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The map label for this gene is thiC [H]

Identifier: 53718925

GI number: 53718925

Start: 1502063

End: 1503994

Strand: Reverse

Name: thiC [H]

Synonym: BPSL1290

Alternate gene names: 53718925

Gene position: 1503994-1502063 (Counterclockwise)

Preceding gene: 53718926

Following gene: 53718924

Centisome position: 36.91

GC content: 65.94

Gene sequence:

>1932_bases
ATGAACGCCAACCCCAAGTTCCTGTCGGCCGACGCCCGCGTCGACGCCGCCGCCGTCGCCCCGCTGCCGAATTCGCGCAA
GGTCTACGTGACGGGCTCGCAACCCGACATCCGCGTGCCGATGCGTGAGATCACGCAGGCCGATACGCCGACGAGCTTCG
GCGGCGAAAAGAACCCGCCGATCTACGTCTACGACACGTCGGGCCCGTACACGGACCCGGACGCGAAGATCGACATTCGC
GCGGGCCTGCCCGCGCTGCGCCAGCGCTGGATCGACGCGCGCGGCGACACCGAGACGCTCGCGGGCCTCACGAGCGACTA
CGGCCGCGAGCGCGCGGCCGATCCGGCGACGGCCGAGCTGCGCTTTCCCGGCCTGCACCGTCATCCGCGCCGCGCGAAGG
CGGGCAAGAACGTCACACAGATGCACTACGCGCGCCAGGGCATCATCACGCCGGAAATGGAATACATCGCGATCCGCGAG
AACCAGCGCCGCGCCGAGTATCTGGAAAGCCTGAAGGCAAGCGGCCCGAACGGCGCGAAGCTCGCCGCGATGATGGGCCG
CCAGCACGCGGGCCAGGCATTCGGCGCCGCCGCGTTCGGCGCGAACGCGCCGGCCGAGATCACGCCGGAGTTCGTGCGCG
ACGAAGTCGCGCGCGGCCGCGCGATCATCCCGGCGAACATCAACCACCCGGAAACCGAGCCGATGATCATCGGCCGCAAC
TTCCTCGTGAAGATCAACGCGAACATCGGCAATTCGGCCGTCACGTCGTCGATCGGCGAGGAAGTCGACAAGATGACGTG
GGCGATCCGCTGGGGCGGCGATACGGTGATGGATCTGTCGACCGGCAAGCACATCCATGAAACGCGCGAGTGGATCATCC
GCAACAGCCCGGTGCCGATCGGCACGGTGCCGATCTACCAGGCGCTGGAGAAGGTCAACGGCAAGGCCGAGGACCTGACC
TGGGAAATCTTCCGCGACACGCTGATCGAGCAGGCCGAGCAAGGCGTCGACTACTTCACGATCCACGCGGGCGTGCGCCT
GCAATACGTGCCGCTCACCGCGAACCGGATGACGGGCATCGTGTCGCGCGGCGGCTCGATCATGGCGAAGTGGTGCCTCG
CGCACCACAAGGAAAGCTTCCTGTACGAACACTTCGAAGAGATCTGCGAGATCATGAAGGCGTACGACGTGAGCTTCTCG
CTCGGCGACGGCCTGCGCCCCGGCTCGATCTACGACGCGAACGACGAAGCGCAGCTCGGCGAACTGAAGACGCTCGGCGA
GCTCACGCAGATCGCGTGGAAGCACGACGTGCAGGTGATGATCGAAGGCCCCGGCCACGTGCCGATGCAGTTGATCAAGG
AGAACATGGATCTTCAGCTCGACTGGTGCAAGGAAGCGCCGTTCTACACGCTCGGGCCGCTGACCACCGACATCGCGCCG
GGCTACGACCACATCACGTCGGGCATCGGCGCCGCGATGATCGGCTGGTTCGGCACCGCGATGCTGTGCTACGTGACGCC
GAAGGAGCACCTCGGGCTGCCGAACAAGGACGACGTGAAGGAAGGCATCATCACGTACAAGCTCGCCGCGCACGCGGCCG
ACCTGGCGAAGGGCCACCCGGGCGCGCAGGTGCGCGACAACGCGCTGTCGAAGGCGCGCTTCGAGTTCCGCTGGCAAGAC
CAGTTCAACCTGGGGCTCGACCCGGACAAGGCGCGAGAATTCCACGACGAAACGCTGCCGAAGGATTCGGCGAAGGTCGC
GCATTTCTGCTCGATGTGCGGCCCGCACTTCTGCTCGATGAAGATCACGCAGGACGTGCGCGAGTTCGCCGCTCAGCAGG
GCGTGTCGGAAAACGACGCGCTGAAGAAGGGGATGGAAGTGAAGGCGGTCGAGTTCGTGAAGAGCGGCTCGGAGATCTAT
CACCGCCAGTGA

Upstream 100 bases:

>100_bases
CGCGTCGCGAATCTCGTCTCCTGCTTAGCGCCCTACCCCCGCTTTGCATGGGACCCGGGCGAGCGCCATAGCGCCAGCTC
GGGTCGACACAGGAGATCGC

Downstream 100 bases:

>100_bases
TCGGCGCACGCGTGCCGCCCCGAAAAAGCCCGCCCGAACGCGGGCTTTTTTGCGCGCGCGCAACCGCGCGGCAACGCCCG
CGGAGAAGCGAAACAATTGA

Product: thiamine biosynthesis protein ThiC

Products: @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine!; 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

Alternate protein names: Hydroxymethylpyrimidine phosphate synthase; HMP-P synthase; HMP-phosphate synthase; HMPP synthase; Thiamine biosynthesis protein thiC [H]

Number of amino acids: Translated: 643; Mature: 643

Protein sequence:

>643_residues
MNANPKFLSADARVDAAAVAPLPNSRKVYVTGSQPDIRVPMREITQADTPTSFGGEKNPPIYVYDTSGPYTDPDAKIDIR
AGLPALRQRWIDARGDTETLAGLTSDYGRERAADPATAELRFPGLHRHPRRAKAGKNVTQMHYARQGIITPEMEYIAIRE
NQRRAEYLESLKASGPNGAKLAAMMGRQHAGQAFGAAAFGANAPAEITPEFVRDEVARGRAIIPANINHPETEPMIIGRN
FLVKINANIGNSAVTSSIGEEVDKMTWAIRWGGDTVMDLSTGKHIHETREWIIRNSPVPIGTVPIYQALEKVNGKAEDLT
WEIFRDTLIEQAEQGVDYFTIHAGVRLQYVPLTANRMTGIVSRGGSIMAKWCLAHHKESFLYEHFEEICEIMKAYDVSFS
LGDGLRPGSIYDANDEAQLGELKTLGELTQIAWKHDVQVMIEGPGHVPMQLIKENMDLQLDWCKEAPFYTLGPLTTDIAP
GYDHITSGIGAAMIGWFGTAMLCYVTPKEHLGLPNKDDVKEGIITYKLAAHAADLAKGHPGAQVRDNALSKARFEFRWQD
QFNLGLDPDKAREFHDETLPKDSAKVAHFCSMCGPHFCSMKITQDVREFAAQQGVSENDALKKGMEVKAVEFVKSGSEIY
HRQ

Sequences:

>Translated_643_residues
MNANPKFLSADARVDAAAVAPLPNSRKVYVTGSQPDIRVPMREITQADTPTSFGGEKNPPIYVYDTSGPYTDPDAKIDIR
AGLPALRQRWIDARGDTETLAGLTSDYGRERAADPATAELRFPGLHRHPRRAKAGKNVTQMHYARQGIITPEMEYIAIRE
NQRRAEYLESLKASGPNGAKLAAMMGRQHAGQAFGAAAFGANAPAEITPEFVRDEVARGRAIIPANINHPETEPMIIGRN
FLVKINANIGNSAVTSSIGEEVDKMTWAIRWGGDTVMDLSTGKHIHETREWIIRNSPVPIGTVPIYQALEKVNGKAEDLT
WEIFRDTLIEQAEQGVDYFTIHAGVRLQYVPLTANRMTGIVSRGGSIMAKWCLAHHKESFLYEHFEEICEIMKAYDVSFS
LGDGLRPGSIYDANDEAQLGELKTLGELTQIAWKHDVQVMIEGPGHVPMQLIKENMDLQLDWCKEAPFYTLGPLTTDIAP
GYDHITSGIGAAMIGWFGTAMLCYVTPKEHLGLPNKDDVKEGIITYKLAAHAADLAKGHPGAQVRDNALSKARFEFRWQD
QFNLGLDPDKAREFHDETLPKDSAKVAHFCSMCGPHFCSMKITQDVREFAAQQGVSENDALKKGMEVKAVEFVKSGSEIY
HRQ
>Mature_643_residues
MNANPKFLSADARVDAAAVAPLPNSRKVYVTGSQPDIRVPMREITQADTPTSFGGEKNPPIYVYDTSGPYTDPDAKIDIR
AGLPALRQRWIDARGDTETLAGLTSDYGRERAADPATAELRFPGLHRHPRRAKAGKNVTQMHYARQGIITPEMEYIAIRE
NQRRAEYLESLKASGPNGAKLAAMMGRQHAGQAFGAAAFGANAPAEITPEFVRDEVARGRAIIPANINHPETEPMIIGRN
FLVKINANIGNSAVTSSIGEEVDKMTWAIRWGGDTVMDLSTGKHIHETREWIIRNSPVPIGTVPIYQALEKVNGKAEDLT
WEIFRDTLIEQAEQGVDYFTIHAGVRLQYVPLTANRMTGIVSRGGSIMAKWCLAHHKESFLYEHFEEICEIMKAYDVSFS
LGDGLRPGSIYDANDEAQLGELKTLGELTQIAWKHDVQVMIEGPGHVPMQLIKENMDLQLDWCKEAPFYTLGPLTTDIAP
GYDHITSGIGAAMIGWFGTAMLCYVTPKEHLGLPNKDDVKEGIITYKLAAHAADLAKGHPGAQVRDNALSKARFEFRWQD
QFNLGLDPDKAREFHDETLPKDSAKVAHFCSMCGPHFCSMKITQDVREFAAQQGVSENDALKKGMEVKAVEFVKSGSEIY
HRQ

Specific function: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction [H]

COG id: COG0422

COG function: function code H; Thiamine biosynthesis protein ThiC

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiC family [H]

Homologues:

Organism=Escherichia coli, GI1790427, Length=637, Percent_Identity=69.3877551020408, Blast_Score=911, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002817 [H]

Pfam domain/function: PF01964 ThiC [H]

EC number: NA

Molecular weight: Translated: 71124; Mature: 71124

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNANPKFLSADARVDAAAVAPLPNSRKVYVTGSQPDIRVPMREITQADTPTSFGGEKNPP
CCCCCCEEECCCCCCCEEECCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCC
IYVYDTSGPYTDPDAKIDIRAGLPALRQRWIDARGDTETLAGLTSDYGRERAADPATAEL
EEEEECCCCCCCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHCHHHCCCCCCCEE
RFPGLHRHPRRAKAGKNVTQMHYARQGIITPEMEYIAIRENQRRAEYLESLKASGPNGAK
ECCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCHH
LAAMMGRQHAGQAFGAAAFGANAPAEITPEFVRDEVARGRAIIPANINHPETEPMIIGRN
HHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCEEECCE
FLVKINANIGNSAVTSSIGEEVDKMTWAIRWGGDTVMDLSTGKHIHETREWIIRNSPVPI
EEEEEECCCCCHHHHHHHHHHHHHEEEEEEECCCEEEECCCCCHHHHHHHHHHCCCCCCC
GTVPIYQALEKVNGKAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVRLQYVPLTANRMTGI
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEEECHHHHHHH
VSRGGSIMAKWCLAHHKESFLYEHFEEICEIMKAYDVSFSLGDGLRPGSIYDANDEAQLG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEECCCCCCHHH
ELKTLGELTQIAWKHDVQVMIEGPGHVPMQLIKENMDLQLDWCKEAPFYTLGPLTTDIAP
HHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCEEEEECCCCCCEEECCCCCCCCC
GYDHITSGIGAAMIGWFGTAMLCYVTPKEHLGLPNKDDVKEGIITYKLAAHAADLAKGHP
CHHHHHHHHHHHHHHHHHHEEEEEECCHHHCCCCCHHHHHHHHEEEHHHHHHHHHHCCCC
GAQVRDNALSKARFEFRWQDQFNLGLDPDKAREFHDETLPKDSAKVAHFCSMCGPHFCSM
CCCHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHEEE
KITQDVREFAAQQGVSENDALKKGMEVKAVEFVKSGSEIYHRQ
HHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHCCCHHHCCC
>Mature Secondary Structure
MNANPKFLSADARVDAAAVAPLPNSRKVYVTGSQPDIRVPMREITQADTPTSFGGEKNPP
CCCCCCEEECCCCCCCEEECCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCC
IYVYDTSGPYTDPDAKIDIRAGLPALRQRWIDARGDTETLAGLTSDYGRERAADPATAEL
EEEEECCCCCCCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHCHHHCCCCCCCEE
RFPGLHRHPRRAKAGKNVTQMHYARQGIITPEMEYIAIRENQRRAEYLESLKASGPNGAK
ECCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCHH
LAAMMGRQHAGQAFGAAAFGANAPAEITPEFVRDEVARGRAIIPANINHPETEPMIIGRN
HHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCEEECCE
FLVKINANIGNSAVTSSIGEEVDKMTWAIRWGGDTVMDLSTGKHIHETREWIIRNSPVPI
EEEEEECCCCCHHHHHHHHHHHHHEEEEEEECCCEEEECCCCCHHHHHHHHHHCCCCCCC
GTVPIYQALEKVNGKAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVRLQYVPLTANRMTGI
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEEECHHHHHHH
VSRGGSIMAKWCLAHHKESFLYEHFEEICEIMKAYDVSFSLGDGLRPGSIYDANDEAQLG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEECCCCCCHHH
ELKTLGELTQIAWKHDVQVMIEGPGHVPMQLIKENMDLQLDWCKEAPFYTLGPLTTDIAP
HHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCEEEEECCCCCCEEECCCCCCCCC
GYDHITSGIGAAMIGWFGTAMLCYVTPKEHLGLPNKDDVKEGIITYKLAAHAADLAKGHP
CHHHHHHHHHHHHHHHHHHEEEEEECCHHHCCCCCHHHHHHHHEEEHHHHHHHHHHCCCC
GAQVRDNALSKARFEFRWQDQFNLGLDPDKAREFHDETLPKDSAKVAHFCSMCGPHFCSM
CCCHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHEEE
KITQDVREFAAQQGVSENDALKKGMEVKAVEFVKSGSEIYHRQ
HHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ?; ?; 5'-phosphoribosyl-5-aminoimidazole [C]

Specific reaction: Synthesis of @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine! 5'-phosphoribosyl-5-aminoimidazole = 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA