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The map label for this gene is menB [H]

Identifier: 52786944

GI number: 52786944

Start: 3100664

End: 3101482

Strand: Reverse

Name: menB [H]

Synonym: BLi03220

Alternate gene names: 52786944

Gene position: 3101482-3100664 (Counterclockwise)

Preceding gene: 52786945

Following gene: 52786943

Centisome position: 73.45

GC content: 49.94

Gene sequence:

>819_bases
ATGACTGTAGAATGGAAAAGCGAACGTCAATACGAAGATGTATTATATGAAACATATAACGGCATCGCCAAAATCACGAT
CAATCGCCCTGAGGTACATAACGCATTTCGTCCAAAAACGGTTTCAGAACTGATCGATGCGTTTGCATATGCGCGGGATG
ATGCCAATATCGGTGTCATTATCCTTGCAGGTGCCGGGGATAAAGCGTTCTGTTCAGGAGGAGACCAGAAAGTAAGGGGA
CACGGAGGCTATGTCGGTGAAGACGAGATTCCGCGTTTGAATGTGCTTGATCTTCAGCGGCTGATCCGCGTCATTCCGAA
GCCTGTTGTAGCGATGGTGTCAGGCTATGCGATCGGCGGCGGCCATGTGCTCCACGTCGTATGCGATTTGACGATTGCTG
CGGACAACGCGATTTTCGGACAAACAGGGCCGAAAGTCGGCAGCTTTGATGCGGGCTACGGATCAGGCTATCTGGCGCGT
ATCGTCGGACATAAAAAAGCGCGCGAAATCTGGTATCTGTGCCGTCAGTACAACGCTCAGGAAGCAAAAGAAATGGGCCT
TGTCAATACGGTTGTACCGCTTGAAAAGCTTGAAGAAGAAACGATTAAATGGTGTGAAGAAATGCTTGAGAAAAGCCCGA
CAGCACTCAGATTCCTTAAAGCGGCCTTTAACGCCGATACGGACGGGCTTGCCGGCATCCAGCAGTTTGCCGGAGATGCG
ACACTGCTTTATTACACAACAGATGAAGCGAAAGAAGGCCGCGATGCGTTTAAAGAAAAACGCCGTCCAGACTTCGGACA
GTTCCCGCGTTTTCCTTAA

Upstream 100 bases:

>100_bases
GAGATTGTTGAACATACCGGTCATGCGGTTCATGTGGAAGAGCCCGATTTTTTTGGTAGAATAGTAAGTGAGTTTATTTT
AAAGTAGGAGGTACACATCA

Downstream 100 bases:

>100_bases
AAATCGGAAGAGAGAAACAGCTTGGTGCGACTGAGCTGTTTCTTTTATCATTCAAGACATTTTTTGGAGATGATGATATG
CTGATGGACCATCCGAATTG

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MTVEWKSERQYEDVLYETYNGIAKITINRPEVHNAFRPKTVSELIDAFAYARDDANIGVIILAGAGDKAFCSGGDQKVRG
HGGYVGEDEIPRLNVLDLQRLIRVIPKPVVAMVSGYAIGGGHVLHVVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLAR
IVGHKKAREIWYLCRQYNAQEAKEMGLVNTVVPLEKLEEETIKWCEEMLEKSPTALRFLKAAFNADTDGLAGIQQFAGDA
TLLYYTTDEAKEGRDAFKEKRRPDFGQFPRFP

Sequences:

>Translated_272_residues
MTVEWKSERQYEDVLYETYNGIAKITINRPEVHNAFRPKTVSELIDAFAYARDDANIGVIILAGAGDKAFCSGGDQKVRG
HGGYVGEDEIPRLNVLDLQRLIRVIPKPVVAMVSGYAIGGGHVLHVVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLAR
IVGHKKAREIWYLCRQYNAQEAKEMGLVNTVVPLEKLEEETIKWCEEMLEKSPTALRFLKAAFNADTDGLAGIQQFAGDA
TLLYYTTDEAKEGRDAFKEKRRPDFGQFPRFP
>Mature_271_residues
TVEWKSERQYEDVLYETYNGIAKITINRPEVHNAFRPKTVSELIDAFAYARDDANIGVIILAGAGDKAFCSGGDQKVRGH
GGYVGEDEIPRLNVLDLQRLIRVIPKPVVAMVSGYAIGGGHVLHVVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI
VGHKKAREIWYLCRQYNAQEAKEMGLVNTVVPLEKLEEETIKWCEEMLEKSPTALRFLKAAFNADTDGLAGIQQFAGDAT
LLYYTTDEAKEGRDAFKEKRRPDFGQFPRFP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=248, Percent_Identity=33.8709677419355, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI31542718, Length=262, Percent_Identity=29.7709923664122, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI4502327, Length=283, Percent_Identity=29.6819787985866, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI45643119, Length=213, Percent_Identity=28.6384976525822, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI260275230, Length=213, Percent_Identity=28.6384976525822, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI260274832, Length=213, Percent_Identity=28.6384976525822, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI37594471, Length=154, Percent_Identity=29.2207792207792, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI37594469, Length=154, Percent_Identity=29.2207792207792, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI70995211, Length=216, Percent_Identity=27.7777777777778, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1788597, Length=273, Percent_Identity=68.8644688644689, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI221142681, Length=265, Percent_Identity=31.6981132075472, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1787659, Length=245, Percent_Identity=31.4285714285714, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082183, Length=265, Percent_Identity=29.4339622641509, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787660, Length=261, Percent_Identity=29.5019157088123, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788682, Length=191, Percent_Identity=25.130890052356, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=246, Percent_Identity=30.8943089430894, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25145438, Length=249, Percent_Identity=32.1285140562249, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17540714, Length=213, Percent_Identity=30.5164319248826, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17549921, Length=216, Percent_Identity=27.3148148148148, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17560910, Length=181, Percent_Identity=31.4917127071823, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17535521, Length=252, Percent_Identity=24.2063492063492, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=241, Percent_Identity=28.2157676348548, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=261, Percent_Identity=26.4367816091954, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI25144160, Length=166, Percent_Identity=26.5060240963855, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25144157, Length=166, Percent_Identity=26.5060240963855, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI20129971, Length=243, Percent_Identity=33.7448559670782, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653477, Length=243, Percent_Identity=33.7448559670782, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653139, Length=255, Percent_Identity=29.8039215686275, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357171, Length=189, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19922422, Length=267, Percent_Identity=26.2172284644195, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24650670, Length=192, Percent_Identity=30.7291666666667, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 30143; Mature: 30011

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVEWKSERQYEDVLYETYNGIAKITINRPEVHNAFRPKTVSELIDAFAYARDDANIGVI
CCCCCCCCHHHHHHHHHHHCCEEEEEECCCHHHCCCCCHHHHHHHHHHHHHCCCCCEEEE
ILAGAGDKAFCSGGDQKVRGHGGYVGEDEIPRLNVLDLQRLIRVIPKPVVAMVSGYAIGG
EEECCCCCHHHCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCC
GHVLHVVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARIVGHKKAREIWYLCRQYNAQ
CCEEEEEEHHHEECCCCEECCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCHH
EAKEMGLVNTVVPLEKLEEETIKWCEEMLEKSPTALRFLKAAFNADTDGLAGIQQFAGDA
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCE
TLLYYTTDEAKEGRDAFKEKRRPDFGQFPRFP
EEEEEECCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TVEWKSERQYEDVLYETYNGIAKITINRPEVHNAFRPKTVSELIDAFAYARDDANIGVI
CCCCCCCHHHHHHHHHHHCCEEEEEECCCHHHCCCCCHHHHHHHHHHHHHCCCCCEEEE
ILAGAGDKAFCSGGDQKVRGHGGYVGEDEIPRLNVLDLQRLIRVIPKPVVAMVSGYAIGG
EEECCCCCHHHCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCC
GHVLHVVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARIVGHKKAREIWYLCRQYNAQ
CCEEEEEEHHHEECCCCEECCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCHH
EAKEMGLVNTVVPLEKLEEETIKWCEEMLEKSPTALRFLKAAFNADTDGLAGIQQFAGDA
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCE
TLLYYTTDEAKEGRDAFKEKRRPDFGQFPRFP
EEEEEECCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]