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The map label for this gene is fumC [H]

Identifier: 52787177

GI number: 52787177

Start: 3326807

End: 3328195

Strand: Reverse

Name: fumC [H]

Synonym: BLi03486

Alternate gene names: 52787177

Gene position: 3328195-3326807 (Counterclockwise)

Preceding gene: 52787178

Following gene: 52787175

Centisome position: 78.82

GC content: 49.17

Gene sequence:

>1389_bases
GTGGACTACAGAATTGAAAAAGATACGATGGGTGAAGTCAAGGTTCCCGCGGATAAGTTTTGGGGAGCCCAAACCCAAAG
AAGCAAGGAGAACTTTAAAATCGGTTCCGAGAAAATGCCGCAGGAAATTGTGTATGCGTTTGCAATCTTGAAAAGAAGCG
CTGCGATTGCCAATGAAAAGCTTGGAAATCTTGAGGCGGAAAAAAAGGAAGCGATTGTTTCCGTATGCGATGATATTTTA
GAAGGAAAGTATGACAGCCATTTTCCGCTGGTCGTCTGGCAGACCGGCAGCGGAACACAGAGCAACATGAATATGAATGA
AGTTGTGGCAAACAGGGGAACGGCTTATTTGCAGGAAAAAGGATCAAGCCTGAAAATCCACCCGAATGATGATGTCAACC
GCAGCCAAAGCTCTAACGACACATTCCCGACAGCTATGCACGTGGCAGCTGTCCTCGCGATTCACGATAAACTGATTCCG
GCGATTGACCGGTTGAGAAGCACGCTGCATGAAAAAGCTGAAGCTTTCAAAGACATTGTCAAAATCGGCCGCACTCATTT
GCAGGATGCGACACCGCTGACATTGGGACAGGAAATCAGCGGCTGGGTATACATGCTGGACCGCTCTAAAGAGATGATTC
TTGAAGCTGCTGAAAAAATCCGCGATCTTGCCATCGGCGGAACTGCCGTCGGAACAGGCATTAATGCCCACCCTGAATTC
GGCAGCACCGTTGCCGAAGAGATCAGCGCTCTGACCGGGCAGACATTCAAAAGCTCGCCTAATAAGTTTCATGCGCTGAC
AAGCCATGATGAACTGACACACGTGCATGGGGCGCTTAAAGCGCTTGCGGCAGATCTCATGAAAATCGCCAATGATGTCA
GATGGCTTGCGAGCGGACCTCGCTGCGGAATCGGCGAGCTGCTTATCCCGGAAAATGAGCCGGGAAGCTCGATCATGCCT
GGAAAAGTAAACCCTACGCAAAGCGAAGCGCTGACAATGGTCGCATCCCAGATCATGGGGAATGACGCAACGATCGGCTT
TGCCGCGAGCCAGGGGAACTTTGAACTGAACGTCTTTAAACCTGTGATTATTTACAACTTCCTCCAATCCGTTCAGCTTC
TTGCCGACGGCATGAATTCATTCCATGACAAGTGTGCTGTAGGAATCGAACCTAATCGGGAAACAATTGAGAAGAACCTG
ACCAACTCTCTCATGCTGGTTACGGCTCTAAACCCGCATATCGGATACGAAAATGCTGCGAAAATCGCGAAGCTGGCTCA
TAAAGAGGGGCTGACGCTGAAAGAAGCGGCTCTCAAGCTGAACCTTTTGACAGAGGAGCAGTTCGACGAAGTTGTTAAAC
CTGAAGAAATGGTGAAACCGAAAGCATAA

Upstream 100 bases:

>100_bases
AGCTAAAATTAAAATAAAGATAAAATTTAAATGGAAGGGTTTTATCGATTTTTATCGAAATATAGAATATTGCAGAATTA
GAGAAGGAAGGGATAAGAAA

Downstream 100 bases:

>100_bases
TCAACAAACCGGCTGCATGCATTGCAGCCGGTTTTGTTTTGCGGATCATCCGTGCGGATGGTGCATGTCTTTTTTGAGCA
ATTCGGCGAGTTTGTCCGTT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MDYRIEKDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPQEIVYAFAILKRSAAIANEKLGNLEAEKKEAIVSVCDDIL
EGKYDSHFPLVVWQTGSGTQSNMNMNEVVANRGTAYLQEKGSSLKIHPNDDVNRSQSSNDTFPTAMHVAAVLAIHDKLIP
AIDRLRSTLHEKAEAFKDIVKIGRTHLQDATPLTLGQEISGWVYMLDRSKEMILEAAEKIRDLAIGGTAVGTGINAHPEF
GSTVAEEISALTGQTFKSSPNKFHALTSHDELTHVHGALKALAADLMKIANDVRWLASGPRCGIGELLIPENEPGSSIMP
GKVNPTQSEALTMVASQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLADGMNSFHDKCAVGIEPNRETIEKNL
TNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLNLLTEEQFDEVVKPEEMVKPKA

Sequences:

>Translated_462_residues
MDYRIEKDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPQEIVYAFAILKRSAAIANEKLGNLEAEKKEAIVSVCDDIL
EGKYDSHFPLVVWQTGSGTQSNMNMNEVVANRGTAYLQEKGSSLKIHPNDDVNRSQSSNDTFPTAMHVAAVLAIHDKLIP
AIDRLRSTLHEKAEAFKDIVKIGRTHLQDATPLTLGQEISGWVYMLDRSKEMILEAAEKIRDLAIGGTAVGTGINAHPEF
GSTVAEEISALTGQTFKSSPNKFHALTSHDELTHVHGALKALAADLMKIANDVRWLASGPRCGIGELLIPENEPGSSIMP
GKVNPTQSEALTMVASQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLADGMNSFHDKCAVGIEPNRETIEKNL
TNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLNLLTEEQFDEVVKPEEMVKPKA
>Mature_462_residues
MDYRIEKDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPQEIVYAFAILKRSAAIANEKLGNLEAEKKEAIVSVCDDIL
EGKYDSHFPLVVWQTGSGTQSNMNMNEVVANRGTAYLQEKGSSLKIHPNDDVNRSQSSNDTFPTAMHVAAVLAIHDKLIP
AIDRLRSTLHEKAEAFKDIVKIGRTHLQDATPLTLGQEISGWVYMLDRSKEMILEAAEKIRDLAIGGTAVGTGINAHPEF
GSTVAEEISALTGQTFKSSPNKFHALTSHDELTHVHGALKALAADLMKIANDVRWLASGPRCGIGELLIPENEPGSSIMP
GKVNPTQSEALTMVASQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLADGMNSFHDKCAVGIEPNRETIEKNL
TNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLNLLTEEQFDEVVKPEEMVKPKA

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=57.5757575757576, Blast_Score=535, Evalue=1e-152,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=64.6929824561403, Blast_Score=600, Evalue=1e-173,
Organism=Escherichia coli, GI87082375, Length=463, Percent_Identity=38.8768898488121, Blast_Score=333, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=58.7852494577007, Blast_Score=558, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=60.5504587155963, Blast_Score=411, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=57.9175704989154, Blast_Score=549, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=56.4655172413793, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=56.4655172413793, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=54.9568965517241, Blast_Score=526, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=52.258064516129, Blast_Score=495, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24583245, Length=465, Percent_Identity=47.3118279569892, Blast_Score=436, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50498; Mature: 50498

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYRIEKDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPQEIVYAFAILKRSAAIANEK
CCCCCCCCCCCCEECCHHHHCCCCHHCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LGNLEAEKKEAIVSVCDDILEGKYDSHFPLVVWQTGSGTQSNMNMNEVVANRGTAYLQEK
HCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHCC
GSSLKIHPNDDVNRSQSSNDTFPTAMHVAAVLAIHDKLIPAIDRLRSTLHEKAEAFKDIV
CCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEISGWVYMLDRSKEMILEAAEKIRDLAIGGTAVGTGINAHPEF
HHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCC
GSTVAEEISALTGQTFKSSPNKFHALTSHDELTHVHGALKALAADLMKIANDVRWLASGP
CHHHHHHHHHHHCCHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RCGIGELLIPENEPGSSIMPGKVNPTQSEALTMVASQIMGNDATIGFAASQGNFELNVFK
CCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHH
PVIIYNFLQSVQLLADGMNSFHDKCAVGIEPNRETIEKNLTNSLMLVTALNPHIGYENAA
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHH
KIAKLAHKEGLTLKEAALKLNLLTEEQFDEVVKPEEMVKPKA
HHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHCCCHHHCCCCC
>Mature Secondary Structure
MDYRIEKDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPQEIVYAFAILKRSAAIANEK
CCCCCCCCCCCCEECCHHHHCCCCHHCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LGNLEAEKKEAIVSVCDDILEGKYDSHFPLVVWQTGSGTQSNMNMNEVVANRGTAYLQEK
HCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHCC
GSSLKIHPNDDVNRSQSSNDTFPTAMHVAAVLAIHDKLIPAIDRLRSTLHEKAEAFKDIV
CCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEISGWVYMLDRSKEMILEAAEKIRDLAIGGTAVGTGINAHPEF
HHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCC
GSTVAEEISALTGQTFKSSPNKFHALTSHDELTHVHGALKALAADLMKIANDVRWLASGP
CHHHHHHHHHHHCCHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RCGIGELLIPENEPGSSIMPGKVNPTQSEALTMVASQIMGNDATIGFAASQGNFELNVFK
CCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHH
PVIIYNFLQSVQLLADGMNSFHDKCAVGIEPNRETIEKNLTNSLMLVTALNPHIGYENAA
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHH
KIAKLAHKEGLTLKEAALKLNLLTEEQFDEVVKPEEMVKPKA
HHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3923430; 9639930; 9384377; 2998952; 2509423; 9353931 [H]