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The map label for this gene is gntZ [H]

Identifier: 52787966

GI number: 52787966

Start: 4135932

End: 4137335

Strand: Direct

Name: gntZ [H]

Synonym: BLi04289

Alternate gene names: 52787966

Gene position: 4135932-4137335 (Clockwise)

Preceding gene: 52787965

Following gene: 52787967

Centisome position: 97.95

GC content: 51.14

Gene sequence:

>1404_bases
ATGTGCAATACAATCGGTGTCATAGGTTTGGGGGTCATGGGGAGCAATATCGCCCTGAACATGGCAAGCAAAGGCGAACA
AGTCGCCGTCTATAACTACACAAGGGATTTAACCGATCAACTCGTCCAAAAAACGGGAGGCCAAACAGTCAAGCCATACT
ATGAGCTTGAAGATTTCGTACAGTCTTTAGAAAAGCCGCGAAAAATCTTTCTTATGGTCACAGCAGGCAAACCGGTCGAT
TCTGTCATCGACTCGCTCGTCCCTCTGCTTGAAGAAGGGGACGTCATCATGGACGGCGGCAACTCCCACTATGAAGATAC
AGAACGACGATATGACAGTTTGAAAGTGAAAGGAATCGGCTACTTGGGAATCGGCATTTCCGGCGGCGAAATCGGCGCTT
TAAAAGGCCCATCCATTATGCCAGGCGGAGACCGGGACGTCTACGAAAAAGCCGCTCCGATTCTCACAAAAATCGCCGCC
CAAGTGGATGGAGATCCATGCTGTGTCTACATCGGTCCGAAAGGCGCGGGTCATTTTGTCAAAATGGTGCACAACGGCAT
CGAATACGCAGACATGCAGCTCATCGCCGAAGCATATACGTTTTTAAGAGAAAAGCTTCTTTTGCCGATAGATGAAATCG
CTGACATTTTCGACACGTGGAATCAAGGAGAGCTGAACAGCTATTTAATCGAAATCACGGCGGAGATCCTGCGGAAAAAG
GATGAGAAGACGGGCGCTCCACTCATCGACGTCATCCTCGACAAAACCGGCCAAAAAGGCACGGGCAAATGGACGAGCCT
GCAGGCCGTCGACAACGGCATTCCATCATCGATTATCACGGAATCCCTGTTTGCCCGTTACCTGTCATCATTAAAAGACG
AACGGACAGCTGCGGAAAAAGTATTGGCCGGACCTGCAACAGAAGAACGGCGCCTGGATCAAAACGTGTGGATCGACCGC
GTCAGACAGGCATTATATATGGGCAAAATCTGCGCCTATGCACAAGGCTTCGCTCAATACAAAATGACATCTGACCTGAA
CGGATGGAACCTGCCGTTAAAGGACATCGCCCTCATCTTCCGCGGCGGCTGCATCATCCGCGCACAATTTTTAAATCTCA
TCAGCGAGGCGTTCGACAAACAGCCGGACCTGTCCAACCTGCTGGTCGCACCTGACTTCGCTGAAAAACTAAAAGAATAC
CAGTCCGGCTTGCGGAAGGTCGTCTGCGAAGGCATCAGCTCAGGCATCTCATTCCCGTGCCTAAGCACTGCCCTTTCCTA
TTACGACGGCTACCGCACAGGCCGCTCAAACGCAAACCTCCTGCAGGCCCAGCGCGATTATTTCGGCGCTCACACGTATG
AGCGGACGGATATGGAAGGCGTGTTTCATACGGACTGGTATTAA

Upstream 100 bases:

>100_bases
GGACACTGCTTGAAACAATTATCGCGGTGGCCGGATTAGGATTTACTTTATTGTTAAGTCTATTTGTATAAAAAAGTTTT
AGTGAAGGAGCAGGTACTAC

Downstream 100 bases:

>100_bases
AAACTGCACCCCGGATCTCGGGGTGCATTCTTATTTCACTCAAATGGATTTTCATACTTTGTTCAACATTTCACAAACTT
ATATTTCAAATTCGTGCTAT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MCNTIGVIGLGVMGSNIALNMASKGEQVAVYNYTRDLTDQLVQKTGGQTVKPYYELEDFVQSLEKPRKIFLMVTAGKPVD
SVIDSLVPLLEEGDVIMDGGNSHYEDTERRYDSLKVKGIGYLGIGISGGEIGALKGPSIMPGGDRDVYEKAAPILTKIAA
QVDGDPCCVYIGPKGAGHFVKMVHNGIEYADMQLIAEAYTFLREKLLLPIDEIADIFDTWNQGELNSYLIEITAEILRKK
DEKTGAPLIDVILDKTGQKGTGKWTSLQAVDNGIPSSIITESLFARYLSSLKDERTAAEKVLAGPATEERRLDQNVWIDR
VRQALYMGKICAYAQGFAQYKMTSDLNGWNLPLKDIALIFRGGCIIRAQFLNLISEAFDKQPDLSNLLVAPDFAEKLKEY
QSGLRKVVCEGISSGISFPCLSTALSYYDGYRTGRSNANLLQAQRDYFGAHTYERTDMEGVFHTDWY

Sequences:

>Translated_467_residues
MCNTIGVIGLGVMGSNIALNMASKGEQVAVYNYTRDLTDQLVQKTGGQTVKPYYELEDFVQSLEKPRKIFLMVTAGKPVD
SVIDSLVPLLEEGDVIMDGGNSHYEDTERRYDSLKVKGIGYLGIGISGGEIGALKGPSIMPGGDRDVYEKAAPILTKIAA
QVDGDPCCVYIGPKGAGHFVKMVHNGIEYADMQLIAEAYTFLREKLLLPIDEIADIFDTWNQGELNSYLIEITAEILRKK
DEKTGAPLIDVILDKTGQKGTGKWTSLQAVDNGIPSSIITESLFARYLSSLKDERTAAEKVLAGPATEERRLDQNVWIDR
VRQALYMGKICAYAQGFAQYKMTSDLNGWNLPLKDIALIFRGGCIIRAQFLNLISEAFDKQPDLSNLLVAPDFAEKLKEY
QSGLRKVVCEGISSGISFPCLSTALSYYDGYRTGRSNANLLQAQRDYFGAHTYERTDMEGVFHTDWY
>Mature_467_residues
MCNTIGVIGLGVMGSNIALNMASKGEQVAVYNYTRDLTDQLVQKTGGQTVKPYYELEDFVQSLEKPRKIFLMVTAGKPVD
SVIDSLVPLLEEGDVIMDGGNSHYEDTERRYDSLKVKGIGYLGIGISGGEIGALKGPSIMPGGDRDVYEKAAPILTKIAA
QVDGDPCCVYIGPKGAGHFVKMVHNGIEYADMQLIAEAYTFLREKLLLPIDEIADIFDTWNQGELNSYLIEITAEILRKK
DEKTGAPLIDVILDKTGQKGTGKWTSLQAVDNGIPSSIITESLFARYLSSLKDERTAAEKVLAGPATEERRLDQNVWIDR
VRQALYMGKICAYAQGFAQYKMTSDLNGWNLPLKDIALIFRGGCIIRAQFLNLISEAFDKQPDLSNLLVAPDFAEKLKEY
QSGLRKVVCEGISSGISFPCLSTALSYYDGYRTGRSNANLLQAQRDYFGAHTYERTDMEGVFHTDWY

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=465, Percent_Identity=49.6774193548387, Blast_Score=430, Evalue=1e-120,
Organism=Escherichia coli, GI1788341, Length=463, Percent_Identity=55.7235421166307, Blast_Score=534, Evalue=1e-153,
Organism=Escherichia coli, GI1786719, Length=201, Percent_Identity=29.3532338308458, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17542558, Length=466, Percent_Identity=49.1416309012876, Blast_Score=454, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6321695, Length=452, Percent_Identity=49.3362831858407, Blast_Score=448, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6321977, Length=456, Percent_Identity=50.219298245614, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24639279, Length=464, Percent_Identity=50.6465517241379, Blast_Score=431, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51610; Mature: 51610

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCNTIGVIGLGVMGSNIALNMASKGEQVAVYNYTRDLTDQLVQKTGGQTVKPYYELEDFV
CCCCCCEEEECEECCCEEEEECCCCCEEEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHH
QSLEKPRKIFLMVTAGKPVDSVIDSLVPLLEEGDVIMDGGNSHYEDTERRYDSLKVKGIG
HHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCEEEEEEE
YLGIGISGGEIGALKGPSIMPGGDRDVYEKAAPILTKIAAQVDGDPCCVYIGPKGAGHFV
EEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHH
KMVHNGIEYADMQLIAEAYTFLREKLLLPIDEIADIFDTWNQGELNSYLIEITAEILRKK
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
DEKTGAPLIDVILDKTGQKGTGKWTSLQAVDNGIPSSIITESLFARYLSSLKDERTAAEK
CCCCCCCHHHHHHCCCCCCCCCCCEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VLAGPATEERRLDQNVWIDRVRQALYMGKICAYAQGFAQYKMTSDLNGWNLPLKDIALIF
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
RGGCIIRAQFLNLISEAFDKQPDLSNLLVAPDFAEKLKEYQSGLRKVVCEGISSGISFPC
HCCHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LSTALSYYDGYRTGRSNANLLQAQRDYFGAHTYERTDMEGVFHTDWY
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MCNTIGVIGLGVMGSNIALNMASKGEQVAVYNYTRDLTDQLVQKTGGQTVKPYYELEDFV
CCCCCCEEEECEECCCEEEEECCCCCEEEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHH
QSLEKPRKIFLMVTAGKPVDSVIDSLVPLLEEGDVIMDGGNSHYEDTERRYDSLKVKGIG
HHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCEEEEEEE
YLGIGISGGEIGALKGPSIMPGGDRDVYEKAAPILTKIAAQVDGDPCCVYIGPKGAGHFV
EEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHH
KMVHNGIEYADMQLIAEAYTFLREKLLLPIDEIADIFDTWNQGELNSYLIEITAEILRKK
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
DEKTGAPLIDVILDKTGQKGTGKWTSLQAVDNGIPSSIITESLFARYLSSLKDERTAAEK
CCCCCCCHHHHHHCCCCCCCCCCCEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VLAGPATEERRLDQNVWIDRVRQALYMGKICAYAQGFAQYKMTSDLNGWNLPLKDIALIF
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
RGGCIIRAQFLNLISEAFDKQPDLSNLLVAPDFAEKLKEYQSGLRKVVCEGISSGISFPC
HCCHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LSTALSYYDGYRTGRSNANLLQAQRDYFGAHTYERTDMEGVFHTDWY
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8535972 [H]