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The map label for this gene is tdh

Identifier: 52785681

GI number: 52785681

Start: 1882979

End: 1884019

Strand: Direct

Name: tdh

Synonym: BLi01923

Alternate gene names: 52785681

Gene position: 1882979-1884019 (Clockwise)

Preceding gene: 52785680

Following gene: 52785682

Centisome position: 44.59

GC content: 50.43

Gene sequence:

>1041_bases
TTGGACGGAAATATGAAAGCGCTTATCAAGAAGCCGGGGGAGCCGGGCGCCAGCTTCGAGCTCGTCCCGATTCCGAAGAT
CGACAAACACGAGGTCCTGATCAAAGTCAAAGCCGCATCGATTTGCGGAACCGATGTCCATATTTATAATTGGGATGAAT
GGGCGAAAAGCAGGGTTAAACCGCCTTATGTGTTCGGCCACGAATTTTCCGGCGAAGTTGTTCAAGTGGGGGAAAATGTG
ACTACGGTAAAAGAAGGGGAGTATGTTTCGGCAGAAACGCACATCGTTTGCGGAAAGTGCCTGCCGTGTTTGACCGGAAA
AGAGCATGTCTGCAAAAAAACGCTGATTCTCGGTGTCGATACAGACGGCTGTTTTGCTGAATATGTCAAAATGCCCGCCG
CAAACATTTGGAAAAACCCGGCCGGCATGCCTGAGGATCTCGCTTCTATTCAAGAACCGCTCGGAAATGCCGTGCATACG
GTTCTGACGGGAATGACGGCTGGAGTGAAAGTCGCTGTCGTCGGCTGCGGACCGATCGGACTGATGGCCGTGGCAGTTGC
AAAAGCGTCTGGGGCGGCGCAGGTGATCGCCATCGATAAAAATGAATACAGGCTCGACCTTGCATTGCAAATGGGGGCAA
CCGATATCATCTCCGTTGAAAAAGAAGATCCGCTCAAAAATGTAAGCGCTTTAACAAATGGTGAAGGGGCGGACTTGGTT
TGCGAAATGTCAGGCCATCCGACGGCAATCCGCCAAAGTTTAAAAATGGCGGCAAACGGAGGACGGGTTCATGTCTTAAG
CTTGCCTGAGCATCCCGTATGCATCGACATGACAAATGATATCGTCTTTAAAGGATTGACGGTCCAAGGAATTACCGGCC
GCAAAATGTTTGAAACGTGGAGACAGGTCAGCGGTCTCCTCCAATCCGGCACGATTCAAATCAAGCCTGTCATCACTCAC
CGTTTCCCGATGGAAGAGTTTGAAAAAGGCTTTGAACTGATGAGAAAAGGGCAATGCGGCAAAGTCGTACTGATACCGTA
G

Upstream 100 bases:

>100_bases
GTTCATCTGTTTTCTCCAGAAGGACACTGGTGTTTACCAAGACTGATTATCGTGCTACAATCCTTTTGTAAAGCGATTTT
ACAAAGGGGGTCTGTTCATC

Downstream 100 bases:

>100_bases
AAAGGAGAGATTAATATGAAAGAATTCAATTTTTTAGCTTCCGAGCTTAATACAATGAAAGAAAACGGAACTTTTCAAGA
GCTGCCGATCATCGAATCAA

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MDGNMKALIKKPGEPGASFELVPIPKIDKHEVLIKVKAASICGTDVHIYNWDEWAKSRVKPPYVFGHEFSGEVVQVGENV
TTVKEGEYVSAETHIVCGKCLPCLTGKEHVCKKTLILGVDTDGCFAEYVKMPAANIWKNPAGMPEDLASIQEPLGNAVHT
VLTGMTAGVKVAVVGCGPIGLMAVAVAKASGAAQVIAIDKNEYRLDLALQMGATDIISVEKEDPLKNVSALTNGEGADLV
CEMSGHPTAIRQSLKMAANGGRVHVLSLPEHPVCIDMTNDIVFKGLTVQGITGRKMFETWRQVSGLLQSGTIQIKPVITH
RFPMEEFEKGFELMRKGQCGKVVLIP

