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The map label for this gene is pcp

Identifier: 52786963

GI number: 52786963

Start: 3129361

End: 3130008

Strand: Direct

Name: pcp

Synonym: BLi03263

Alternate gene names: 52786963

Gene position: 3129361-3130008 (Clockwise)

Preceding gene: 52786962

Following gene: 52786964

Centisome position: 74.11

GC content: 52.31

Gene sequence:

>648_bases
ATGGGAAAGAAAGTACTGCTGACAGGATTTGACCCCTTTGGGGGAGAAACAGTCAATCCGTCCTGGGAAGCTGTAAAACG
GCTGAACGGAGAGGAAGCAGAAGGCGTCTCTATCGCAGCGGAGCAGATTCCGACCGTTTTTCATCATTCAGCGGCCGTTT
TGAAAAAAGCGATCGAAAAGCACAAACCCGATGTCGTCATTTGCGCAGGGCAAGCAGGCGGCAGGGCTCATATTACGCCG
GAACGCATCGCAATCAACATCGATGATGCTCGCATTCCGGATAATGAAGACCGGGAACCGATCGATGAACCCATCGCGGC
AGACGGGCCTGCTGCTTACTGGTCCGCGCTTCCGATCAAGCTCATTGTGAAAGAGTTGAGAAAAAACGGAATACCGGCCT
CCGTCTCCAATTCAGCGGGAACTTTCGTATGCAACCATCTCTTTTACCAGTTAATGCACCGTATAGACCGCACCTCGGCA
AACATCCGCGGAGGGTTCATCCACATTCCGTTTCTCCCCGAACAAACAATCGATAAACCCGAGCCGAGTCTCAGCCTTGA
AACGATCGTCGAAGGACTTAGAATAGCTGCGGTCATCTCCGCCCTGCACGAAAAAGATATTCGCGAAACGGGCGGATCGA
TCAGCTGA

Upstream 100 bases:

>100_bases
TCTCGTGGAGCAGGCGGGTGACTACATCCTCAAAATACCCATTCAGACATCTGCTGAATGGGTATTTTGCACTTTACATT
CATATTCAGGAGTGATCGAT

Downstream 100 bases:

>100_bases
CACCGCAGCCGCCTCAAAGCGCCCTCCGGCTTCACCTTCCGGATTCTTGTACATCCCAGTGTGTTTTTCTTAAAAAAAGT
AAACACTATAAGAAAAACAG

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MGKKVLLTGFDPFGGETVNPSWEAVKRLNGEEAEGVSIAAEQIPTVFHHSAAVLKKAIEKHKPDVVICAGQAGGRAHITP
ERIAINIDDARIPDNEDREPIDEPIAADGPAAYWSALPIKLIVKELRKNGIPASVSNSAGTFVCNHLFYQLMHRIDRTSA
NIRGGFIHIPFLPEQTIDKPEPSLSLETIVEGLRIAAVISALHEKDIRETGGSIS

Sequences:

>Translated_215_residues
MGKKVLLTGFDPFGGETVNPSWEAVKRLNGEEAEGVSIAAEQIPTVFHHSAAVLKKAIEKHKPDVVICAGQAGGRAHITP
ERIAINIDDARIPDNEDREPIDEPIAADGPAAYWSALPIKLIVKELRKNGIPASVSNSAGTFVCNHLFYQLMHRIDRTSA
NIRGGFIHIPFLPEQTIDKPEPSLSLETIVEGLRIAAVISALHEKDIRETGGSIS
>Mature_214_residues
GKKVLLTGFDPFGGETVNPSWEAVKRLNGEEAEGVSIAAEQIPTVFHHSAAVLKKAIEKHKPDVVICAGQAGGRAHITPE
RIAINIDDARIPDNEDREPIDEPIAADGPAAYWSALPIKLIVKELRKNGIPASVSNSAGTFVCNHLFYQLMHRIDRTSAN
IRGGFIHIPFLPEQTIDKPEPSLSLETIVEGLRIAAVISALHEKDIRETGGSIS

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

Organism=Homo sapiens, GI8923198, Length=171, Percent_Identity=28.6549707602339, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP_BACLD (Q65FR5)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_080374.1
- RefSeq:   YP_092792.1
- HSSP:   P46107
- ProteinModelPortal:   Q65FR5
- SMR:   Q65FR5
- STRING:   Q65FR5
- MEROPS:   C15.001
- EnsemblBacteria:   EBBACT00000055272
- EnsemblBacteria:   EBBACT00000060143
- GeneID:   3027696
- GeneID:   3099266
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi03263
- KEGG:   bli:BL02514
- NMPDR:   fig|279010.5.peg.3468
- eggNOG:   COG2039
- GeneTree:   EBGT00050000001251
- HOGENOM:   HBG360405
- OMA:   NTAGTYV
- ProtClustDB:   PRK13197
- BioCyc:   BLIC279010-1:BLI03263-MONOMER
- BioCyc:   BLIC279010:BL02514-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706
- TIGRFAMs:   TIGR00504

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 23277; Mature: 23146

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 81-81 ACT_SITE 144-144 ACT_SITE 168-168

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKKVLLTGFDPFGGETVNPSWEAVKRLNGEEAEGVSIAAEQIPTVFHHSAAVLKKAIEK
CCCEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HKPDVVICAGQAGGRAHITPERIAINIDDARIPDNEDREPIDEPIAADGPAAYWSALPIK
CCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHH
LIVKELRKNGIPASVSNSAGTFVCNHLFYQLMHRIDRTSANIRGGFIHIPFLPEQTIDKP
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHCCCC
EPSLSLETIVEGLRIAAVISALHEKDIRETGGSIS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
GKKVLLTGFDPFGGETVNPSWEAVKRLNGEEAEGVSIAAEQIPTVFHHSAAVLKKAIEK
CCEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HKPDVVICAGQAGGRAHITPERIAINIDDARIPDNEDREPIDEPIAADGPAAYWSALPIK
CCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHH
LIVKELRKNGIPASVSNSAGTFVCNHLFYQLMHRIDRTSANIRGGFIHIPFLPEQTIDKP
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHCCCC
EPSLSLETIVEGLRIAAVISALHEKDIRETGGSIS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA