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The map label for this gene is pepA

Identifier: 52787082

GI number: 52787082

Start: 3239885

End: 3241375

Strand: Reverse

Name: pepA

Synonym: BLi03387

Alternate gene names: 52787082

Gene position: 3241375-3239885 (Counterclockwise)

Preceding gene: 52787084

Following gene: 52787081

Centisome position: 76.76

GC content: 50.77

Gene sequence:

>1491_bases
ATGTTTTATGCCTTTAAAGATTTCGAAAAAAAAGAAACGCTTTTAATCGGACTGTTTAAAAAAAGCCGGCTGTACGGTAA
GGCTGAAGAAATCGACCGCCTTTTGAACGGCCAGCTTTCTCAGCTGCTGAAAGACGGGGATGTATCTTCCAAAAAAGCGA
AAGTGTCTAAAATATTTACCCCTTCGCTTCAGGGAGTCAAACGCATTTATATCGTCGGATTGGGCCGTGAAGCGGAATTT
ACCTTCGAGGATGCGAAGCAGTGCTTTGCCGAAGCTGTTCAGCTGATTCACAAAGATCGAAAGCAGGAGTTAACCGTCAT
GCTCGACAGCTTCGTATCCGAAGAAGTCCCAGCTGCTGACGCCGCACATGCATTGGCTGAATCGTGCATGCTGTCATGCT
ATGAAGTGCAGGATTACAAGCACAGATCAAATGTGCCTGATCAATGTCTGCAAAGCGTCTATGTTTTGACAGACCATGAC
CTGAAGGAGATTCAGGCGAGTCTGCATGTCGGACAGGTGTACGGAAATGCGACGAATTCGGCGAGAACCCTCGTGAACAT
GCCGGGGAACATGCTGACAGCGGCGGATCTCGCGTCATATGCCGCTGAATTGGCGGCGAAATACGAATTTGAATGTGAAA
TTCTTGAAAAGGCTGAAATGGAAGAGCTCGGGATGGGCGGTCTCCTCGCGGTCAACCAAGGATCAGAAGAGCCGCCGAAA
ATGATCGTCTTGAAATATCAAGGAAAAGAAACATGGGATGACGTCATCGGTTTAGTCGGCAAAGGGATTACGTTTGATAC
CGGAGGCTATTCGATTAAGACAAAGAGCGGGATTGTCGGCATGAAGTCCGATATGGGCGGAGCCGCCAGCGTTTTGGGAG
CGATGGAAGCGATCGGCGAATTGAGGCCGGAACAAAACGTGCTTGCCGTGATTCCGTCGACTGATAACATGATTTCGGGA
AGCGCAATGAAGCCGGACGACGTCATCGTTTCCTTGAGCGGCAAGACGATTGAGATCTTGAATACGGACGCCGAAGGAAG
GCTGGCGCTCGCTGACGGACTGACATATGCGAAGCACCACGGAGCTTCCGTGCTGATCGATGTCGCGACACTGACCGGAG
GCGTCGTCGTAGCTCTGGGAACGGAAACGACGGGAGCGATGACAAATCATGATCCGCTTTATCAGCAGGTGAGACAGGCG
GCTGAAGAAGCGGGAGAAGCGATTTGGCAGCTTCCGATTACTGAAAAAGACAAAAAAAGAGTAAAAAACAGCCAAATGGC
CGATCTTAACAATTCACCGGGCAGGGAAGGCCATGCGATTATGGCCGGAACGTTCCTCGGCGAATTCGCCGAGCAGACGC
CATGGGTTCACCTTGACATCGCCGGAACGGCAACGACAGCTCAAAACTCATGCTTTGGACCGAAAGGCGGAACGGGCGTG
ATGGTGAGAACGCTTGTCACGTTTGTCGAGCGGTTTTCGGGAAATTTGTAG

Upstream 100 bases:

>100_bases
AAAATATATGATATGAAACCCCATCGGGAAAAAATGTTTTTCCTATTATAACATTGTTGTTTTAATTTTACTCACTTTGC
TGATAAGGAGCTGTGAACGC

Downstream 100 bases:

>100_bases
TCTTTCATCCCCTTTGCTAGAAGGGGATTTTTTTATGGAAAAAACGCAGATGTCTCATTGACGCATTCATAAAACATGTG
GTAATATACGTTCATTACTT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MFYAFKDFEKKETLLIGLFKKSRLYGKAEEIDRLLNGQLSQLLKDGDVSSKKAKVSKIFTPSLQGVKRIYIVGLGREAEF
TFEDAKQCFAEAVQLIHKDRKQELTVMLDSFVSEEVPAADAAHALAESCMLSCYEVQDYKHRSNVPDQCLQSVYVLTDHD
LKEIQASLHVGQVYGNATNSARTLVNMPGNMLTAADLASYAAELAAKYEFECEILEKAEMEELGMGGLLAVNQGSEEPPK
MIVLKYQGKETWDDVIGLVGKGITFDTGGYSIKTKSGIVGMKSDMGGAASVLGAMEAIGELRPEQNVLAVIPSTDNMISG
SAMKPDDVIVSLSGKTIEILNTDAEGRLALADGLTYAKHHGASVLIDVATLTGGVVVALGTETTGAMTNHDPLYQQVRQA
AEEAGEAIWQLPITEKDKKRVKNSQMADLNNSPGREGHAIMAGTFLGEFAEQTPWVHLDIAGTATTAQNSCFGPKGGTGV
MVRTLVTFVERFSGNL

Sequences:

>Translated_496_residues
MFYAFKDFEKKETLLIGLFKKSRLYGKAEEIDRLLNGQLSQLLKDGDVSSKKAKVSKIFTPSLQGVKRIYIVGLGREAEF
TFEDAKQCFAEAVQLIHKDRKQELTVMLDSFVSEEVPAADAAHALAESCMLSCYEVQDYKHRSNVPDQCLQSVYVLTDHD
LKEIQASLHVGQVYGNATNSARTLVNMPGNMLTAADLASYAAELAAKYEFECEILEKAEMEELGMGGLLAVNQGSEEPPK
MIVLKYQGKETWDDVIGLVGKGITFDTGGYSIKTKSGIVGMKSDMGGAASVLGAMEAIGELRPEQNVLAVIPSTDNMISG
SAMKPDDVIVSLSGKTIEILNTDAEGRLALADGLTYAKHHGASVLIDVATLTGGVVVALGTETTGAMTNHDPLYQQVRQA
AEEAGEAIWQLPITEKDKKRVKNSQMADLNNSPGREGHAIMAGTFLGEFAEQTPWVHLDIAGTATTAQNSCFGPKGGTGV
MVRTLVTFVERFSGNL
>Mature_496_residues
MFYAFKDFEKKETLLIGLFKKSRLYGKAEEIDRLLNGQLSQLLKDGDVSSKKAKVSKIFTPSLQGVKRIYIVGLGREAEF
TFEDAKQCFAEAVQLIHKDRKQELTVMLDSFVSEEVPAADAAHALAESCMLSCYEVQDYKHRSNVPDQCLQSVYVLTDHD
LKEIQASLHVGQVYGNATNSARTLVNMPGNMLTAADLASYAAELAAKYEFECEILEKAEMEELGMGGLLAVNQGSEEPPK
MIVLKYQGKETWDDVIGLVGKGITFDTGGYSIKTKSGIVGMKSDMGGAASVLGAMEAIGELRPEQNVLAVIPSTDNMISG
SAMKPDDVIVSLSGKTIEILNTDAEGRLALADGLTYAKHHGASVLIDVATLTGGVVVALGTETTGAMTNHDPLYQQVRQA
AEEAGEAIWQLPITEKDKKRVKNSQMADLNNSPGREGHAIMAGTFLGEFAEQTPWVHLDIAGTATTAQNSCFGPKGGTGV
MVRTLVTFVERFSGNL

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=491, Percent_Identity=34.2158859470468, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI47155554, Length=299, Percent_Identity=35.1170568561873, Blast_Score=152, Evalue=5e-37,
Organism=Escherichia coli, GI1790710, Length=491, Percent_Identity=35.4378818737271, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI87082123, Length=317, Percent_Identity=37.2239747634069, Blast_Score=172, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17556903, Length=304, Percent_Identity=36.1842105263158, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17565172, Length=244, Percent_Identity=34.4262295081967, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21355725, Length=464, Percent_Identity=29.0948275862069, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24661038, Length=466, Percent_Identity=29.3991416309013, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI20129969, Length=495, Percent_Identity=26.6666666666667, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24662227, Length=493, Percent_Identity=25.7606490872211, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21355645, Length=496, Percent_Identity=27.2177419354839, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24662223, Length=496, Percent_Identity=27.2177419354839, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI21357381, Length=321, Percent_Identity=33.3333333333333, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI221379063, Length=321, Percent_Identity=33.3333333333333, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI221379062, Length=321, Percent_Identity=33.3333333333333, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI161077148, Length=482, Percent_Identity=25.9336099585062, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI20130057, Length=482, Percent_Identity=25.9336099585062, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI19922386, Length=479, Percent_Identity=27.5574112734864, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI20129963, Length=487, Percent_Identity=27.3100616016427, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646701, Length=252, Percent_Identity=29.3650793650794, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24646703, Length=252, Percent_Identity=29.3650793650794, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21358201, Length=252, Percent_Identity=29.3650793650794, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_BACLD (Q65FE6)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_080487.1
- RefSeq:   YP_092911.1
- HSSP:   P68767
- ProteinModelPortal:   Q65FE6
- SMR:   Q65FE6
- STRING:   Q65FE6
- MEROPS:   M17.010
- EnsemblBacteria:   EBBACT00000054269
- EnsemblBacteria:   EBBACT00000058732
- GeneID:   3027485
- GeneID:   3099687
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi03387
- KEGG:   bli:BL05323
- NMPDR:   fig|279010.5.peg.3610
- eggNOG:   COG0260
- GeneTree:   EBGT00050000002613
- HOGENOM:   HBG742580
- OMA:   CTEEAQL
- ProtClustDB:   PRK00913
- BioCyc:   BLIC279010-1:BLI03387-MONOMER
- BioCyc:   BLIC279010:BL05323-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 53578; Mature: 53578

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 273-273 ACT_SITE 347-347

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYAFKDFEKKETLLIGLFKKSRLYGKAEEIDRLLNGQLSQLLKDGDVSSKKAKVSKIFT
CCCCCCCCCCCCEEEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
PSLQGVKRIYIVGLGREAEFTFEDAKQCFAEAVQLIHKDRKQELTVMLDSFVSEEVPAAD
CCHHCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AAHALAESCMLSCYEVQDYKHRSNVPDQCLQSVYVLTDHDLKEIQASLHVGQVYGNATNS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEECCCCHHHHHHHHHHHHHCCCCCCC
ARTLVNMPGNMLTAADLASYAAELAAKYEFECEILEKAEMEELGMGGLLAVNQGSEEPPK
CEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHCCHHHCCCCCEEEECCCCCCCCC
MIVLKYQGKETWDDVIGLVGKGITFDTGGYSIKTKSGIVGMKSDMGGAASVLGAMEAIGE
EEEEEECCCCCHHHHHHHHCCCCEECCCCEEEEECCCCEEECCCCCHHHHHHHHHHHHHH
LRPEQNVLAVIPSTDNMISGSAMKPDDVIVSLSGKTIEILNTDAEGRLALADGLTYAKHH
CCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCEEEECCCHHHHHC
GASVLIDVATLTGGVVVALGTETTGAMTNHDPLYQQVRQAAEEAGEAIWQLPITEKDKKR
CCEEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCHHHHH
VKNSQMADLNNSPGREGHAIMAGTFLGEFAEQTPWVHLDIAGTATTAQNSCFGPKGGTGV
HCCCHHCCCCCCCCCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHH
MVRTLVTFVERFSGNL
HHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFYAFKDFEKKETLLIGLFKKSRLYGKAEEIDRLLNGQLSQLLKDGDVSSKKAKVSKIFT
CCCCCCCCCCCCEEEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
PSLQGVKRIYIVGLGREAEFTFEDAKQCFAEAVQLIHKDRKQELTVMLDSFVSEEVPAAD
CCHHCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AAHALAESCMLSCYEVQDYKHRSNVPDQCLQSVYVLTDHDLKEIQASLHVGQVYGNATNS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEECCCCHHHHHHHHHHHHHCCCCCCC
ARTLVNMPGNMLTAADLASYAAELAAKYEFECEILEKAEMEELGMGGLLAVNQGSEEPPK
CEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHCCHHHCCCCCEEEECCCCCCCCC
MIVLKYQGKETWDDVIGLVGKGITFDTGGYSIKTKSGIVGMKSDMGGAASVLGAMEAIGE
EEEEEECCCCCHHHHHHHHCCCCEECCCCEEEEECCCCEEECCCCCHHHHHHHHHHHHHH
LRPEQNVLAVIPSTDNMISGSAMKPDDVIVSLSGKTIEILNTDAEGRLALADGLTYAKHH
CCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCEEEECCCHHHHHC
GASVLIDVATLTGGVVVALGTETTGAMTNHDPLYQQVRQAAEEAGEAIWQLPITEKDKKR
CCEEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCHHHHH
VKNSQMADLNNSPGREGHAIMAGTFLGEFAEQTPWVHLDIAGTATTAQNSCFGPKGGTGV
HCCCHHCCCCCCCCCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHH
MVRTLVTFVERFSGNL
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA