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The map label for this gene is hyuA [H]

Identifier: 52785739

GI number: 52785739

Start: 1934221

End: 1936326

Strand: Direct

Name: hyuA [H]

Synonym: BLi01982

Alternate gene names: 52785739

Gene position: 1934221-1936326 (Clockwise)

Preceding gene: 52785738

Following gene: 52785740

Centisome position: 45.81

GC content: 49.81

Gene sequence:

>2106_bases
ATGATGAATGAAAAAAACCAATGGGTATTTGGAATTGATGTCGGCGGGACGTTTACAGATTTAGTGGCAGTCAACAAGGA
CGGAAAAATGGTTTCGACGAAGACGCCTTCAACCCCAGACCAGTCTGATGGTGTCATGAACGGAATTAAAAAAATGGCTG
AAATCATCGGAATAGACGTAAAGGATCTATTAGCCAATAGTCCATTGGTTGTCCATGGAACAACAGTTGCCACTAACGCC
TTGCTGGAATATAACGGAGCAAAGGTGGGGCTTCTCACAACGGAAGGCTTTCGGGACGAAATCGAATTCCGCCGCGCGTA
TAAAGAAAGCGTGTTTTCTCCGCGCTTAGAAGCTCCTTATCAAATTGTCCCAAGAAGGTATCGTGTGGGGATTCCTGAAC
GACTGGATCATACAGGAAATGTCGTAACTAAGCTTGATGAAGAAGCCGTCCGCCGGGCAGTCCGCGGGTTTATCCAAGAG
GGGGTCGAAGCCGTTGCTGTCTGCTTTCTGTTCAGCTTCATGAATCCTTCACATGAAATCCGTGTCAAAGAGATTATTCA
AGAGGAAGCTCCCGGCATGTTTGTATCGTTATCGTATGAAGTGCTGCCGCAGATTCGGGAATTTGAACGGGTGAGCACGA
CCATTGTCAATGCGTTTACCGGCCCTTCCATGCAAAGCTACTTAAACCATCTTGACGAACGGTTTCGCGAAGACGGATTT
ACTGGAGAACTGTTTGTTATGCAATCAAACGGGGGGGTCCAAAATGTCATTCAAAGCGGGAAATTTGCCGCGGGTGGCCT
TTTGTCAGGTCCAGCCGGAGGAGTGACGGCTGCTTCCTTTATCGGGGAAAAATCGGGCTACGAGAACGTCATTACCGTAG
ACATGGGCGGAACAAGCTATGATGTCTCGGTTATCGAAAAATTAAATCCGGCGATCACGACGGAAAATTGGATCAGCAGA
TACAGGGTTGCCTTGCCGATGATGGATATCCATACGATCGGCTCCGGCGGCGGAAGCATCGCCTGGATTGACAGCGGCGG
AGCTTTACAAGTCGGCCCGCGAAGCGCAGGCTCAAATCCGGGGCCGGCCTGCTACGGAAGGGGCGGAGAAGAACCGACTG
TTACAGACGTGAATGTCTTCTTAGGCTATATCAACCCTGATAACTTCCTTGGCGGAGAAATGAAGCTTGACCGTTCGCTG
GCTGAAAAAGCCATTCGTACACGAATTGCCGAACCGCTCGGAATTTCGACAGTGGAAGCCGCGCTTGCAATCTCACAAAT
CGTCAATAGTGATATGTCAAATGCAGTCCACTTTGTAACGACACAGCGAGGCCATGATCCAAGGAACTTCGCCCTGATGG
CTGTCGGCGGCGCCGGAGCCATCCATGCAGGCAAGCAGGCGGAAGACCTGGGCATTAAAACCGTTATCGTTCCGTCCCTT
GCTCCGGTCTTTTGTGCGCTCGGCGATGTGGCGGCAAACCTTAAAGTAACGGAGCTCAGGACGCGCTTTGAAAGTTTGAA
AAACGTTGACCTGCAAGCGATGAACGCCGATTTTGAAAAGATGGAACAGACGGCCCGCGAAAAACTTGGAGGCCAATCGG
TCACCAATCAATATGAAACGCGTCGCTTTATCGATATGCGCTACGCGGGGGAAGTCCATGAAGTAACCGTACCGGTGAAG
TCAAGGACGCGAAGGATTACAGAGTTGAATCTTGAAGCAACGGCGGCAGACTTCCATGACCTTCATGAAAGAATGTTTGC
CCATAAAGACCCTGAGCACGACATTGAAATCTTAAACCTCCGTCTTGATCTGGTGGGAGTCAGAGAGCCGTTAAAGCTTA
AGGAGGAGCAGTTTGAACAAGAGGATCCTTCAAAAGCGAAAACAGGTGAACGCGATATGTATTTTGACATCGAACCGGCG
AAAACGCCTATTTTCAACGGGTCAATGCTTGAGCCGGGCAACCTGATTGTCGGTCCTGCCATCATTGAGCAATGGGGTAC
GACCATTGTTGTTTACCCGGGACATGAGGCTCTAATCGATTCATACCGCAACTGTGTCATCGAAGTAAAGCATGCTCAAC
AGGCGACAAGAGGTGGAAATGCATGA

Upstream 100 bases:

>100_bases
CTTTACGTTTATTTTCACAAAATTAAATCTCCGTTACGAAATCGGAGAAGCGACAGAGGAATCGTCTGGTTTTTAAGCGG
ATAAGGAGGAAAGGTTTTCA

Downstream 100 bases:

>100_bases
TCCAAGCTCAAATTCTTTATAGAAAGCTGCAAGCGATCGGCAGAGAAGTCGGGGATAATTTGCAGCGAATCTCCCGTTCT
CCTGTGCTTTCGCAAGACCG

Product: hypothetical protein

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 701; Mature: 701

Protein sequence:

>701_residues
MMNEKNQWVFGIDVGGTFTDLVAVNKDGKMVSTKTPSTPDQSDGVMNGIKKMAEIIGIDVKDLLANSPLVVHGTTVATNA
LLEYNGAKVGLLTTEGFRDEIEFRRAYKESVFSPRLEAPYQIVPRRYRVGIPERLDHTGNVVTKLDEEAVRRAVRGFIQE
GVEAVAVCFLFSFMNPSHEIRVKEIIQEEAPGMFVSLSYEVLPQIREFERVSTTIVNAFTGPSMQSYLNHLDERFREDGF
TGELFVMQSNGGVQNVIQSGKFAAGGLLSGPAGGVTAASFIGEKSGYENVITVDMGGTSYDVSVIEKLNPAITTENWISR
YRVALPMMDIHTIGSGGGSIAWIDSGGALQVGPRSAGSNPGPACYGRGGEEPTVTDVNVFLGYINPDNFLGGEMKLDRSL
AEKAIRTRIAEPLGISTVEAALAISQIVNSDMSNAVHFVTTQRGHDPRNFALMAVGGAGAIHAGKQAEDLGIKTVIVPSL
APVFCALGDVAANLKVTELRTRFESLKNVDLQAMNADFEKMEQTAREKLGGQSVTNQYETRRFIDMRYAGEVHEVTVPVK
SRTRRITELNLEATAADFHDLHERMFAHKDPEHDIEILNLRLDLVGVREPLKLKEEQFEQEDPSKAKTGERDMYFDIEPA
KTPIFNGSMLEPGNLIVGPAIIEQWGTTIVVYPGHEALIDSYRNCVIEVKHAQQATRGGNA

Sequences:

>Translated_701_residues
MMNEKNQWVFGIDVGGTFTDLVAVNKDGKMVSTKTPSTPDQSDGVMNGIKKMAEIIGIDVKDLLANSPLVVHGTTVATNA
LLEYNGAKVGLLTTEGFRDEIEFRRAYKESVFSPRLEAPYQIVPRRYRVGIPERLDHTGNVVTKLDEEAVRRAVRGFIQE
GVEAVAVCFLFSFMNPSHEIRVKEIIQEEAPGMFVSLSYEVLPQIREFERVSTTIVNAFTGPSMQSYLNHLDERFREDGF
TGELFVMQSNGGVQNVIQSGKFAAGGLLSGPAGGVTAASFIGEKSGYENVITVDMGGTSYDVSVIEKLNPAITTENWISR
YRVALPMMDIHTIGSGGGSIAWIDSGGALQVGPRSAGSNPGPACYGRGGEEPTVTDVNVFLGYINPDNFLGGEMKLDRSL
AEKAIRTRIAEPLGISTVEAALAISQIVNSDMSNAVHFVTTQRGHDPRNFALMAVGGAGAIHAGKQAEDLGIKTVIVPSL
APVFCALGDVAANLKVTELRTRFESLKNVDLQAMNADFEKMEQTAREKLGGQSVTNQYETRRFIDMRYAGEVHEVTVPVK
SRTRRITELNLEATAADFHDLHERMFAHKDPEHDIEILNLRLDLVGVREPLKLKEEQFEQEDPSKAKTGERDMYFDIEPA
KTPIFNGSMLEPGNLIVGPAIIEQWGTTIVVYPGHEALIDSYRNCVIEVKHAQQATRGGNA
>Mature_701_residues
MMNEKNQWVFGIDVGGTFTDLVAVNKDGKMVSTKTPSTPDQSDGVMNGIKKMAEIIGIDVKDLLANSPLVVHGTTVATNA
LLEYNGAKVGLLTTEGFRDEIEFRRAYKESVFSPRLEAPYQIVPRRYRVGIPERLDHTGNVVTKLDEEAVRRAVRGFIQE
GVEAVAVCFLFSFMNPSHEIRVKEIIQEEAPGMFVSLSYEVLPQIREFERVSTTIVNAFTGPSMQSYLNHLDERFREDGF
TGELFVMQSNGGVQNVIQSGKFAAGGLLSGPAGGVTAASFIGEKSGYENVITVDMGGTSYDVSVIEKLNPAITTENWISR
YRVALPMMDIHTIGSGGGSIAWIDSGGALQVGPRSAGSNPGPACYGRGGEEPTVTDVNVFLGYINPDNFLGGEMKLDRSL
AEKAIRTRIAEPLGISTVEAALAISQIVNSDMSNAVHFVTTQRGHDPRNFALMAVGGAGAIHAGKQAEDLGIKTVIVPSL
APVFCALGDVAANLKVTELRTRFESLKNVDLQAMNADFEKMEQTAREKLGGQSVTNQYETRRFIDMRYAGEVHEVTVPVK
SRTRRITELNLEATAADFHDLHERMFAHKDPEHDIEILNLRLDLVGVREPLKLKEEQFEQEDPSKAKTGERDMYFDIEPA
KTPIFNGSMLEPGNLIVGPAIIEQWGTTIVVYPGHEALIDSYRNCVIEVKHAQQATRGGNA

Specific function: HyuA and hyuB convert D- and L-substituted hydantoins to corresponding N-carbamyl-amino acids [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=752, Percent_Identity=28.9893617021277, Blast_Score=210, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI133901900, Length=720, Percent_Identity=26.8055555555556, Blast_Score=169, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6322634, Length=760, Percent_Identity=28.2894736842105, Blast_Score=210, Evalue=7e-55,
Organism=Drosophila melanogaster, GI45550492, Length=737, Percent_Identity=29.8507462686567, Blast_Score=239, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: 3.5.2.14

Molecular weight: Translated: 76701; Mature: 76701

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNEKNQWVFGIDVGGTFTDLVAVNKDGKMVSTKTPSTPDQSDGVMNGIKKMAEIIGIDV
CCCCCCCEEEEEECCCCEEEEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCH
KDLLANSPLVVHGTTVATNALLEYNGAKVGLLTTEGFRDEIEFRRAYKESVFSPRLEAPY
HHHHCCCCEEEECCHHHHHHHEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCH
QIVPRRYRVGIPERLDHTGNVVTKLDEEAVRRAVRGFIQEGVEAVAVCFLFSFMNPSHEI
HHCCCHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
RVKEIIQEEAPGMFVSLSYEVLPQIREFERVSTTIVNAFTGPSMQSYLNHLDERFREDGF
HHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
TGELFVMQSNGGVQNVIQSGKFAAGGLLSGPAGGVTAASFIGEKSGYENVITVDMGGTSY
CEEEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCC
DVSVIEKLNPAITTENWISRYRVALPMMDIHTIGSGGGSIAWIDSGGALQVGPRSAGSNP
HHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCEEEECCCCCCCCC
GPACYGRGGEEPTVTDVNVFLGYINPDNFLGGEMKLDRSLAEKAIRTRIAEPLGISTVEA
CCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
ALAISQIVNSDMSNAVHFVTTQRGHDPRNFALMAVGGAGAIHAGKQAEDLGIKTVIVPSL
HHHHHHHHCCHHHCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCHHHCCCEEEEHHHH
APVFCALGDVAANLKVTELRTRFESLKNVDLQAMNADFEKMEQTAREKLGGQSVTNQYET
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHCCCCHHHHHHHH
RRFIDMRYAGEVHEVTVPVKSRTRRITELNLEATAADFHDLHERMFAHKDPEHDIEILNL
HHHEEEEECCCEEEEEECHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEEE
RLDLVGVREPLKLKEEQFEQEDPSKAKTGERDMYFDIEPAKTPIFNGSMLEPGNLIVGPA
EEEEEECCCCHHHHHHHHCCCCCCHHCCCCCCEEEEECCCCCCCCCCCCCCCCCEEECHH
IIEQWGTTIVVYPGHEALIDSYRNCVIEVKHAQQATRGGNA
HHHHHCCEEEEECCHHHHHHHHHHHEEEEHHHHHHHCCCCC
>Mature Secondary Structure
MMNEKNQWVFGIDVGGTFTDLVAVNKDGKMVSTKTPSTPDQSDGVMNGIKKMAEIIGIDV
CCCCCCCEEEEEECCCCEEEEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCH
KDLLANSPLVVHGTTVATNALLEYNGAKVGLLTTEGFRDEIEFRRAYKESVFSPRLEAPY
HHHHCCCCEEEECCHHHHHHHEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCH
QIVPRRYRVGIPERLDHTGNVVTKLDEEAVRRAVRGFIQEGVEAVAVCFLFSFMNPSHEI
HHCCCHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
RVKEIIQEEAPGMFVSLSYEVLPQIREFERVSTTIVNAFTGPSMQSYLNHLDERFREDGF
HHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
TGELFVMQSNGGVQNVIQSGKFAAGGLLSGPAGGVTAASFIGEKSGYENVITVDMGGTSY
CEEEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCC
DVSVIEKLNPAITTENWISRYRVALPMMDIHTIGSGGGSIAWIDSGGALQVGPRSAGSNP
HHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCEEEECCCCCCCCC
GPACYGRGGEEPTVTDVNVFLGYINPDNFLGGEMKLDRSLAEKAIRTRIAEPLGISTVEA
CCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
ALAISQIVNSDMSNAVHFVTTQRGHDPRNFALMAVGGAGAIHAGKQAEDLGIKTVIVPSL
HHHHHHHHCCHHHCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCHHHCCCEEEEHHHH
APVFCALGDVAANLKVTELRTRFESLKNVDLQAMNADFEKMEQTAREKLGGQSVTNQYET
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHCCCCHHHHHHHH
RRFIDMRYAGEVHEVTVPVKSRTRRITELNLEATAADFHDLHERMFAHKDPEHDIEILNL
HHHEEEEECCCEEEEEECHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEEE
RLDLVGVREPLKLKEEQFEQEDPSKAKTGERDMYFDIEPAKTPIFNGSMLEPGNLIVGPA
EEEEEECCCCHHHHHHHHCCCCCCHHCCCCCCEEEEECCCCCCCCCCCCCCCCCEEECHH
IIEQWGTTIVVYPGHEALIDSYRNCVIEVKHAQQATRGGNA
HHHHHCCEEEEECCHHHHHHHHHHHEEEEHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1732229 [H]