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The map label for this gene is mutL

Identifier: 52785687

GI number: 52785687

Start: 1890845

End: 1892755

Strand: Direct

Name: mutL

Synonym: BLi01929

Alternate gene names: 52785687

Gene position: 1890845-1892755 (Clockwise)

Preceding gene: 52785686

Following gene: 52785688

Centisome position: 44.78

GC content: 51.91

Gene sequence:

>1911_bases
TTGGCAAAAATTGTTCAGCTGCCTGACGATTTATCGAATAAAATCGCGGCGGGTGAAGTAGTGGAAAGGCCGGCGTCGGT
CGTCAAAGAGCTTGTCGAAAATGCAATCGATGCGAACAGCTCCGTGATTGAAATCGATGTTGAAGAAGCGGGTCTCGCCT
CGATTAAAGTGCTTGACGACGGCGAAGGGATGGACGCAGAAGACTGCAGAACGGCTTTTTTGCGTCATGCCACAAGCAAA
ATCAAAGACGAAAACGACCTGTTTCGCGTCAGAACGCTCGGATTTCGCGGAGAAGCTTTGCCAAGTATCGCGTCTGTCTC
ACACTTAAGCATTAAAACGAGCACCGGAGAAGGGGCAGGCACCCATTTGACGCTGCAGGGGGGAAGAATCATTTCCGAGC
AAAAAGCGCCAAGCCGCAGAGGAACCGAAATTACGGTTACCAACCTGTTTTTCAATACGCCGGCAAGGCTGAAATACATG
AAAACGATTCATACCGAGCTTGGCAACATCACAGATGTGGTCAACAGAATCGCCCTTGCCCATCCGGAAGTTTCGATCAG
GCTGCGTCATCAAGGGAAAACGCTTCTGCAGACAAACGGAAACGGCGATGTCCGCCACGTGCTTGCGGCGATTTACGGCA
CGGCGGTTGCCAAAAAAATGCTCCCGCTTGAAGCGAGATCTCTTGACTTTGAAGTGAAGGGCTATATCGCTCTTCCTGAA
ATTACGCGCGCCTCGCGAAATTACATGTCATCTGTCGTCAACGGCAGATACATTAAAAACTTCCCGCTCGTAAAAGCGAT
CCACGAGGGCTACCATACGCTTCTTCCGATCGGCCGCCATCCGATCACGTTCATTGAAATCAACATGGACCCGCTCCTTG
TGGACGTCAACGTGCACCCGTCAAAGCTGGAGGTCAGGCTGAGCAAAGAGACGGAGCTTCACGAGCTGATTCGCGACGCC
ATCAAAGACGTCTTTAAACAGCAGCAGCTCATTCCAAGCGTGCAGGTCCCGAAAAAAACCGCACCTCTGATCAATAAACC
AGAGCAGCAAAAGCTTGATTTCGACCAGGTACGAGAACCGGCACCTCTTTCTGATTCTGATGTTGAAAGAGAGTATAAGC
CGGAGCCTTCGTTTTCGGCGATGAAATTAAGCTCGCTTGTCAAAGACCCGCCGCCTTCCGCTCCCGTAGAGCGCGAAGAA
AACGTAATGCAGGACACCGAGCCTGAATGGCCCGGAGCTGAAGAGTATACGCCTGAAGCCGCGCCGGCCGTACAAGCAGA
ACCGGAACAGGCAGGAGAGAACGTCCAGGACGAAGAGACGCCAAAAGAAAGGGTGCCGATCATGTATCCGATCGGCCAAA
TGCACGGCACCTACATACTTGCCCAAAATGAAAACGGGCTGTACATCATCGATCAGCACGCCGCACAGGAGCGGATCAAA
TACGAATATTTCCGTGAAAAAGTCGGGGAAGTCGAATCGGAAGTCCAGGACCTGCTTGTGCCGCTGACATTCCATTATTC
AAAAAATGAAGCGCTGACGATCGACCAGCACTTGGACGATTTAGCCAAAGTCGGCGTCTTTCTCGAATCGTTCGGCGCCG
GCAGCTATATCGTCCGATGCCACCCGACATGGTTTCCGAAAGGGGAAGAAACGACGATCATTGAAGACATCATTCAGCAG
GTCCTTGATGACCGCACGATCGACATCAAAAAACTGCGCGAAGAAGCCGCAATCATGATGAGCTGCAAAGGCTCCATCAA
AGCCAATCATCACCTGCGGGACGACGAAATCACCGCCCTGCTCGATGAGCTGCGCAGAACATCCGACCCTTTCACATGCC
CGCACGGCCGGCCGATCATCATCCACTACTCCACCTATGAGATGGAGAAGATGTTTAAGCGGGTAATGTAA

Upstream 100 bases:

>100_bases
AATTTAAAGCGATGGATCTGCTCGATATGACGCCTATACAAGTCATGAATGAACTGTACAGGCTGCAAAAAAAATTAAAG
TAACAAAGAGGTGAGCCAAC

Downstream 100 bases:

>100_bases
TTTTTAATCGCTCACAACCTTTGGTATATCAATGGCTGTGGGCGATTTTGATTTTATTGACCACATTTTGACCGCATTAA
CACTAGACGGCCTGCTTTAA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 636; Mature: 635

Protein sequence:

>636_residues
MAKIVQLPDDLSNKIAAGEVVERPASVVKELVENAIDANSSVIEIDVEEAGLASIKVLDDGEGMDAEDCRTAFLRHATSK
IKDENDLFRVRTLGFRGEALPSIASVSHLSIKTSTGEGAGTHLTLQGGRIISEQKAPSRRGTEITVTNLFFNTPARLKYM
KTIHTELGNITDVVNRIALAHPEVSIRLRHQGKTLLQTNGNGDVRHVLAAIYGTAVAKKMLPLEARSLDFEVKGYIALPE
ITRASRNYMSSVVNGRYIKNFPLVKAIHEGYHTLLPIGRHPITFIEINMDPLLVDVNVHPSKLEVRLSKETELHELIRDA
IKDVFKQQQLIPSVQVPKKTAPLINKPEQQKLDFDQVREPAPLSDSDVEREYKPEPSFSAMKLSSLVKDPPPSAPVEREE
NVMQDTEPEWPGAEEYTPEAAPAVQAEPEQAGENVQDEETPKERVPIMYPIGQMHGTYILAQNENGLYIIDQHAAQERIK
YEYFREKVGEVESEVQDLLVPLTFHYSKNEALTIDQHLDDLAKVGVFLESFGAGSYIVRCHPTWFPKGEETTIIEDIIQQ
VLDDRTIDIKKLREEAAIMMSCKGSIKANHHLRDDEITALLDELRRTSDPFTCPHGRPIIIHYSTYEMEKMFKRVM

Sequences:

>Translated_636_residues
MAKIVQLPDDLSNKIAAGEVVERPASVVKELVENAIDANSSVIEIDVEEAGLASIKVLDDGEGMDAEDCRTAFLRHATSK
IKDENDLFRVRTLGFRGEALPSIASVSHLSIKTSTGEGAGTHLTLQGGRIISEQKAPSRRGTEITVTNLFFNTPARLKYM
KTIHTELGNITDVVNRIALAHPEVSIRLRHQGKTLLQTNGNGDVRHVLAAIYGTAVAKKMLPLEARSLDFEVKGYIALPE
ITRASRNYMSSVVNGRYIKNFPLVKAIHEGYHTLLPIGRHPITFIEINMDPLLVDVNVHPSKLEVRLSKETELHELIRDA
IKDVFKQQQLIPSVQVPKKTAPLINKPEQQKLDFDQVREPAPLSDSDVEREYKPEPSFSAMKLSSLVKDPPPSAPVEREE
NVMQDTEPEWPGAEEYTPEAAPAVQAEPEQAGENVQDEETPKERVPIMYPIGQMHGTYILAQNENGLYIIDQHAAQERIK
YEYFREKVGEVESEVQDLLVPLTFHYSKNEALTIDQHLDDLAKVGVFLESFGAGSYIVRCHPTWFPKGEETTIIEDIIQQ
VLDDRTIDIKKLREEAAIMMSCKGSIKANHHLRDDEITALLDELRRTSDPFTCPHGRPIIIHYSTYEMEKMFKRVM
>Mature_635_residues
AKIVQLPDDLSNKIAAGEVVERPASVVKELVENAIDANSSVIEIDVEEAGLASIKVLDDGEGMDAEDCRTAFLRHATSKI
KDENDLFRVRTLGFRGEALPSIASVSHLSIKTSTGEGAGTHLTLQGGRIISEQKAPSRRGTEITVTNLFFNTPARLKYMK
TIHTELGNITDVVNRIALAHPEVSIRLRHQGKTLLQTNGNGDVRHVLAAIYGTAVAKKMLPLEARSLDFEVKGYIALPEI
TRASRNYMSSVVNGRYIKNFPLVKAIHEGYHTLLPIGRHPITFIEINMDPLLVDVNVHPSKLEVRLSKETELHELIRDAI
KDVFKQQQLIPSVQVPKKTAPLINKPEQQKLDFDQVREPAPLSDSDVEREYKPEPSFSAMKLSSLVKDPPPSAPVEREEN
VMQDTEPEWPGAEEYTPEAAPAVQAEPEQAGENVQDEETPKERVPIMYPIGQMHGTYILAQNENGLYIIDQHAAQERIKY
EYFREKVGEVESEVQDLLVPLTFHYSKNEALTIDQHLDDLAKVGVFLESFGAGSYIVRCHPTWFPKGEETTIIEDIIQQV
LDDRTIDIKKLREEAAIMMSCKGSIKANHHLRDDEITALLDELRRTSDPFTCPHGRPIIIHYSTYEMEKMFKRVM

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=349, Percent_Identity=33.2378223495702, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI4505911, Length=326, Percent_Identity=29.1411042944785, Blast_Score=134, Evalue=4e-31,
Organism=Homo sapiens, GI4505913, Length=341, Percent_Identity=26.9794721407625, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI189458898, Length=326, Percent_Identity=29.1411042944785, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI310128478, Length=341, Percent_Identity=26.9794721407625, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI263191589, Length=255, Percent_Identity=29.4117647058824, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI189458896, Length=317, Percent_Identity=28.391167192429, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI91992162, Length=347, Percent_Identity=26.2247838616715, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI91992160, Length=347, Percent_Identity=26.2247838616715, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI310128480, Length=307, Percent_Identity=25.7328990228013, Blast_Score=105, Evalue=2e-22,
Organism=Escherichia coli, GI1790612, Length=545, Percent_Identity=31.3761467889908, Blast_Score=233, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71991825, Length=401, Percent_Identity=32.4189526184539, Blast_Score=178, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17562796, Length=359, Percent_Identity=27.2980501392758, Blast_Score=131, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6323819, Length=356, Percent_Identity=30.6179775280899, Blast_Score=167, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6324247, Length=401, Percent_Identity=28.6783042394015, Blast_Score=150, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6325093, Length=550, Percent_Identity=21.8181818181818, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323063, Length=365, Percent_Identity=23.8356164383562, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17136968, Length=330, Percent_Identity=33.9393939393939, Blast_Score=189, Evalue=7e-48,
Organism=Drosophila melanogaster, GI17136970, Length=459, Percent_Identity=27.2331154684096, Blast_Score=129, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_BACLD (Q65JE1)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_079102.1
- RefSeq:   YP_091516.1
- HSSP:   P23367
- ProteinModelPortal:   Q65JE1
- SMR:   Q65JE1
- STRING:   Q65JE1
- EnsemblBacteria:   EBBACT00000055076
- EnsemblBacteria:   EBBACT00000062438
- GeneID:   3031148
- GeneID:   3098957
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi01929
- KEGG:   bli:BL03664
- NMPDR:   fig|279010.5.peg.2632
- eggNOG:   COG0323
- GeneTree:   EBGT00050000002475
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- ProtClustDB:   PRK00095
- BioCyc:   BLIC279010-1:BLI01929-MONOMER
- BioCyc:   BLIC279010:BL03664-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 71390; Mature: 71259

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIVQLPDDLSNKIAAGEVVERPASVVKELVENAIDANSSVIEIDVEEAGLASIKVLDD
CCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEC
GEGMDAEDCRTAFLRHATSKIKDENDLFRVRTLGFRGEALPSIASVSHLSIKTSTGEGAG
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHCCEEEEEEECCCCCCC
THLTLQGGRIISEQKAPSRRGTEITVTNLFFNTPARLKYMKTIHTELGNITDVVNRIALA
CEEEEECCEEECCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHC
HPEVSIRLRHQGKTLLQTNGNGDVRHVLAAIYGTAVAKKMLPLEARSLDFEVKGYIALPE
CCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEEEEEECCH
ITRASRNYMSSVVNGRYIKNFPLVKAIHEGYHTLLPIGRHPITFIEINMDPLLVDVNVHP
HHHHHHHHHHHHHCCCEECCCHHHHHHHCCHHHCCCCCCCCEEEEEEECCEEEEEEECCC
SKLEVRLSKETELHELIRDAIKDVFKQQQLIPSVQVPKKTAPLINKPEQQKLDFDQVREP
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHCCCC
APLSDSDVEREYKPEPSFSAMKLSSLVKDPPPSAPVEREENVMQDTEPEWPGAEEYTPEA
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCC
APAVQAEPEQAGENVQDEETPKERVPIMYPIGQMHGTYILAQNENGLYIIDQHAAQERIK
CCCCCCCHHHHCCCCCCCCCHHHCCCEEEECCCCCCEEEEEECCCCEEEEECHHHHHHHH
YEYFREKVGEVESEVQDLLVPLTFHYSKNEALTIDQHLDDLAKVGVFLESFGAGSYIVRC
HHHHHHHHHHHHHHHHHHEEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCCEEEEE
HPTWFPKGEETTIIEDIIQQVLDDRTIDIKKLREEAAIMMSCKGSIKANHHLRDDEITAL
CCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHH
LDELRRTSDPFTCPHGRPIIIHYSTYEMEKMFKRVM
HHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHCC
>Mature Secondary Structure 
AKIVQLPDDLSNKIAAGEVVERPASVVKELVENAIDANSSVIEIDVEEAGLASIKVLDD
CCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEC
GEGMDAEDCRTAFLRHATSKIKDENDLFRVRTLGFRGEALPSIASVSHLSIKTSTGEGAG
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHCCEEEEEEECCCCCCC
THLTLQGGRIISEQKAPSRRGTEITVTNLFFNTPARLKYMKTIHTELGNITDVVNRIALA
CEEEEECCEEECCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHC
HPEVSIRLRHQGKTLLQTNGNGDVRHVLAAIYGTAVAKKMLPLEARSLDFEVKGYIALPE
CCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEEEEEECCH
ITRASRNYMSSVVNGRYIKNFPLVKAIHEGYHTLLPIGRHPITFIEINMDPLLVDVNVHP
HHHHHHHHHHHHHCCCEECCCHHHHHHHCCHHHCCCCCCCCEEEEEEECCEEEEEEECCC
SKLEVRLSKETELHELIRDAIKDVFKQQQLIPSVQVPKKTAPLINKPEQQKLDFDQVREP
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHCCCC
APLSDSDVEREYKPEPSFSAMKLSSLVKDPPPSAPVEREENVMQDTEPEWPGAEEYTPEA
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCC
APAVQAEPEQAGENVQDEETPKERVPIMYPIGQMHGTYILAQNENGLYIIDQHAAQERIK
CCCCCCCHHHHCCCCCCCCCHHHCCCEEEECCCCCCEEEEEECCCCEEEEECHHHHHHHH
YEYFREKVGEVESEVQDLLVPLTFHYSKNEALTIDQHLDDLAKVGVFLESFGAGSYIVRC
HHHHHHHHHHHHHHHHHHEEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCCEEEEE
HPTWFPKGEETTIIEDIIQQVLDDRTIDIKKLREEAAIMMSCKGSIKANHHLRDDEITAL
CCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHH
LDELRRTSDPFTCPHGRPIIIHYSTYEMEKMFKRVM
HHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA