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The map label for this gene is yveA [H]

Identifier: 52785707

GI number: 52785707

Start: 1910169

End: 1911746

Strand: Direct

Name: yveA [H]

Synonym: BLi01949

Alternate gene names: 52785707

Gene position: 1910169-1911746 (Clockwise)

Preceding gene: 52785706

Following gene: 52785711

Centisome position: 45.24

GC content: 48.16

Gene sequence:

>1578_bases
TTGTCAAATCAGGGCAATTTCAAAAAAACGATCTCTCTGCTTGACCTGATTTTGATCGGCATGGGTGCGATATTCGGATC
GGCTTGGCTGTTTGCCGTCAGCAATGTCGCTTCAAAAGCCGGGCCCGCTGGAAGCTTTTCGTGGATTATCGGCGGCGTCA
TTATCCTTTTAATCGGCCTCGTTTATGCCGAGCTGGGAGCTGCGTTGCCGCGGACGGGCGGGATTATCCGCTATCCGGTG
TATACCCACGGCCACCTTGTCGGATATTTGATTTCATTTATCACGATTGTTGCCTATACAAGCCTGATTTCGATCGAAGT
GACGGCTGTCAGGCAATACGTAGCCTATTGGTTTCCCGGTTTGACGATAAAAGGTTCTGAATCGCCGACGATTATCGGCT
GGCTTTTGCAGTTTGCGCTGCTTTGTTTGTTCTTTTTACTGAATTATTGGAGTGTCAAAGCGTTTGCGAAATCAAATTTA
ATTATTTCGGTTTTTAAGTATTTTGTTCCTTTGACAATCATCATCGTGTTGATATTCCATTTTAAATCGGCGAACTTTGC
GGGAGAATTTGCGCCGTTTGGCTTTGGCGGGGTTCAGACATCCATTTCGACCGGCGGGGTGATGTTCGCATACCTCGGTC
TACATCCGATCGTTTCGGTCGCCGGCGAAGTGAAAAATCCGCAGCGGAACATCCCGGTTGCTCTGCTGATTTGCATCATT
GTTTCGGCTTGCGTCTATACGATACTGCAAGTGGTGTTTATCGGAGCCATACCGACTGATATGCTAAATGACGGATGGAA
AGCGATCGGCAGGGAATTTTCTCTTCCGTTTAAAGATATCGCGGTGCTGCTCGGGATGGGCTGGCTTGCCACTCTTGTCG
TTCTGGATGCGATTTTATCACCCGGCGGAAACGGCAATATTTTTATGAATACAACATCGCGCTTGGTTTATGCATGGGCG
CGGAACGGCACATTGTTCAAAATCTTTGCCAAGGTGAATAAACCAACGGGAATTCCGCGTCCGTCGTTGTGGCTGTCGTT
TGCGCTCGCCGTTTTTTGGACGCTTCCGTTTCCGTCTTGGGACGCGCTCGTCAATGTTTGCTCTGTTGCCCTGATCCTCT
CCTATGCGATTGCTCCGGTTTCAGCAGCGGCGCTGAATGTGAATGCCAAGCAGCTTAAAAAGCCTCTGCAAATCAAAGGA
ATGGCTGTCATCGCTCCTGTCTCCTTCATATTTGCGTCGTATATCGTCTATTGGTCAGGGTGGAACACCGTGTCATGGCT
GCTCGGATCACAGCTTGTGATGTTTGCTGTTTATTGCGCGTGTAAAAAATACGTTCCGCAGGACGATGTTTCGTTTGCAC
AGCAGCTTAAATCAAGCTGGTGGATCGTCGGATATTATGTGATGCTCCTGATTTTATCGTTTCTGGGCTCATTCGGTAAC
GGCCTTGGCCTATTGAGAACGCCGGTCGATTTAATCTTGATCGCGCTAGGATCGATTGCGGTATTTTACTGGGCGAAATA
TACGGCGCTGCCAAAGGCAGTCATTGATTATGATGAGAAAAAAGAAGAAACCGTTTAA

Upstream 100 bases:

>100_bases
CGGGTTTTTTGTTGCTGCCGTAAGGAAGCGGGAAAAGTATACAGCGGCGCTTTTTGAACATACTACCTTCTATTAAATGT
ATTAAAAAGGAGGAAGTGTT

Downstream 100 bases:

>100_bases
GTATGAAAACCCCGCTGTATGGACTGCGGGGTATTCACACGTTTTTATTACAGTTGCGGAAGATCTTTAGCCGTTTCGGC
AGCTTTGGTATCAATCTGAA

Product: YveA

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: L-aspartate transporter [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MSNQGNFKKTISLLDLILIGMGAIFGSAWLFAVSNVASKAGPAGSFSWIIGGVIILLIGLVYAELGAALPRTGGIIRYPV
YTHGHLVGYLISFITIVAYTSLISIEVTAVRQYVAYWFPGLTIKGSESPTIIGWLLQFALLCLFFLLNYWSVKAFAKSNL
IISVFKYFVPLTIIIVLIFHFKSANFAGEFAPFGFGGVQTSISTGGVMFAYLGLHPIVSVAGEVKNPQRNIPVALLICII
VSACVYTILQVVFIGAIPTDMLNDGWKAIGREFSLPFKDIAVLLGMGWLATLVVLDAILSPGGNGNIFMNTTSRLVYAWA
RNGTLFKIFAKVNKPTGIPRPSLWLSFALAVFWTLPFPSWDALVNVCSVALILSYAIAPVSAAALNVNAKQLKKPLQIKG
MAVIAPVSFIFASYIVYWSGWNTVSWLLGSQLVMFAVYCACKKYVPQDDVSFAQQLKSSWWIVGYYVMLLILSFLGSFGN
GLGLLRTPVDLILIALGSIAVFYWAKYTALPKAVIDYDEKKEETV

Sequences:

>Translated_525_residues
MSNQGNFKKTISLLDLILIGMGAIFGSAWLFAVSNVASKAGPAGSFSWIIGGVIILLIGLVYAELGAALPRTGGIIRYPV
YTHGHLVGYLISFITIVAYTSLISIEVTAVRQYVAYWFPGLTIKGSESPTIIGWLLQFALLCLFFLLNYWSVKAFAKSNL
IISVFKYFVPLTIIIVLIFHFKSANFAGEFAPFGFGGVQTSISTGGVMFAYLGLHPIVSVAGEVKNPQRNIPVALLICII
VSACVYTILQVVFIGAIPTDMLNDGWKAIGREFSLPFKDIAVLLGMGWLATLVVLDAILSPGGNGNIFMNTTSRLVYAWA
RNGTLFKIFAKVNKPTGIPRPSLWLSFALAVFWTLPFPSWDALVNVCSVALILSYAIAPVSAAALNVNAKQLKKPLQIKG
MAVIAPVSFIFASYIVYWSGWNTVSWLLGSQLVMFAVYCACKKYVPQDDVSFAQQLKSSWWIVGYYVMLLILSFLGSFGN
GLGLLRTPVDLILIALGSIAVFYWAKYTALPKAVIDYDEKKEETV
>Mature_524_residues
SNQGNFKKTISLLDLILIGMGAIFGSAWLFAVSNVASKAGPAGSFSWIIGGVIILLIGLVYAELGAALPRTGGIIRYPVY
THGHLVGYLISFITIVAYTSLISIEVTAVRQYVAYWFPGLTIKGSESPTIIGWLLQFALLCLFFLLNYWSVKAFAKSNLI
ISVFKYFVPLTIIIVLIFHFKSANFAGEFAPFGFGGVQTSISTGGVMFAYLGLHPIVSVAGEVKNPQRNIPVALLICIIV
SACVYTILQVVFIGAIPTDMLNDGWKAIGREFSLPFKDIAVLLGMGWLATLVVLDAILSPGGNGNIFMNTTSRLVYAWAR
NGTLFKIFAKVNKPTGIPRPSLWLSFALAVFWTLPFPSWDALVNVCSVALILSYAIAPVSAAALNVNAKQLKKPLQIKGM
AVIAPVSFIFASYIVYWSGWNTVSWLLGSQLVMFAVYCACKKYVPQDDVSFAQQLKSSWWIVGYYVMLLILSFLGSFGNG
LGLLRTPVDLILIALGSIAVFYWAKYTALPKAVIDYDEKKEETV

Specific function: Uptake of L-aspartate with the concomitant import of a proton. Can also transport aspartate hydroxamate and L-glutamate with lower affinity and efficiency [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. AGT (TC 2.A.3.11) family [H]

Homologues:

Organism=Homo sapiens, GI187423910, Length=412, Percent_Identity=25.9708737864078, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI7657591, Length=412, Percent_Identity=25.9708737864078, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI114326544, Length=433, Percent_Identity=24.7113163972286, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI114326550, Length=433, Percent_Identity=24.7113163972286, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI258614005, Length=420, Percent_Identity=24.2857142857143, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI258614003, Length=420, Percent_Identity=24.2857142857143, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI110347453, Length=355, Percent_Identity=26.1971830985915, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI181337167, Length=351, Percent_Identity=26.2108262108262, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI258645169, Length=423, Percent_Identity=23.4042553191489, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI115648063, Length=364, Percent_Identity=25, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI115648022, Length=364, Percent_Identity=25, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI9790235, Length=435, Percent_Identity=26.2068965517241, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI186910308, Length=362, Percent_Identity=24.585635359116, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI186910306, Length=362, Percent_Identity=24.585635359116, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI186910304, Length=362, Percent_Identity=24.585635359116, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4507047, Length=212, Percent_Identity=32.5471698113208, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI33286428, Length=408, Percent_Identity=26.9607843137255, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1788480, Length=359, Percent_Identity=27.5766016713092, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87081708, Length=364, Percent_Identity=26.6483516483516, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790653, Length=349, Percent_Identity=22.9226361031519, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI2367353, Length=445, Percent_Identity=24.0449438202247, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1786302, Length=355, Percent_Identity=25.6338028169014, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87082250, Length=361, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789017, Length=337, Percent_Identity=24.0356083086053, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1786602, Length=357, Percent_Identity=25.2100840336134, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1786789, Length=420, Percent_Identity=22.8571428571429, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI48994972, Length=367, Percent_Identity=25.6130790190736, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI87081915, Length=417, Percent_Identity=22.3021582733813, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17531343, Length=396, Percent_Identity=24.4949494949495, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540018, Length=408, Percent_Identity=23.2843137254902, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17532491, Length=432, Percent_Identity=24.7685185185185, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71995388, Length=307, Percent_Identity=26.0586319218241, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71995382, Length=307, Percent_Identity=26.0586319218241, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI32566699, Length=351, Percent_Identity=26.2108262108262, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17533459, Length=407, Percent_Identity=25.0614250614251, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17568033, Length=355, Percent_Identity=25.9154929577465, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71990446, Length=377, Percent_Identity=24.4031830238727, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71993915, Length=337, Percent_Identity=26.1127596439169, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24667468, Length=403, Percent_Identity=25.3101736972705, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI221331183, Length=348, Percent_Identity=27.0114942528736, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17647653, Length=348, Percent_Identity=27.0114942528736, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24664379, Length=348, Percent_Identity=27.0114942528736, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24668806, Length=431, Percent_Identity=23.2018561484919, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356285, Length=431, Percent_Identity=23.2018561484919, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24668802, Length=431, Percent_Identity=23.2018561484919, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21357367, Length=354, Percent_Identity=24.8587570621469, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221512776, Length=398, Percent_Identity=23.8693467336683, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24666159, Length=398, Percent_Identity=23.8693467336683, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24651635, Length=422, Percent_Identity=23.696682464455, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24651633, Length=422, Percent_Identity=23.696682464455, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45550968, Length=415, Percent_Identity=23.855421686747, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19921172, Length=415, Percent_Identity=23.855421686747, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 57276; Mature: 57144

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCC
>Mature Secondary Structure 
SNQGNFKKTISLLDLILIGMGAIFGSAWLFAVSNVASKAGPAGSFSWIIGGVIILLIGL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VYAELGAALPRTGGIIRYPVYTHGHLVGYLISFITIVAYTSLISIEVTAVRQYVAYWFPG
HHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LTIKGSESPTIIGWLLQFALLCLFFLLNYWSVKAFAKSNLIISVFKYFVPLTIIIVLIFH
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FKSANFAGEFAPFGFGGVQTSISTGGVMFAYLGLHPIVSVAGEVKNPQRNIPVALLICII
HCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
VSACVYTILQVVFIGAIPTDMLNDGWKAIGREFSLPFKDIAVLLGMGWLATLVVLDAILS
HHHHHHHHHHHHHHHCCCHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
PGGNGNIFMNTTSRLVYAWARNGTLFKIFAKVNKPTGIPRPSLWLSFALAVFWTLPFPSW
CCCCCCEEEECCCCEEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCH
DALVNVCSVALILSYAIAPVSAAALNVNAKQLKKPLQIKGMAVIAPVSFIFASYIVYWSG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHCC
WNTVSWLLGSQLVMFAVYCACKKYVPQDDVSFAQQLKSSWWIVGYYVMLLILSFLGSFGN
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
GLGLLRTPVDLILIALGSIAVFYWAKYTALPKAVIDYDEKKEETV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 12730183 [H]