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The map label for this gene is cvrA [H]

Identifier: 52785698

GI number: 52785698

Start: 1901756

End: 1903225

Strand: Direct

Name: cvrA [H]

Synonym: BLi01940

Alternate gene names: 52785698

Gene position: 1901756-1903225 (Clockwise)

Preceding gene: 52785697

Following gene: 52785699

Centisome position: 45.04

GC content: 44.22

Gene sequence:

>1470_bases
TTGGAACACATTAATATGGAGCAGTTTATTTTATTAGCGGCCTTATTGCTGATTATCGGTGTACTGACAACGAAATTTTC
GACTAGGCTCGGAGTGCCCGCCCTTGTATTGTTCTTGATTGTCGGGATGATCATGGGGAGCGATGGTCTCGGAATTATTT
ATTTTAATAATCCCGAGCTTGCCCAGCTGATTGGAATTATCGCACTTGTCGTCATCCTTTTTGAAGGCGGTTTGCAAACA
AAGTGGTCTTCGGTCAAAGCGGTCGCCGTTCCTTCATTGTCGCTCGCGACGATTGGCGTTTTGCTGACCACCTGCGTGGT
TGCGGTTGCCGCCAAGCTGATTTTTAATGTTTCTTGGATGGAGGGCTTTTTATTCGGAGCGATTGTCGGCTCTACAGACG
CAGCCGCGATTTTCGCCGTATTGAAAGGCCAGAATATTAGAGACAGATTGAGCTCCACTCTAGAAGCAGAGTCGGGTACA
AATGATCCGATGGCGATGTTTTTGACTTTATCGCTCATCCAGCTGCTGACGGCTGACCATTCATCTTATTTCATGCTTGT
TATTTCATTTTTCTGGCAGATGGGAATGGGACTTTTGCTCGGATATTTACTCGGGCGGTTCGCCAGCTTTGCCATCAATA
AAATCAACTTGGATTCGAGCGGACTTTATCCGATCTTCGCTCTTGCTTTTGCGCTTCTTACCTACAGTCTTACAGATGTC
ATCGGGGCGAGCGGCTTACTGGCCGTCTACATTGCCGCGCTTGTCATCGGAAATCAAGATTTGACTTACCGACATTCCAT
TTTCAGGTTTAATGAAGGCTTTGCCTGGATGATGCAGATTTTGATGTTTATCATTCTCGGATTATTGGTTTTTCCTGCCC
AATTTTTATCCTTCGATATTATTTTCAAGGGCTTCTTGCTTTCCCTGATTTTAATTTTTATCGCCCGGCCGGTTGCCGTT
TTTCTGTCGACCATCAAAATGGGCTTTAATTTTAACGAAAAAATCTTCTTATCATGGGCCGGATTAAAAGGGGCAGTCCC
GATCGTTCTTGCAACATTTCCGATGACGATGGGGCTTGAAAACAGCCAATTGATCTTTAATGTCGTATTCTTCGTCGTTT
TAACATCGGCTTTGATCCAAGGGTCAACCATATCGGTCTTCGCAGAAAAATTGAAATTGAACGGACCGCAGAAAGTAGAA
GCGCCGCATTCGCTGGAGCTTGTTTCCATCGGCAAGGCGAACGCCGAAATTATCGAATTTGAAGTCGATGACCAAGCAGC
CATTACCAGGCAGATGCTGAAAGACATCAGCTTTCCAAAAGATGCCCTGATCAATGCGATCATCCGAAATGGGGATTTGG
TCACGCCGCATGGAGAAACGAAAATTAAACCAGGCGATATTTTATATATCCTCGTATCGAAAAAACAAAAGAAGGAACTG
AAAAAATTTTTAAACAGAGAATTTGATTAA

Upstream 100 bases:

>100_bases
GAACCATCGATTGTTACATATGTTTTATGAAGGTGCAAGTCCGGGTAATAGGACGGGGAAAAGCACCAGTATCGGTTAAG
ATTGGGAGGAGGATAAATGG

Downstream 100 bases:

>100_bases
GCCGTCGGAAAAGCACAGTACAAGGCAGACTTGCTCAGTATGTCACGAATAAAGGTCAATGAAGGGTACTGCACCGGTAT
TCTTCATTGGCCTTTTTTTG

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MEHINMEQFILLAALLLIIGVLTTKFSTRLGVPALVLFLIVGMIMGSDGLGIIYFNNPELAQLIGIIALVVILFEGGLQT
KWSSVKAVAVPSLSLATIGVLLTTCVVAVAAKLIFNVSWMEGFLFGAIVGSTDAAAIFAVLKGQNIRDRLSSTLEAESGT
NDPMAMFLTLSLIQLLTADHSSYFMLVISFFWQMGMGLLLGYLLGRFASFAINKINLDSSGLYPIFALAFALLTYSLTDV
IGASGLLAVYIAALVIGNQDLTYRHSIFRFNEGFAWMMQILMFIILGLLVFPAQFLSFDIIFKGFLLSLILIFIARPVAV
FLSTIKMGFNFNEKIFLSWAGLKGAVPIVLATFPMTMGLENSQLIFNVVFFVVLTSALIQGSTISVFAEKLKLNGPQKVE
APHSLELVSIGKANAEIIEFEVDDQAAITRQMLKDISFPKDALINAIIRNGDLVTPHGETKIKPGDILYILVSKKQKKEL
KKFLNREFD

Sequences:

>Translated_489_residues
MEHINMEQFILLAALLLIIGVLTTKFSTRLGVPALVLFLIVGMIMGSDGLGIIYFNNPELAQLIGIIALVVILFEGGLQT
KWSSVKAVAVPSLSLATIGVLLTTCVVAVAAKLIFNVSWMEGFLFGAIVGSTDAAAIFAVLKGQNIRDRLSSTLEAESGT
NDPMAMFLTLSLIQLLTADHSSYFMLVISFFWQMGMGLLLGYLLGRFASFAINKINLDSSGLYPIFALAFALLTYSLTDV
IGASGLLAVYIAALVIGNQDLTYRHSIFRFNEGFAWMMQILMFIILGLLVFPAQFLSFDIIFKGFLLSLILIFIARPVAV
FLSTIKMGFNFNEKIFLSWAGLKGAVPIVLATFPMTMGLENSQLIFNVVFFVVLTSALIQGSTISVFAEKLKLNGPQKVE
APHSLELVSIGKANAEIIEFEVDDQAAITRQMLKDISFPKDALINAIIRNGDLVTPHGETKIKPGDILYILVSKKQKKEL
KKFLNREFD
>Mature_489_residues
MEHINMEQFILLAALLLIIGVLTTKFSTRLGVPALVLFLIVGMIMGSDGLGIIYFNNPELAQLIGIIALVVILFEGGLQT
KWSSVKAVAVPSLSLATIGVLLTTCVVAVAAKLIFNVSWMEGFLFGAIVGSTDAAAIFAVLKGQNIRDRLSSTLEAESGT
NDPMAMFLTLSLIQLLTADHSSYFMLVISFFWQMGMGLLLGYLLGRFASFAINKINLDSSGLYPIFALAFALLTYSLTDV
IGASGLLAVYIAALVIGNQDLTYRHSIFRFNEGFAWMMQILMFIILGLLVFPAQFLSFDIIFKGFLLSLILIFIARPVAV
FLSTIKMGFNFNEKIFLSWAGLKGAVPIVLATFPMTMGLENSQLIFNVVFFVVLTSALIQGSTISVFAEKLKLNGPQKVE
APHSLELVSIGKANAEIIEFEVDDQAAITRQMLKDISFPKDALINAIIRNGDLVTPHGETKIKPGDILYILVSKKQKKEL
KKFLNREFD

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=458, Percent_Identity=40.8296943231441, Blast_Score=328, Evalue=4e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 53539; Mature: 53539

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHINMEQFILLAALLLIIGVLTTKFSTRLGVPALVLFLIVGMIMGSDGLGIIYFNNPEL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCH
AQLIGIIALVVILFEGGLQTKWSSVKAVAVPSLSLATIGVLLTTCVVAVAAKLIFNVSWM
HHHHHHHHHHHHHHCCCCCCHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGFLFGAIVGSTDAAAIFAVLKGQNIRDRLSSTLEAESGTNDPMAMFLTLSLIQLLTADH
HHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
SSYFMLVISFFWQMGMGLLLGYLLGRFASFAINKINLDSSGLYPIFALAFALLTYSLTDV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHH
IGASGLLAVYIAALVIGNQDLTYRHSIFRFNEGFAWMMQILMFIILGLLVFPAQFLSFDI
HCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFKGFLLSLILIFIARPVAVFLSTIKMGFNFNEKIFLSWAGLKGAVPIVLATFPMTMGLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCC
NSQLIFNVVFFVVLTSALIQGSTISVFAEKLKLNGPQKVEAPHSLELVSIGKANAEIIEF
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEEE
EVDDQAAITRQMLKDISFPKDALINAIIRNGDLVTPHGETKIKPGDILYILVSKKQKKEL
ECCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCEEEEEECCHHHHHH
KKFLNREFD
HHHHCCCCC
>Mature Secondary Structure
MEHINMEQFILLAALLLIIGVLTTKFSTRLGVPALVLFLIVGMIMGSDGLGIIYFNNPEL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCH
AQLIGIIALVVILFEGGLQTKWSSVKAVAVPSLSLATIGVLLTTCVVAVAAKLIFNVSWM
HHHHHHHHHHHHHHCCCCCCHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGFLFGAIVGSTDAAAIFAVLKGQNIRDRLSSTLEAESGTNDPMAMFLTLSLIQLLTADH
HHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
SSYFMLVISFFWQMGMGLLLGYLLGRFASFAINKINLDSSGLYPIFALAFALLTYSLTDV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHH
IGASGLLAVYIAALVIGNQDLTYRHSIFRFNEGFAWMMQILMFIILGLLVFPAQFLSFDI
HCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFKGFLLSLILIFIARPVAVFLSTIKMGFNFNEKIFLSWAGLKGAVPIVLATFPMTMGLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCC
NSQLIFNVVFFVVLTSALIQGSTISVFAEKLKLNGPQKVEAPHSLELVSIGKANAEIIEF
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEEE
EVDDQAAITRQMLKDISFPKDALINAIIRNGDLVTPHGETKIKPGDILYILVSKKQKKEL
ECCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCEEEEEECCHHHHHH
KKFLNREFD
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA