Click here to switch to the map view.

The map label for this gene is gyaR [H]

Identifier: 52787107

GI number: 52787107

Start: 3261729

End: 3262691

Strand: Reverse

Name: gyaR [H]

Synonym: BLi03415

Alternate gene names: 52787107

Gene position: 3262691-3261729 (Counterclockwise)

Preceding gene: 52787108

Following gene: 52787106

Centisome position: 77.27

GC content: 51.4

Gene sequence:

>963_bases
ATGGACAAACCGTTTGTATATGTGACGAGAAAATTACCTGAAGAACAGCTTTCTGCGTTAAAAGAAGAAGCCCATATTGA
AATGTGGGAAAAGGAAGAAGAACCGTGTCCGCGCGCCATTCTGAAAGAAAAAGCAAAAAAGGCGCACGGACTGTTGACGA
TGCTTTCCGACACGATTGATGAGGAGCTTTTAAAAGGCGCGCCGCATTTAAAAGTCGTGGCCAACTTGGCGGTAGGCTAT
GACAACATCGATGTGGAGGCTGCGCAAAAGCATCGCGTCATCTGCTGCAACACGCCTGGCGTGCTGACAGAGTCAACGGC
AGATTTGACGTTTGCTCTGCTGATGGCATCCGCCCGCAGAATCGTCGAAGCGAGCGACTGGATTAGACAAGGGAAGTGGA
CGGGCTGGGGTCCTCTGCTTTTGGCCGGTGCGGATGTCCATCATAAAACGATCGGCATTGTCGGGATGGGGAGCATCGGA
CAAGCCGTCGCCCGGCGTGCGAAAGGCTTCGGCATGAAAATTTTATATCATAACCGCACCCGCAATCCAGATGCAGAAGC
AGAACTGGGCGCATCCTATCTGCCCTTCGATGAACTGCTTGAACAGGCGGATTTTGTTGTCTGCCTGACACCTCTGACTC
ATGAAACGAAGCATCTGTTTAACCGCAGCGCTTTTAAAAAGATGAAGCGCTCCGCTATTTTTATCAATGTCTCAAGAGGA
CAGGTTGTCAATGAAGACGATTTATATGAAGCGCTGGTCGAAAAAGATATTGCCGGCGCAGGACTCGACGTCTTTGCGGA
AGAACCTGTGCAAAAGGATCACCCGCTCGTCAGCCTGCCGCAAGTCACCGCGCTGCCTCACATCGGCAGCGCCGCCGTCG
AAACGAGAGAAGCCATGATGAGGCTTTGTGCGGAAAATATTGCGCTTGTCCTGAGAGGAAAGCAGGCAAAGACCGAGATT
TGA

Upstream 100 bases:

>100_bases
GGACACCATAGCTTCGCGGTGTTCTTTTCTTCTGTTAACATTTTCGGATTTTTTCGATATGCTTAGAGTGGAAGCTACTC
TTAGAAAGGAACGAGGCAGC

Downstream 100 bases:

>100_bases
CGTTTCTTCCGGCTGCCCTGAGCGGCTCGGAAGATTTTCTTACAAAAATATTTCTGAATATATAGAATCTTATTATATCA
ACGACTAAAGCGTTTTCACG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MDKPFVYVTRKLPEEQLSALKEEAHIEMWEKEEEPCPRAILKEKAKKAHGLLTMLSDTIDEELLKGAPHLKVVANLAVGY
DNIDVEAAQKHRVICCNTPGVLTESTADLTFALLMASARRIVEASDWIRQGKWTGWGPLLLAGADVHHKTIGIVGMGSIG
QAVARRAKGFGMKILYHNRTRNPDAEAELGASYLPFDELLEQADFVVCLTPLTHETKHLFNRSAFKKMKRSAIFINVSRG
QVVNEDDLYEALVEKDIAGAGLDVFAEEPVQKDHPLVSLPQVTALPHIGSAAVETREAMMRLCAENIALVLRGKQAKTEI

Sequences:

>Translated_320_residues
MDKPFVYVTRKLPEEQLSALKEEAHIEMWEKEEEPCPRAILKEKAKKAHGLLTMLSDTIDEELLKGAPHLKVVANLAVGY
DNIDVEAAQKHRVICCNTPGVLTESTADLTFALLMASARRIVEASDWIRQGKWTGWGPLLLAGADVHHKTIGIVGMGSIG
QAVARRAKGFGMKILYHNRTRNPDAEAELGASYLPFDELLEQADFVVCLTPLTHETKHLFNRSAFKKMKRSAIFINVSRG
QVVNEDDLYEALVEKDIAGAGLDVFAEEPVQKDHPLVSLPQVTALPHIGSAAVETREAMMRLCAENIALVLRGKQAKTEI
>Mature_320_residues
MDKPFVYVTRKLPEEQLSALKEEAHIEMWEKEEEPCPRAILKEKAKKAHGLLTMLSDTIDEELLKGAPHLKVVANLAVGY
DNIDVEAAQKHRVICCNTPGVLTESTADLTFALLMASARRIVEASDWIRQGKWTGWGPLLLAGADVHHKTIGIVGMGSIG
QAVARRAKGFGMKILYHNRTRNPDAEAELGASYLPFDELLEQADFVVCLTPLTHETKHLFNRSAFKKMKRSAIFINVSRG
QVVNEDDLYEALVEKDIAGAGLDVFAEEPVQKDHPLVSLPQVTALPHIGSAAVETREAMMRLCAENIALVLRGKQAKTEI

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=319, Percent_Identity=43.2601880877743, Blast_Score=260, Evalue=9e-70,
Organism=Homo sapiens, GI23308577, Length=294, Percent_Identity=33.3333333333333, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI61743967, Length=266, Percent_Identity=31.203007518797, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4557497, Length=266, Percent_Identity=31.203007518797, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI145580578, Length=267, Percent_Identity=31.4606741573034, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4557499, Length=267, Percent_Identity=31.4606741573034, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI145580575, Length=262, Percent_Identity=31.6793893129771, Blast_Score=122, Evalue=6e-28,
Organism=Escherichia coli, GI87082289, Length=320, Percent_Identity=43.125, Blast_Score=246, Evalue=1e-66,
Organism=Escherichia coli, GI1787645, Length=271, Percent_Identity=30.2583025830258, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789279, Length=283, Percent_Identity=30.0353356890459, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87081824, Length=267, Percent_Identity=27.7153558052434, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=258, Percent_Identity=33.7209302325581, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI25147481, Length=259, Percent_Identity=28.957528957529, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=262, Percent_Identity=38.5496183206107, Blast_Score=169, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6320925, Length=321, Percent_Identity=27.1028037383178, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322116, Length=287, Percent_Identity=28.9198606271777, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=277, Percent_Identity=25.2707581227437, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6325144, Length=166, Percent_Identity=33.1325301204819, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=173, Percent_Identity=32.3699421965318, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=162, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28571528, Length=318, Percent_Identity=41.8238993710692, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI45551003, Length=306, Percent_Identity=39.8692810457516, Blast_Score=214, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24585514, Length=306, Percent_Identity=39.8692810457516, Blast_Score=214, Evalue=5e-56,
Organism=Drosophila melanogaster, GI28574282, Length=306, Percent_Identity=39.8692810457516, Blast_Score=214, Evalue=5e-56,
Organism=Drosophila melanogaster, GI28574284, Length=306, Percent_Identity=39.8692810457516, Blast_Score=214, Evalue=5e-56,
Organism=Drosophila melanogaster, GI45552429, Length=306, Percent_Identity=39.8692810457516, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI28574286, Length=317, Percent_Identity=38.4858044164038, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24585516, Length=254, Percent_Identity=37.007874015748, Blast_Score=177, Evalue=6e-45,
Organism=Drosophila melanogaster, GI19921140, Length=255, Percent_Identity=35.6862745098039, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24646446, Length=281, Percent_Identity=31.6725978647687, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646448, Length=281, Percent_Identity=31.6725978647687, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646452, Length=281, Percent_Identity=31.6725978647687, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646450, Length=281, Percent_Identity=31.6725978647687, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI62472511, Length=257, Percent_Identity=32.6848249027237, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35378; Mature: 35378

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKPFVYVTRKLPEEQLSALKEEAHIEMWEKEEEPCPRAILKEKAKKAHGLLTMLSDTID
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EELLKGAPHLKVVANLAVGYDNIDVEAAQKHRVICCNTPGVLTESTADLTFALLMASARR
HHHHCCCCCHHHHHHHHHCCCCCCCEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHH
IVEASDWIRQGKWTGWGPLLLAGADVHHKTIGIVGMGSIGQAVARRAKGFGMKILYHNRT
HHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEEECCHHHHHHHHHHCCCCEEEEEECCC
RNPDAEAELGASYLPFDELLEQADFVVCLTPLTHETKHLFNRSAFKKMKRSAIFINVSRG
CCCCCHHHCCCCCCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCEEEEEECCC
QVVNEDDLYEALVEKDIAGAGLDVFAEEPVQKDHPLVSLPQVTALPHIGSAAVETREAMM
CCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEECCCHHCCCCCCHHHHHHHHHHH
RLCAENIALVLRGKQAKTEI
HHHHHHHEEEEECCHHCCCC
>Mature Secondary Structure
MDKPFVYVTRKLPEEQLSALKEEAHIEMWEKEEEPCPRAILKEKAKKAHGLLTMLSDTID
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EELLKGAPHLKVVANLAVGYDNIDVEAAQKHRVICCNTPGVLTESTADLTFALLMASARR
HHHHCCCCCHHHHHHHHHCCCCCCCEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHH
IVEASDWIRQGKWTGWGPLLLAGADVHHKTIGIVGMGSIGQAVARRAKGFGMKILYHNRT
HHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEEECCHHHHHHHHHHCCCCEEEEEECCC
RNPDAEAELGASYLPFDELLEQADFVVCLTPLTHETKHLFNRSAFKKMKRSAIFINVSRG
CCCCCHHHCCCCCCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCEEEEEECCC
QVVNEDDLYEALVEKDIAGAGLDVFAEEPVQKDHPLVSLPQVTALPHIGSAAVETREAMM
CCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEECCCHHCCCCCCHHHHHHHHHHH
RLCAENIALVLRGKQAKTEI
HHHHHHHEEEEECCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA