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The map label for this gene is strD [H]

Identifier: 53718299

GI number: 53718299

Start: 745363

End: 746082

Strand: Reverse

Name: strD [H]

Synonym: BPSL0656

Alternate gene names: 53718299

Gene position: 746082-745363 (Counterclockwise)

Preceding gene: 53718300

Following gene: 53718297

Centisome position: 18.31

GC content: 73.19

Gene sequence:

>720_bases
ATGACGCACACACTCGATACGGCGATGATCTTCGCCGCCGGGCGCGGCGAACGGATGCGCCCGCTCACCGACACGACGCC
GAAGCCGCTGCTCGCCGCGGGCGGCAAGCCGCTCATCGTCTGGCAGATCGAGCGGCTCGCGGCGGCGGGCATCCGCACGA
TCGTCGTCAACCATGCTTGGCTCGGCGCGCAGATCGAGGCCGCGCTCGGCGACGGCGCGCGCTGGGGCGTGCGGCTGCGC
TATTCGGCCGAGCGCGAGGCCCTCGAGACGGCGGGCGGGATCGCGCGGGCGCTGCCGCTCATCGAGGACGGCGCGGGCGC
GAAGGTGTTCGTCGGCGTATCGGGCGACATTTACACCGGTTTCGACTATGCGGCGCTGTCGGCTCGCGCGGACGCGCTTG
CCGGCGCGCGCGAGCCCGGCATGCATCTCGTGATGGTGCCCAACCCGCCGTTTCACCCGGCGGGCGACTTCGCGCTCGGC
GACGACGGCGTGCTGTCGCTCGACGGCGCGCCGCGCGCGACGTTCGGCAACATCGGGCTCTATGACACGCGGATGTTCCG
CGATCTGCCCGCCGGCACGCGCCGCGCGCTCACGCCCTATTACCGCGAGACGATCGCCGCGCGCCGCGCGACGGGCGAGC
TCTACACCGGGGCGTGGGAGAACGTCGGCACGCCCGCGCAGCTGGGCGAACTCGACGCGGCGTTGAAGGCCGGCCGCTGA

Upstream 100 bases:

>100_bases
GCGCCGCGTCGCGCTGCGCTACCGGCCGCTCGCGCCGTTCGCGAAGCTCCTCGACGATCTCGAAGGCAAGACGGCCGACG
TCGGCTATACGTTCTGAACG

Downstream 100 bases:

>100_bases
CGGCGCCGGGCCGACGGCCGGGTGAACGGGGAACGTCGGCGCATTTCGGCGCGGTCCGCCGCGCTCGGGCGTACGCGACG
CATCAGCCGCCTCATGCCGC

Product: putative nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MTHTLDTAMIFAAGRGERMRPLTDTTPKPLLAAGGKPLIVWQIERLAAAGIRTIVVNHAWLGAQIEAALGDGARWGVRLR
YSAEREALETAGGIARALPLIEDGAGAKVFVGVSGDIYTGFDYAALSARADALAGAREPGMHLVMVPNPPFHPAGDFALG
DDGVLSLDGAPRATFGNIGLYDTRMFRDLPAGTRRALTPYYRETIAARRATGELYTGAWENVGTPAQLGELDAALKAGR

Sequences:

>Translated_239_residues
MTHTLDTAMIFAAGRGERMRPLTDTTPKPLLAAGGKPLIVWQIERLAAAGIRTIVVNHAWLGAQIEAALGDGARWGVRLR
YSAEREALETAGGIARALPLIEDGAGAKVFVGVSGDIYTGFDYAALSARADALAGAREPGMHLVMVPNPPFHPAGDFALG
DDGVLSLDGAPRATFGNIGLYDTRMFRDLPAGTRRALTPYYRETIAARRATGELYTGAWENVGTPAQLGELDAALKAGR
>Mature_238_residues
THTLDTAMIFAAGRGERMRPLTDTTPKPLLAAGGKPLIVWQIERLAAAGIRTIVVNHAWLGAQIEAALGDGARWGVRLRY
SAEREALETAGGIARALPLIEDGAGAKVFVGVSGDIYTGFDYAALSARADALAGAREPGMHLVMVPNPPFHPAGDFALGD
DGVLSLDGAPRATFGNIGLYDTRMFRDLPAGTRRALTPYYRETIAARRATGELYTGAWENVGTPAQLGELDAALKAGR

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=120, Percent_Identity=35, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI11761619, Length=120, Percent_Identity=35, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=239, Percent_Identity=27.1966527196653, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21355443, Length=120, Percent_Identity=35, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24644084, Length=120, Percent_Identity=35, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 25282; Mature: 25151

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHTLDTAMIFAAGRGERMRPLTDTTPKPLLAAGGKPLIVWQIERLAAAGIRTIVVNHAW
CCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHCCCCEEEEEEEHHHHHCCEEEEEEECCC
LGAQIEAALGDGARWGVRLRYSAEREALETAGGIARALPLIEDGAGAKVFVGVSGDIYTG
CCEEEEEECCCCCEEEEEEEECCHHHHHHHHCCHHHHCCEEECCCCCEEEEEECCCEECC
FDYAALSARADALAGAREPGMHLVMVPNPPFHPAGDFALGDDGVLSLDGAPRATFGNIGL
CCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCEECCCCEEEECCCCCCEECCCCC
YDTRMFRDLPAGTRRALTPYYRETIAARRATGELYTGAWENVGTPAQLGELDAALKAGR
CHHHHHHHCCCCCHHHCCHHHHHHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
THTLDTAMIFAAGRGERMRPLTDTTPKPLLAAGGKPLIVWQIERLAAAGIRTIVVNHAW
CCCCCEEEEEECCCCCCCCCCCCCCCCCHHHCCCCEEEEEEEHHHHHCCEEEEEEECCC
LGAQIEAALGDGARWGVRLRYSAEREALETAGGIARALPLIEDGAGAKVFVGVSGDIYTG
CCEEEEEECCCCCEEEEEEEECCHHHHHHHHCCHHHHCCEEECCCCCEEEEEECCCEECC
FDYAALSARADALAGAREPGMHLVMVPNPPFHPAGDFALGDDGVLSLDGAPRATFGNIGL
CCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCEECCCCEEEECCCCCCEECCCCC
YDTRMFRDLPAGTRRALTPYYRETIAARRATGELYTGAWENVGTPAQLGELDAALKAGR
CHHHHHHHCCCCCHHHCCHHHHHHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]