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The map label for this gene is mhpR [H]

Identifier: 53718904

GI number: 53718904

Start: 1470736

End: 1471563

Strand: Reverse

Name: mhpR [H]

Synonym: BPSL1269

Alternate gene names: 53718904

Gene position: 1471563-1470736 (Counterclockwise)

Preceding gene: 53718905

Following gene: 53718903

Centisome position: 36.12

GC content: 69.44

Gene sequence:

>828_bases
GTGACGACACGCTCCAATGCCCAAGCCATCCCCCGTGAACGGGAAGCCACCACCGACGAAATCACGGCCCTCGCGCGCGG
TTTGGCGGTGTTGCGCCGCATCGCCACCTCCGATGCGCCGGTCAGCAACCGGGAACTAGCAGAATTGACAGGCATTCCGA
AGCCGACCGTATCGCGCATCACGGCGACGCTCGTCAGCGCCGGCTTCCTGTTCCAGTTGCCCGACAGCGAGCGCTTCGTG
CTGACGGCATCGGTGCTCGAGCTCAGCAACGGCTTCCTGCGCAACTTCGACATTCGCGCGCGCTCGCGGCCGTTTCTCGT
CGAGCTCGCCGAAAAGACGTCGCTGTCCGTCCATCTCGCGGTGCGCGACCGCCTCGACATGGTCGCGATCGACGTGATCC
GCCCGCGCTCGGCCGTGCTCGTCACACGGCTCGAAACGGGCTCGCGGATGGACATCGCGCGCACCGCGGTCGGCCGCGCC
TACCTCGCCGCGCTCGAGGACGACGCGCGCCGCGAGTTGATCGGCGCGCTGCAGGCGGCGGCGGGCGACGACTGGCCGTT
CGTCGTGTCGCGGCTGAACGCCGCGCTCGCCGACATCGCGCAACACGGCTACGCGATCGCGATCGGCGAGTGGCGCGAGG
AACTGAACGCGATCGCGGCGGGCTTCGTCGCGCCGACCGGCCAATGCTACGCGGTCAACTGCGGCGGTTCCGCGCACCAG
TGCACGCCCGATTTCCTGCGCTCGGTCGCGGTGCCCGCGCTGCGCGAGTGCATCGCGAAGATCACGCGTGAAATCGGCGG
CGCCGCGTGGCCGAATCTCGCGCGCTGA

Upstream 100 bases:

>100_bases
GCGCATTGCGAAAGAAAGTGGCAAATCGCGCACACTTTTTCGGCATTCGTCTTACAATTGATAAAAATCTGAAATCAAGT
TTCGAAAAAGAGAGATTTCC

Downstream 100 bases:

>100_bases
GATAGCGCGCGCATCGCGGGCCGGCCCGCGCCGTGCGGGGCGCGGGCCGGCCGCGCGACGACGGCGCCGACGACCACGGA
CGCACCGGCCGCCGCCCGTC

Product: IclR family transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MTTRSNAQAIPREREATTDEITALARGLAVLRRIATSDAPVSNRELAELTGIPKPTVSRITATLVSAGFLFQLPDSERFV
LTASVLELSNGFLRNFDIRARSRPFLVELAEKTSLSVHLAVRDRLDMVAIDVIRPRSAVLVTRLETGSRMDIARTAVGRA
YLAALEDDARRELIGALQAAAGDDWPFVVSRLNAALADIAQHGYAIAIGEWREELNAIAAGFVAPTGQCYAVNCGGSAHQ
CTPDFLRSVAVPALRECIAKITREIGGAAWPNLAR

Sequences:

>Translated_275_residues
MTTRSNAQAIPREREATTDEITALARGLAVLRRIATSDAPVSNRELAELTGIPKPTVSRITATLVSAGFLFQLPDSERFV
LTASVLELSNGFLRNFDIRARSRPFLVELAEKTSLSVHLAVRDRLDMVAIDVIRPRSAVLVTRLETGSRMDIARTAVGRA
YLAALEDDARRELIGALQAAAGDDWPFVVSRLNAALADIAQHGYAIAIGEWREELNAIAAGFVAPTGQCYAVNCGGSAHQ
CTPDFLRSVAVPALRECIAKITREIGGAAWPNLAR
>Mature_274_residues
TTRSNAQAIPREREATTDEITALARGLAVLRRIATSDAPVSNRELAELTGIPKPTVSRITATLVSAGFLFQLPDSERFVL
TASVLELSNGFLRNFDIRARSRPFLVELAEKTSLSVHLAVRDRLDMVAIDVIRPRSAVLVTRLETGSRMDIARTAVGRAY
LAALEDDARRELIGALQAAAGDDWPFVVSRLNAALADIAQHGYAIAIGEWREELNAIAAGFVAPTGQCYAVNCGGSAHQC
TPDFLRSVAVPALRECIAKITREIGGAAWPNLAR

Specific function: Activator of the mhpRABCDEF operon coding for components of the 3-hydroxyphenylpropionate degradation pathway [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI145693096, Length=216, Percent_Identity=29.6296296296296, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082359, Length=159, Percent_Identity=28.3018867924528, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786468, Length=215, Percent_Identity=25.1162790697674, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788581, Length=253, Percent_Identity=26.4822134387352, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29688; Mature: 29557

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRSNAQAIPREREATTDEITALARGLAVLRRIATSDAPVSNRELAELTGIPKPTVSRI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHH
TATLVSAGFLFQLPDSERFVLTASVLELSNGFLRNFDIRARSRPFLVELAEKTSLSVHLA
HHHHHHCCCEEECCCCCCEEEEHHHHHHCCCHHCCCCCCCCCCCCEEEECCCCCEEEEEE
VRDRLDMVAIDVIRPRSAVLVTRLETGSRMDIARTAVGRAYLAALEDDARRELIGALQAA
EHHCCCEEEHEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGDDWPFVVSRLNAALADIAQHGYAIAIGEWREELNAIAAGFVAPTGQCYAVNCGGSAHQ
CCCCHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
CTPDFLRSVAVPALRECIAKITREIGGAAWPNLAR
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TTRSNAQAIPREREATTDEITALARGLAVLRRIATSDAPVSNRELAELTGIPKPTVSRI
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHH
TATLVSAGFLFQLPDSERFVLTASVLELSNGFLRNFDIRARSRPFLVELAEKTSLSVHLA
HHHHHHCCCEEECCCCCCEEEEHHHHHHCCCHHCCCCCCCCCCCCEEEECCCCCEEEEEE
VRDRLDMVAIDVIRPRSAVLVTRLETGSRMDIARTAVGRAYLAALEDDARRELIGALQAA
EHHCCCEEEHEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGDDWPFVVSRLNAALADIAQHGYAIAIGEWREELNAIAAGFVAPTGQCYAVNCGGSAHQ
CCCCHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
CTPDFLRSVAVPALRECIAKITREIGGAAWPNLAR
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]