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The map label for this gene is dut [H]

Identifier: 53718544

GI number: 53718544

Start: 1054042

End: 1054488

Strand: Reverse

Name: dut [H]

Synonym: BPSL0903

Alternate gene names: 53718544

Gene position: 1054488-1054042 (Counterclockwise)

Preceding gene: 53718545

Following gene: 53718538

Centisome position: 25.88

GC content: 68.9

Gene sequence:

>447_bases
ATGAAACTCGATCTGAAGATTCTCGACGCGCGCATGCGCGACTACCTGCCGAAATACGCGACGACGGGCAGCGCGGGGCT
CGACCTGCGCGCGTGCCTCGACGCGCCCGTCACGCTGAAGCCGGGCGACACGGCGCTCGTGCCGACGGGCCTCGCGATCC
ATCTCGCCGATCCCGGCTATGCGGCGCTGATCCTGCCGCGCTCGGGCCTCGGCCACAAGCACGGCATCGTGCTCGGCAAC
CTGGTCGGCCTCATCGATTCGGACTACCAGGGCGAGCTGATGATCTCGACGTGGAACCGCGGCCAGACCGAGTTCGCGCT
GAACCCGTTCGAGCGCCTCGCGCAGCTCGTGATCGTGCCGGTCGTGCAGGCGAGGTTCAACCTGGTCGACGATTTCGCGC
AAAGCGAGCGCGGCGCGGGCGGCTTCGGCAGCACCGGCCGCGGCTGA

Upstream 100 bases:

>100_bases
AATCGCGAAACGGCTGCCCGATACGCGCCTCATTTGACGCATCGCCGCGGCCGCGCAGCGCGGCCGCCCCTTCTCAACCT
CCGTCACCGATTTTCGCCGC

Downstream 100 bases:

>100_bases
TTCGAAACGGCGACGCTCGCGAGGGGCCCCGCCGCTCCCGCGCGCGCGGCTCCGCCCCGTCCCCGGCCCTTTCGCGGCTC
GGCGGCGCTCACTCCTCGAG

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MKLDLKILDARMRDYLPKYATTGSAGLDLRACLDAPVTLKPGDTALVPTGLAIHLADPGYAALILPRSGLGHKHGIVLGN
LVGLIDSDYQGELMISTWNRGQTEFALNPFERLAQLVIVPVVQARFNLVDDFAQSERGAGGFGSTGRG

Sequences:

>Translated_148_residues
MKLDLKILDARMRDYLPKYATTGSAGLDLRACLDAPVTLKPGDTALVPTGLAIHLADPGYAALILPRSGLGHKHGIVLGN
LVGLIDSDYQGELMISTWNRGQTEFALNPFERLAQLVIVPVVQARFNLVDDFAQSERGAGGFGSTGRG
>Mature_148_residues
MKLDLKILDARMRDYLPKYATTGSAGLDLRACLDAPVTLKPGDTALVPTGLAIHLADPGYAALILPRSGLGHKHGIVLGN
LVGLIDSDYQGELMISTWNRGQTEFALNPFERLAQLVIVPVVQARFNLVDDFAQSERGAGGFGSTGRG

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=131, Percent_Identity=35.8778625954198, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI4503423, Length=145, Percent_Identity=33.7931034482759, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI70906441, Length=145, Percent_Identity=33.7931034482759, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI1790071, Length=148, Percent_Identity=70.9459459459459, Blast_Score=217, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71988561, Length=133, Percent_Identity=40.6015037593985, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319729, Length=145, Percent_Identity=37.2413793103448, Blast_Score=81, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24583610, Length=149, Percent_Identity=32.2147651006711, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19921126, Length=149, Percent_Identity=32.2147651006711, Blast_Score=73, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15802; Mature: 15802

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDLKILDARMRDYLPKYATTGSAGLDLRACLDAPVTLKPGDTALVPTGLAIHLADPGY
CCCCHHHHHHHHHHHCCCCCCCCCCCCEEHHHCCCCEEECCCCCEEECCCEEEEECCCCE
AALILPRSGLGHKHGIVLGNLVGLIDSDYQGELMISTWNRGQTEFALNPFERLAQLVIVP
EEEEEECCCCCCCCCEEHHHHHHHCCCCCCCEEEEEECCCCCEEEEECHHHHHHHHHHHH
VVQARFNLVDDFAQSERGAGGFGSTGRG
HHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKLDLKILDARMRDYLPKYATTGSAGLDLRACLDAPVTLKPGDTALVPTGLAIHLADPGY
CCCCHHHHHHHHHHHCCCCCCCCCCCCEEHHHCCCCEEECCCCCEEECCCEEEEECCCCE
AALILPRSGLGHKHGIVLGNLVGLIDSDYQGELMISTWNRGQTEFALNPFERLAQLVIVP
EEEEEECCCCCCCCCEEHHHHHHHCCCCCCCEEEEEECCCCCEEEEECHHHHHHHHHHHH
VVQARFNLVDDFAQSERGAGGFGSTGRG
HHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA