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The map label for this gene is ytkP [H]

Identifier: 52786873

GI number: 52786873

Start: 3030090

End: 3031022

Strand: Direct

Name: ytkP [H]

Synonym: BLi03148

Alternate gene names: 52786873

Gene position: 3030090-3031022 (Clockwise)

Preceding gene: 52786867

Following gene: 52786877

Centisome position: 71.76

GC content: 51.55

Gene sequence:

>933_bases
GTGAGAGCCGTTCAAAATATTGCAGAATTAATCGGGGAAACGCCCCTTGTCAAGTTGAACCGCGTTCAGCCCGAAAACGC
GGCCCAAGTTTATATCAAGCTTGAATCTTTTAATCCGAGCGGAAGCGTAAAAGACCGCGCGGCCTACCAAATGATCCTGG
ATGCCGAAGAAAAAGGCCTGCTGAAACCGGGTTCAACCATCATTGAACCGACGAGCGGGAACACCGGCATCGGCCTTGCG
ATGAACGCGGCGGCAAGAGGCTACAAAGCCATTCTTGTCATGCCTGATACGATGACGAAGGAGCGGATCAATCTTCTGAA
AGCGTACGGAGCCGAAGTCGTCCTGACGCCGGGGGATGAAAGAATGCCGGGCAGCATCAAAAAAGCGCAGGAGCTCGCTC
GGCAAATCCCAGGCAGCTTTATTCCGATGCAGTTTGATAATGAAGCCAATCCGGAGGCTCACCGGAGATCAACCGCTCTG
GAAATTGCCCGGGCAATAGAAGAAATCGGCAAACCTCTCGCTGCATTTGTTGCAACAGCAGGGACAGGGGGAACGATTAC
CGGAACAGGCGAAAAGCTGAAAGCTTTATTTCCGGGAATAACCGTTCACGTGGCAGAACCTGCAGGGTCGCCTGTTTTAT
CCGGCGGCAAACCCGGAAAACACAAGCTTGTCGGGACAAGCCCGGGATTTATCCCAAACATTTTAAACGAAAACGTCTAT
GACGAAATCTTAAAGATCAAGGATGAAGAAGCCTATGAGATGACGCGCAGATTGGCGCGGGAAGAAGGAATCCTTGTCGG
CCCTTCTTCAGGAGCCGCTTGCTTCGCTGCTGTTGAAACGGCCAAGAAGCTCCCTCCCGACAAAGTGGTCGTCTGCATGA
CGGCCGATACAGGGGAACGCTATTTATCAAGCGATTTATTTCAATTTGATTAA

Upstream 100 bases:

>100_bases
TAACAAAAAATATGGACTTATAACCTCTCTATTTTCCACTTTCCAAGGGCTTATGATAGGATATTGACAGAATCATGTTT
TCTAGAAAGGGTGCACAGTT

Downstream 100 bases:

>100_bases
GAGAGAAAAGCCTGGATTTCTGTTTTGAAATCAGGCTCAGATTGTTGAAAAAATCCCAAAGCTAAGAGACGTTTTGGGAT
TTTTTCATCCTTTCAGCGTG

Product: YtkP

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRAVQNIAELIGETPLVKLNRVQPENAAQVYIKLESFNPSGSVKDRAAYQMILDAEEKGLLKPGSTIIEPTSGNTGIGLA
MNAAARGYKAILVMPDTMTKERINLLKAYGAEVVLTPGDERMPGSIKKAQELARQIPGSFIPMQFDNEANPEAHRRSTAL
EIARAIEEIGKPLAAFVATAGTGGTITGTGEKLKALFPGITVHVAEPAGSPVLSGGKPGKHKLVGTSPGFIPNILNENVY
DEILKIKDEEAYEMTRRLAREEGILVGPSSGAACFAAVETAKKLPPDKVVVCMTADTGERYLSSDLFQFD

Sequences:

>Translated_310_residues
MRAVQNIAELIGETPLVKLNRVQPENAAQVYIKLESFNPSGSVKDRAAYQMILDAEEKGLLKPGSTIIEPTSGNTGIGLA
MNAAARGYKAILVMPDTMTKERINLLKAYGAEVVLTPGDERMPGSIKKAQELARQIPGSFIPMQFDNEANPEAHRRSTAL
EIARAIEEIGKPLAAFVATAGTGGTITGTGEKLKALFPGITVHVAEPAGSPVLSGGKPGKHKLVGTSPGFIPNILNENVY
DEILKIKDEEAYEMTRRLAREEGILVGPSSGAACFAAVETAKKLPPDKVVVCMTADTGERYLSSDLFQFD
>Mature_310_residues
MRAVQNIAELIGETPLVKLNRVQPENAAQVYIKLESFNPSGSVKDRAAYQMILDAEEKGLLKPGSTIIEPTSGNTGIGLA
MNAAARGYKAILVMPDTMTKERINLLKAYGAEVVLTPGDERMPGSIKKAQELARQIPGSFIPMQFDNEANPEAHRRSTAL
EIARAIEEIGKPLAAFVATAGTGGTITGTGEKLKALFPGITVHVAEPAGSPVLSGGKPGKHKLVGTSPGFIPNILNENVY
DEILKIKDEEAYEMTRRLAREEGILVGPSSGAACFAAVETAKKLPPDKVVVCMTADTGERYLSSDLFQFD

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=311, Percent_Identity=40.5144694533762, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI295821200, Length=311, Percent_Identity=40.5144694533762, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI4557415, Length=311, Percent_Identity=40.5144694533762, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI11345492, Length=321, Percent_Identity=24.6105919003115, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI2367138, Length=305, Percent_Identity=41.9672131147541, Blast_Score=221, Evalue=5e-59,
Organism=Escherichia coli, GI1788754, Length=312, Percent_Identity=46.1538461538462, Blast_Score=213, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI17535051, Length=307, Percent_Identity=45.6026058631922, Blast_Score=237, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI17562970, Length=308, Percent_Identity=44.1558441558442, Blast_Score=227, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI32566674, Length=302, Percent_Identity=45.0331125827815, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI115535073, Length=307, Percent_Identity=45.2768729641694, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17561720, Length=309, Percent_Identity=42.0711974110032, Blast_Score=200, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17534315, Length=318, Percent_Identity=40.5660377358491, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI32566672, Length=216, Percent_Identity=42.5925925925926, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25147552, Length=319, Percent_Identity=37.9310344827586, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17561716, Length=117, Percent_Identity=41.8803418803419, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71996324, Length=330, Percent_Identity=26.0606060606061, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321594, Length=319, Percent_Identity=38.871473354232, Blast_Score=204, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6321449, Length=334, Percent_Identity=33.8323353293413, Blast_Score=136, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24643623, Length=308, Percent_Identity=42.2077922077922, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI20129101, Length=308, Percent_Identity=42.2077922077922, Blast_Score=213, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33103; Mature: 33103

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVQNIAELIGETPLVKLNRVQPENAAQVYIKLESFNPSGSVKDRAAYQMILDAEEKGL
CCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCC
LKPGSTIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKERINLLKAYGAEVVLTPGDE
CCCCCEEEECCCCCCCEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEECCCCC
RMPGSIKKAQELARQIPGSFIPMQFDNEANPEAHRRSTALEIARAIEEIGKPLAAFVATA
CCCCHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
GTGGTITGTGEKLKALFPGITVHVAEPAGSPVLSGGKPGKHKLVGTSPGFIPNILNENVY
CCCCEEECCCHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCHHHHCCHHH
DEILKIKDEEAYEMTRRLAREEGILVGPSSGAACFAAVETAKKLPPDKVVVCMTADTGER
HHHHHCCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHH
YLSSDLFQFD
HHHHHHHCCC
>Mature Secondary Structure
MRAVQNIAELIGETPLVKLNRVQPENAAQVYIKLESFNPSGSVKDRAAYQMILDAEEKGL
CCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCC
LKPGSTIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKERINLLKAYGAEVVLTPGDE
CCCCCEEEECCCCCCCEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEECCCCC
RMPGSIKKAQELARQIPGSFIPMQFDNEANPEAHRRSTALEIARAIEEIGKPLAAFVATA
CCCCHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
GTGGTITGTGEKLKALFPGITVHVAEPAGSPVLSGGKPGKHKLVGTSPGFIPNILNENVY
CCCCEEECCCHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCHHHHCCHHH
DEILKIKDEEAYEMTRRLAREEGILVGPSSGAACFAAVETAKKLPPDKVVVCMTADTGER
HHHHHCCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHH
YLSSDLFQFD
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]