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The map label for this gene is tdk

Identifier: 52787632

GI number: 52787632

Start: 3779017

End: 3779601

Strand: Reverse

Name: tdk

Synonym: BLi03954

Alternate gene names: 52787632

Gene position: 3779601-3779017 (Counterclockwise)

Preceding gene: 52787633

Following gene: 229312736

Centisome position: 89.51

GC content: 51.45

Gene sequence:

>585_bases
ATGTACATCATGAAGCAAAGCGGCTGGCTTGAACTCATATGCGGAAGCATGTTTTCGGGCAAATCAGAGGAGCTCATCCG
CCGGATCAAAAGGGCGACGTTTGCGAAGCAGGAAGTCAAAGTGTTTAAACCAGCCATTGATAATCGCTACAGCAGCGAAT
CGGTTGTATCGCATAATGGGACATCCATTGTGTGCCATGCCATCGCATCTCCGGAAGAAATTTTTCAATACATAAGCAAA
GAAACGGATGTCATCGGCGTCGATGAAGTGCAGTTTTTTGACGAAACGATTGTCGGCACGTTAACTTCTCTGGCTGATCA
GGGCTACCGTGTGATTGCAGCAGGCCTTGATTTGGATTTCCGGGGCGAGCCTTTCGGCGTCGTGCCCGATCTGATGGCTT
TAGCGGAAACGGTGACCAAGCTGCAAGCCGTGTGCTCTGTCTGCGGATCTCCAGCCAGCCGCACGCAGAGGCTGATCAAT
GGAAAACCTGCTTCTTATGACGATCCGGTCATTTTGGTTGGGGCCTCCGAAGCATATGAAGCGCGCTGCCGCCACCATCA
TGAAGTGCCTGGAAACCCGAAATGA

Upstream 100 bases:

>100_bases
CAAAAAATACGGTCTTAAGTAATAATAGATATGATAAACAGGCAGGGATTCTTCTTGCCTGTTTTTTACTTGCAATAATT
GCTGGAGAGGAGTTAGTTGG

Downstream 100 bases:

>100_bases
AATCGGAAAAACATATAGATTTTCACTCGAAAACACTTGGTAAAAACAAGTGTTTTTTTTATTGAATCCTTTTTGCGGGA
ATTAATGTAATTAAAAAACT

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MYIMKQSGWLELICGSMFSGKSEELIRRIKRATFAKQEVKVFKPAIDNRYSSESVVSHNGTSIVCHAIASPEEIFQYISK
ETDVIGVDEVQFFDETIVGTLTSLADQGYRVIAAGLDLDFRGEPFGVVPDLMALAETVTKLQAVCSVCGSPASRTQRLIN
GKPASYDDPVILVGASEAYEARCRHHHEVPGNPK

Sequences:

>Translated_194_residues
MYIMKQSGWLELICGSMFSGKSEELIRRIKRATFAKQEVKVFKPAIDNRYSSESVVSHNGTSIVCHAIASPEEIFQYISK
ETDVIGVDEVQFFDETIVGTLTSLADQGYRVIAAGLDLDFRGEPFGVVPDLMALAETVTKLQAVCSVCGSPASRTQRLIN
GKPASYDDPVILVGASEAYEARCRHHHEVPGNPK
>Mature_194_residues
MYIMKQSGWLELICGSMFSGKSEELIRRIKRATFAKQEVKVFKPAIDNRYSSESVVSHNGTSIVCHAIASPEEIFQYISK
ETDVIGVDEVQFFDETIVGTLTSLADQGYRVIAAGLDLDFRGEPFGVVPDLMALAETVTKLQAVCSVCGSPASRTQRLIN
GKPASYDDPVILVGASEAYEARCRHHHEVPGNPK

Specific function: Phosphorylates Both Thymidine And Deoxyuridine. [C]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family

Homologues:

Organism=Homo sapiens, GI164698438, Length=194, Percent_Identity=37.1134020618557, Blast_Score=108, Evalue=3e-24,
Organism=Escherichia coli, GI1787490, Length=180, Percent_Identity=29.4444444444444, Blast_Score=65, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17543396, Length=183, Percent_Identity=32.7868852459016, Blast_Score=90, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KITH_BACLD (Q65DU6)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_081031.1
- RefSeq:   YP_093461.1
- ProteinModelPortal:   Q65DU6
- SMR:   Q65DU6
- STRING:   Q65DU6
- EnsemblBacteria:   EBBACT00000056833
- EnsemblBacteria:   EBBACT00000062181
- GeneID:   3027778
- GeneID:   3101344
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi03954
- KEGG:   bli:BL03975
- NMPDR:   fig|279010.5.peg.4091
- eggNOG:   COG1435
- GeneTree:   EBGT00050000002762
- HOGENOM:   HBG522108
- OMA:   NEIRSTP
- ProtClustDB:   PRK04296
- BioCyc:   BLIC279010-1:BLI03954-MONOMER
- BioCyc:   BLIC279010:BL03975-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00124
- InterPro:   IPR001267
- InterPro:   IPR020633
- InterPro:   IPR020634
- PANTHER:   PTHR11441
- PIRSF:   PIRSF035805

Pfam domain/function: PF00265 TK

EC number: =2.7.1.21

Molecular weight: Translated: 21298; Mature: 21298

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: ACT_SITE 89-89

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIMKQSGWLELICGSMFSGKSEELIRRIKRATFAKQEVKVFKPAIDNRYSSESVVSHNG
CEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCC
TSIVCHAIASPEEIFQYISKETDVIGVDEVQFFDETIVGTLTSLADQGYRVIAAGLDLDF
CEEEEEECCCHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
RGEPFGVVPDLMALAETVTKLQAVCSVCGSPASRTQRLINGKPASYDDPVILVGASEAYE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEECCHHHH
ARCRHHHEVPGNPK
HHHHHCCCCCCCCC
>Mature Secondary Structure
MYIMKQSGWLELICGSMFSGKSEELIRRIKRATFAKQEVKVFKPAIDNRYSSESVVSHNG
CEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCC
TSIVCHAIASPEEIFQYISKETDVIGVDEVQFFDETIVGTLTSLADQGYRVIAAGLDLDF
CEEEEEECCCHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
RGEPFGVVPDLMALAETVTKLQAVCSVCGSPASRTQRLINGKPASYDDPVILVGASEAYE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEECCHHHH
ARCRHHHEVPGNPK
HHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA