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The map label for this gene is aroA/tyrA [H]

Identifier: 161723198

GI number: 161723198

Start: 3030977

End: 3032998

Strand: Reverse

Name: aroA/tyrA [H]

Synonym: BPSL2517

Alternate gene names: 161723198

Gene position: 3032998-3030977 (Counterclockwise)

Preceding gene: 53720128

Following gene: 53720126

Centisome position: 74.44

GC content: 70.82

Gene sequence:

>2022_bases
GTGCTGCTCGCCGCGCCCGTCGCTCAGACGGGCCCGCTGCTTGCGCGGATCGCGCCGTTTCTCGACGCATCGACGATCGT
CACCGACGCGGGCAGCACGAAATCGGACGTCGTCGCGGCCGCGCGCGCGGCGCTCGGCGCGCGGATCGGCCAGTTCGTGC
CGGGCCACCCGATCGCCGGGCGCGAATCGAGCGGCGTCGACGCGGCGCTCGCCGATCTGTACGTCGGCCGCAACGTCGTG
CTATGCGCGCTGCCGGAGAACGCGCCCGACGCGCTCGCGCGCGTCGAAGCGATGTGGCGCGCGGCGCGCGCCGACGTGCG
CGCGATGAGCGCCGAGCAGCACGACCGCGTGTTCGCGGCGGTGAGCCACCTGCCGCACGTGCTGTCGTTCGCGCTCGTCG
AGCAGATTCTCGGCGAATCCGACGCCGAGCTGAAGTTCTCGTATGCGGCGGGCGGTTTCCGCGATTTCACGCGCATCGCC
GCGTCGAGCCCCGAAATGTGGCGCGACGTCTGCCTCGCGAACCGCGCGGCGCTCCTCGACGAGCTCGACGCGTACACCGC
GGTGCTCGCGCGTCTGCGCGCGGCGATCGACGCGGGTGACGGCGCCGCGCTCGAGGCCGTGTTCGCGCGCTCGCGCGCCG
CGCGCGCCGCCTGGCGCGAGCGCGGCGCGAAGCCCGCCCCCGCTGTCCGTTCAGACACTTCCGGAACAGGATCTCACATG
GAACATCTCGATCTCGGCCCGTTCTCCCATGCGCAAGGCACGGTGCGCCTGCCCGGCTCGAAGAGCATTTCGAACCGCGT
GCTGCTGCTCGCGGCGCTCGCGGAGGGCGAGACGACCGTCACGAACCTGCTCGATTCCGACGATACGCGCGTGATGCTCG
ATGCGTTGACGAAGCTCGGCGTGAAGCTGTCGCGCGACGGCGGCACCTGCGTCGTCGGCGGCACGCGCGGCGCGTTCACC
GCGAAGACCGCCGATCTCTTCCTCGGCAACGCGGGCACCGCGGTGCGGCCGCTGACGGCGGCGCTCGCGGTCAACGGCGG
CGAGTACCGGATTCACGGGGTGCCGCGGATGCACGAGCGCCCGATCGGCGACCTCGTCGACGGGTTGCGCCAGATCGGCG
CGCGGATCGACTACGAGGGCAACGAGGGCTTCCCGCCGCTCAGGATCCGGCCCGCGACGATTTCGGTCGACGCGCCGATC
CGCGTGCGCGGCGACGTGTCGAGCCAGTTCCTGACCGCGCTGCTGATGACGCTGCCGCTCGTGAAGGCGAAGGATGGCGC
GAGCGTCGTCGAGATCGACGGCGAGCTGATCTCTAAGCCGTACATCGAGATCACGATCAAGCTGATGGCGCGCTTCGGCG
TGACGGTGGAGCGCGACGGCTGGCAGCGCTTCACGGTGCCGGCGGGCGTGCGCTACCGGTCGCCCGGCACGATCATGGTC
GAGGGCGACGCGTCGTCGGCGTCGTATTTCCTCGCGGCGGGCGCGCTCGGCGGCGGGCCGCTGCGCGTCGAGGGCGTCGG
CCGCGCGAGCATCCAGGGCGACGTCGGCTTCGCGAACGCGCTGATGCAGATGGGCGCGAACGTGACGATGGGCGACGACT
GGATCGAGGTGCGCGGCATCGGCCATGACCACGGCAGGCTCGCGCCGATCGACATGGACTTCAACCTGATTCCGGACGCC
GCGATGACGATCGCGGTCGCCGCGCTGTTCGCCGACGGCCCGAGCACGCTGCGCAACATCGGCAGCTGGCGCGTGAAGGA
GACCGACCGGATCGCCGCGATGGCGACCGAGCTGCGCAAGGTCGGCGCGACGGTCGAAGAGGGTGCGGACTACCTCGTCG
TGACTCCGCCCGCGCAACTCACGCCGAATGCGTCGATCGATACCTACGACGATCACCGGATGGCGATGTGCTTTTCGCTC
GTGAGCCTGGGCGGCGTGCCCGTGCGCATCAACGATCCGAAGTGCGTCGGCAAGACGTTCCCCGACTATTTCGACCGTTT
CCTCGCGCTCGCGAACGCGTGA

Upstream 100 bases:

>100_bases
GGCGTCGATCGGGCGCGCGCTCGCGTTGCGCGTGATCGATCGCGCGGCGGCGCTCGACGACGATGCGCAACTGCGCGATG
CGCTCGCGGGCGCGGACCTC

Downstream 100 bases:

>100_bases
CGCCCGTATTGACCCACCCGATGAAATCGACTCGACCTTTTCACCCGACCCCAGTTATTACGATCGACGGCCCGACGGCG
TCCGGCAAGGGCACCGTCGC

Product: bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS [H]

Number of amino acids: Translated: 673; Mature: 673

Protein sequence:

>673_residues
MLLAAPVAQTGPLLARIAPFLDASTIVTDAGSTKSDVVAAARAALGARIGQFVPGHPIAGRESSGVDAALADLYVGRNVV
LCALPENAPDALARVEAMWRAARADVRAMSAEQHDRVFAAVSHLPHVLSFALVEQILGESDAELKFSYAAGGFRDFTRIA
ASSPEMWRDVCLANRAALLDELDAYTAVLARLRAAIDAGDGAALEAVFARSRAARAAWRERGAKPAPAVRSDTSGTGSHM
EHLDLGPFSHAQGTVRLPGSKSISNRVLLLAALAEGETTVTNLLDSDDTRVMLDALTKLGVKLSRDGGTCVVGGTRGAFT
AKTADLFLGNAGTAVRPLTAALAVNGGEYRIHGVPRMHERPIGDLVDGLRQIGARIDYEGNEGFPPLRIRPATISVDAPI
RVRGDVSSQFLTALLMTLPLVKAKDGASVVEIDGELISKPYIEITIKLMARFGVTVERDGWQRFTVPAGVRYRSPGTIMV
EGDASSASYFLAAGALGGGPLRVEGVGRASIQGDVGFANALMQMGANVTMGDDWIEVRGIGHDHGRLAPIDMDFNLIPDA
AMTIAVAALFADGPSTLRNIGSWRVKETDRIAAMATELRKVGATVEEGADYLVVTPPAQLTPNASIDTYDDHRMAMCFSL
VSLGGVPVRINDPKCVGKTFPDYFDRFLALANA

Sequences:

>Translated_673_residues
MLLAAPVAQTGPLLARIAPFLDASTIVTDAGSTKSDVVAAARAALGARIGQFVPGHPIAGRESSGVDAALADLYVGRNVV
LCALPENAPDALARVEAMWRAARADVRAMSAEQHDRVFAAVSHLPHVLSFALVEQILGESDAELKFSYAAGGFRDFTRIA
ASSPEMWRDVCLANRAALLDELDAYTAVLARLRAAIDAGDGAALEAVFARSRAARAAWRERGAKPAPAVRSDTSGTGSHM
EHLDLGPFSHAQGTVRLPGSKSISNRVLLLAALAEGETTVTNLLDSDDTRVMLDALTKLGVKLSRDGGTCVVGGTRGAFT
AKTADLFLGNAGTAVRPLTAALAVNGGEYRIHGVPRMHERPIGDLVDGLRQIGARIDYEGNEGFPPLRIRPATISVDAPI
RVRGDVSSQFLTALLMTLPLVKAKDGASVVEIDGELISKPYIEITIKLMARFGVTVERDGWQRFTVPAGVRYRSPGTIMV
EGDASSASYFLAAGALGGGPLRVEGVGRASIQGDVGFANALMQMGANVTMGDDWIEVRGIGHDHGRLAPIDMDFNLIPDA
AMTIAVAALFADGPSTLRNIGSWRVKETDRIAAMATELRKVGATVEEGADYLVVTPPAQLTPNASIDTYDDHRMAMCFSL
VSLGGVPVRINDPKCVGKTFPDYFDRFLALANA
>Mature_673_residues
MLLAAPVAQTGPLLARIAPFLDASTIVTDAGSTKSDVVAAARAALGARIGQFVPGHPIAGRESSGVDAALADLYVGRNVV
LCALPENAPDALARVEAMWRAARADVRAMSAEQHDRVFAAVSHLPHVLSFALVEQILGESDAELKFSYAAGGFRDFTRIA
ASSPEMWRDVCLANRAALLDELDAYTAVLARLRAAIDAGDGAALEAVFARSRAARAAWRERGAKPAPAVRSDTSGTGSHM
EHLDLGPFSHAQGTVRLPGSKSISNRVLLLAALAEGETTVTNLLDSDDTRVMLDALTKLGVKLSRDGGTCVVGGTRGAFT
AKTADLFLGNAGTAVRPLTAALAVNGGEYRIHGVPRMHERPIGDLVDGLRQIGARIDYEGNEGFPPLRIRPATISVDAPI
RVRGDVSSQFLTALLMTLPLVKAKDGASVVEIDGELISKPYIEITIKLMARFGVTVERDGWQRFTVPAGVRYRSPGTIMV
EGDASSASYFLAAGALGGGPLRVEGVGRASIQGDVGFANALMQMGANVTMGDDWIEVRGIGHDHGRLAPIDMDFNLIPDA
AMTIAVAALFADGPSTLRNIGSWRVKETDRIAAMATELRKVGATVEEGADYLVVTPPAQLTPNASIDTYDDHRMAMCFSL
VSLGGVPVRINDPKCVGKTFPDYFDRFLALANA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1787137, Length=437, Percent_Identity=57.6659038901602, Blast_Score=459, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6320332, Length=455, Percent_Identity=38.021978021978, Blast_Score=241, Evalue=4e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.19 [H]

Molecular weight: Translated: 71081; Mature: 71081

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00104 EPSP_SYNTHASE_1 ; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLAAPVAQTGPLLARIAPFLDASTIVTDAGSTKSDVVAAARAALGARIGQFVPGHPIAG
CEEECCCCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
RESSGVDAALADLYVGRNVVLCALPENAPDALARVEAMWRAARADVRAMSAEQHDRVFAA
CCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSHLPHVLSFALVEQILGESDAELKFSYAAGGFRDFTRIAASSPEMWRDVCLANRAALLD
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ELDAYTAVLARLRAAIDAGDGAALEAVFARSRAARAAWRERGAKPAPAVRSDTSGTGSHM
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
EHLDLGPFSHAQGTVRLPGSKSISNRVLLLAALAEGETTVTNLLDSDDTRVMLDALTKLG
HHCCCCCCCCCCCEEECCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCCCHHHHHHHHCC
VKLSRDGGTCVVGGTRGAFTAKTADLFLGNAGTAVRPLTAALAVNGGEYRIHGVPRMHER
EEEECCCCEEEECCCCCCCEEEEHHEEECCCCCCHHHEEEEEEECCCCEEEECCCCHHCC
PIGDLVDGLRQIGARIDYEGNEGFPPLRIRPATISVDAPIRVRGDVSSQFLTALLMTLPL
CHHHHHHHHHHHCCEEECCCCCCCCCEEEEEEEEEECCCEEEECCCHHHHHHHHHHHHCC
VKAKDGASVVEIDGELISKPYIEITIKLMARFGVTVERDGWQRFTVPAGVRYRSPGTIMV
EECCCCCEEEEECHHHHCCCHHHHHHHHHHHHCCEEECCCCEEEECCCCEEECCCCEEEE
EGDASSASYFLAAGALGGGPLRVEGVGRASIQGDVGFANALMQMGANVTMGDDWIEVRGI
ECCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCEECCCEEEEEEC
GHDHGRLAPIDMDFNLIPDAAMTIAVAALFADGPSTLRNIGSWRVKETDRIAAMATELRK
CCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCEECCHHHHHHHHHHHHH
VGATVEEGADYLVVTPPAQLTPNASIDTYDDHRMAMCFSLVSLGGVPVRINDPKCVGKTF
HCCHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCC
PDYFDRFLALANA
HHHHHHHHHHCCC
>Mature Secondary Structure
MLLAAPVAQTGPLLARIAPFLDASTIVTDAGSTKSDVVAAARAALGARIGQFVPGHPIAG
CEEECCCCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
RESSGVDAALADLYVGRNVVLCALPENAPDALARVEAMWRAARADVRAMSAEQHDRVFAA
CCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSHLPHVLSFALVEQILGESDAELKFSYAAGGFRDFTRIAASSPEMWRDVCLANRAALLD
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ELDAYTAVLARLRAAIDAGDGAALEAVFARSRAARAAWRERGAKPAPAVRSDTSGTGSHM
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
EHLDLGPFSHAQGTVRLPGSKSISNRVLLLAALAEGETTVTNLLDSDDTRVMLDALTKLG
HHCCCCCCCCCCCEEECCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCCCHHHHHHHHCC
VKLSRDGGTCVVGGTRGAFTAKTADLFLGNAGTAVRPLTAALAVNGGEYRIHGVPRMHER
EEEECCCCEEEECCCCCCCEEEEHHEEECCCCCCHHHEEEEEEECCCCEEEECCCCHHCC
PIGDLVDGLRQIGARIDYEGNEGFPPLRIRPATISVDAPIRVRGDVSSQFLTALLMTLPL
CHHHHHHHHHHHCCEEECCCCCCCCCEEEEEEEEEECCCEEEECCCHHHHHHHHHHHHCC
VKAKDGASVVEIDGELISKPYIEITIKLMARFGVTVERDGWQRFTVPAGVRYRSPGTIMV
EECCCCCEEEEECHHHHCCCHHHHHHHHHHHHCCEEECCCCEEEECCCCEEECCCCEEEE
EGDASSASYFLAAGALGGGPLRVEGVGRASIQGDVGFANALMQMGANVTMGDDWIEVRGI
ECCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCEECCCEEEEEEC
GHDHGRLAPIDMDFNLIPDAAMTIAVAALFADGPSTLRNIGSWRVKETDRIAAMATELRK
CCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCEECCHHHHHHHHHHHHH
VGATVEEGADYLVVTPPAQLTPNASIDTYDDHRMAMCFSLVSLGGVPVRINDPKCVGKTF
HCCHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCC
PDYFDRFLALANA
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA