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The map label for this gene is mdtD [H]

Identifier: 53718527

GI number: 53718527

Start: 1030572

End: 1032011

Strand: Reverse

Name: mdtD [H]

Synonym: BPSL0888

Alternate gene names: 53718527

Gene position: 1032011-1030572 (Counterclockwise)

Preceding gene: 53718529

Following gene: 53718526

Centisome position: 25.33

GC content: 67.15

Gene sequence:

>1440_bases
ATGCCTCCAGCCCCGCCCGCCGCCGCCCCGAGCGAGAAATCGTTGACCGTGATGCTGTGGCTCGTCGCCACCGGCTTCTT
CATGCAAACGCTCGACGCGACGATCGTCAACACCGCGCTGCCCTCGATGGCCGCGAGCCTCGGTGAATCGCCGCTCAGGA
TGCAGTCGGTCGTGATCGCGTACTCGCTGACGATGGCCGTGATGATCCCCGTATCCGGCTGGCTCGCCGATACGCTCGGC
ACGCGCCGCGTGTTCTTCAGCGCGATCCTGATCTTCACGCTCGGCTCGCTCCTGTGCGCGAACGCGCACACGCTGCCGCT
TCTCGTCGCGTTCCGCGTGATCCAGGGCGTGGGCGGCGCGATGCTGCTGCCCGTCGGGCGGCTCGCGGTGCTGCGCACGT
TCCCCGCCGAGCGCTATCTGCCCGCGCTGTCGTTCGTCGCGATCCCGGGCCTGATCGGCCCGCTGATCGGGCCGACGCTC
GGCGGCTGGCTCGTGAAGATCGCATCGTGGCACTGGATTTTCCTCATCAACGTGCCTGTCGGCATCGCCGGCTGCATCGC
GACGTTCTACTCGATGCCCGACTCGCGCAATCCGGCAGCGGGGCGCTTCGATCTGAAGGGCTATCTGCTGCTGACGATCG
GGATGATCGCGATCTCGCTGTCGCTCGACGGCCTCGCCGATCTCGGCATGCAGCACGCGATGGTGCTCGTGCTGCTGATC
CTGAGTCTCGCGTGCTTCGTCGCGTATGGCCTGTACGCGGTGCGCGCGCCGCAGCCGATCTTCTCGCTCGAGCTCTTTGG
GATCCACACGTTCAGCGTGGGCCTGCTCGGCAACCTGTTCGCGCGGATCGGCAGCGGCGCGATGCCGTATCTGATTCCGC
TGCTGCTGCAGGTGAGCCTCGGCTACGGCGCGTTCGAGGCGGGCCTGATGATGCTGCCCGTCGCGGCTGCCGGAATGTTC
TCGAAACGGATCATCACGGTGCTCATCACTCGCCACGGCTACCGCAAGGTGCTGCTCGCGAACACGATCATGGTCGGGCT
GATGATGGCGAGCTTCGCGCTCGTGAGCGACGCGATGCCGACCTGGCTGAAGATCGCGCAGCTCGCGCTGTTCGGCGGCT
TCAACTCGATGCAGTTCACCGCGATGAACACCCTCACGCTGAAGGACCTCGGCACGGGCGGCGCGAGTAGCGGCAACAGC
CTGTTCTCGCTCGTGCAGATGCTGTCGATGAGCCTCGGCGTGACGGTGGCGGGCGCGCTGCTCGCGACCTTCACCGGCAT
GATGCGCAGCGTCACGCCGACGCACACGCTGCCCGCGTTCCATGCGACGTTCGTGTGCGTCGGCCTCATCACCGCCGCGT
CGGCCTGGATCTTCGCGCAACTGTCGCCCGACGTGCGCGGCGCCGTGCGACGCAAGACCGATCCGTCCGAGCGCGCGTGA

Upstream 100 bases:

>100_bases
CCGCCGCGCAACGCGCCCGCATGCCGGTCACTGCACGCCCCGCCGGCTTTCCCTACAATGTCGGCTGCCCGCCCGAACGC
GCACGCAGCGCCCCGTTCTC

Downstream 100 bases:

>100_bases
CGTGGGCATGACCGCCGGCGTGCGGCAAGCGCACGCGCCGCGTGCGCGGCGACATGGGGCGGCGTAATCGCGCAGGCGGC
GGCGGTCGCGGCGCGAGGCG

Product: putative transporter protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MPPAPPAAAPSEKSLTVMLWLVATGFFMQTLDATIVNTALPSMAASLGESPLRMQSVVIAYSLTMAVMIPVSGWLADTLG
TRRVFFSAILIFTLGSLLCANAHTLPLLVAFRVIQGVGGAMLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTL
GGWLVKIASWHWIFLINVPVGIAGCIATFYSMPDSRNPAAGRFDLKGYLLLTIGMIAISLSLDGLADLGMQHAMVLVLLI
LSLACFVAYGLYAVRAPQPIFSLELFGIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSLGYGAFEAGLMMLPVAAAGMF
SKRIITVLITRHGYRKVLLANTIMVGLMMASFALVSDAMPTWLKIAQLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNS
LFSLVQMLSMSLGVTVAGALLATFTGMMRSVTPTHTLPAFHATFVCVGLITAASAWIFAQLSPDVRGAVRRKTDPSERA

Sequences:

>Translated_479_residues
MPPAPPAAAPSEKSLTVMLWLVATGFFMQTLDATIVNTALPSMAASLGESPLRMQSVVIAYSLTMAVMIPVSGWLADTLG
TRRVFFSAILIFTLGSLLCANAHTLPLLVAFRVIQGVGGAMLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTL
GGWLVKIASWHWIFLINVPVGIAGCIATFYSMPDSRNPAAGRFDLKGYLLLTIGMIAISLSLDGLADLGMQHAMVLVLLI
LSLACFVAYGLYAVRAPQPIFSLELFGIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSLGYGAFEAGLMMLPVAAAGMF
SKRIITVLITRHGYRKVLLANTIMVGLMMASFALVSDAMPTWLKIAQLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNS
LFSLVQMLSMSLGVTVAGALLATFTGMMRSVTPTHTLPAFHATFVCVGLITAASAWIFAQLSPDVRGAVRRKTDPSERA
>Mature_478_residues
PPAPPAAAPSEKSLTVMLWLVATGFFMQTLDATIVNTALPSMAASLGESPLRMQSVVIAYSLTMAVMIPVSGWLADTLGT
RRVFFSAILIFTLGSLLCANAHTLPLLVAFRVIQGVGGAMLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTLG
GWLVKIASWHWIFLINVPVGIAGCIATFYSMPDSRNPAAGRFDLKGYLLLTIGMIAISLSLDGLADLGMQHAMVLVLLIL
SLACFVAYGLYAVRAPQPIFSLELFGIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSLGYGAFEAGLMMLPVAAAGMFS
KRIITVLITRHGYRKVLLANTIMVGLMMASFALVSDAMPTWLKIAQLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNSL
FSLVQMLSMSLGVTVAGALLATFTGMMRSVTPTHTLPAFHATFVCVGLITAASAWIFAQLSPDVRGAVRRKTDPSERA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=470, Percent_Identity=47.8723404255319, Blast_Score=428, Evalue=1e-121,
Organism=Escherichia coli, GI1788392, Length=459, Percent_Identity=50.1089324618736, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1788710, Length=325, Percent_Identity=32, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1789042, Length=455, Percent_Identity=27.4725274725275, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI87081983, Length=318, Percent_Identity=30.8176100628931, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322958, Length=156, Percent_Identity=32.0512820512821, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6325455, Length=125, Percent_Identity=29.6, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321663, Length=151, Percent_Identity=30.4635761589404, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323735, Length=256, Percent_Identity=26.171875, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50705; Mature: 50574

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPAPPAAAPSEKSLTVMLWLVATGFFMQTLDATIVNTALPSMAASLGESPLRMQSVVIA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
YSLTMAVMIPVSGWLADTLGTRRVFFSAILIFTLGSLLCANAHTLPLLVAFRVIQGVGGA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCH
MLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTLGGWLVKIASWHWIFLINVPV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCH
GIAGCIATFYSMPDSRNPAAGRFDLKGYLLLTIGMIAISLSLDGLADLGMQHAMVLVLLI
HHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LSLACFVAYGLYAVRAPQPIFSLELFGIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSL
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
GYGAFEAGLMMLPVAAAGMFSKRIITVLITRHGYRKVLLANTIMVGLMMASFALVSDAMP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
TWLKIAQLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNSLFSLVQMLSMSLGVTVAGAL
HHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LATFTGMMRSVTPTHTLPAFHATFVCVGLITAASAWIFAQLSPDVRGAVRRKTDPSERA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PPAPPAAAPSEKSLTVMLWLVATGFFMQTLDATIVNTALPSMAASLGESPLRMQSVVIA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
YSLTMAVMIPVSGWLADTLGTRRVFFSAILIFTLGSLLCANAHTLPLLVAFRVIQGVGGA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCH
MLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTLGGWLVKIASWHWIFLINVPV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCH
GIAGCIATFYSMPDSRNPAAGRFDLKGYLLLTIGMIAISLSLDGLADLGMQHAMVLVLLI
HHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LSLACFVAYGLYAVRAPQPIFSLELFGIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSL
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
GYGAFEAGLMMLPVAAAGMFSKRIITVLITRHGYRKVLLANTIMVGLMMASFALVSDAMP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
TWLKIAQLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNSLFSLVQMLSMSLGVTVAGAL
HHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LATFTGMMRSVTPTHTLPAFHATFVCVGLITAASAWIFAQLSPDVRGAVRRKTDPSERA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA