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The map label for this gene is murQ2

Identifier: 52788023

GI number: 52788023

Start: 4196558

End: 4197454

Strand: Direct

Name: murQ2

Synonym: BLi04351

Alternate gene names: 52788023

Gene position: 4196558-4197454 (Clockwise)

Preceding gene: 52788022

Following gene: 52788024

Centisome position: 99.38

GC content: 50.5

Gene sequence:

>897_bases
ATGAGGAAGACAGAGAATACGAACGACAAAAGCACAGCACTTGATGAAATGAATGCTTTAGATATCGTCACCTTGATGAA
TGAGGAGGATCACACAGTCCCTCGCGCCATTACGCCCTGCCTTCCCCTGATCGCTGAAGCGGCGGAGACGATTGTCAGCC
GTTTTGAGCAAGGCGGAAGAGTGTTTACCGCAGGCGCCGGCACAAGCGGCAGAATCGCAGTTCTTGATGCCGCGGAACTG
CCGCCGACCTTCTCTATTGACGAGAGCCGTTGGACCGGCCTGATCGCCGGCGGATATGACGCAATGTGGATGCCTCTTGA
AGAAAATGAAGATGACCGTGAAAAAATCGTCGCTGACCTGAAAGCGCAATCATTCTCGAAAGATGACGTCTTAATCGGAG
TCACTGCGAGCGGTTCGACCCCTTATGTCCTCGGCGCTTTATCCTATGCCAAACAGATCGGAGCCGCTTCTGTTTCGATC
AGCTGCAACGCGGATACAGAAGCGGGCAAATTAAGCGATATCGCGATTGAGGTTCAAACAGGACCGGAAATTATCCGCGG
TTCAACGCGGCTGAAAGCAGGAACCGCTCAGAAAATGATCTTGAACATGCTGTCAACAGCGGCAATGGTGAGGCTTGGCC
GCGTCTATCAAAACGAGATGGTGAATATGAGGCTGCTCAATCAAAAATTAGCCGGGCGCGCTGTCACCATTCTGATGAAT
ACCACCGGGTTATCGGAGGATGAGGCTCTGCAAGCTTTAAAAGAAAGCGGCAATGACATCAAGGCAGCGATCTTTATGAC
GTTGACAAACGGAACGCTTGAAGTTGCCCGCCGCTGTTTATCCCATGAAAATGGACATTTGAAAAAAGCGATTCAATATC
ATCGAAAGGGGTTTTAA

Upstream 100 bases:

>100_bases
GCTTGAGCTATTTGGACGACGGCAGACCGTTTGAAGTGGTCAAATCCGTTTACAGAGGCGACCGCTATAAATTCGTCATT
GATATGAAGAGGAAAGACCA

Downstream 100 bases:

>100_bases
CTATGTTGGGATTTCTTCAAAATATCGGCCGCGCGCTCATGCTGCCGATTGCCGTTCTTCCTGCTGCGGGCCTCCTGCTC
GCACTGGGACGGGAAGACCT

Product: N-acetylmuramic acid-6-phosphate etherase

Products: NA

Alternate protein names: MurNAc-6-P etherase 2; N-acetylmuramic acid 6-phosphate hydrolase 2; N-acetylmuramic acid 6-phosphate lyase 2

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MRKTENTNDKSTALDEMNALDIVTLMNEEDHTVPRAITPCLPLIAEAAETIVSRFEQGGRVFTAGAGTSGRIAVLDAAEL
PPTFSIDESRWTGLIAGGYDAMWMPLEENEDDREKIVADLKAQSFSKDDVLIGVTASGSTPYVLGALSYAKQIGAASVSI
SCNADTEAGKLSDIAIEVQTGPEIIRGSTRLKAGTAQKMILNMLSTAAMVRLGRVYQNEMVNMRLLNQKLAGRAVTILMN
TTGLSEDEALQALKESGNDIKAAIFMTLTNGTLEVARRCLSHENGHLKKAIQYHRKGF

Sequences:

>Translated_298_residues
MRKTENTNDKSTALDEMNALDIVTLMNEEDHTVPRAITPCLPLIAEAAETIVSRFEQGGRVFTAGAGTSGRIAVLDAAEL
PPTFSIDESRWTGLIAGGYDAMWMPLEENEDDREKIVADLKAQSFSKDDVLIGVTASGSTPYVLGALSYAKQIGAASVSI
SCNADTEAGKLSDIAIEVQTGPEIIRGSTRLKAGTAQKMILNMLSTAAMVRLGRVYQNEMVNMRLLNQKLAGRAVTILMN
TTGLSEDEALQALKESGNDIKAAIFMTLTNGTLEVARRCLSHENGHLKKAIQYHRKGF
>Mature_298_residues
MRKTENTNDKSTALDEMNALDIVTLMNEEDHTVPRAITPCLPLIAEAAETIVSRFEQGGRVFTAGAGTSGRIAVLDAAEL
PPTFSIDESRWTGLIAGGYDAMWMPLEENEDDREKIVADLKAQSFSKDDVLIGVTASGSTPYVLGALSYAKQIGAASVSI
SCNADTEAGKLSDIAIEVQTGPEIIRGSTRLKAGTAQKMILNMLSTAAMVRLGRVYQNEMVNMRLLNQKLAGRAVTILMN
TTGLSEDEALQALKESGNDIKAAIFMTLTNGTLEVARRCLSHENGHLKKAIQYHRKGF

Specific function: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate

COG id: COG2103

COG function: function code R; Predicted sugar phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1788768, Length=288, Percent_Identity=41.6666666666667, Blast_Score=228, Evalue=4e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURQ2_BACLD (Q65CQ5)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_081416.1
- RefSeq:   YP_093852.1
- HSSP:   P44862
- ProteinModelPortal:   Q65CQ5
- SMR:   Q65CQ5
- STRING:   Q65CQ5
- EnsemblBacteria:   EBBACT00000056678
- EnsemblBacteria:   EBBACT00000061753
- GeneID:   3030099
- GeneID:   3098446
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi04351
- KEGG:   bli:BL00087
- NMPDR:   fig|279010.5.peg.3633
- eggNOG:   COG2103
- GeneTree:   EBGT00050000002902
- HOGENOM:   HBG703490
- OMA:   VENIEDN
- ProtClustDB:   PRK12570
- BioCyc:   BLIC279010-1:BLI04351-MONOMER
- BioCyc:   BLIC279010:BL00087-MONOMER
- HAMAP:   MF_00068
- InterPro:   IPR005561
- InterPro:   IPR005488
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00274

Pfam domain/function: PF03861 ANTAR; PF01380 SIS

EC number: NA

Molecular weight: Translated: 32165; Mature: 32165

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS01272 GCKR; PS51464 SIS

Important sites: ACT_SITE 79-79 ACT_SITE 110-110

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTENTNDKSTALDEMNALDIVTLMNEEDHTVPRAITPCLPLIAEAAETIVSRFEQGGR
CCCCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCE
VFTAGAGTSGRIAVLDAAELPPTFSIDESRWTGLIAGGYDAMWMPLEENEDDREKIVADL
EEEECCCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHH
KAQSFSKDDVLIGVTASGSTPYVLGALSYAKQIGAASVSISCNADTEAGKLSDIAIEVQT
HHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEEEEEEEC
GPEIIRGSTRLKAGTAQKMILNMLSTAAMVRLGRVYQNEMVNMRLLNQKLAGRAVTILMN
CHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
TTGLSEDEALQALKESGNDIKAAIFMTLTNGTLEVARRCLSHENGHLKKAIQYHRKGF
CCCCCHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MRKTENTNDKSTALDEMNALDIVTLMNEEDHTVPRAITPCLPLIAEAAETIVSRFEQGGR
CCCCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCE
VFTAGAGTSGRIAVLDAAELPPTFSIDESRWTGLIAGGYDAMWMPLEENEDDREKIVADL
EEEECCCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHH
KAQSFSKDDVLIGVTASGSTPYVLGALSYAKQIGAASVSISCNADTEAGKLSDIAIEVQT
HHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEEEEEEEC
GPEIIRGSTRLKAGTAQKMILNMLSTAAMVRLGRVYQNEMVNMRLLNQKLAGRAVTILMN
CHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
TTGLSEDEALQALKESGNDIKAAIFMTLTNGTLEVARRCLSHENGHLKKAIQYHRKGF
CCCCCHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA