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The map label for this gene is dltA

Identifier: 52787757

GI number: 52787757

Start: 3903815

End: 3905323

Strand: Direct

Name: dltA

Synonym: BLi04080

Alternate gene names: 52787757

Gene position: 3903815-3905323 (Clockwise)

Preceding gene: 52787756

Following gene: 52787758

Centisome position: 92.45

GC content: 47.32

Gene sequence:

>1509_bases
ATGAAACTGATTGAAACAATTAAAAAATACGCGCAAACACAACCCGATACCCTTGCTTTTGTGAATGAAGAAGAAAAGCT
GACATACGGAGAGCTTTGGTCACAATCTGAGCGCCTTGCCGCAAGGATTCAAAGCGAAGCTTTAACAGATGCTTCTCCGA
TCATTGTCTACGGACATATGAAACCGGTTATGGCGGTTTCCTTCCTGGCTTGTGTAAAAGCCGGGCATCCGTACATTCCA
GTTGACGTATCGATTCCGGCAGACCGGATTCTGAAAATCATCAACAGTTCAAAAGCCGAGCTTCTGCTCAATAATTCAGG
CACTTCGGTTGACACGGGAGATGCCCTCATTTCCGTAGTGGAACCGGGCGTTCTTGAAGGAGACGGGGTGCCGGAGACAG
ATCCCGGACGCTGGGTACATGGGGAAGATACTTTTTACATTATCTACACATCCGGAAGCACGGGAAATCCAAAAGGCGTG
CAAATCTCAGCCGATAACCTTCAGAGCTTCACAGATTGGATCACGAATGACTTTCCGGTGGAAAGCGGCCAAGTGTTCTT
AAATCAAGCCCCGTTTTCCTTTGATTTATCGGTAATGGACCTTTATCCGTGCCTGCAGTCCGGAGGCACCTTATGGACGG
TTACGAAAGACATGATTAATCGGCCGAAACTATTGTTTGAAGCACTGAAACAGTCCAACGTCAACGTCTGGACATCGACG
CCTTCATTCGCACAAATGTGCTTGATGGATCCGTCTTATTCGGAAGAGCTGCTTCCGGAGCTGAGCTTGTTTATGTTCTG
CGGAGAAACGCTTCCTGCGTCAGTCGCCAGACAGCTTAAAGAAAGATTTCCAAAGGCTCGTGTTTTTAACACATACGGCC
CGACCGAAGCGACCGTTGCCGTCACTTCCATCGAAGTAACAGACGACGTATTAAACAAGTATTCTTCTCTTCCCGTCGGT
TCTGAAAAGCCCGAAACCGAAATCGTAATCATCAATGAAGACGGAAAAGCCGTCCAAGACGGGGAAAAAGGCGAGATCAT
AATTACCGGAGCAAGCGTCAGCAAAGGCTATTTAGGCGAAAAAGCGCTGACGGAAAAAGCGTTTTTCTCTTACAACGGCT
CCCCTGCTTACCGCACCGGTGACGCAGGTTACAAAGAAAACGGCCAGCTCTTCTTCCTCGGAAGACTCGATTTCCAAATC
AAACTGCACGGCTACCGGATTGAGCTTGAAGAAATCGAATATCAGATCAATCAGTCCCGATATGTGCAGTCGGCAGTCGT
TATTCCATTCTACCGCGAGGAGAAAATCGAGTATCTGATCGCCATGATTGTGCCTGCCGAACACGATTTCGAAAAGGAAT
ACCAGTTAACCAGCGCGATTAAGAAAGATTTGGGCAGCAAGCTGCCGGCCTATATGATTCCGAGAAAATTCATGTATCAA
AAAGAGATTCCGATGACAGCAAACGGTAAAATCGACCGCAAGAGATTAAAAGAAGAGGTAACCGTATGA

Upstream 100 bases:

>100_bases
ATTACTTTCTCATTCTGGTGCTGCTGTTTTTAATTTACGGATTCCATACAGCAAATACAGGTTCATATATTTATAATGAC
TTTTAATGGAGAAGAAAACA

Downstream 100 bases:

>100_bases
CGCCTTATGGTTCATTTCTTTTCTTCATTATATTAGGAATTTTACTGGCGCCGACCATCATTCTCGGACTGAACGGAAAA
AGCTTCCGCTTATATAATAT

Product: D-alanine--poly(phosphoribitol) ligase subunit 1

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MKLIETIKKYAQTQPDTLAFVNEEEKLTYGELWSQSERLAARIQSEALTDASPIIVYGHMKPVMAVSFLACVKAGHPYIP
VDVSIPADRILKIINSSKAELLLNNSGTSVDTGDALISVVEPGVLEGDGVPETDPGRWVHGEDTFYIIYTSGSTGNPKGV
QISADNLQSFTDWITNDFPVESGQVFLNQAPFSFDLSVMDLYPCLQSGGTLWTVTKDMINRPKLLFEALKQSNVNVWTST
PSFAQMCLMDPSYSEELLPELSLFMFCGETLPASVARQLKERFPKARVFNTYGPTEATVAVTSIEVTDDVLNKYSSLPVG
SEKPETEIVIINEDGKAVQDGEKGEIIITGASVSKGYLGEKALTEKAFFSYNGSPAYRTGDAGYKENGQLFFLGRLDFQI
KLHGYRIELEEIEYQINQSRYVQSAVVIPFYREEKIEYLIAMIVPAEHDFEKEYQLTSAIKKDLGSKLPAYMIPRKFMYQ
KEIPMTANGKIDRKRLKEEVTV

Sequences:

>Translated_502_residues
MKLIETIKKYAQTQPDTLAFVNEEEKLTYGELWSQSERLAARIQSEALTDASPIIVYGHMKPVMAVSFLACVKAGHPYIP
VDVSIPADRILKIINSSKAELLLNNSGTSVDTGDALISVVEPGVLEGDGVPETDPGRWVHGEDTFYIIYTSGSTGNPKGV
QISADNLQSFTDWITNDFPVESGQVFLNQAPFSFDLSVMDLYPCLQSGGTLWTVTKDMINRPKLLFEALKQSNVNVWTST
PSFAQMCLMDPSYSEELLPELSLFMFCGETLPASVARQLKERFPKARVFNTYGPTEATVAVTSIEVTDDVLNKYSSLPVG
SEKPETEIVIINEDGKAVQDGEKGEIIITGASVSKGYLGEKALTEKAFFSYNGSPAYRTGDAGYKENGQLFFLGRLDFQI
KLHGYRIELEEIEYQINQSRYVQSAVVIPFYREEKIEYLIAMIVPAEHDFEKEYQLTSAIKKDLGSKLPAYMIPRKFMYQ
KEIPMTANGKIDRKRLKEEVTV
>Mature_502_residues
MKLIETIKKYAQTQPDTLAFVNEEEKLTYGELWSQSERLAARIQSEALTDASPIIVYGHMKPVMAVSFLACVKAGHPYIP
VDVSIPADRILKIINSSKAELLLNNSGTSVDTGDALISVVEPGVLEGDGVPETDPGRWVHGEDTFYIIYTSGSTGNPKGV
QISADNLQSFTDWITNDFPVESGQVFLNQAPFSFDLSVMDLYPCLQSGGTLWTVTKDMINRPKLLFEALKQSNVNVWTST
PSFAQMCLMDPSYSEELLPELSLFMFCGETLPASVARQLKERFPKARVFNTYGPTEATVAVTSIEVTDDVLNKYSSLPVG
SEKPETEIVIINEDGKAVQDGEKGEIIITGASVSKGYLGEKALTEKAFFSYNGSPAYRTGDAGYKENGQLFFLGRLDFQI
KLHGYRIELEEIEYQINQSRYVQSAVVIPFYREEKIEYLIAMIVPAEHDFEKEYQLTSAIKKDLGSKLPAYMIPRKFMYQ
KEIPMTANGKIDRKRLKEEVTV

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily

Homologues:

Organism=Homo sapiens, GI45580730, Length=371, Percent_Identity=25.6064690026954, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI156151445, Length=371, Percent_Identity=25.8760107816712, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI42544132, Length=546, Percent_Identity=23.2600732600733, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38505220, Length=368, Percent_Identity=22.8260869565217, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI115511026, Length=535, Percent_Identity=22.803738317757, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786801, Length=511, Percent_Identity=27.2015655577299, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI145693145, Length=528, Percent_Identity=21.969696969697, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI221142682, Length=501, Percent_Identity=21.9560878243513, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17550940, Length=438, Percent_Identity=25.3424657534247, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17557194, Length=363, Percent_Identity=26.9972451790634, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI32563687, Length=510, Percent_Identity=23.3333333333333, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17531443, Length=377, Percent_Identity=24.6684350132626, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17556356, Length=360, Percent_Identity=26.1111111111111, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71985884, Length=386, Percent_Identity=24.8704663212435, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI32564422, Length=420, Percent_Identity=23.5714285714286, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI32564420, Length=420, Percent_Identity=23.5714285714286, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17558820, Length=510, Percent_Identity=22.7450980392157, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17560308, Length=351, Percent_Identity=24.2165242165242, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17538037, Length=371, Percent_Identity=26.4150943396226, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319591, Length=561, Percent_Identity=24.0641711229947, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319699, Length=383, Percent_Identity=24.8041775456919, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24648676, Length=465, Percent_Identity=27.5268817204301, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21355181, Length=369, Percent_Identity=26.0162601626016, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI18859661, Length=377, Percent_Identity=24.1379310344828, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24648260, Length=515, Percent_Identity=22.3300970873786, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24582852, Length=365, Percent_Identity=24.1095890410959, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24653035, Length=373, Percent_Identity=23.5924932975871, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356947, Length=524, Percent_Identity=21.3740458015267, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648253, Length=429, Percent_Identity=22.6107226107226, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24648255, Length=429, Percent_Identity=22.6107226107226, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DLTA_BACLD (Q65DH1)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_081158.1
- RefSeq:   YP_093586.1
- HSSP:   P0C061
- ProteinModelPortal:   Q65DH1
- STRING:   Q65DH1
- EnsemblBacteria:   EBBACT00000058165
- EnsemblBacteria:   EBBACT00000060547
- GeneID:   3028795
- GeneID:   3101368
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi04080
- KEGG:   bli:BL03934
- NMPDR:   fig|279010.5.peg.3295
- eggNOG:   COG1020
- GeneTree:   EBGT00070000032008
- HOGENOM:   HBG320748
- OMA:   PNERITQ
- ProtClustDB:   PRK04813
- BioCyc:   BLIC279010-1:BLI04080-MONOMER
- BioCyc:   BLIC279010:BL03934-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00593
- InterPro:   IPR010071
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010072
- PANTHER:   PTHR11968:SF34
- TIGRFAMs:   TIGR01733
- TIGRFAMs:   TIGR01734

Pfam domain/function: PF00501 AMP-binding

EC number: =6.1.1.13

Molecular weight: Translated: 56010; Mature: 56010

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIETIKKYAQTQPDTLAFVNEEEKLTYGELWSQSERLAARIQSEALTDASPIIVYGHM
CCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHCHHHHHHHHHHHHHCCCCCCEEEEECC
KPVMAVSFLACVKAGHPYIPVDVSIPADRILKIINSSKAELLLNNSGTSVDTGDALISVV
CHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHH
EPGVLEGDGVPETDPGRWVHGEDTFYIIYTSGSTGNPKGVQISADNLQSFTDWITNDFPV
CCCEECCCCCCCCCCCCEECCCCEEEEEEECCCCCCCCCEEEEHHHHHHHHHHHCCCCCC
ESGQVFLNQAPFSFDLSVMDLYPCLQSGGTLWTVTKDMINRPKLLFEALKQSNVNVWTST
CCCEEEEECCCCEECCHHHHHHHHHHCCCEEEEEEHHHHCCHHHHHHHHHHCCCEEEECC
PSFAQMCLMDPSYSEELLPELSLFMFCGETLPASVARQLKERFPKARVFNTYGPTEATVA
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCCEEEE
VTSIEVTDDVLNKYSSLPVGSEKPETEIVIINEDGKAVQDGEKGEIIITGASVSKGYLGE
EEEEECCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCC
KALTEKAFFSYNGSPAYRTGDAGYKENGQLFFLGRLDFQIKLHGYRIELEEIEYQINQSR
HHHHHHHHEEECCCCCEECCCCCCCCCCCEEEEEEEEEEEEEEEEEEEHHHHHHHHCHHH
YVQSAVVIPFYREEKIEYLIAMIVPAEHDFEKEYQLTSAIKKDLGSKLPAYMIPRKFMYQ
HEEEEEEEEEHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHCCHHHHHH
KEIPMTANGKIDRKRLKEEVTV
CCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MKLIETIKKYAQTQPDTLAFVNEEEKLTYGELWSQSERLAARIQSEALTDASPIIVYGHM
CCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHCHHHHHHHHHHHHHCCCCCCEEEEECC
KPVMAVSFLACVKAGHPYIPVDVSIPADRILKIINSSKAELLLNNSGTSVDTGDALISVV
CHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHH
EPGVLEGDGVPETDPGRWVHGEDTFYIIYTSGSTGNPKGVQISADNLQSFTDWITNDFPV
CCCEECCCCCCCCCCCCEECCCCEEEEEEECCCCCCCCCEEEEHHHHHHHHHHHCCCCCC
ESGQVFLNQAPFSFDLSVMDLYPCLQSGGTLWTVTKDMINRPKLLFEALKQSNVNVWTST
CCCEEEEECCCCEECCHHHHHHHHHHCCCEEEEEEHHHHCCHHHHHHHHHHCCCEEEECC
PSFAQMCLMDPSYSEELLPELSLFMFCGETLPASVARQLKERFPKARVFNTYGPTEATVA
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCCEEEE
VTSIEVTDDVLNKYSSLPVGSEKPETEIVIINEDGKAVQDGEKGEIIITGASVSKGYLGE
EEEEECCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCC
KALTEKAFFSYNGSPAYRTGDAGYKENGQLFFLGRLDFQIKLHGYRIELEEIEYQINQSR
HHHHHHHHEEECCCCCEECCCCCCCCCCCEEEEEEEEEEEEEEEEEEEHHHHHHHHCHHH
YVQSAVVIPFYREEKIEYLIAMIVPAEHDFEKEYQLTSAIKKDLGSKLPAYMIPRKFMYQ
HEEEEEEEEEHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHCCHHHHHH
KEIPMTANGKIDRKRLKEEVTV
CCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA