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The map label for this gene is hemN [H]

Identifier: 52786477

GI number: 52786477

Start: 2637810

End: 2638949

Strand: Reverse

Name: hemN [H]

Synonym: BLi02742

Alternate gene names: 52786477

Gene position: 2638949-2637810 (Counterclockwise)

Preceding gene: 52786478

Following gene: 52786476

Centisome position: 62.5

GC content: 45.79

Gene sequence:

>1140_bases
ATGAAAGCAGCATATATACATATTCCGTTTTGCGAGCACATTTGCCATTATTGCGACTTCAACAAGTTTTTTATTCAATC
TCAGCCCGTTGATGAATATTTGCGTTCCTTAGAGAAGGAAATGGCCAATTCAATGGAGGCAACCGGACATCCGGAGCTGA
AAACGATCTTTATCGGGGGAGGAACGCCGACATCGCTGTCGGCAGCTCAGCTCGAACGGCTCCTCGATTCCATTCATCGC
GTTTTGAAACCGTCCGAAAGCCTTGCTGAATTTGCAGTGGAAGCCAATCCCGACGATTTATCAGCTGAAAAGCTGGATGT
TTTAAAAGCTGCCGGTGTAGACAGGCTGAGCTTTGGCGTGCAGACGTTTGAAGACGAGCTGCTGAAAAAAATCGGCAGGG
TTCACGAGCAAAAAGACGTACTCGTTTCGTTTGAAAGAGCGAGAAAGGCGGGGTTTGATAATATCAGCCTTGATCTGATG
TTCGGTCTGCCCGGACAAACCATCGGCCACCTCGCTTCATCGCTCGATACGGCGCTTGCCCTCGGTGCTGAACACTATTC
GGTTTATTCGCTGATCGTCGAACCGAAAACCGTTTTCTACAACTTGATGAAAAAAGGCCGGCTTCACCTGCCGCCGCAGG
ATCAGGAAGCTGAAATGTACGAACTCGTTATGCGGAAAATGGAAGAAGCGGGCATCGGCCAATACGAAATCAGCAACTAC
GCCAAAAAAGGATATGAGAGCAAACATAACCTCACATATTGGAACAATGAGGATTATTTCGGTTTTGGCGCGGGCGCACA
CGGTTATATCAATGGTGAAAGAACGGTAAATGCGGGCCCTGTCAAACATTATATCGACCTGATTGAACAATCCGGCTTTC
CTTATAAGGAAAAGCACATGGTCACAAAAAATGAACAGATTGAAGAAGAAATGTTTCTCGGTCTTCGAAAAACTGAGGGA
GTAAACAAAGAGCGCTTTTTCGAAACATATGGAAGATCTGTTGACGATCTCTTTCCGAAGGTGCTCCATTCGCTGGAAGA
AACAGGGTTGATTGTGAACACGAACAAAAACGTGTTTCTAACACATAATGGAAAACTGTTGGGAAATGAAGTATTTCAGG
CATTCCTGGGTGAGTTATAA

Upstream 100 bases:

>100_bases
TGGCAGTCCTGAAAATGGACGACAGCGGCCCGAAATCATAATCATGAGCCGCCGCAGCGTAACACACTGCGGCTTCTTCC
TGTAAAAGAAGGTGAAAACA

Downstream 100 bases:

>100_bases
TTGACATTTTGATTTCGGTTTGGTAATTTTGATATACAATTAGCACTCAGTTGTGCCGAGTGCTAACAGGGGTGATATGG
ATGTTAACAAATCGTCAGCT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MKAAYIHIPFCEHICHYCDFNKFFIQSQPVDEYLRSLEKEMANSMEATGHPELKTIFIGGGTPTSLSAAQLERLLDSIHR
VLKPSESLAEFAVEANPDDLSAEKLDVLKAAGVDRLSFGVQTFEDELLKKIGRVHEQKDVLVSFERARKAGFDNISLDLM
FGLPGQTIGHLASSLDTALALGAEHYSVYSLIVEPKTVFYNLMKKGRLHLPPQDQEAEMYELVMRKMEEAGIGQYEISNY
AKKGYESKHNLTYWNNEDYFGFGAGAHGYINGERTVNAGPVKHYIDLIEQSGFPYKEKHMVTKNEQIEEEMFLGLRKTEG
VNKERFFETYGRSVDDLFPKVLHSLEETGLIVNTNKNVFLTHNGKLLGNEVFQAFLGEL

Sequences:

>Translated_379_residues
MKAAYIHIPFCEHICHYCDFNKFFIQSQPVDEYLRSLEKEMANSMEATGHPELKTIFIGGGTPTSLSAAQLERLLDSIHR
VLKPSESLAEFAVEANPDDLSAEKLDVLKAAGVDRLSFGVQTFEDELLKKIGRVHEQKDVLVSFERARKAGFDNISLDLM
FGLPGQTIGHLASSLDTALALGAEHYSVYSLIVEPKTVFYNLMKKGRLHLPPQDQEAEMYELVMRKMEEAGIGQYEISNY
AKKGYESKHNLTYWNNEDYFGFGAGAHGYINGERTVNAGPVKHYIDLIEQSGFPYKEKHMVTKNEQIEEEMFLGLRKTEG
VNKERFFETYGRSVDDLFPKVLHSLEETGLIVNTNKNVFLTHNGKLLGNEVFQAFLGEL
>Mature_379_residues
MKAAYIHIPFCEHICHYCDFNKFFIQSQPVDEYLRSLEKEMANSMEATGHPELKTIFIGGGTPTSLSAAQLERLLDSIHR
VLKPSESLAEFAVEANPDDLSAEKLDVLKAAGVDRLSFGVQTFEDELLKKIGRVHEQKDVLVSFERARKAGFDNISLDLM
FGLPGQTIGHLASSLDTALALGAEHYSVYSLIVEPKTVFYNLMKKGRLHLPPQDQEAEMYELVMRKMEEAGIGQYEISNY
AKKGYESKHNLTYWNNEDYFGFGAGAHGYINGERTVNAGPVKHYIDLIEQSGFPYKEKHMVTKNEQIEEEMFLGLRKTEG
VNKERFFETYGRSVDDLFPKVLHSLEETGLIVNTNKNVFLTHNGKLLGNEVFQAFLGEL

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=266, Percent_Identity=35.7142857142857, Blast_Score=182, Evalue=6e-46,
Organism=Escherichia coli, GI1789325, Length=378, Percent_Identity=33.5978835978836, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI87082341, Length=387, Percent_Identity=25.3229974160207, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 42861; Mature: 42861

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAYIHIPFCEHICHYCDFNKFFIQSQPVDEYLRSLEKEMANSMEATGHPELKTIFIGG
CCEEEEECHHHHHHHHHHCCCHHEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
GTPTSLSAAQLERLLDSIHRVLKPSESLAEFAVEANPDDLSAEKLDVLKAAGVDRLSFGV
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHH
QTFEDELLKKIGRVHEQKDVLVSFERARKAGFDNISLDLMFGLPGQTIGHLASSLDTALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
LGAEHYSVYSLIVEPKTVFYNLMKKGRLHLPPQDQEAEMYELVMRKMEEAGIGQYEISNY
HCCHHHEEEEEEECHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHH
AKKGYESKHNLTYWNNEDYFGFGAGAHGYINGERTVNAGPVKHYIDLIEQSGFPYKEKHM
HHHCCCCCCCEEEECCCCCEEECCCCCCEECCCCEECCCHHHHHHHHHHHCCCCCHHHCC
VTKNEQIEEEMFLGLRKTEGVNKERFFETYGRSVDDLFPKVLHSLEETGLIVNTNKNVFL
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEECCCCEEE
THNGKLLGNEVFQAFLGEL
EECCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKAAYIHIPFCEHICHYCDFNKFFIQSQPVDEYLRSLEKEMANSMEATGHPELKTIFIGG
CCEEEEECHHHHHHHHHHCCCHHEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
GTPTSLSAAQLERLLDSIHRVLKPSESLAEFAVEANPDDLSAEKLDVLKAAGVDRLSFGV
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHH
QTFEDELLKKIGRVHEQKDVLVSFERARKAGFDNISLDLMFGLPGQTIGHLASSLDTALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
LGAEHYSVYSLIVEPKTVFYNLMKKGRLHLPPQDQEAEMYELVMRKMEEAGIGQYEISNY
HCCHHHEEEEEEECHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHH
AKKGYESKHNLTYWNNEDYFGFGAGAHGYINGERTVNAGPVKHYIDLIEQSGFPYKEKHM
HHHCCCCCCCEEEECCCCCEEECCCCCCEECCCCEECCCHHHHHHHHHHHCCCCCHHHCC
VTKNEQIEEEMFLGLRKTEGVNKERFFETYGRSVDDLFPKVLHSLEETGLIVNTNKNVFL
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEECCCCEEE
THNGKLLGNEVFQAFLGEL
EECCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]