Sequences:

>Translated_346_residues
MDGNMKALIKKPGEPGASFELVPIPKIDKHEVLIKVKAASICGTDVHIYNWDEWAKSRVKPPYVFGHEFSGEVVQVGENV
TTVKEGEYVSAETHIVCGKCLPCLTGKEHVCKKTLILGVDTDGCFAEYVKMPAANIWKNPAGMPEDLASIQEPLGNAVHT
VLTGMTAGVKVAVVGCGPIGLMAVAVAKASGAAQVIAIDKNEYRLDLALQMGATDIISVEKEDPLKNVSALTNGEGADLV
CEMSGHPTAIRQSLKMAANGGRVHVLSLPEHPVCIDMTNDIVFKGLTVQGITGRKMFETWRQVSGLLQSGTIQIKPVITH
RFPMEEFEKGFELMRKGQCGKVVLIP
>Mature_346_residues
MDGNMKALIKKPGEPGASFELVPIPKIDKHEVLIKVKAASICGTDVHIYNWDEWAKSRVKPPYVFGHEFSGEVVQVGENV
TTVKEGEYVSAETHIVCGKCLPCLTGKEHVCKKTLILGVDTDGCFAEYVKMPAANIWKNPAGMPEDLASIQEPLGNAVHT
VLTGMTAGVKVAVVGCGPIGLMAVAVAKASGAAQVIAIDKNEYRLDLALQMGATDIISVEKEDPLKNVSALTNGEGADLV
CEMSGHPTAIRQSLKMAANGGRVHVLSLPEHPVCIDMTNDIVFKGLTVQGITGRKMFETWRQVSGLLQSGTIQIKPVITH
RFPMEEFEKGFELMRKGQCGKVVLIP

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI156627571, Length=345, Percent_Identity=29.2753623188406, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4501929, Length=368, Percent_Identity=28.5326086956522, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI156523966, Length=372, Percent_Identity=25.5376344086022, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4501933, Length=367, Percent_Identity=28.3378746594005, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI34577061, Length=367, Percent_Identity=28.3378746594005, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI4501939, Length=365, Percent_Identity=25.4794520547945, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI71743840, Length=356, Percent_Identity=27.5280898876405, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI262073058, Length=356, Percent_Identity=27.5280898876405, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI71565154, Length=375, Percent_Identity=26.6666666666667, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=48.2352941176471, Blast_Score=331, Evalue=5e-92,
Organism=Escherichia coli, GI1788075, Length=360, Percent_Identity=30.2777777777778, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1787863, Length=345, Percent_Identity=31.8840579710145, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1788073, Length=333, Percent_Identity=29.1291291291291, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI226510992, Length=313, Percent_Identity=30.0319488817891, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1786825, Length=394, Percent_Identity=28.1725888324873, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI87082125, Length=342, Percent_Identity=30.1169590643275, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1788407, Length=340, Percent_Identity=27.9411764705882, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790718, Length=329, Percent_Identity=25.8358662613982, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786552, Length=382, Percent_Identity=30.8900523560209, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI87081918, Length=322, Percent_Identity=30.4347826086957, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562876, Length=336, Percent_Identity=28.2738095238095, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17562878, Length=203, Percent_Identity=33.0049261083744, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25146526, Length=384, Percent_Identity=26.3020833333333, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=386, Percent_Identity=26.1658031088083, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=281, Percent_Identity=27.0462633451957, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=26.530612244898, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562582, Length=291, Percent_Identity=25.085910652921, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=350, Percent_Identity=30.2857142857143, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6319955, Length=350, Percent_Identity=30.2857142857143, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323099, Length=340, Percent_Identity=30.8823529411765, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=28.8409703504043, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319258, Length=366, Percent_Identity=28.6885245901639, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6324486, Length=329, Percent_Identity=31.9148936170213, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323961, Length=326, Percent_Identity=32.2085889570552, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319621, Length=340, Percent_Identity=27.3529411764706, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=329, Percent_Identity=29.1793313069909, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=255, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323980, Length=271, Percent_Identity=27.3062730627306, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17137530, Length=329, Percent_Identity=29.1793313069909, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI17737897, Length=329, Percent_Identity=27.9635258358663, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI17737895, Length=353, Percent_Identity=27.1954674220963, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TDH_BACLD (Q65JE7)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_079096.1
- RefSeq:   YP_091510.1
- ProteinModelPortal:   Q65JE7
- SMR:   Q65JE7
- STRING:   Q65JE7
- EnsemblBacteria:   EBBACT00000054394
- EnsemblBacteria:   EBBACT00000060787
- GeneID:   3031140
- GeneID:   3099859
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi01923
- KEGG:   bli:BL03658
- NMPDR:   fig|279010.5.peg.2626
- eggNOG:   COG1063
- GeneTree:   EBGT00050000000383
- HOGENOM:   HBG753318
- OMA:   CFAEYVK
- ProtClustDB:   PRK05396
- BioCyc:   BLIC279010-1:BLI01923-MONOMER
- BioCyc:   BLIC279010:BL03658-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00627
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695
- TIGRFAMs:   TIGR00692

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.103

Molecular weight: Translated: 37241; Mature: 37241

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGNMKALIKKPGEPGASFELVPIPKIDKHEVLIKVKAASICGTDVHIYNWDEWAKSRVK
CCCCEEEEEECCCCCCCCEEEEECCCCCCCEEEEEEEEEEECCCEEEEEECHHHHHHCCC
PPYVFGHEFSGEVVQVGENVTTVKEGEYVSAETHIVCGKCLPCLTGKEHVCKKTLILGVD
CCEEECCCCCCCEEEECCCEEEEECCCEECCCCEEEECCCCCCCCCCHHHCCEEEEEEEC
TDGCFAEYVKMPAANIWKNPAGMPEDLASIQEPLGNAVHTVLTGMTAGVKVAVVGCGPIG
CCCHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHH
LMAVAVAKASGAAQVIAIDKNEYRLDLALQMGATDIISVEKEDPLKNVSALTNGEGADLV
HHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCEEEEECCCCCHHHHHHHCCCCCCEEE
CEMSGHPTAIRQSLKMAANGGRVHVLSLPEHPVCIDMTNDIVFKGLTVQGITGRKMFETW
EEECCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCEEEECEEEECCCCHHHHHHH
RQVSGLLQSGTIQIKPVITHRFPMEEFEKGFELMRKGQCGKVVLIP
HHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MDGNMKALIKKPGEPGASFELVPIPKIDKHEVLIKVKAASICGTDVHIYNWDEWAKSRVK
CCCCEEEEEECCCCCCCCEEEEECCCCCCCEEEEEEEEEEECCCEEEEEECHHHHHHCCC
PPYVFGHEFSGEVVQVGENVTTVKEGEYVSAETHIVCGKCLPCLTGKEHVCKKTLILGVD
CCEEECCCCCCCEEEECCCEEEEECCCEECCCCEEEECCCCCCCCCCHHHCCEEEEEEEC
TDGCFAEYVKMPAANIWKNPAGMPEDLASIQEPLGNAVHTVLTGMTAGVKVAVVGCGPIG
CCCHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHH
LMAVAVAKASGAAQVIAIDKNEYRLDLALQMGATDIISVEKEDPLKNVSALTNGEGADLV
HHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCEEEEECCCCCHHHHHHHCCCCCCEEE
CEMSGHPTAIRQSLKMAANGGRVHVLSLPEHPVCIDMTNDIVFKGLTVQGITGRKMFETW
EEECCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCEEEECEEEECCCCHHHHHHH
RQVSGLLQSGTIQIKPVITHRFPMEEFEKGFELMRKGQCGKVVLIP
HHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA