHWFVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWL
CCCEEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHC
DAGEGERQLAYWRATLDASRDALLLPGAATRPAQRGASGARHAFDISAELARRMRALAQA
CCCCCCCEEEEEEHHHCCCCCEEEECCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHH
RRATPFAVLLAALATLLARASGETGIRIGVPSANRERGETVGLIGFFVNTLTLAASTPAT
HCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCCHH
LAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASHHPLFQVMAAYGARRVLPSFA
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHH
EVRATELPSGMPYAKFDLALSFDERDDGGLDARFVYATDLFDADAIERFAARYVELLAHA
HHHHHHCCCCCCCEEEEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
LDTPGAAIGDLQWLPEAERRQLAAWNGQTHDFTGRASPARAGAGVSGEPAGAAVPRERAG
HCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCC
QAGGEPFVPVHDRIAQHARRRPDARGVADIGRALTRGEVDARATRLAKRLVAAGVGAEMR
CCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEE
VGVALSRSVDLLVGLIAALKSGGAFVPLDPSHPRERLAQMLEDAQIAHVITERGSVDALP
ECCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LAGATRAWLVDDAIADAEIDGVALPAVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCE
CCCCCHHHEEHHHHCCCCCCCEECCCCCCCCEEEEEEECCCCCCCCCEEEECCHHHHHHH
AIAARYGATERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTADTLWPPARTCALAAREG
HHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCC
VTMTYVPPGCATQLAEWALEHGAPPSLRSITVGGEATSREAFALMRRAFPNARVVNGYGP
CEEEEECCCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEECCCCC
TETVITPMLWMFAPGDDPAKLADAAYLPIGTLVGARTAHVLDARLNPLPVGVIGELYLGG
HHHHHHHHHHEECCCCCHHHHHHHHHCCHHHHHHCHHHHHHHCCCCCCCCCHHEEEEECC
EGVGLARGYLGRAALTAERFVPDPYGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLR
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEEEE
GLRIELGEIEAQLAAHDDVREAVAVVFGEGAHARLAAFVELTGDARARARRADAAELDAH
EEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEEECCCHHHHHHHCCHHHHHHH
LRRTLPDYMVPAHIVVLDALPRNANSKVDRAALPEPAHVARAYEAPDGELETALAEIWRE
HHHHCHHHHCCCCEEEEECCCCCCCCCCCHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHH
VLGVERVGRADHFFELGGHSLAAVRVATRVAERLARDVPVRALFEAPILAPYAQRVAAAA
HHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHC
PAHAPQRAGSASYAPDADGVLPLSAAQRGLWFLWRAQPDSAAYNIPVALRLRGALDVDAL
CCCCCHHCCCCCCCCCCCCEEEHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCHHHH
ADALAHAAVRHPALRTRIVARADGAPGQRIAPARRIELPVVDLRADARIADDDARLAAAI
HHHHHHHHHHCHHHHHHHEEECCCCCCCCCCCCHHEECCEEEECCCCEECCCCHHEEEEE
ALTDADALAPFDLAADAPLWRARVIRLGAHDHVLSLVVHHIVSDGQSIDLWLDAVRAAYV
EEECCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ARRADEPATAAARAAADRRTDRHAGSRAASLAPARAKEAPAQSATIAPIQAPADAPQPAP
HHHCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHCCCCCCCEECCCCCCCCCCCCCC
DAPVLPAAAPHARLAFWREALAGAPSHALPPPRAGRACAPRWDAGRLAFEFDAALVRRAR
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHH
AMALDAHATLPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAVVV
HHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
RTRLSGADTPATLVAAVRDAALAAYAHADAPFCDVVAALRAPRTVNGNPLFQVMFNYLRP
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
AGAAARDWAGLAVDAFNDVRHRVVFELELDIVEHPDGRVTGAFSYAAERVDGAFVAALAA
CCCCCCCCCCEEHHHHHHHHHEEEEEEEEEEEECCCCCEEEHHHHHHHHHCHHHHHHHHH
DYLDVVRGFVDAPARALGACAARFPLASHEAYAPPPPAAADARAAARAARALAELWRASL
HHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GHAAPAPEANLFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSLAALGERAAHTAGQP
CCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCEEHHHHHHHCCHHHHHHHHHHHCCCCC
ATQARDAD
CCCCCCCC
>Mature Secondary Structure
MRSTHEGARMTPPDLLSLAARFARLPDTQRKQFLAKLGDAGIDFRMLPIPPREDRAASVP
CCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCC
ASFAQTRLWLHARLLGESAAYHITERLRLDGGLDANALRLSCDALIARHEALRTTFAEGA
HHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AGVLQTVHAPMRCPWRFTDLADASAGSREQRAAAIAERDEAEPFDLAHGPLVRAHLIRLD
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHEEC
AATHWFVLTTHHIVSDGWSADVMLAELSSFYRSYATGDAVSLAPLPVQYADYALWQRRWL
CCCEEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHC
DAGEGERQLAYWRATLDASRDALLLPGAATRPAQRGASGARHAFDISAELARRMRALAQA
CCCCCCCEEEEEEHHHCCCCCEEEECCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHH
RRATPFAVLLAALATLLARASGETGIRIGVPSANRERGETVGLIGFFVNTLTLAASTPAT
HCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCCHH
LAFDALVDATQRGLIDAQSHQDVPFDQVVDALGVARSASHHPLFQVMAAYGARRVLPSFA
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHH
EVRATELPSGMPYAKFDLALSFDERDDGGLDARFVYATDLFDADAIERFAARYVELLAHA
HHHHHHCCCCCCCEEEEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
LDTPGAAIGDLQWLPEAERRQLAAWNGQTHDFTGRASPARAGAGVSGEPAGAAVPRERAG
HCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCC
QAGGEPFVPVHDRIAQHARRRPDARGVADIGRALTRGEVDARATRLAKRLVAAGVGAEMR
CCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEE
VGVALSRSVDLLVGLIAALKSGGAFVPLDPSHPRERLAQMLEDAQIAHVITERGSVDALP
ECCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LAGATRAWLVDDAIADAEIDGVALPAVSPHQAAYVIYTSGSTGKPKGVVVDHGAFARHCE
CCCCCHHHEEHHHHCCCCCCCEECCCCCCCCEEEEEEECCCCCCCCCEEEECCHHHHHHH
AIAARYGATERDVFMLFQSVNFDGAHEGWFSQYMSGAAVAVTADTLWPPARTCALAAREG
HHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCC
VTMTYVPPGCATQLAEWALEHGAPPSLRSITVGGEATSREAFALMRRAFPNARVVNGYGP
CEEEEECCCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEECCCCC
TETVITPMLWMFAPGDDPAKLADAAYLPIGTLVGARTAHVLDARLNPLPVGVIGELYLGG
HHHHHHHHHHEECCCCCHHHHHHHHHCCHHHHHHCHHHHHHHCCCCCCCCCHHEEEEECC
EGVGLARGYLGRAALTAERFVPDPYGAPGARLYRTGDLVRRRADGVFDFIGRIDHQVKLR
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEEEE
GLRIELGEIEAQLAAHDDVREAVAVVFGEGAHARLAAFVELTGDARARARRADAAELDAH
EEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEEECCCHHHHHHHCCHHHHHHH
LRRTLPDYMVPAHIVVLDALPRNANSKVDRAALPEPAHVARAYEAPDGELETALAEIWRE
HHHHCHHHHCCCCEEEEECCCCCCCCCCCHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHH
VLGVERVGRADHFFELGGHSLAAVRVATRVAERLARDVPVRALFEAPILAPYAQRVAAAA
HHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHC
PAHAPQRAGSASYAPDADGVLPLSAAQRGLWFLWRAQPDSAAYNIPVALRLRGALDVDAL
CCCCCHHCCCCCCCCCCCCEEEHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCHHHH
ADALAHAAVRHPALRTRIVARADGAPGQRIAPARRIELPVVDLRADARIADDDARLAAAI
HHHHHHHHHHCHHHHHHHEEECCCCCCCCCCCCHHEECCEEEECCCCEECCCCHHEEEEE
ALTDADALAPFDLAADAPLWRARVIRLGAHDHVLSLVVHHIVSDGQSIDLWLDAVRAAYV
EEECCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ARRADEPATAAARAAADRRTDRHAGSRAASLAPARAKEAPAQSATIAPIQAPADAPQPAP
HHHCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHCCCCCCCEECCCCCCCCCCCCCC
DAPVLPAAAPHARLAFWREALAGAPSHALPPPRAGRACAPRWDAGRLAFEFDAALVRRAR
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHH
AMALDAHATLPMLLHAALNAAFYRATGATDQPVGVLASTRELTGDAAERALGLFINAVVV
HHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
RTRLSGADTPATLVAAVRDAALAAYAHADAPFCDVVAALRAPRTVNGNPLFQVMFNYLRP
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
AGAAARDWAGLAVDAFNDVRHRVVFELELDIVEHPDGRVTGAFSYAAERVDGAFVAALAA
CCCCCCCCCCEEHHHHHHHHHEEEEEEEEEEEECCCCCEEEHHHHHHHHHCHHHHHHHHH
DYLDVVRGFVDAPARALGACAARFPLASHEAYAPPPPAAADARAAARAARALAELWRASL
HHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GHAAPAPEANLFEAGATSFDVVRFVDAARSAGFALAIADVFAAPSLAALGERAAHTAGQP
CCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCEEHHHHHHHCCHHHHHHHHHHHCCCCC
ATQARDAD
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA